View Full Version : Possible New Genetic Associations with ASD


Amtram
02-10-13, 02:04 PM
New research investigates inherited causes of autism (http://www.broadinstitute.org/news/4624?utm_medium=twitter&utm_source=twitterfeed)

Autism spectrum disorders (ASD) are among the most heritable of all neuropsychiatric conditions. Yet, most genetic links to ASD found in recent years have involved de novo mutations, which are not passed from parent to child, but instead arise spontaneously. While these mutations help explain how ASD develops in a fraction of cases, they donít help us understand why autism so often runs in families.

Some interesting alternatives to direct association with DNA. I'm going to see if I can get more information from the studies cited in the article.

Spacemaster
02-10-13, 03:00 PM
That's interesting, my father (never present), has a son with autism, though I've never met him. I have quite a few Asperger-like traits, so maybe it's from dad?

My mom and grandma most certainly have undiagnosed ADHD, so I'm sure that's where I got it.

I don't really know if I officially have Aspergers, or if my symptoms are just a result of ADHD impacting my social behaviour, I don't know. I brought up the subject with my doctor, but he dismissed it, because he felt that it was a diagnosis that was getting phased out. He didn't bother putting me in a sub-category for ADHD either, it seems he doesn't feel the need for sub-types.

So, I wonder if I got a little autism tendencies from dad, and ADHD from mom? It would be fairly interesting. I'll say that my environment impacting a lot too, she raised me all by herself, and is probably ADHD herself.

Amtram
02-10-13, 08:01 PM
What's strange is that looking at the two studies (the links in the article aren't direct, so here are the redirect links: http://www.sciencedirect.com/science/article/pii/S0896627312009932 and http://www.sciencedirect.com/science/article/pii/S0896627313000330) it seems that these are X-linked and homozygous knockout genes. I would have thought this would imply maternal rather than paternal links, but I'm going to have to look at the charts in the articles more closely to see if I'm interpreting it incorrectly.