View Full Version : Research:Clonidine Effective Mainly On Behavior Than Cognition


RhapsodyInBlue
03-17-05, 06:53 AM
Tricyclic antidepressants<SUP> </SUP>(imipramine, nortriptyline, desipramine) and clonidine are effective,<SUP> </SUP>mainly on behaviour rather than cognition, but have the potential<SUP> </SUP>for cardiac toxicity. Regular cardiovascular system and ECG appraisal<SUP> </SUP>is good practice, but imipramine has been so widely prescribed<SUP> </SUP>as a symptomatic treatment for enuresis without excessive mortality<SUP> </SUP>that ECG monitoring for daily doses of 100 mg or less is probably<SUP> </SUP>wasteful.

A combination of daytime stimulant and evening clonidine<SUP> </SUP>is quite popular as a way of avoiding the sleep onset insomnia<SUP> </SUP>common with stimulants, but its long term safety is not established.<SUP> </SUP>Adding risperidone to stimulants is favoured by a few enthusiasts<SUP> </SUP>and can be dramatically effective in controlling aggressive behaviour<SUP> </SUP>but again there are safety concerns and no systematic evidence<SUP> </SUP>for benefit.

Problems with weight gain, galactorrhoea, and waning<SUP> </SUP>efficacy over months are the main limitations. It is not completely<SUP> </SUP>free from long term neurological complications, and it is frankly<SUP> </SUP>shocking to see that some practitioners use it freely with young<SUP> </SUP>children. There have been trials showing benefit for other agents<SUP> </SUP>including buspirone, bupropion, venlafaxine, or amantadine but<SUP> </SUP>the deployment of these should be reserved to specialist centres.<SUP> </SUP>
<SUP></SUP>
http://adc.bmjjournals.com/cgi/content/full/79/5/381

abre los ojos
03-30-05, 02:16 AM
Guanfacine, an a2 agonist like clonidine, is a lot more impressive as a cognitive enhancer for ADHD. ADD = working memory deficit. Both, Guanfacine and Clonidine substantially increase working memory, but Guanfacine is superior with a lot less side-effects. It makes no sense to take clonidine instead of guanfacine, but Dr.'s are too lazy to keep up with the research.

Way Too Flighty
06-15-05, 12:54 AM
I have read a lot of research by Amy Arnsten and others confirming exactly what you say, Abre. And you really hit on exactly what ADD is for me, a working memory deficit. I may try Guanfacine. If anyone has tried Guanfacine, or brand name Tenex (I think it's something like that, no?), please do report on how it has affected you.

Ian
06-15-05, 03:01 AM
I have read a lot of research by Amy Arnsten and others confirming exactly what you say, Abre. And you really hit on exactly what ADD is for me, a working memory deficit. I may try Guanfacine. If anyone has tried Guanfacine, or brand name Tenex (I think it's something like that, no?), please do report on how it has affected you.
Why don't you post something to this effect in the meds section and put both Guanfacine and Tenex in the subject title? It might flush out some others with similar interests, maybe.
Cheers!

netsavy006
09-21-05, 09:41 AM
I tried guanfacine (brand name tenex) and I had side effects that were no good so I had to stop taking it and switch to clonodine (which the only side effect I get is dry mouth).

speedo
05-29-06, 06:02 PM
This is a really old thread, but since I have recebtly started on Tenex, I thought it might be good to revive it.

I've been on tenex for several weeks and it seemed to work right away. I'm in the process ofworking up to 1 mg twice a day . I started at 0.5 mg twice a day (morning and eveing).

It seems to work fo rme , with no side effects. It does a good job of curbing my hyperactivity, but does nothing for focusing difficulties.

The down side is that I need to monitor my blood pressure as Tenex can cause it to get rather low.

ME :D

ME :D

Why don't you post something to this effect in the meds section and put both Guanfacine and Tenex in the subject title? It might flush out some others with similar interests, maybe.
Cheers!

KellyD
02-13-07, 09:34 PM
We were prescribed this and it had no effect (but it was mostly for restlessness).

speedo
02-13-07, 10:47 PM
I'm still on tenex. I take 0.5 mg three times a day.

It works very well for hyperactivity, but does nothing for attention.
I take a small dose of wellbutrin along with it for attention and it works rather well.

Me :D

ShawnB
04-02-07, 04:15 PM
I just started taking Tenex last night. The Dr prescribed 1mg to take at night, but I since learned it was best to start low and wean up, so I decided to cut my pill in half and start at .5mg at night for 4 days, then wean up to .5mg in the am, and the .5mg at night until my next appt on the 30th.

My Blood Pressure was 140/90, so that was the biggest factor of starting it. Plus I'm on 80mg Strattera and that was not helping the hyperactive part of my ADHD. First day, I've noticed dry mouth (but my Strattera still causes this too so it's not unusual for me) and I feel dizzy. I don't feel any of the Strattera at all though. This may be because it's that time of the month and I was noticing the past few days that Strattera wasn't working at all for me. Hopefully once this is over it'll go back to working.

I bought a blood pressure monitor today and it's already lowered to normal! First reading was 119/78 around noon, and just took it again aroun d 4pm and it was 97/71= Yay! Back to what my normal bp was before meds!

qinkin
05-03-07, 07:22 AM
wait, what about stimulants + clonidine?

like adderall + clonidene, is there experience w/this, among any?

restlessness seems not to lower much, if at all, w/adderall

in the thingy, riperidal is in combination w/clonidine. now, personally, risperidal works somewhat, but not is as effective by itself, as adderall is.

so, maybe a combination of adderall and risperidal, or adderall and clonidine has amazing potential for many. dunno, no experience, though.

well, thanks

Vickie
05-03-07, 01:57 PM
Clonidine and guanfacine in combination with stims have been shown (small studies) to work better than either the stim or the a2 agonist alone.
http://www.askdrjones.com/search/tenex
There is a current trial going on of the combo of guanfacine and focalin:
http://www.clinicaltrials.gov/ct/show/NCT00429273?order=2

Momofadder
05-05-07, 02:29 PM
wait, what about stimulants + clonidine?

like adderall + clonidene, is there experience w/this, among any?

restlessness seems not to lower much, if at all, w/adderall

in the thingy, riperidal is in combination w/clonidine. now, personally, risperidal works somewhat, but not is as effective by itself, as adderall is.

so, maybe a combination of adderall and risperidal, or adderall and clonidine has amazing potential for many. dunno, no experience, though.

well, thanksMy son take cloninidine at bedtime, adderall and dexedrine, along with prozac in the morning. Takes the clonidine for a tic caused by adderall.

optimum00
05-05-07, 03:44 PM
My son take cloninidine at bedtime, adderall and dexedrine, along with prozac in the morning. Takes the clonidine for a tic caused by adderall.Why doesn't your son switch to d-amp and then he could remove clonidine from his med list?

QueensU_girl
05-05-07, 08:13 PM
Galactorrhea. Yuck. Glad I don't have behavioural issues with my ADD enough to need Clonidine.

qinkin
06-01-07, 05:40 PM
side-affects, like small ones are ok. kinda' better to have some side-affects, or else, what is fun if not?

lol, Desoxyn has a few less side-affects to Adderall. This comes from experience. .

Hey, MOMOFADDER! how does this Clonidine help, specifically, besides that simple tic.

RichardJ
06-01-07, 08:20 PM
To anyone it concerns: I can't imagine why anyone would let their doctor prescribe a psychotropic medication to counteract the side effects of another psychoactive medication, the only exception I make to this is the use of certain meds used to eliminate s.e.'s from antipsychotics in Schizophrenics who can't be managed any other way.

In the case of treating ADHD, there are so many choices that addition of another medication to diminish adverse effects is, basically, never necessary.

This is poor practice except in rare cases, IMHO. I've been involved with about 8,000 ADHD kids and can recall only having seen the necessity to do this once.

Vickie
06-02-07, 10:03 PM
These meds which were originally used for blood pressure control have some effectiveness with some ADHD symptoms on their own. They are not just used for control of side effects of other meds, although they can be effective in reducing tics so that a person who would benefit from a stim (but who's tics get worse) can actually use a stim. The addition of guanfacine (or clonidine) can be for augmenting a stimulant when for some reason the stim cannot be increased to a fully effective dose due to sleep, weight or aniety issues. This way you can get effectiveness without side effects. Also the combo has been shown to be more effective at controlling symptoms than either alone.They can also be used for control of symptoms at times (like evening) when having stim in the system can interfer with sleep, thus giving coverage for all areas of life that the ADHD adversely effects.

speedo
06-02-07, 10:40 PM
tenex (guanfacine) and clonidine are both listed as approved for the treatment of ADHD.

In short, they reduce hyperactivity, but do not do much for attention, so an add-on stimulant is common. Tenex is touted as being more effective and having fewer side effects than clonidine.

They also reduce anxiety and tics a bit so thay are good meds for people who have adhd along with anxiety or ocd, or even with tourettes syndrome.... and for those people an antidepressant or an atypical antipsychotic is sometimes added to further control anxiety, particularly for persons with OCD or TS.

Me :D

qinkin
06-04-07, 02:24 PM
maybe having Schizophrenia is slightly fun?

being on powerful anti-pyschotics sounds so good rigth now (lol) honestly though

lars
06-04-07, 02:35 PM
tenex (guanfacine) and clonidine are both listed as approved for the treatment of ADHD.
Approved by the FDA?

I know they are often used off label, but I did not know they were approved for the treatment of ADHD.

Do you know when they were approved by any chance?

speedo
06-04-07, 06:15 PM
I don't know if it is approved, but it is commonly listed as a second line medication for adhd.

ME :D

lars
06-04-07, 06:21 PM
Ok ;)

TygerSan
06-15-07, 01:11 PM
FYI, guanfacine in long acting form is under review by the FDA for approval for treatment of ADHD. I don't know how long it'll take before the final decision. (and remember that Provigil was up for approval and was not approved due to side effects, so it's not a 100% shoe-in.)

http://healthnews.uc.edu/clinicaltrials/?/4175/


From a news article about the approval of the Adderall XR triple beads:
http://www.medicalnewstoday.com/medicalnews.php?newsid=71519&nfid=crss
Shire ADHD Portfolio

In addition to SPD465, Shire's portfolio of ADHD treatments includes VYVANSE(TM) (lisdexamfetamine dimesylate), the first prodrug stimulant, which is planned to launch 2Q 2007, DAYTRANA(TM) (methylphenidate transdermal system), the first and only ADHD patch, and ADDERALL XR(R) (mixed salts of a single-entity amphetamine product), a long-acting formulated stimulant. SPD503 (guanfacine HCl extended release) is currently under review with FDA.