View Full Version : new research on distinguishing bipolar from depression


peripatetic
08-10-15, 01:59 AM
apparently "biomarkers", which can be detected by urine testing, are different for those with bipolar and depression. they've found some difference before, but now they've identified multiple biomarkers that in combination could one day offer more accuracy in diagnosis.

i thought this part was especially compelling:

The paper adds: A large percentage of BD subjects are incorrectly treated with antidepressants in clinical practice. The consequences can be lethal. Selective seratonin reuptake inhibitors (SSRIs) such as Prozac and Celexa probably don't help people with bipolar. SSRIs are alleged to increase suicide risk among bipolar patients, a major concern since bipolar sufferers have suicide rates around 20 times the population as a whole.


While efforts have been made to alert doctors to the dangers of this sort of misdiagnosis, as long as we continue to rely only on multiple signs[/URL], the problem will remain.



where i first learned of this (and where i lifted the above quote): http://www.iflscience.com/brain/urine-test-distinguish-forms-depression (http://www.news-medical.net/news/20150429/Clinical-features-identified-to-distinguish-bipolar-I-disorder-from-MDD.aspx)

actual journal abstract:
[url]http://pubs.acs.org/doi/abs/10.1021/acs.jproteome.5b00434

sarahsweets
08-10-15, 02:35 PM
I have always said that about SSRI's and bipolar. The only sucessful treatment for me has been an SNRI, mood stabilizer and atypical antipsychotic.

SB_UK
08-12-15, 04:46 AM
SSRIs linked to suicide in all people taking the drugs ? as opposed to just bipolars ?

Patients who take selective serotonin reuptake inhibitors (SSRIs) such as Prozac (http://www.drugwatch.com/prozac/) (fluoxetine), Paxil (http://www.drugwatch.com/paxil/) (paroxetine) or Zoloft (http://www.drugwatch.com/zoloft/) (sertraline) may experience side effects such as violent behavior, mania or aggression, which can all lead to suicide.

SB_UK
08-12-15, 04:55 AM
Came up in a conversation to a dentist who was telling me that fluoride isn't having the effect that people believe.
Researchers have good reasons to believe that keto may alleviate bipolar symptoms.
eg http://www.neurorexia.com/2014/02/06/quieting-the-bipolar-mind-can-a-ketogenic-diet-stabilize-mood/ (http://www.neurorexia.com/2014/02/06/quieting-the-bipolar-mind-can-a-ketogenic-diet-stabilize-mood/)

Conversation.
dentist - Is it true that you feel euphoric in ketosis ?
reply - No - mood stable.


Which is what, I guess, you'd need in bipolar disorder.

KarmanMonkey
08-14-15, 11:23 AM
SSRIs linked to suicide in all people taking the drugs ? as opposed to just bipolars ?

It can be, yes. Ironic, isn't it, that the first line of treatment for depression has an increase in suicidal thoughts as a common side-effect.

The kicker: Often docs don't mention that side-effect to patients.