View Full Version : Molecular level treatments


Amtram
04-23-13, 02:51 PM
New research has produced 3-D images of g-coupled protein receptors (http://publications.nigms.nih.gov/insidelifescience/vital-proteins.html), which will help with targeted medical treatments for many neurological and psychiatric conditions.

Here are the renderings, with information about what these receptors do:

GPCR Gallery

Here are some of the key structures that the Stevens group and its collaborators, including Kobilka and other scientists around the world, have solved using the family tree approach:
http://publications.nigms.nih.gov/insidelifescience/images/beta2-th.jpg (http://publications.nigms.nih.gov/insidelifescience/images/beta2.gif)The first high-resolution structure of a human GPCR, the molecular "fight or flight" switch called the 2 adrenergic receptor.
High res. image (http://publications.nigms.nih.gov/insidelifescience/images/beta2.gif)






http://publications.nigms.nih.gov/insidelifescience/images/A2A-th.jpg (http://publications.nigms.nih.gov/insidelifescience/images/A2A.jpg) The A2A adenosine receptor, sometimes called the "caffeine receptor." Our bodies sense and respond to caffeine the same way they do to fragrances, light and other stimuli. Tweaks to this GPCR molecule make it send a signal from the cell's external environment to its interior. High res. image (http://publications.nigms.nih.gov/insidelifescience/images/A2A.jpg)

http://publications.nigms.nih.gov/insidelifescience/images/CXCR4-th.jpg (http://publications.nigms.nih.gov/insidelifescience/images/CXCR4.jpg) The CXCR4 chemokine receptor, which normally helps activate the immune system and stimulate cell movement. But when the signals that activate the receptor aren't properly regulated, CXCR4 can spur the growth and spread of cancer cells. To date, CXCR4 has been linked to more than 20 types of cancer. High res. image (http://publications.nigms.nih.gov/insidelifescience/images/CXCR4.jpg)

http://publications.nigms.nih.gov/insidelifescience/images/Dopamine-D3-th.jpg (http://publications.nigms.nih.gov/insidelifescience/images/Dopamine-D3.jpg) The D3 dopamine receptor, which plays a vital role in the central nervous system, affecting our movement, cognition and emotion. High res. image (http://publications.nigms.nih.gov/insidelifescience/images/Dopamine-D3.jpg)







http://publications.nigms.nih.gov/insidelifescience/images/histamine-th.jpg (http://publications.nigms.nih.gov/insidelifescience/images/histamine.jpg) The H1 histamine receptor, which plays a role in how the immune system produces allergic reactions to pollen, food and pets. Many allergy medications work by blocking the action of this type of GPCR. High res. image (http://publications.nigms.nih.gov/insidelifescience/images/histamine.jpg)




http://publications.nigms.nih.gov/insidelifescience/images/kappa-opioid-th.jpg (http://publications.nigms.nih.gov/insidelifescience/images/kappa-opioid.jpg) The kappa opioid receptor, a protein on the surface of brain cells that is centrally involved in pleasure as well as in pain, addiction, depression, psychosis and related conditions. Dozens of legal and illegal drugs, from anesthetics to heroin, work by targeting these receptors.
High res. image (http://publications.nigms.nih.gov/insidelifescience/images/kappa-opioid.jpg)

Amtram
04-23-13, 03:07 PM
Found this video, which may or may not make sense to a lot of people, but shows an animated version of the interplay between g-coupled proteins and neurotransmission:

http://youtu.be/K7WSMybZeA8