View Full Version : Who has benefits in motivation/drive from Desoxyn?


Morpheus-2396
12-20-13, 11:03 AM
Hello guys,

I'm currently withdrawing from Strattera, as it did not improve my lack of drive and motivation in any matter. Since drive & motivation is my main problem since my adolescence, I'd be interrested to know confirmed cases of benefit among you in regards to drive & motivation.

Methamphetamine is much more effectively active in the Nucleus Accumbens than amphetamine (from what I've read so far) - the region of the brain, that rewards and reinforces certain behavior. So, my theory is, Desoxyn *should* be particularily effective in patients who suffer lack of drive and motivation.

Who got benefits in motivation, mental energy, mental stamina, physical energy and physical stamina from Desoxyn? And how does it compare to Dextroamphetamine/Dexedrine?


Thanks,

M-2396

Tantalus
12-28-13, 07:32 PM
IMO it works better than all other ADD drugs i've tried in all areas that you mentioned, and with less peripheral side effects (jitters, vasoconstriction, etc). Yep, it kills amotivation, kills anhedonia, kills depression, kills lethargy.

The caveat: meth, legal or illicit, and at any dosage, is neurotoxic.

Morpheus-2396
12-31-13, 11:07 AM
The caveat: meth, legal or illicit, and at any dosage, is neurotoxic.

Truly? How do you know, it is neurotoxic at therapeutic dosages:confused:

Chivalry
01-19-14, 03:05 PM
IMO it works better than all other ADD drugs i've tried in all areas that you mentioned, and with less peripheral side effects (jitters, vasoconstriction, etc). Yep, it kills amotivation, kills anhedonia, kills depression, kills lethargy.

The caveat: meth, legal or illicit, and at any dosage, is neurotoxic.

All you anti-drug people can JUST stop please. Really, IF YOU want to go preaching the bad of ADHD DRUGS, your not moving forward anyone or anything, your wasting your own time.

Blackstar
01-20-14, 05:03 AM
.....

turbowned
02-28-14, 11:49 AM
I just got a prescription for Desoxyn. It has been a good experience for me so far with the two doses i've taken. Much cleaner than Adderall in that it doesn't FORCE me to do anything. It might not have the "motivation" factor that adderall does though. I don't feel like i HAVE to be doing something the way that adderall makes me feel. Hope this helps. feel free to PM me.

asilaydying84
10-29-14, 09:37 PM
I just got a prescription for Desoxyn. It has been a good experience for me so far with the two doses i've taken. Much cleaner than Adderall in that it doesn't FORCE me to do anything. It might not have the "motivation" factor that adderall does though. I don't feel like i HAVE to be doing something the way that adderall makes me feel. Hope this helps. feel free to PM me.

agree with you 100% Adderall to me is a drug that makes you want to get something done. there is no wait till later its get it don't know. that was annoying to me. desoxyn feels like it will let you have motivation if you need it. its good for focus and hyperactivity. each stimulant treats everyone differently because no 2 people are alike. I might need more dopamine than that person and that person needs nor-ep. each drug works for someone ,you just have to find that one.

Lloyd_
02-20-16, 08:38 PM
All you anti-drug people can jUST stop please for the love of god.

Really, IF YOU want to go preaching the bad of ADHD DRUGS, your not moving forward anyone or anything, your wasting your own god dam time.

go study the bible or SOMETHING, but for goodness sake, stop with all this anti-drug crap,, really just stop god dang it.

Lotta those same 'anti drug' people have no problem sitting around and smoking an ounce of high potency pharmaceutical grade marijuana. :lol:

They call that stuff 'dope' for a reason. :D

b3nault
08-19-18, 01:06 AM
IMO it works better than all other ADD drugs i've tried in all areas that you mentioned, and with less peripheral side effects (jitters, vasoconstriction, etc). Yep, it kills amotivation, kills anhedonia, kills depression, kills lethargy.

The caveat: meth, legal or illicit, and at any dosage, is neurotoxic.

Someone called RahMaz posted to the LongeCity forum that a low dose of methamphetamine prescribed for ADHD "healed their mind".

Kunga Dorji
08-19-18, 02:14 AM
IMO it works better than all other ADD drugs i've tried in all areas that you mentioned, and with less peripheral side effects (jitters, vasoconstriction, etc). Yep, it kills amotivation, kills anhedonia, kills depression, kills lethargy.

The caveat: meth, legal or illicit, and at any dosage, is neurotoxic.


You need to reference this, otherwise you will create unnecessary distress.

The studies that I have skimmed through show a clear neurotoxic effect at high doses (ie 5-30mg/kg).
a dosage of more than 50mg for a 70kg adult is very unusual- well below that dose range. It also seems to be temperature dependent:


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008711/
Amphetamine- and methamphetamine-induced hyperthermia: Implications of the effects produced in brain vasculature and peripheral organs to forebrain neurotoxicity





Animal models of neurotoxicity from high-dose amphetamine exposure indicate that the occurrence of hyperpyrexia (i.e.,core body temperature ≥ 40 C) is necessary for the development of amphetamine-induced neurotoxicity.[129] (https://en.wikipedia.org/wiki/Dextroamphetamine#cite_note-Amph-induced_hyperthermia_and_neurotoxicity_review-149) Prolonged elevations of brain temperature above 40 C likely promote the development of amphetamine-induced neurotoxicity in laboratory animals by facilitating the production of reactive oxygen species, disrupting cellular protein function, and transiently increasing blood brain barrier permeability.



Equally stimulants are gaining a place in neuro-rehabilitation as they acceleraate learning and neuroplastic rehabilitation.

Funky1
08-19-18, 02:10 PM
I tried to get my last therapist to prescribe desoxyn for me, but he didn't know a lot about it and the fact that it is essentially methamphetamine definitely turned him off. Everything I've read points to it being a viable option, and would address all of the issues I've had with the other stimulants have tried. Oh well, I've already accepted I'm going to be shopping for a new therapist once my insurance starts back up, so maybe I will have better luck then.

CharlesH
08-19-18, 02:40 PM
Everything I've read points to it being a viable option, and would address all of the issues I've had with the other stimulants have tried.


If all the other stimulants haven't worked out for you, what makes you think desoxyn would be any different? It's chemically very similar to Adderall/Dexedrine.

Kunga Dorji
08-20-18, 03:57 AM
If all the other stimulants haven't worked out for you, what makes you think desoxyn would be any different? It's chemically very similar to Adderall/Dexedrine.


Strangely, even small chemical differences can translate to a big difference in individual effect.

Funky1
08-20-18, 08:47 AM
Strangely, even small chemical differences can translate to a big difference in individual effect.

This!

As it is now, I cannot tolerate adderal, dexedrine is a little bit better, but I still suffer from a lot of the side effects. Everyone has a different body chemistry, as stated, we all react a little bit differently to these meds. Do I think desoxyn is the answer? I don't know. But I'd like to find out for myself.

T-Bonez
08-30-18, 04:28 PM
IMO it works better than all other ADD drugs i've tried in all areas that you mentioned, and with less peripheral side effects (jitters, vasoconstriction, etc). Yep, it kills amotivation, kills anhedonia, kills depression, kills lethargy.

The caveat: meth, legal or illicit, and at any dosage, is neurotoxic.

You clearly don't haven't read this article : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939399/

Here is the conclusion from article to save time.

<In conclusion, the present work shows that long-term administration with a low dose of METH promoted the differentiation of immature neurons and enhanced LTP in differentiating and mature DGCs. It will be fundamental to understand how prolonged use of METH will convert such “positive” effects on neurogenesis and synaptic plasticity into the well known dysfunctional effects that strongly impair cognitive performance in METH-addicted subjects>

Alphawave
09-20-18, 12:04 PM
I've taken, with regret, all sorts of things and nothing has cured motivation. Sometimes you just need to get out there and make an effort. Do it yourself and stop waiting for a cure all drug to do it for you. To date, nothing has cured my motivation more than willpower. As far as my other symptoms go? Meds have worked brilliantly.

Edit: actually exercise helps, but you still have to do it in the first place, which requires? Motivation