View Full Version : Some genetic links


Amtram
04-01-13, 05:42 PM
These disappeared when the forums got split, or because they got old, or whatever, but I'm going to put them up for people who are interested in reading more.
Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2961109-9/fulltext?_eventId=login) (The Lancet)

Pedigree disequilibrium test (PDT) replicates association and linkage between DRD4 and ADHD in multigenerational and extended pedigrees from a genetic isolate (http://www.nature.com/mp/journal/v9/n3/full/4001396a.html) (Nature, Molecular Psychiatry)

Vulnerability genes or plasticity genes? (http://www.nature.com/mp/journal/v14/n8/full/mp200944a.html) (Nature, Molecular Psychiatry)

Researchers Identify Gene Associated with ADHD Susceptibility (http://www.genome.gov/27538023) Genomics Study of Complex Inherited Disorder May Lead to Improved Drug Therapies (http://www.genome.gov/27538023) (National Human Genome Research Institute)

Attention-Deficit Hyperactivity Disorder (ADHD) (http://www.medscape.com/viewarticle/495640_print) (Medscape article from Journal of Child Neurology)

Molecular genetics of attention-deficit/hyperactivity disorder: an overview (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839490/?tool=pubmed) (European Child and Adolescent Psychiatry)

An autism brain signature? (http://www.the-scientist.com/?articles.view/articleNo/29713/title/An-autism-brain-signature-/) A set of molecular pathways abnormally expressed in the brains of autism patients may provide new therapeutic targets (http://www.the-scientist.com/?articles.view/articleNo/29713/title/An-autism-brain-signature-/) (The Scientist article on a Nature published article)

Out-of-Africa migration selected novelty-seeking genes (http://www.newscientist.com/article/mg21028114.400-outofafrica-migration-selected-noveltyseeking-genes.html)(New Scientist, several sources)

Gene regulator in brain's executive hub tracked across lifespan — NIH study (http://www.nih.gov/news/health/feb2012/nimh-02.htm) (National Institute of Mental Health)

New gene study of ADHD points to defects in brain signaling pathways (http://www.eurekalert.org/pub_releases/2011-12/chop-ngs120111.php) (Children's Hospital of Philadelphia, from article in Nature Genetics)

Pooled genome-wide linkage data on 424 ADHD ASPs suggests genetic heterogeneity and a common risk locus at 5p13 (http://www.nature.com/mp/journal/v11/n1/full/4001760a.html) (Nature Molecular Psychiatry)

The Claim: Identical Twins Have Identical DNA (http://www.nytimes.com/2008/03/11/health/11real.html?_r=4&)(New York Times)

Scripps Research Institute Scientists Find the Structure of a Key ‘Gene Silencer’ Protein (http://www.scripps.edu/news/press/2012/20120426mcrae.html) (Scripps Research Institute)

Researchers Studying Chromosomal Abnormalities Uncover New Genes Contributing to Autism and Related Neurodevelopmental Disorders (http://www.brighamandwomens.org/about_bwh/publicaffairs/news/pressreleases/PressRelease.aspx?sub=0&PageID=1124)(Brigham and Women's Hospital, based on publication from Cell)

Etiologic Classification of Attention-Deficit/Hyperactivity Disorder (http://pediatrics.aappublications.org/content/121/2/e358.long) (Journal of the American Association of Pediatrics)

Probabilistic inheritance and neurodevelopmental phenotypes: location, location, location (http://www.wiringthebrain.com/2012/06/probabilistic-inheritance-and.html) (Wiring the Brain)

Excessive protein synthesis linked to autistic-like behaviors (http://scienceblog.com/58710/excessive-protein-synthesis-linked-to-autistic-like-behaviors/) (Science Blog, from Nature)

First Direct Evidence That ADHD Is a Genetic Disorder: Children With ADHD More Likely to Have Missing or Duplicated Segments of DNA (http://www.sciencedaily.com/releases/2010/09/100929191312.htm) (Science Daily, on research in The Lancet)

ATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD (http://omim.org/entry/143465) (List of genes and loci with links to sources)

And just to finish off, some realistic information about "genetic determinism" and what is realistically expected from genetic research. . .DNA has limits, but so does study questioning its value, geneticists say (http://blogs.nature.com/news/2012/04/questioning-value-personal-genomics.html) (Nature News)

Amtram
04-02-13, 09:07 PM
Some more interesting genetic links:
Seeking Common Ground in the Syndromes of Autism (http://scienceoveracuppa.com/2013/01/27/seeking-common-ground-in-the-syndromes-of-autism/) (blog of a molecular biologist)

Robustness and fragility in neural development (http://www.wiringthebrain.com/2012/04/robustness-and-fragility-in-neural.html)(Wiring the Brain)

An anthropologist explains the gene! (http://blogs.discovermagazine.com/gnxp/2013/03/an-anthropologist-explains-the-gene/#more-20385)
(Razib Khan's blog on Discover. He has some other interesting posts.)

Amtram
04-03-13, 11:10 AM
Here are a few more. I'm working my way through a very long list. One might say that we haven't reached a definitive conclusion on the genetic links that correlate with ADHD, but not only is it being studied, but there have been many useful discoveries.

Genetic Linkage of Attention-Deficit/Hyperactivity Disorder on Chromosome 16p13, in a Region Implicated in Autism (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC378550/)
(Am J Hum Genet. 2002 October; 71(4): 959–963.)

A Genomewide Scan for Attention-Deficit/Hyperactivity Disorder in an Extended Sample: Suggestive Linkage on 17p11 (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180278/)
(Am J Hum Genet. 2003 May; 72(5): 1268–1279.)

Attention deficit hyperactivity disorder: fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182053/)
(Am J Hum Genet. 2004 October; 75(4): 661–668.)

GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice. (http://www.ncbi.nlm.nih.gov/pubmed/21499268)
(Nature Medicine, abstract only)

A Genomewide Scan for Loci Involved in Attention-Deficit/Hyperactivity Disorder (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC447594/)
(Am J Hum Genet. 2002 May; 70(5): 1183–1196.)

Quantitative trait locus for reading disability on chromosome 6p is pleiotropic for attention-deficit/hyperactivity disorder. (http://www.ncbi.nlm.nih.gov/pubmed/11920845)
(Am J Med Genet. 2002 Apr 8;114(3):260-8. abstract only)

A Whole-Genome Scan in 164 Dutch Sib Pairs with Attention-Deficit/Hyperactivity Disorder: Suggestive Evidence for Linkage on Chromosomes 7p and 15q (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180276/)
(Am J Hum Genet. 2003 May; 72(5): 1251–1260.)

Attention-deficit/hyperactivity disorder (ADHD): feasibility of linkage analysis in a genetic isolate using extended and multigenerational pedigrees. (http://www.ncbi.nlm.nih.gov/pubmed/12081716)
(Clin Genet. 2002 May;61(5):335-43. abstract only)

Attention-Deficit/Hyperactivity Disorder in a Population Isolate: Linkage to Loci at 4q13.2, 5q33.3, 11q22, and 17p11 (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182160/)
(Am J Hum Genet. 2004 December; 75(6): 998–1014)

Association of attention-deficit disorder and the dopamine transporter gene. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801209/)
(Am J Hum Genet. 1995 April; 56(4): 993–998)

Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD. (http://www.ncbi.nlm.nih.gov/pubmed/15007392)
(Nature Mol Psychiatry. 2004 Aug;9(8):801-10. abstract only)

Joint Analysis of the DRD5 Marker Concludes Association with Attention-Deficit/Hyperactivity Disorder Confined to the Predominantly Inattentive and Combined Subtypes (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1181932/)
(Am J Hum Genet. 2004 February; 74(2): 348–356.)

immabum
04-04-13, 11:33 PM
Amtram: wow thanks for the links.
Another interesting gene I learned about recently is the "clock" gene and it's role in circadian rhythm, personality traits, bipolar disorder and ADHD.

http://www.ncbi.nlm.nih.gov/pubmed/17948273
http://www.ncbi.nlm.nih.gov/pubmed/22537959

I recently found out I had the 'not so good' variant allele . Which would help explain why I've never really had a normal circadian rhythm.