View Full Version : Nutritional Therapies Can Treat Common Mental Disorders

12-22-11, 09:02 AM
Nutritional supplements in appropriate doses can help treat the four most common mental disorders – major depression, bipolar disorder, schizophrenia and obsessive compulsive disorder (OCD), according to a study published in the Nutrition Journal as well as a number of other studies done over time

Normally, mental disorders are treated using pharmaceutical drugs. Although these drugs are highly effective, some of them come with severe side effects. For example, lithium that is used in the treatment of bipolar disorder causes side effects such as weight gain, increased thirst and urination, muscle weakness, hand tremors, hair loss, impaired memory, drowsiness and decreased thyroid function.

Earlier studies have shown that a lack of certain dietary nutrients, especially, essential vitamins, minerals, and omega-3 fatty acids contribute to the development of mental disorders. And daily supplementation of vital nutrients, more so, supplements containing amino acids can effectively reduce the symptoms of major depression, bipolar depression, schizophrenia, anxiety disorders, ADD (attention deficit disorder), ADHD (attention deficit hyperactivity disorder), addiction and even autism.

So, what does nutrition have to do with mental depression? ‘The brain is a chemical factory that produces serotonin, dopamine, norepinephrine, and other brain chemicals 24 hours a day. The only raw materials for their syntheses are nutrients, namely, amino acids, vitamins, minerals, essential fatty acids, etc. If the brain receives improper amounts of these nutrient building blocks, we can expect serious problems with our neurotransmitters,’ explains Dr Rima Laibow from Natural Solutions Foundation.

For example, omega-3 and omega-6 are essential fatty acids that are obtained through diet. Omega-6 leads to production of arachidonic acid and eicosanoids which promote inflammation, platelet clotting and production of prostaglandins. Omega-3 produces eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that possess anti-inflammatory properties and decrease platelet stickiness. When the proportion of omega-6 becomes 20 times that of omega-3, DHA depletes causing a change in neurotransmitter receptors leading to dysregulation of serotonins. In other words, omega-3 helps the brain to transmit signals that enable proper thinking, moods and emotions.

According to Dr Jerry Cott, a senior pharmacologist at the FDA Center for Drug Research and Review, countries in which individuals consume a large amount of fish are at lower risk for mental disorders such as major depression. This is because fish and fish oil contain high levels of omega-3 fatty acids.

Shaheen Lakhan and Karen Vieira from the Global Neuroscience Initiative Foundation, Los Angeles, reviewed the available literature on nutritional therapies for mental disorders focusing on the nutritional deficiencies that are associated with mental disorders and outlined how dietary supplements can be implemented in the treatment of four most common mental disorders: major depression, bipolar disorder, schizophrenia, and obsessive compulsive disorder (OCD).

This is what they came up with:

Major depression – Caused by a combination of stress, genes and temperament, major depression is a disorder that has symptoms viz. bad moods, sleeping problems, increased sadness and anxiety, loss of appetite and loss of interest in daily activities. In addition to omega-3, vitamin B (folate) and magnesium deficiencies are also linked to depression. Clinical trials and case studies show that 0.8mg of folic acid per day or 0.4mg of vitamin B12 per day or 125mg to 300mg of magnesium helps reduce depression symptoms.

Bipolar disorder – This disorder is characterized by debilitating depression, uncontrollable mania or a manic and depressive episode. Biochemical abnormalities include excess vanadium and acetylcholine, taurine (amino acid that plays a role in the brain by eliciting a calming effect) deficiency, omega-3 deficiency, and vitamins B and C deficiency. Vitamin C has been shown to protect the body from the damage caused by excess vanadium. A controlled study revealed that a single 3g dose of vitamin C could significantly decrease manic symptoms. Other studies show that 1 to 2 grams of omega-3 fatty acids in the form of EPA added to one's daily intake decreases manic/depressive symptoms. Interestingly, studies have shown that taurine can be used as an alternative to lithium (prescription medication for bipolar disorder). This is because taurine blocks the effects of excess acetylcholine that contributes to bipolar disorder.

Schizophrenia – It is a mental disorder characterized by abnormalities in the perception or expression of reality. It most commonly manifests as hallucinations, paranoia, delusions, and speech / thinking impairments. Studies have shown that EPA, which is found in omega-3 fish oils, can be used to treat schizophrenia. Trials reveal that 2g of EPA taken daily in addition to one's existing medication effectively decreases symptoms in schizophrenic patients.

Obsessive-Compulsive disorder – OCD is an anxiety disorder which causes recurrent, unwanted thoughts (obsessions) and / or repetitive behaviors (compulsions), which are repeated in an uncontrollable manner as a means of repressing the stressful thought. Selective serotonin reuptake inhibitors (SSRIs) are known to help patients with OCD. A supplement called Amoryn with St. John's wort as its main ingredient, has been shown to help OCD patients better deal with their obsessions and compulsions.

The results depict that nutritive supplements can be effective treatments for mental disorders.

The authors concluded –

‘Proper medical diagnosis and a clear description of all possible treatment options should always be the first plan of action when treating mental disorders. However, the final decision on whether or not to try nutritional supplements as a treatment must be based on the patient preferences’.

‘Those with influence in this field should continue to examine natural treatments on the scientific level in order to increase the availability of grant money for this type of research’.

‘Psychiatrists treating patients with mental disorders should be aware of available nutritional therapies, appropriate doses, and possible side effects in order to provide alternative and complementary treatments for their patients’.

Reference: Lakhan SE, Vieira KF. Nutritional therapies for mental disorders. Nutr J. 2008

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12-22-11, 09:05 AM
Moderate to severe manifestations of chronic depression, bipolar, schiz and OCD cannot be treated effectively with nutritional supplementation alone.

Pharmocotheraphy with or without psychotherapy is -always- required.

12-22-11, 09:09 AM
for most mental disorders, psychiatric or neurological, there is rarely one simpal treatment, treatments of such things often require a range of approaches, from behavioural therapy, to medication, to changes in diet... one should never try to negate all other approaches just because they have heard something might work better....

it is important that in the modern age we live in, pseudoscience is easily spread... and very, very, dangerous

12-22-11, 02:18 PM
"Nutrition Journal" is not exactly a reputable medical source.

12-22-11, 03:52 PM
I have seen a lot of sources that people who claim to think nutrition and diet treat adhd but this article written by a guy who wrote a book with obscure references does little to convince me of anything other than a man with an ego problem. He doesn't even describe his methods for testing. With me than method of clinical studies I should be able to use the same model to conclude that peanut m&m's are far superior to plain m&m's.

12-22-11, 05:09 PM
"Nutrition Journal" is not exactly a reputable medical source.


Do some research to see if what you're citing is a reputable source, including checking the credentials of the author and any 'experts' cited.

12-22-11, 08:01 PM
Among Nutrition Journal's stated raisons-d'etre are to publish papers that point out flaws in the status quo, to provide a venue for studies showing typical therapies are ineffective, etc.

OK. It's valuable to have a place where people can air negative results and challenge dogma, as long as it's done rigorously.

NJ is, at least nominally, a peer-reviewed journal. However, I feel compelled to point out that all peer-reviewed journals are not created equal!

And after reading Lakhan and Vieira's stunningly poorly-written review paper ( [open access -- free full text], my respect for the journal's standards is extremely low. (Though the open access part is nice.)

The authors make some valid and reasonable points -- e.g. side effects from medications are one reason for "noncompliance" with prescribed treatment, many clinicians are hesitant to prescribe treatments with which they are unfamiliar, etc.

But they also make some utterly nonsensical statements and sweeping generalizations unsupported by evidence.

They cite a number of very questionable sources (like wildly speculative papers from Medical Hypotheses) in "support" of their statements. I do not have confidence that they are representing even the better studies accurately.

And they rely heavily on "ecological" studies of the sort that say things like, "people who eat Western diets are more often diagnosed with depression". While such observations are intriguing and often worthy of further investigation, they do not demonstrate a clear individual-level association between the behavior (diet eaten) and the outcome (depression), let alone cause and effect.

In sum: Where were the reviewers? The study certainly does not make a strong case for the effectiveness of nutritional therapies in treating mental disorders. And it provides ammunition to those who would like to paint all research on nutritional interventions as shoddy and agenda-driven. (Which is a shame.)

12-24-11, 05:57 PM
As I've said many times before, the "gold standard" for all

scientific research remains longitudinal validity & reliability.

Excellent points made, as all research isn't created equal.