Hi all,

I've just started a trial of Reboxetine for my ADHD and was wondering if anyone else had tried it for ADHD and what effects and/or side effects they had experienced.

Regards,

-CrashDr

No Crash-Dr, but many of us would be very interested in your experience with this drug. :)

Thank you for telling us, and hopefully someone else will come along who can give you some input.

Good Luck!

One poster here with an avatar of some rock singer has had experience with this drug, do a search on it and you'll see how it went. It was slightly positive but he eventually gave up on it because of a metallic taste in his mouth, he says.

Hi all,

I've just started a trial of Reboxetine for my ADHD and was wondering if anyone else had tried it for ADHD and what effects and/or side effects they had experienced.

Regards,

-CrashDr

Thanks for the replies, guys.
My findings on this drug are that it did not agree with me in the slightest - after only almost two weeks of taking it the side effects became unnacceptable, a real shame as I was very interested to see what the therapeutic effect would be with regard to ADHD (the drug having a similar action to Strattera, ie. selective nor-epinephrine re-uptake inhibitor, but not anywhere near as expensive here in Australia.).

One of the worst side effects was my seeming inability to get a restful night's sleep, I would have dreams that were extremely vivid and seemed to last the entire night - that is inbetween my constant waking up and tossing and turning. The closest things I can liken it to is; being delirious, and inadvertently taking pseudoephedrine for a cold before going to bed (without something like Chlorpheniramine added to counteract the stimulant effect). The net effect being that I would wake up feeling like I had not slept at all - and using the phrase "wake up" would be a stretch in this case anyway ;)

Also, (and this could also perhaps be attributed to my coming off both Citalopram and Dexamphetamine to trial Reboxetine rather than an adverse effect, however cessation of these have not resulted in such extreme results in the past) I have been experiencing severe emotional instability and mood swings, often crying over fairly trivial things (and all non trivial things! :) ) even to the point of not being able to watch some news reports on TV as I'd just burst into tears. I had also been quite irritable and reacting angrily to my family in situations where otherwise I'd be nowhere near as bothered.

...and an all consuming tiredness like I could not believe :(

All in all, the net experience seemed to have me feeling like I was losing control of myself, so after discussions with my doc the trial was terminated.

Oh well, back to the tried and true ;)
I've decided that I'll take the crashes from dex and the inattention in the evenings gladly after this little experience.

Regards,

-M@/CrashDr

Crash-Dr, thank you for replying. I am sorry to hear you had such a bad experience, but I think if you hadn't tried, you would always have wondered.

I would think that going back onto your usual drug regime may help to stabilize your emotions a little. You have given them quite a shake up, and I hope you feel better soon. :)

Thank you for letting us all know how you went.

Take Care, and rest,
~Viktoria

I've been on edronax for a few months now. I feel it has helped my depression, but I'm not so sure about it's affect on my add. My wife also dosen't think it has had any great affect on my add.

I don't seem to have had any adverse side effects from taking it. I've always woken often during the night and found it difficult to get 'comfortable' and that hasn't really changed.

In some ways I'm tempted to try and stay on it (I only had a script for 6mnths and my psych's final comments were ease off of it when near the end of the last box and hopefully I won't have to see you again). Sometimes I feel I could tackle my add tendencies with management strategies with the edronax keeping my depression in check.

Other times I wish I could just go to work and act like a normal person and get things done properly.

It dosen't seem to be widely used. But I'll keep up with it for now.

thought I would bump this old thread instead of starting a new one...

Im on my second week of edronax after trialing strattera for 6 weeks without success (no improvement of ADHD symptoms & bad side effects).

The psych has put me on edronax more for depression than ADHD however I am interested in the reports that it may help for the ADHD.

So far the side effects have been minimal compared with strattera however still somewhat concerning. I can put up with the sweats, back chills, and sleeplessness however the raised anxiety levels and increased short temper is making life and homelife harder.

I have never really had a problem with anxiety before - is this a common side effect of such medication?

I have also read the dangers of taking both NARI & stim meds? Should I raise this with my psych? I am currently waiting on approval for stim meds (history of substance abuse) and if it comes through I want to ensure Im not walking into 'another' situation...

Too tired to reply fully now, but I will later, as I have extensive experience with Strattera and some experience with Edronax.

r2d2: The concern is for having too high a level of norepinephrine, which stimulants and Strattera both increase. Your symptoms sound bad and you should proceed with serious caution. If you were not having these symptoms, then perhaps your doctor would allow a very low dose of stimulant to test the waters, so to speak, but I doubt this is a good idea due to your side effect profile. However, I am an amateur at this pharmacology stuff so please do your own research and discuss this with your doctor (hopefully he is a good one).

If you are interested in learning more about the nitty-gritty of it all, a good resource might be:
Free online neuroscience textbooks and related resources (http://www.neurotransmitter.net/textbooks.html)

Highly recommended reading : "A Primer of Drug Action : A Concise Nontechnical Guide to the Actions, Uses, and Side Effects of Psychoactive Drugs," Revised and Updated by Dr. Robert M. Julien (http://www.amazon.com/exec/obidos/tg/detail/-/080507158X/qid=1078035443//ref=sr_8_xs_ap_i1_xgl14/002-5379645-3248841?v=glance&s=books&n=507846) (amazon.com)

Yeah I worked the dose up to 20 mg a day for a week. Reboxetine can treat ADD but it has some nasty side effects. I would not recommend it.

The side-effects are no worse than Strattera, in my experience, although I've only gone as high as 12 mg/day. Working the dose up more gradually and/or using a lower dose altogether might be helpful to reduce side effects. Side effects are generally only seen at doses of 8mg or above, according to some literature that I've seen.

cheers for the links flatlinez

well, I have just passed 30 days on edronax -most of the side effects have passed, Im still on 8mg/day and I can honestly say there is absolutely no improvement in my depression/mood swings!!!

I'll be talking to the psych about an increase in the dosage - however I am losing confidence in these meds!!! If only SSRI's agread with me!!!!!!

r2d2: It might not be right for you. It is interesting how Strattera was not effective for ADHD but was effective for the depressive symptoms. This might be the euphoria effect of Strattera, which I was also fortunate enough to experience for a time. There is further mention of the euphoria effect on www.crazymeds.us (http://www.crazymeds.us)

It may be that Norepinephrine is not the key to your symptoms. For a good overview of the psychiatric landscape, there is an excellent read at http://www.biopsychiatry.com/
I am very familiar with the material and would be happy to discuss any of it with you.

6+ weeks on edronax and I have given up! No improvements in symptoms and still getting the side effects of excessive sweating and constipation, made it an easy choice!

So that crosses off SSRIs & NARIs.....

I am now going to trial a Reversable MAOI (or RIMA "Reversible Inhibitors of Monoamine Oxidase") called Aurorix (moclobemide).

Hopefully once I get approved for ADHD stim meds it may actually improve these symptoms and I may not require anti-dep meds!

fingers crossed!

Moclobemide (Manerix, Aurorix), the "gentle MAOI", is both a selective and reversible inhibitor of MAO-A. It marks the first RIMA (http://www.biopsychiatry.com/rimas.html) to win clinical acceptance. Moclobemide lacks anti-cholinergic side-effects. It promotes the healthy growth of new neurons (http://www.biopsychiatry.com/moclobemide-neogenesis.htm) in the hippocampus. No dietary restrictions are needed. It is valuable as more than a mood-enhancer and resilience-booster. For moclobemide is often useful in overcoming social phobia (http://biopsychiatry.com/moclobsocphob.htm), panic disorder (http://www.biopsychiatry.com/moclobpan.htm), obsessive-compulsive (http://biopsychiatry.com/ocdtreat.htm) symptoms, irritability and aggression owing to the way it enhances serotonin function. (The casual use of gobbledygook such as "enhanced x function" will rightly alert the reader that many complications are being skirted or omitted. Those hungry for the greater technical (http://www.biopsychiatry.com/refs/index.html) detail of a non-popular account can rest assured the literature will leave them feeling abundantly well-nourished). [from www.biopsychiatry.com]

i enjoy reading your posts flatlinez - great work!

out of interest, do you have 1st hand experience with RIMAs?

also, the psych said to stop taking edronax without tapering off, give it a 1 day break and then start on 300mg/daily of Aurorix, however the chemist strongly advised a 1 week break....I know who to trust however I have read some interesting stuff about RIMA's & other drug interactions - again, anybody with 1st hand experience?

cheers

edit: found an informative link re anti-dep changeover
http://www.nps.org.au/resources/Health_Professional_Tools/depressionaudit_drugs_insert.pdf

I've only had experience with the irreversible MAOI Selegeline (Deprenyl) at MAO-B selective dosages (10mg or less). I found that its combination with Reboxetine made me quite irritable and angry -- not fun. However, Moclobemide seems to be MAO-A selective only. "The inhibition (http://biopsychiatry.com/rimah.html) of MAO-A cause the rise of norepinephrine, dopamine and serotonin in the synaptic cleft, of MAO-B only of dopamine." This means that the effect on dopamine should be much less compared with an MAO-B such as Selegeline. Also in my experience, I feel it if I miss a dose of Reboxetine within a day, so hopefully it should clear out of the system very quickly. Good luck on your trial of the RIMA!

I have used moclobemide. I first read about it in the early 90's when a study
compared it to nardil in efficacy for social phobia. Anyway I used it not noting any special properties. It had no side effects though. I did combine a low dose
of it with paxil when I had no idea of the danger and I became extremely happy, followed by drunk like then my airway became highly restricted
(serotonin syndrome).

searching through this site and others it appears that the occurrence of "serotonin syndrome" associated with moclobemide is way too high to not take very seriously! Even the use of pseudoephedrine is a danger!

I assume when/if I start with dex/ritalin that I will have to discontinue with the aurorix - or monitor the intake very closely!

theta: sorry to hear of your experience - have there been any long effects?

theta: sorry to hear of your experience - have there been any long effects?

No long term problems. I was fine several hours later.

Hi there

I am also on my second week of Edronax for ADHD. This is the first medication I am trying for this as I was a bit cautious of the stimulants, and Strattera is a bit expensive. I've been having bad side effects though. After the first day of taking it, I started with really bad insomnia, which I am still experiencing. I get tired, but I only sleep really lightly and get hot and uncomfortable easily.

I have also been getting goosebumps very easily and often I can feel my heart beating on my chest really fast. I run about 3 times a week in the afternoons, but on this medication, I get very bad chest pains and can't seem to run for more than a kilometer before I need to walk.

Other than these side effects, my mood seems to be much more stable, but it doesn't seem to be doing anything for my concentration.

I read on the package insert that this medication can take a couple of weeks to start working properly, but for now, the side effects aren't that bearable. Maybe it will clear up. Anyway, I have made an appointment at the doc for next week so we'll see what happens. Its a pity, because the doc said this was a cheaper, more convenient and much less addictive route...

Oh well, hope this helps