Links concerning Canada's response to Adderall, the FDAs position and Shire's position:

http://www.medscape.com/pages/sites/infosite/adderall/article-canadaletter

http://www.fda.gov/cder/drug/advisory/adderall.htm (http://www.fda.gov/cder/drug/advisory/adderall.htm)

http://www.fda.gov/cder/drug/InfoSheets/HCP/AdderallHCPSheet.pdf (http://www.medscape.com/px/trk.svr/isite-adderall?exturl=http://www.fda.gov/cder/drug/InfoSheets/HCP/AdderallHCPSheet.pdf)

Thanks for posting those. The only concern I recall about amphetamine is that they used to use it in the 50's for obesity but then they realized long-term usage could cause psychosis in patients. Perhaps they overdosed their patients? I'd have to research it more from an historic standpoint.