View Full Version : New class of antidepressants?

10-31-13, 08:55 AM
Well, it seems to work on mice, so it's not ready for prime time, but if it works, it might be of particular interest to those of us with comorbid Depression and ADHD. A potential new class of fast-acting antidepressant ( is looking at an SSRI that targets a different serotonin receptor, S2, which is not currently the primary target of existing antidepressants. It also doesn't seem to have the problematic side effects of ketamine and scopolamine, which is especially good. However, what intrigued me was this:

Serotonin 2C receptors normally inhibit the release of dopamine, another neurotransmitter commonly associated with mood, from certain neurons. When 2C is blocked, the researchers believe, more dopamine is released into regions of the brain such as the prefrontal cortex. The team also observed the induction of biomarkers that indicate antidepressant action.

Even though dopamine regulation may not be the ne plus ultra of ADHD treatment, it does seem to help most people with ADHD to some degree, so this might be a really promising treatment. At some point in the future. . .