View Full Version : Nitric Oxide


SB_UK
05-11-13, 04:37 AM
pubmed -1- (http://www.ncbi.nlm.nih.gov/pubmed/23163510)
"Vascular effects of dietary nitrate (as found in green leafy vegetables & beetroot) via the nitrate-nitrite-nitric oxide pathway."

pubmed -2- (http://www.ncbi.nlm.nih.gov/pubmed/16597326)
"Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice"

pubmed -3- (http://jcs.biologists.org/content/119/14/2855.long)
"NO and [driving] mitochondrial biogenesis"

-*-
-- sun --
CO2 + N2 source (animal faeces)
-> plant ->
oxygen + vegan protein [no animal IGF-1 response] + nitrate
-> animal ->
mitochondrial biogenesis (increased aerobic efficiency, greater O2 uptake, greater reactive oxygen species [good if controlled -> mitochondrial biogenesis, bad if uncontrolled] formation) (mitochondrial wt. ~ 10% body weight !!)

[noting --sun-- Calcitriol, the active metabolite of vitamin D [sun] synthesized in the kidney, increases glutathione levels [master endogenous anti-oxidant] in the brain and appears to be a catalyst for glutathione production]


->
CO2 + N2 source (animal faeces)
-- sun --

We've evolved to handle the 'waste products' of plants; as we become more aerobic - we're required to optimise endogenous (and consumed) anti-oxidant levels.

This is impossible under the societal stress of living life immorally - through having to earn the immoral construct of money, for some immoral task (delivering addiction) enforcing (as we do it) - the immoral construct of societal hierarchy.

Note:
http://nutritionfacts.org/video/antioxidant-level-dynamics/
Using an argon laser to measure human antioxidant levels in real time, researchers uncover how fast stress can deplete the body and how slowly it takes to restore antioxidant levels.

SB_UK
05-11-13, 04:55 AM
So ... ... ... evolution has brought the animal and plant kingdom into homeostasis - whereby the chloroplast / mitochondria mediate the exchange - evolutionarily speaking - we're looking at the male : female archetype of

cyanobacteria o+ [stationary] -> chloroplast <- fix starch (note resistant starch)
proteobacteria o-> [motile] -> mitochondria <- use chloroplast derived 'energy'

But starch versus resistant starch ?
Starch -> hyperglycaemic not ideal
Resistant starch -> digests to small chain / medium chain fatty acids -> zero glycaemic index

Ideal diet ?? (Raw) green plant (veggie) based fibre -> bacterially digested -> fatty acids which power us under a 'ketosis' paradigm.

pubmed (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867088/)
The Ketogenic Diet: Stoking the Powerhouse of the CellKetogenic diet -> drives -> mitochondrial biogenesis.

SB_UK
05-11-13, 05:10 AM
So - general feeling.

We may have (courtesy of our colonic microbiome) shifted to an optimal metabolic profile which operates on what we would ordinarily consider an ultra-low caloric load - if we've shifted to the use of fibre for energy - where we, generally, have treated fibre as a 'free' (zero energy) foodstuff.

This idea is pretty neat - and suggests that manageable stress manifests itself as increasing mitochondrial load - impacts on the organism through requiring an ever more austere life - to handle the needs of the lil' guys within.
As we become more 'aerobic' - we'll be come susceptible to deviation from an optimal lifestyle.

Where the optimal lifestyle is one in which unmanageable stress is eliminated (requiring an end to money and law ie societal infrastructure which enforces inequality) and a shift to a fibrous vegetable diet.

Both simple to envisage occurring as the global economic system collapses and as we destroy planetary soil to sterilizing over-intensive farming methodologies.

SB_UK
05-11-13, 05:12 AM
Details on downstream fibre digestion products within the human large colon here:
http://www.addforums.com/forums/showpost.php?p=1482862&postcount=12

SB_UK
05-11-13, 05:19 AM
Where the optimal lifestyle is one in which unmanageable stress is eliminated (requiring an end to money and law ie societal infrastructure which enforces inequality) and a shift to a fibrous vegetable diet.


Stresses to be encouraged:
-1- Frequent cold exposure
-2- Frequent fasting days up to 3 regularly, occasionally 3 weeks [hunger vanishes after 5 days but you do get quite cold], maybe even 7 weeks
-3- Intense aerobic to exhaustion, prolonged aerobic and stretch exercising
-4- Early am wake (rolling with melatonin levels)

-*-

The Mount Athos lifestyle from birth to death - with a couple of changes.

meadd823
05-11-13, 02:25 PM
I am a fan of diversity there for tend to toward challenging assumptions that generally speaks "one size fits all" mentality


You may find a vegan diat very helpful but that by no means applies to us all


I personally do best on a omnivorous diet, my husband eat primary a carnivorous diet while I know several folks who feel their best on a strict vegan diet.


For discussion sake - please allow me to throw out the following article as a point for consideration

Gene-culture coevolution between cattle milk protein genes and human lactase genes (http://www.nature.com/ng/journal/v35/n4/abs/ng1263.html)



There is a significant change in the archaeological record associated with the introduction of plant domestication (ie the Neolithic period in Europe and the Near East), such as the appearance of pottery, stone tools for plant processing, and the remains of the domesticated plants themselves (Gebauer & Price, 1992). There is, in many areas, an associated general decrease in body stature, dentition size, and an increase in caries rates. The smaller dentition is not due to more meat, but instead to the consumption of easier to chew processed foods like bread and porridges, and the carbohydrate contents of those foods result in the increased caries rates. There is also a range of diseases associated with the consumption of these processed foods and related to the sedentism and urbanization that often follow from the increased reliance on domesticated plants (Cohen & Armelegos, 1984).

However, associated with the general decrease in health associated with the adoption of agriculture, as evidenced in skeletal remains, is a significant and dramatic population increase, which is the trade-off that our ancestors made. To increase population size food production must increase beyond the carrying capacity of the environment, and domestication and control of plants and animals allow this. However, associated with this is overcrowding and the observed general decline in individual health, and we are still living with the effects of this Neolithic revolution today.



Gene-culture coevolution between cattle milk protein genes and human lactase genes (http://www.nature.com/ng/journal/v35/n4/abs/ng1263.html)



Milk from domestic cows has been a valuable food source for over 8,000 years, especially in lactose-tolerant human societies that exploit dairy breeds. We studied geographic patterns of variation in genes encoding the six most important milk proteins in 70 native European cattle breeds. We found substantial geographic coincidence between high diversity in cattle milk genes, locations of the European Neolithic cattle farming sites (>5,000 years ago) and present-day lactose tolerance in Europeans. This suggests a gene-culture coevolution between cattle and humans.





. . . .

SB_UK
05-11-13, 02:48 PM
Ref -1-
The wrong sort of agriculture - we chased high gluten, high starch, high sugar Starch -> hyperglycaemic not idealand not the high fibre green types Resistant starch -> digests to small chain / medium chain fatty acids -> zero glycaemic indexwhich I believe are the food types which we're required to eat for health.

Ref -2-
Functional enzyme lactase refers only to a single component of milk - what we really need to ascertain is the body's ability to handle other components of milk - saturated fat, endotoxin, cholesterol, caseomorphin, IGF-1, other steroid hormones ... ... I don't believe I'm lactose intolerant - however - definitely milk sensitive.

One size fits all ?
I think so.

Great video:
Chocolate, Cheese, Meat, and Sugar -- Physically Addictive
http://www.youtube.com/watch?v=5VWi6dXCT7I

No exceptions - one size fits all - from a biological perspective.

Do better on a meat-based diet ?
But - could it be argued that an alcoholic does better on alcohol - than the state of 'cold turkey' at least -

funny choice of phrase 'cold turkey' given the addiction to meat.

SB_UK
05-11-13, 03:38 PM
Where to start with milk ?

How about - milk blocks important phytonutrients/anti-oxidants etc... ... in all people.

http://www.youtube.com/watch?v=fUOexcqfX4k

Diversity isn't always good - if we were to vary randomly in body pH from 0 to 14 - we'd be dead before too long ... ... travelling back many years to a thread with MeADD823 - resurrecting the alkaline (alkalizing) theory - have noticed that background inflammation is swept aside by drinking pure lemon juice.

Hands and feet become cold !! Not used to that.

No way of 'fixing' that experiment - remarkable effect - the acid/base theory (of ash left post-oxidation internally / burning) and needing to be corrected (to pH 7.4) is right.

Amtram
05-11-13, 04:55 PM
meadd made an excellent point. We are all different, and our diets need to reflect that. The diet you describe would be excellent for weight loss for many people who are on lifesaving medications (like the Warfarin that is helping my 73 year old mother not have a stroke like her mother or aunts or maternal grandmother did. . .) or have certain genetic enzyme processing deficiencies - but they would not live long on zero calories per day.

SB_UK
05-12-13, 01:24 PM
Great video:
Chocolate, Cheese, Meat, and Sugar -- Physically Addictive

Along the same lines ... ... ...
Are Carbs More Addictive Than Cocaine? (http://www.details.com/style-advice/the-body/201103/carbs-caffeine-food-cocaine-addiction?currentPage=3)What's left ?

Low GI fruit (berries)/veg (greens), MUFA (EVOO,avocado) <- neither considered entirely satisfactory due to processing/persin, nuts and seeds.

That turns out to be the specification for the raw (garden) vegan diet (wikiP/raw veganism).

Prepare yourself for the laxative effect of raw foods ! ... ... and a period of 'confusion' re-orienting away from carbs.

Starch is more physically addictive (personal experience) than all of the rest (chocolate, cheese, meat, sugar).

Which is why the starch came to dominate agriculture, I guess - the addictive allure was too great to turn away from.

"The brain does indeed need carbohydrates for fuel," Taubes says, "but the body is perfectly happy to make those out of protein, leafy green vegetables, and the animal fat you're burning." As a pair of Harvard doctors (one an endocrinologist and one an epidemiologist) wrote in the Journal of the American Medical Association last summer, carbohydrates are "a nutrient for which humans have no absolute requirement."
Read More http://www.details.com/style-advice/the-body/201103/carbs-caffeine-food-cocaine-addiction#ixzz2T6JERGsk

SB_UK
05-12-13, 03:03 PM
lectin levels -> reject legumes and grains (both which're out in a raw vegan diet)
high GI -> removes many of the foods permitted on a raw vegan diet
saturated fat -> removes nuts and seeds (permitted on a raw vegan diet)

Sorry!

ALL FOOD REJECTED APART FROM GREEN VEGETABLES - RAW/ORGANIC.

[1] green leaf class [2] allium class [3] cruciferous class.

However - even these in moderation - oxalates in spinach, goitrogens in cruciferous class.

SB_UK
05-12-13, 03:06 PM
I'm really gonna' need the theory of the human microbiome generating amino acids and small chain saturated fatty acids from the various types of fibre contained within the 3 food types above - to seal this idea.

http://www.addforums.com/forums/showpost.php?p=1482935&postcount=15

SB_UK
05-12-13, 03:25 PM
1. Onions/garlic fried in olive oil.
2. Add any and every non-starchy vegetable you can get your hands on in.
[If you've an Aldi - you'll find affordable vegetables]
3. Add a pre-made sauce which you've verified hasn't anything much other than vegetables and herbs/spices in it (no starch, sugar etc...).


1. 15ml olive oil - heat
2. T-3 mins - add allium class
3. T-2 mins - add cruciferous class
4. T-1 min - add green leaf class
5. Take-off - add pre-prepared tomato-based sauce made using tomatoes (tomatoes benefit (anti-oxidant levels) from cooking), (dried or otherwise) herbs (noteworthy - marjoram, oregano and parsley) and spices (noteworthy - turmeric, cloves, cinnamon, cayenne pepper).

Live long and prosper.

SB_UK
05-12-13, 03:29 PM
45 years to generate 1 healthy (the only one you'll ever) recipe (need) !

SB_UK
05-12-13, 03:54 PM
1. 15ml olive oil - heat
2. T-3 mins - add allium class
3. T-2 mins - add cruciferous class
4. T-1 min - add green leaf class
5. Take-off - add pre-prepared tomato-based sauce made using tomatoes (tomatoes benefit (anti-oxidant levels) from cooking), (dried or otherwise) herbs (noteworthy - marjoram, oregano and parsley) and spices (noteworthy - turmeric, cloves, cinnamon, cayenne pepper).

ooops!

Serve with a large selection of the happy raw vegetable set - of note - the red pepper class - any form of heating destroys (75% of) the nutritional load of the red bell pepper (from nutrition facts website).

http://nutritionfacts.org/video/raw-food-diet-myths/
http://nutritionfacts.org/video/best-cooking-method/

SB_UK
05-13-13, 06:17 AM
Low glycaemic diet essential for use of fat as energy source and heat source (uncoupling)

[1] Carbs with non-zero Glycaemic Index + Fast metabolized (essential (particularly BCAAs)) proteins (animal) drive Insulin production.
ref eg here (http://advances.nutrition.org/content/2/6/445.full)
[2] Insulin stimulates lipogenesis in two main ways: The enzymes pyruvate dehydrogenase (PDH), which forms acetyl-CoA, and acetyl-CoA carboxylase (ACC), which forms malonyl-CoA from acetyl-CoA, are obvious control points.
ref (http://en.wikipedia.org/wiki/Lipogenesis)
[3] Carnitine palmitoyltransferase I ... is a mitochondrial enzyme ...and... can be inhibited by malonyl CoA.
ref (http://en.wikipedia.org/wiki/Carnitine_palmitoyltransferase_I)
[4] Low quality protein sources (green leaf, allium and cruciferous class) will not drive an insulin response whether via BCAA or increasing plasma glucose levels.
eg ref (http://www.health.state.mn.us/divs/fh/mcshn/ncfu/cond/msud.htm)
[5] And finally ... ... appropriate nutrition through veggies which opens the floodgates to mitochondrial usage of fat as energetic source / in heat production.

http://nutritionfacts.org/video/how-to-upregulate-metabolism/ <- on how to upregulate mitochondrial activity

http://www.ncbi.nlm.nih.gov/pubmed/18772587

Go with Karlic !! - a bulb a day minimum!

Number one against breast cancer? Garlic. Number one against brain tumors: garlic. Number two against kidney cancer: garlic. Lung cancer: garlic. Childhood brain tumors: garlic. Pancreatic cancer: garlic. Prostate cancer: garlic. And stomach cancer? Garlic. So might I suggest a garlicky salad dressing?
Wait a second, though. Is it just that garlic is toxic to all cells? Yes, it stops the growth of cancer cells, but maybe it stops the growth of healthy cells too? That wouldn’t be good. They tested for that. The black bars are cancer cells; the white bars are normal cells. As you can see garlic slams cancer cells, but doesn’t touch normal cells, and the same thing with pretty much all the vegetables. They’re selective; they go after the cancer cells but leave the normal cells alone. Veggies are amazing.
http://nutritionfacts.org/video/1-anticancer-vegetable/ <- on garlic as #1 anti-cancer veggie

And everybody knows that garlics and onions - love mushrooms !

http://nutritionfacts.org/2013/04/02/ergothioneine-a-new-vitamin/ <- ergothioneine upregulates mitochondrial activity

SB_UK
05-13-13, 06:41 AM
But still stress mobilizes glucose which must frive an insulin response.

Sedentary mental stress won't utilize the mobilized glucose - will drive an insulin response - will make you fat.

An unstressful societal infrastructure (one without money, law, human hierarchy) and a diet (as outlined above) -> leads to -> an eradication of disease.

The psychosocialnutritional model of medicine.