View Full Version : SEEKING emotion system, addiction, ADHD, chain link.

03-31-14, 01:17 PM
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SEEKING emotion system, addiction, ADHD, chain link

..In our view, the rewarding properties of drugs of abuse are, in part, caused by the activation of the SEEKING disposition, ranging from appetitive

drive to persistent craving depending on the intensity of the affect.

The implications of such a view for understanding addiction are considered, with particular emphasis on factors predisposing individuals to develop compulsive drug

seeking behaviors.

Keywords: Mesolimbic, Dopamine, Motivation, Reward, Accumbens, Addiction


1.1. The mesolimbic dopamine (ML-DA) system

The ML-DA system (Fig.1) has received considerable attention due to its involvement in a range of psychological processes and neuropsychiatric diseases.

In fact, after the development of a DA theory of schizophrenia (Carlsson, 1974; 1978; Snyder, 1972; Meltzer & Stahl, 1976), additional ML-DA hypotheses have

been proposed to explain addiction (Wise & Bozarth, 1981; 1987; Koob, 1992), attention deficit hyperactivity disorder (ADHD) (Oades, 1987; Levy, 1991; Russel,

2000), depression (Willner, 1983a, 1983b, Dailly et al., 2004) as well as global behavioral activation (Gray, 1995) ranging from response persistence to behavioral

compulsions (Salamone & Correa, 2002; Everitt & Robbins, 2005)...

Behavioral Functions of the Mesolimbic Dopaminergic System: an Affective Neuroethological Perspective

Also see thread:ADHD linked to physical abuse (