View Full Version : Comorbidity of Diabetes and Depression

02-21-13, 09:43 AM
I found a couple of articles that do a pretty good job of explaining the interrelationship of Diabetes and Depression, along with some of the challenges of diagnosis and concurrent treatment.

Treatment Implications for Comorbid Diabetes Mellitus and Depression ( begins:

Major depression and type 2 diabetes mellitus are common chronic illnesses within the general US population, with prevalence rates of approximately 5% to 10% and 11%, respectively.1,2 Moreover, depression and type 2 diabetes mellitus, individually, can be among the most disabling chronic disorders one can acquire, and when they occur comorbidly, they are even more detrimental. Together they exhibit a bidirectional relationship, with each disease an independent risk factor for development of the other.

and later mentions:

Some general concepts can be helpful when thinking about depression in diabetes. Dividing the symptoms of depression into somatic (energy, sleep, appetite/weight, concentration) and psychological (mood, interest, suicidal thoughts, guilt, worthlessness) is important. The psychological symptoms of depression have little overlap with the signs or symptoms of diabetes, which make them particularly specific to depression in this context.

It addresses the ways the two conditions aggravate one another, and how to treat the two separately but with coordination between approaches to maximize successful outcome.

Obesity and Bipolar Disorder (

brings up the idea that there may be a neurological connection between the brain functions that cause bipolar disorder and the executive function deficits that can lead to obesity, in addition to the mutual perpetuation of the two.

I would suggest reading both of them. They both strongly suggest that rather than one condition causing the other, or one causing symptoms that mimic the other, the two may co-exist because of a similar neurochemical process that results in a predisposition or predilection in which they contribute to one another in a cyclical fashion.