View Full Version : Cambridge Study Regarding Dopamine

03-14-15, 02:42 PM
What does everyone think of this article? I thought ADHD was the result of insufficient dopamine and norepinephedrine receptor stimulation. I've also read that there are white-matter abnormalities involved. But this article is suggesting that it's the result of reduced grey matter, therefore it's a condition resulting from structural abnormalities rather than dopamine.

If these findings are true, then what does that mean regarding all the research that's been done regarding dopamine, which in turns effects stimulant treatment?

"Imaging study shows dopamine dysfunction is not the main cause of Attention Deficit Hyperactivity Disorder (ADHD)":

This is the link to the medical study quoted in the article:

03-14-15, 06:24 PM
Disclaimer: I've read the news article and the abstract of the paper, but haven't yet had a chance to read the full paper.

It sounds like the researchers were able to identify people with poor attentional performance both with and without a diagnosis of ADHD. These people did seem to have "reduced left caudate dopamine activity" and showed greater improvements with methylphenidate compared with people who had better attentional performance.

However, not all of the people diagnosed with ADHD had poor attentional performance on the test they used to measure attentional performance. As a group, it was more common for ADHDers to have low attentional performance, but low attentional performance wasn't a fool-proof measure of who had ADHD or not.

The authors state that, despite the similarities in D2/D3 dopamine receptor density between ADHD cases and non-ADHD controls when considering the attention tests, "Patients with attention deficit/hyperactivity disorder as a group showed...reduced grey matter volume in fronto-striato-cerebellar and limbic networks."

This gray matter reduction in those areas seems to be a separate finding / feature than the left caudate dopamine activity associated with the researchers' measure of attentional performance. Keep in mind that structural differences may still be associated with affects on neurotransmitter networks, but the D2/D3 receptors that researchers looked at didn't seem to be the defining neurological difference associated with ADHD, and that there's variation within the normal and ADHD population in these receptor densities that is linked to attentional performance.

So this would suggest again that there are multiple possible contributing factors to the nature and degree of ADHD symptoms based on underlying brain differences, and these differences likely also affect responses to particular treatments.

Will comment further after reading the whole paper, if I find other interesting features (or mistakes in my summary above!).

03-15-15, 05:10 AM
Chronic stress leads to Languor

'tiredness or inactivity, especially when pleasurable'

For something pleasurable no longer to motivate - the D/NE system must have been altered (resistance syndrome).

Resistance syndromes occur in persistently high exposures to hormones and neurotransmitters.

So ... ... the question becomes what's setting off our stress response.

Easy enough - ask the ADDer.

Generally agreed - all over internet - that ADDers are 'highly sensitive' people (Kunga Dorji/Barliman threads on site).

What do highly sensitive people like (see my latest thread in this section under media) ?
We like doing our thing without hassle - ie somebody telling us we have to do something pointless in order to achieve something meaningful.

So - the entire fabric of our current society is stressful to us.

Everything to do with money and law - mostly bureaucracy and lots of systems which keep us as wage slaves.

The diseases which human beings are dying of are called the Diseases of Western living.
Western living is characterized by an economic system which favours the use of money/law, encourages ownership and competition - leads to pan-global degradation at every level - from pollution to human slave trafficking.

The ADDer is sensitive to the illogic of society is gifted in forming a logically consistent worldview and has passed from the construction of mind into the generation of beauty ie a neocortex to cerebellar shift in 'quality' as our reward system.

03-15-15, 05:26 AM
ps the key to understanding why this idea (actually any idea) is so hard to relay on - is that words all occupy different contexts in people's minds
- it's why one set of words (the same set of words) will be the most meaningful and another set of words will fly straight in one ear and out the other in 2 sets of people.


The trick to use of words is partly to use very simple words eg words like socialism will never mean the same thing to two different minds ... ... to know (objectively) whether the idea is important to other people (don't bore the ADDer!!) and to provide evidence whilst having no attachment to the conclusion (idea you're offering) - because there's every chance you (one) might be wrong.
It's often useful to examine whether one/you personally are personally gaining through the idea and whether you're naturally resistant to other perspectives.

Would a politician ever support an anarchy (absence of politics through collectiv rule) ?
Would a doctor that makes money from prescribing medication ever support completely preventative medicine ? Would a vet make any money if nobody attends his clinic ? Would a dentist make any money if nobody had a filling ?

... ... etc etc etc ... ....

ADDer perspective - human beings are completely F.O.S.

And it all comes down to the pursuit of money/materialism/consumerism/capitalism which is the enemy of (sensory) quality.
Quality of life.

03-15-15, 05:50 AM
Excellent page

The symptoms of Attention Deficit Hyperactivity Disorder ( closely mirror the symptoms of Directed Attention Fatigue.

wikiP/directed attention fatigue

Drawing the comments together - I'd simply suggest that we pay attention using the 'distracted' model (eg solving problems by letting one's mind wander eg) ... ...

... ... actually forced paying attention is stressful to us - distressful / directed attention fatigue
-> leads to stress-related problems -> languid, lassitude, perpetual sleepiness, physical weakness

--> eg SCT (ADHD-PI) -> solution simple.

Identify what the ADDer's actual true reward system is - create and experience beauty, elegance etc ... ... and change society accordingly by eliminating the use of money - and allowing people to develop quality because it brings them personal pleasure so to do - something worthwhile so to choose.

03-15-15, 05:56 AM
What will we find ADDer love ?

Cloud computing
Virtual reality
Diversity in all things natural world
Environmental travel
Everything art
A shift from dwelling in history to making a better future - the past isn't coming back
Realization that the structures of history will crumble - no thing lasts forever
No form of chemical modification to life - we aren't smart enough to modify natural systems (the human body)
We're Gods of IT not of the human body (as an example) ... ... GM is only there to maximise corporate profits - we don't need it - aquaponics solves the problems which GM is suggested (as a false flag) that it's being brought in for.

Easy stuff - a better list can be compiled from reading Lennon's Imagine lyrics.
ADDers are dreamers, there's not only one - because we're in the middle of a speciation event in which ADDers are emerging as a novel species.

Homo neosapiens sapienses - just a switch from understanding (neocortex) to sensory quality (cerebellum) as our reward system.

BEAUTY ! not the economy STUPID !!!

Little Missy
03-15-15, 06:40 AM
Huh. I thought this was a scientific discussion.

03-15-15, 10:46 AM
"Imaging study shows dopamine dysfunction is not the main cause of Attention Deficit Hyperactivity Disorder (ADHD)"

03-15-15, 01:33 PM
Here is a great link to help understand the dopaminergic pathways ( involved in the discussion.


03-15-15, 05:24 PM
I'm not particularly surprised by the article. Catecholamine function doesn't exist independent of neuroanatomy, nor is the reverse true.

My sense is there is a number of neurological conditions that lead to a diagnosis of ADHD, and this has much to do with varying response to pharmacological treatment, the number of people who manifest symptomology as adults versus those who experience a lessening of ADHD disability in post-pubescence, the subtypes of ADHD, and so on.