View Full Version : Guanfacine better for ADHD

abre los ojos
02-13-05, 04:56 AM
The alpha-2a receptor is the receptor important in ADHD, and Guanfacine is a selective alpha-2a agonist, while Clonidine affects several other receptors, increasing side-effects.

J Am Acad Child Adolesc Psychiatry,39:10,1330-1333 October 2000

"Drugs that mimic norepinephrine at the a2-receptor are also used in the treatment of ADHD. Despite its wide use in children with ADHD, there have been very few studies (n = 4 studies [2 controlled]; n = 122 children) supporting the efficacy of clonidine. Treatment with clonidine appears to have mostly a behavioral effect in disinhibited and agitated youths, with limited impact on cognition. Several cases of sudden death have been reported in children treated with clonidine plus methylphenidate, raising concerns about the safety of this combination. Limited literature exists for guanfacine, a more selective a2A-receptor agonist with fewer side effects. There are 3 small open studies of guanfacine in children and adolescents with ADHD. In these studies, beneficial effects on hyperactive behaviors and attentional abilities were reported. In addition, in a controlled study in normal adults, guanfacine, but not clonidine, improved planning and spatial working memory. In another controlled study in adults with ADHD, guanfacine was reported to improve ADHD symptoms (K. Fletcher, personal communication, 2000). Most recently, a controlled trial in children with ADHD and tics has shown that guanfacine can improve ADHD symptoms and reduce tics (L. Scahill, personal communication, 2000). Thus a variety of noradrenergic agents can improve ADHD symptoms."

09-21-05, 09:49 AM
:confused: How much of the clonodine is needed to help people taking it for agitation or aggression?