View Full Version : Gut Dysbiosis and Neurocognitive Symptoms


Kunga Dorji
09-14-14, 01:11 AM
For some time there has been increasing concern that abnormal gut bacteria may be contributing to symptoms in a wide range of conditions including psychiatric conditions, chronic fatigue and fibromyalgia.

I attended a lecture on the weekend relating to "intestinal dysbiosis" (leaky gut) in chronic fatigue syndrome. The issue here is not so much presence of abnormal gut bacteria but the presence of abnormal populations of normal bacteria.

However- the symptoms discussed overlap considerably with many ADHD symptoms. It is being postulated that stress and suboptimal diet may contribute to these abnormal bacterial populations - and stress and a suboptimal diet are common in ADHD- so this material is relevant for anyone with ADHD - especially if there is any instability in our symptoms.

What follows is a transcript of my lecture notes. This material should be understood as discussing a possible contributor to symptoms in ADHD patients- not as proposing a cause or a cure.

It is clearly something that is worth considering- though the trouble is most medical practitioners are nowhere near being up to date with the state of research.

GUT DYSBIOSIS AND ASSOCIATED SYMPTOMS
Dr Henry Butt- (Bioscreen) lecture 13 September 2013 Alfred Hospial Melbourne

Recent research comparing healthy controls with CFS patients
GI BACTERIAL POPULATION: Aerobes vs anaerobes, colon is the important site

AEROBES

E. Coli 90-95% of aerobes in 97% of healthy controls , but only in 27% of CFS patients

Streptococci
Enterococci together: <5% of aerobes in 88% of controls, but in only 15% of CFS patients
also bifidobacter and lactobacillus


These findings had extremely high statistical significance-- p values of 0.01 or 0.001


SYMPTOMS
Low E. Coli:
especially


[SIZE=2]poor appetite
abdominal pain
nausea
diarrhoea or cyclic diarrhoea/constipation
gastrooesophageal reflux
food cravings
increased food sensitivity
increased reactivity to smells
increased fatigue
increased neurocognitive dysfunction (brain fog)



High Bifidobacterium


poor mood



High Streptococcus


decreased energy & vigour
worse sleep
neurocognitive symptoms

High lactobacillus


increased confusion
increased tension
increased anger
increased depression



Stretococci and enterococci
- probable association with pain via D-lactic acid
PROBABLE BIOCHEMICAL MECHANISMS


E. Coli is responsible for intraintestinal manufacture of


Folic Acid
Tryptophan
Tyrosine
Phenylalanine - both low tyrosine and phenylalanine are associated with neurocognitive
dysfunction, tyrosine being the precursor for dopamine, noradrenaline, adrenaline
and thyroid hormone
Ubiquinol (Coenzyme Q10)
Methaqinone (Vitamin K2)


Critically Coenzyme Q10 is necessary within the Krebs (Citric Acid) cycle to convert succinic acid into fumaric acid


The Krebs cycle is an intramitochondrial series of chemical reactions and mitochondrial dysfunction is posited as amajor issue in chronic fatigue.


Consequently individuals with deficient CoQ10 will have a downregulated an inefficient conversion of glucose into useable energy and have a high urinary Succinic Acid


High Urinary Succinic Acid is a consistent feature in fatigue patients




Lactic Acid Accumulation
regarded as a major source of pain in fibromyalgia


Streptococci
Enterococci
Lactobacillus
Bifidobacter- all produce lactic acid


Lactic Acid Isomers D and L
L- lactic acid is required in normal metabolism and our bodies can handle it efficiently


D- Lactic Acid is more difficult to dispose of- and requires “lactate racemase” found in low levels in mitochondria


Mitochondrial function is usually suboptimal in fibromyalgia/CFS


Enterococcus
Streptococcus- both produce largely D lactic acid, and especially when the diet is high in sugar or fruit


Therefore if Strep populations are high glucose and fruit should be excluded for a month.



TESTING:


Urinary succinic acid


a marker of CoQ10 deficiency therefore associated with low E Coli



Faecal Testing
Bioscreen Medical - in Melbourne Australia- but no doubt elsewhere as well.



TREATMENT:
best treatment is yet to be resolved
Antibiotics are being used- especially Erythromycin.



Erythromycin
preferentially concentrated in the bowel (via excretion in the bile- so suboptimal liver function may be an issue).



(Much more toxic to streptococci and enterococci than to E. Coli)

Single week treatments produce an improvement but not a lasting one


Longer treatments (2 weeks) are about to be trialled.


Much longer treatments are sometimes used by some clinicians working in the area


RESEARCH
there is ongoing research being organised through bioscreen and in conjunction with Melbourne University and other institutions around the world.


A series of papers are about to be released by the end of this year.


A list of current papers can be found at the parent site-

Bioscreen Medical (I can't link to it as it is a commercial site)



(click on the “Download for Overview” link on the home page).

sarek
09-14-14, 04:04 AM
Thank you for this important information on an issue that has hitherto been very much overlooked. Our bodies have a far greater degree of intelligence than only that which is situated in our brain, and the gut is a critical node when it comes to our functioning.

Lunacie
09-14-14, 09:58 AM
Funny how it says that antibiotics are being used to treat this problem,
from what I've heard, there is concern that antibiotics are actually the cause.
.

SB_UK
09-14-14, 03:32 PM
Dr Henry Butt:-)

Unholy faecal transplants Barliman !!!

Kunga Dorji
09-14-14, 05:25 PM
Funny how it says that antibiotics are being used to treat this problem,
from what I've heard, there is concern that antibiotics are actually the cause.
.


Antibiotics are only one approach.
However from that point of view erythromycin is ideal because it is excreted in the bile and reaches high concentrations in the colon and secondly E Coli- which we want is very resistant to it- while the streptcocci and enterococci are very sensitive to it.

The other approach is endoscopic faecal implant from a healthy donor-- usually preceded by a bowel washout such as you would have prior to a colonoscopy.

( Yes I know it sounds unattractive)

The Russians have been doing this for many decades- and it is now being used in Australia.

Kunga Dorji
09-15-14, 01:23 AM
:-)

Unholy faecal transplants Barliman !!!


Total tangent-- but:

Yes- -- I think that a few people have spotted that one!
However it is worth remembering that one of the early textbooks of neurology was edited by a Professor Brain.
The book is called Brain's Clinical Neurology- and newer versions are still being produced.
http://brain.oxfordjournals.org/content/125/10/2370.2.full
from Wikipedia

Walter Russell Brain, 1st Baron Brain (23 October 1895 – 29 December 1966) was a British Neurologist He was principal author of the standard work of neurology, Brain's Diseases of the Nervous System, and longtime editor of the homonymous neurological medical Journal titled Brain.
You couldn't make this stuff up!

SB_UK
09-15-14, 07:00 AM
Funny - bifidobacteria and lactobacillus are the ones which come up again and again as the 'good guys' - now bein recharacterized as the bad guys ?

SB_UK
09-15-14, 07:06 AM
Enterococcus
Streptococcus- both produce largely D lactic acid, and especially when the diet is high in sugar or fruitEliminate sugar, fruit, blood glucose elevating agents (wheat etc ?) ?


Lactobacillus
Bifidobacter- all produce lactic acid

Eliminate dairy ?

All still consistent with nuts, seeds, low GI veggies, CP oils, olives, dark chocolate and avocados ??
[Nearly there bar soft cheese]

SB_UK
09-15-14, 07:39 AM
Just at the simplest level imaginable.

Living a depressing stressed out life which most of us do - drives us to eat food which 'peps' us up ie sugar/simple carbs/animal meat ie gives us a short term energy boost - but which presumably selects for a certain type of particularly invasive bacterial growth inside of us - which results in our internal bacterial community losing diversity.

There's no real point in suggesting the ideal diet - because nobody's going to comply in a world in which the ideal diet is not cheap, not attractive, not easily sourced, not 'comforting' to come home to.

I don't know whether we can correct gut bacterial diversity until people are no longer reaching for 'morphine' (sweet mlky fat) in rat park.

-*-

The lactobacillus/bifidobacteria thing is unexpected though - up until now - those 2 come up strongly as the ones we want to encourage eg

http://www.drmyhill.co.uk/wiki/Fermentation_in_the_gut_and_CFS


Lactobacilli. These ferment sugars to lactic acid, which provides an acid environment in the large bowel to protect against infection. Also highly protective against bowel cancer. Abundant in Kefir. '
Bifidobacteria. These assist digestion, protect against development of allergies and cancer.

SB_UK
09-15-14, 07:42 AM
I think that the only way I've found to be attracted to the healthy option is to go without food until ANYTHING tastes wonderful.

In a world of food availability on a moment by moment basis - think rats carrying their morphine dispensers around with them in rat park -
- and food with an immediate neurochemical effect ie sweet/salty/umami -

foods without any hit fall behind.

Leg up though if we're hungry when we come to them.

SB_UK
09-15-14, 08:07 AM
Dr Butt ... motility

The first workout routine to be roundly endorsed by the entire medical establishment.

http://www.drmyhill.co.uk/wiki/Fermentation_in_the_gut_and_CFS

Bacteroides. These are by far and away the most abundant bacteria. It is bacteroides which allow us to digest soluble fibre and make short chain fatty acids. This is the main source of food for the colonocytes, the cells lining the bowel and if this is low, then it will result in atrophy of the colon. Short chain fatty acids also protect us from hypoglycaemia. Indeed, it is estimated that over 500Kcal per day may be generated - a very significant source of energy!
There is no probiotic which contains bacteroides simply because bacteroides cannot exist outside the human gut - oxygen kills it quickly. We just have to feed the gut with the right food (prebiotics) found in pulses, nuts, seeds and vegetables

-- Require --
[1] Behaviour compatible with and development of a moral mind -> eliminate psychological distress
[2] Plentiful Soluble fibre rich diet -> eliminate physical distress

Ideally in a shed in the sun - so we're not cold.

SB_UK
09-15-14, 08:09 AM
It's a bit unfair that the Olympics has no event which seeks to applaud smooth muscle.

How about the 100g vacate ?

IE who can vacate 100g of solid matter in the quickest of times.

Yeah - I'm thinking laxative abuse too ... ...

We're definitely going to have to define what solid means.

Human beings do so want to win even the most bizarre of challenges.

SB_UK
09-15-14, 08:11 AM
It's a bit unfair that the Olympics has no event which seeks to applaud smooth muscle.

How about the 100g vacate ?

IE who can vacate 100g of solid matter in the quickest of times.

Yeah - I'm thinking laxative abuse too ... ...

Human beings do so want to win even the most bizarre of challenges.

1kg for long distance 'runners' ?

:goodpost:

SB_UK
09-15-14, 08:16 AM
-- Require --
[1] Behaviour compatible with and development of a moral mind -> eliminate psychological distress
[2] Plentiful Soluble fibre rich diet -> eliminate physical distress

Ideally in a shed in the sun - so we're not cold.

Back to the garden.

I start this weekend.

SB_UK
09-15-14, 10:13 AM
organic gardening

1. exercise
2. moral
3. sun exposure
4. perfectly sustainable
5. health-promoting (gut bacterial diversity)
6. health-promoting (human processes also)
7. human waste handling or else disease and lots of it !!
8. accessible to anybody
9. community promoting

ie gut dysbiosis and neurocognitive decline remediated.

-*-

What else is there to say ?

endurance exercise [hit the wall] -> fasting [4 days] -> ketosis through vegan CP oils -> soluble fibre rich (SCFAs) diet [seeds, nuts, CP oils, olives, avocados, low GI veg]
= the fatty fat fat (ketone body) pro-mitochondrial way
with moral mind in moral environment allowing (promoting/necessitating) moral behaviour

as endorsed by Jedi everywhere.

Kunga Dorji
09-16-14, 05:57 AM
Eliminate sugar, fruit, blood glucose elevating agents (wheat etc ?) ?



Eliminate dairy ?

All still consistent with nuts, seeds, low GI veggies, CP oils, olives, dark chocolate and avocados ??
[Nearly there bar soft cheese]


Looking at this closely- lactic acid is a problem for some people with fibromyalgia pain. No pain- no problem.

I think that lactobacilli &bifudibcter produce L lactic acid- which our bodies can handle easily.

However the main thrust of the talk was that it is the good chemicals produced by E. Coli that are important and that a total colonic aerobic bacteria load of 95%+ E. Coli is associated with good health versus CFS (confidence interval p between 0.01 and 0.001-- which is highly statistically significant.

Enterococci and streps are clearly associated strongly with production of undesirable D lactic acid, with significant neurocognitive dysfunction and pain (and in the context of neurocognitive dysfunction I wonder if it is the D Lactic acid here or the absence of metabolites produced by the E Coli that is the issue here - but do not know).

Watch this space - the remainder of the research is about to be published- before the end of this year.

Now re diet-- it seems very clear that the nasties (Streptococci and Enterococci) both breed better and produce more undesirable toxic metabolic byproducts in the presence of a diet higher in starch or glucose.

Bottom line- the stuff you have been beating us over the head with about the desirability of a ketogenic diet is not only right -- it is CUTTING EDGE right.

As the psychiatrist and ADHD specialist John Ratey says - the diseases of civilisation (which include depression and ADHD) are the diseases of GLUCOSE.

We weren't evolved to have lots of it in our diet-- and if we ignore that obvious fact, we do so at our own peril.

Kunga Dorji
09-16-14, 06:01 AM
1kg for long distance 'runners' ?

:goodpost:


One does have to be careful to avoid "lowering the tone" of the conversation.
Even verbal incontinence can be embarrassing.

Kunga Dorji
09-16-14, 06:02 AM
I think that the only way I've found to be attracted to the healthy option is to go without food until ANYTHING tastes wonderful.

In a world of food availability on a moment by moment basis - think rats carrying their morphine dispensers around with them in rat park -
- and food with an immediate neurochemical effect ie sweet/salty/umami -

foods without any hit fall behind.

Leg up though if we're hungry when we come to them.


Salt is another issue-- and very important.
Look for the next thread.

Mantaray14
09-16-14, 08:36 AM
This thread piqued my interest. Are there any books you could recommend on how to implement such a diet if one were inclined to try?

Kunga Dorji
09-16-14, 05:51 PM
This thread piqued my interest. Are there any books you could recommend on how to implement such a diet if one were inclined to try?

At the moment this is all up in the air- the research is unfolding as we speak.

IT has been known to be a problem for decades- but the quantitative techniques to assess the problem did not exist until very recently.
I have been given a number of weblinks to review- and when they are checked out I will pass them on.

Mantaray14
09-16-14, 09:13 PM
At the moment this is all up in the air- the research is unfolding as we speak.

IT has been known to be a problem for decades- but the quantitative techniques to assess the problem did not exist until very recently.
I have been given a number of weblinks to review- and when they are checked out I will pass them on.

I'm gonna pick this up at local library tomorrow, the author claims it's similar to a ketone diet...I read his other book about building a better kids brain.

http://www.amazon.com/Grain-Brain-Surprising-Sugar-Your-Killers/dp/031623480X

someothertime
09-17-14, 01:29 PM
Very little is known about the gut in western medicine.... i would suggest buddhist / eastern / ayuverdic etc. readings if one were to venture into this arena.

My gut tells me it is moreso what is not consumed just as much if not more that what is.....

;)

( p.s. re: ^ i read a nice book on mood and diet ( mostly ayurvedic stuff )...... more sort of "horoscopey"....... aka 5 types of person..... fire person benefits from cloves type of thing............ it is rather specific......... though i believe the underlying philisophies / ingredients are indeed extremely beneficia, might be able to track fdown the name if anyone is keen PM mel )

Kunga Dorji
09-19-14, 05:04 AM
Very little is known about the gut in western medicine.... i would suggest buddhist / eastern / ayuverdic etc. readings if one were to venture into this arena.

My gut tells me it is more so what is not consumed just as much if not more that what is.....

;)

( p.s. re: ^ i read a nice book on mood and diet ( mostly ayurvedic stuff )...... more sort of "horoscopey"....... aka 5 types of person..... fire person benefits from cloves type of thing............ it is rather specific......... though i believe the underlying philosophies / ingredients are indeed extremely beneficial, might be able to track down the name if anyone is keen PM mel )

There is much more in the Eastern approaches than most of us Westerners are prepared to admit-- but the philosophies are rather vague and hard to understand from a Western biomedical point of view- so many people find it hard to make the potentially substantial dietary changes recommended. The Ayurvedic and Taoist/Traditional Chinese Medicine approaches are the best systematised.

I have been looking quite hard at these and clearly there are very significantly important issues with acid base balance (a major aim of Ayurvedic diets is to alkalinise our systems. Western diets are acid heavy and that probably has a big role in increasing free radical damage to our bodies.

SB_UK
09-19-14, 06:23 AM
Are Dietary Fiber, the Gut Microbiome, and Asthma Connected? - See more at: http://www.jwatch.org/na33813/2014/03/04/are-dietary-fiber-gut-microbiome-and-asthma-connected#sthash.21FQGw2d.dpuf

Day 1 of psyllium husk (1 tsp (50% soluble fibre consumption) and ?? immediate ?? reduction in bronchial hyper-reactivity.

A little too good to be true - continuing to observe.

So - new regime:
chia seeds + psyllium husk + pear + lentils + nuts/seeds
+
veggies/salad + olives/pesto/EVOO
+
some cheese <- may need to eliminate

Soluble fibre rich.

1. Endurance exercise - ketosis
2. MUFA - ketosis
3. Soluble fibre SCFA - ketosis

An evolutionary tale of fat over carbs ?

SB_UK
09-19-14, 06:27 AM
As the psychiatrist and ADHD specialist John Ratey says - the diseases of civilisation (which include depression and ADHD) are the diseases of GLUCOSE.


Yay!!
Makes sense though doesn't it - on a grand scale carbs aren't fit to go the distance - and we've evolved to go the distance ie long distance / persistence hunters - Eboy described us as the most 'aerobic' of organisms.

Very strange - am going to up psyllium husk levels - I've a relaxed airway - very strange ... ...

SB_UK
09-19-14, 06:30 AM
Salt is another issue-- and very important.
Look for the next thread.

Been worrying about salt on account of the usual preparation of olives ... ...

SB_UK
09-19-14, 06:38 AM
Now re diet-- it seems very clear that the nasties (Streptococci and Enterococci) both breed better and produce more undesirable toxic metabolic byproducts in the presence of a diet higher in starch or glucose.


Presumably the glucose/carb digesting bacteria are more virulent than the soluble fibre digesting bacteria ie overgrowth of a few bacterial types when eating carbs vs diversity of many slower growing abcterial types when eating soluble fibre

- the point being you can't do both ie expect a bit of salad and a few nuts to overcome the pack of 6 doughnuts you eat on 30 minute rotation ... ...

We need to eliminate the blood glucose raising agent (or reduce it to very low level) and increase soluble fibre consumption at the same time.

What's interesting is that fasting, fat consumption are OK ... ... but neither feed the gut bacteria so low GI veggies mixed into the vegan ketogenic (maybe with some cheese) round off the lifestyle ?

I certainly know that I've a perpetual craving for lentils which're apparently one of the highest sources of soluble fibre.

SB_UK
09-19-14, 06:44 AM
At the moment this is all up in the air- the research is unfolding as we speak.

IT has been known to be a problem for decades- but the quantitative techniques to assess the problem did not exist until very recently.
I have been given a number of weblinks to review- and when they are checked out I will pass them on.

And now the quantitative techniques are trivial to use.

Far more impressive than the human genome - assessing gut bacterial diversity will change how we live overnight.

We're due to find that distress, poor diet and lack of exercise drop our bacterial complement.

How do I know ?

Well - we can just steal the info from IBS research.

Just basically combat stress, exercise more and dramatically change food to be (ideally) fresh organic ketogenic vegan soluble fibre-rich ... ...

http://www.patient.co.uk/health/irritable-bowel-syndrome-diet-sheet#

SB_UK
09-19-14, 06:55 AM
I'm gonna pick this up at local library tomorrow, the author claims it's similar to a ketone diet...I read his other book about building a better kids brain.

http://www.amazon.com/Grain-Brain-Surprising-Sugar-Your-Killers/dp/031623480X

Excellent find

Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

There's a head of steam building here.

Thing is is that the human genome project was never going to lead anywhere useful ... ... the off-shoot of next generation sequencing has been useful though

- though there's going to be a large amount of head slapping when the conclusion that fresh organic vegan low GI soluble fibre rich food in a fasting, low stress and high exercise environment is best for us.

I think that we'd have elected for that approach as being the healthiest option without any molecular info.

But what has mol research helped us to see ?
That carbs (generally thought of as good ie whole grains) are a major problem ... ... but we all know that carbs aren't a great foodstuff at least compared to fat
- and so there's no great surprise there.

Perhaps there's some useful information on the benefit of soluble fibre as opposed to insoluble fibre ?
But studying IBS sufferer discomfort is enough to get us there.

Maybe molecular data will be able to throw out artificial pesticides and fertilizers as plant-changing -- ie giving us a rational basis for having a natural method of farming - a method that's sustainable ... ...

Anyway - all of that's do-able ... ... it's relatively easy I guess on an experimental model - simple experiments - simple analyses ...

But take-home will simply be pro-ketogenic lifestyle from 3 angles (fasting, exercise MUFA-rich + soluble fibre rich) alongside distress absence from eliminating money.

Maybe effects of distress on gut bacteria would be useful - but we all kinda' suspect - especially as stress often operates from the stomach - that there's going to be something up there.

-*-

The really cool thing about this model for optimal psych/physiological health ie prevention of disease is that it's probably the easiest, nicest, best and only sustainable way to go

- so we've little choice other than to take the route anyway.

It's just nice to have scientifically validated that it is actually the right approach - from a medical science perspective also.

SB_UK
09-19-14, 06:56 AM
Perly should have called his book Grain Drain.

SB_UK
09-19-14, 07:45 AM
Trying to come up with a simple explanation of why the carbs -> fat transition should be obvious ?

Talked about it previously but the thought came up again last week ... ...

If we look at muscle cramp, epilepsy (a sort of electrical cramp), heart attack (a sort of electrical cramp), asthma (a sort of smooth muscle cramp) ... ... they're all just diseases of over-excitability over-activity ie operating frenetically - uncontrolled over-activity.

Carbs are rocket fuel vs fat (ketones) -

- multiple scientific studies show that ketosis does have an impact on explosive sporting endeavour as opposed to steady aerobic ... ...

It's just that taking these ideas together - though cramp (I'm guessing) isn't ever used to connect the principle in those diseases together - gives us a clue (over-excitability through feeding the organism the wrong (too energy laden) fuel)

-- but I'd like also to wager that human longevity relates to blood glucose variability above the standard (6 mM) level.

ie that persistent elevation of blood glucose for whatever reason from food type, to stimulation, to fight, to flight ... ... all use up a little more than we need of our time

ie reduces our longevity.

First thought - the athlete paradox - that athletes live statistically highly significantly shorter lives.

-*-

Is it hard to live in a low GI vegan MUFA world ? ... ... well CP oils help and I think that veggies can taste much better than the plastic cultivars which're favoured for reasons relating to spoilability.
Overall no - not too difficult - just more effort required than buying a year's supply of crisps and having one for breakfast, lunch and dinner.

[That's what my wife did]

SB_UK
09-19-14, 07:53 AM
Salt ... ...
still sdtruggling with this one.

Salt is used in the natural world to kill things.

What's the effect of salt on the gut biome ?

We have previously identified a number of novel salt tolerance loci from the human gut microbiota using a combination of functional metagenomic screening, next-generation sequencing and bioinformatic analyses.

Looks like osmotic stress wipes the little guys out too ... ...
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0103318

-*-

Genuinely - we're just proving what we all pretty much new to be true - in the first place before (sadly) medical research became involved and you must have HRT, must have antibiotics, must be vaccinated, must avoid fat, must eat plenty of whole grains, must have a large intake of insoluble fibre

-- we're just ending up with a model which is what you'd have thought if nobody (bearing the credentials of expert) had told you otherwise.

SB_UK
09-19-14, 09:29 AM
Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis
Trompette et al.

I know it's wrong but we've had research by Drs Butt, Trompette so far in this thread.

it's just not right.

Kunga Dorji
09-21-14, 08:21 AM
First thought - the athlete paradox - that athletes live statistically highly significantly shorter lives.

-*-

Now that is an interesting factoid.

I am about to post a post on a probable association between tissue hyperelasticity syndromes and difficulty in maintaining stable cerebral perfusion.

This is a very, very good explanation for the majority of ADHD inattentive and hyperactive symptoms - and links to a good explanation for the associated dyspraxias and dysgnosia.

Equally, the orthostatic intolerance syndromes cause a proneness to sympathetic hyperactivation-- which is the primary driver of metabolic syndrome and the associated insulin resistance.

However-I picked up the information on a lecture on tissue hyperelasticity syndromes and the speaker, ageneral physician who has a special interest in hyperelasticity syndromes, specifically mentioned that he thought that the 20% of the population with the most elastic connective tissues was most prone to the problem and was also the population that would give rise to most athletes, dancers, artists and musicians.

(So also an association with creativity - no doubt to our sensitivity to the emotional turbulence driven by our unruly autonomic system regulation).

However- to follow the thread of inferences here

Tissue hyperelasticity
1) Increases the odds of being an athlete- as being fit will help you feel better.
2) Increases the odds of metabolic syndrome in a world where the athlete will have trouble maintaining fitness after the end of his paid athletic career.
3) Therefore in a society which virtually enforces a sedentary existence at school and at home will leave the athletes in our society not getting the long term health protection from fitness that they need because of their hyperelasticity.
4) This is probably worsened by the insane competition that drives many athletes to injure themselves by overly aggressive competition.
I don't know about the USA- but in Australia there is always some idiot sports commentator praising our top athletes for their willingness to "put their body on the line". (I work fixing up some of these damaged bodies- so to me that attitude is nothing short of insanity).

Kunga Dorji
09-21-14, 08:23 AM
Btw SB-- have you any papers or links to the athleticism- early mortality link.
That would be very interesting.