View Full Version : ADHD : glutamate / glutamine imbalance

08-13-15, 10:52 AM
While the neurobiological basis and developmental course of attention-deficit/hyperactivity disorder (ADHD) have not yet been fully established, an imbalance between inhibitory/excitatory neurotransmitters is thought to have an important role in the pathophysiology of ADHD.

Epilepsy - imbalance between excitatory / inhibitory nts
Gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tone that counterbalances neuronal excitation. When this balance is perturbed, seizures may ensue.

Ketone bodies (ketosis) -> treat -> epilepsy therefore re-establish inhibiory/excitatory balance ... ....

from previously

Ketone bodies [decrease] brain glutamate and [favour] GABA metabolism.



-a- Consistent with ADDers keto-adapted from the 'start' - as a sign of a transition from carb into exclusively fat usage in metabolism.

08-13-15, 10:53 AM
Personal note.

Parmesan (very high glutamate levels) -> triggers -> intense pain (hands + feet) - almost unbearable.

If you take a look at a large chunk of Parmesan cheese, you will find small white crystals. These are glutamate crystals which were formed during maturation.
The little salty type crackly bits in parmesan.


Salt taste receptor -> wired into reward system (ie food)
Sweet taste receptor -> wired into reward system (ie food) -> 'growth'-promoting -> pro-insulin -> glycolytic flux (see Warburg effect in cancer)
Umami taste receptor -> wired into reward system (ie food) -> 'growth'-promoting -> pro-insulin -> glycolytic flux (see Warburg effect in cancer)

So growth complete - switch to mitochondrial ketone body metabolism.

But - who wants to drink 100ml of oil a day ?
It's a neat solution but we can do better ?


ADDers keto-adapted from the start.

Carb supercharges ADDers into T2D/obesity.

08-13-15, 11:12 AM
Type 1 diabetes

Glutamic acid decarboxylase (GAD) is considered to be one of the strongest candidate autoantigens involved in triggering beta-cell-specific autoimmunity.

glutamate -> glutamic acid decarboxylase -> GABA

T1D knocks out the body's capacity to produce insulin.

The backdrop to this story - is of human beings shifting from an 'insulin' growth story to a 'leptin' aerobic respiration, maintenance story ... ...

Insulin to Leptin.

08-13-15, 02:53 PM
So what's the answer?