View Full Version : magnesium-L-threonate + aging, and we all like magnesium...

01-11-12, 11:07 PM
This is a toss-up between product advertising and research. At the end of the day, Life Extension is in the supplement business. However they do dig up some interesting research to support their products and put it in layman terms for the general population (with a bunch of "wow!!!!" terms, for emphasis).

Not sure if 'synaptic density' could benefit ADHD'ers, but we sure seem to like our magnesium around here.

Interesting tidbits:

"In a remarkable discovery, the loss of synapses has been shown to occur early in the process of Alzheimers and may trigger onset of the disease.12" (they reference all the studies in the article, at the bottom)

"Before neurons encounter this severe damage [alzheimers pathology], scientists have found a marked decline in synaptic density. This loss of synaptic density causes a decline in neuronal connectivity that strongly correlates to the cognitive impairment observed in Alzheimers disease.14-17"

"In a series of unprecedented laboratory experiments, a highly absorbable form of magnesium was shown to not only increase magnesium blood levels, but it also substantially increases magnesium brain concentrations.13"

"In response to this elevation in cerebral magnesium, there were significant increases in synaptic density and corresponding improvements in synaptic functioning and neuronal signaling.13"

The interesting one for me, glycinate is one of the chelated types:
"Other forms of magnesium (such as magnesium chloride, magnesium citrate, magnesium glycinate, and magnesium gluconate) did not significantly elevate brain magnesium compared to the control group.13,22"

"The scientists concluded that magnesium-L-threonate treatment can enhance the spatial working memory in young and aged rats.13"

"...autopsy findings showed synaptic density was 67% higher in the group supplemented with magnesium-L-threonate. This study showed that even in old animals, magnesium-L-threonate increased the density of synaptic components essential for youthful neurotransmitter release.13"

We aren't rats:
"Clinical trials are now beginning to assess whether magnesium-L-threonate functions as well in aging humans as it does in rodents."

01-11-12, 11:41 PM
the article about the "newly developed magnesium compound (magnesium-L-threonate, MgT)"

(and a cool site that lets you read scientific journals!!!)