View Full Version : Methylphenidate to Treat Mania?


APSJ
02-27-13, 10:16 PM
Came across this:

Background

Treatment of patients with acute mania remains a considerable medical challenge since onset of action of antimanic medication is delayed for several days. Psychostimulants could have an earlier onset of action. This assumption is based on the 'vigilance regulation model of mania' which postulates that vigilance is unstable in manic patients. Accordingly, vigilance-stabilising psychostimulants could be more useful than conventional treatment in acute mania. We present here the study protocol of a trial intended to study the efficacy and safety of methylphenidate in the initial treatment of acute mania.

http://www.biomedcentral.com/1471-244X/13/71/abstract


This is a study that's proposed, but apparently not done yet, but I find it interesting as I've never heard of methylphenidate as a treatment for mania, and actually would have thought it would exacerbate it.

Amtram
02-27-13, 10:46 PM
Well, you'd think that a stimulant would exacerbate ADHD, too, but it doesn't. . .yes, this should be interesting. Obviously, results will take a few years. . .

Abi
02-28-13, 08:45 AM
Came across this:


http://www.biomedcentral.com/1471-244X/13/71/abstract


This is a study that's proposed, but apparently not done yet, but I find it interesting as I've never heard of methylphenidate as a treatment for mania, and actually would have thought it would exacerbate it.

Yup. Exacerbate would be a mild way off putting it :)