View Full Version : ADHD : glutamate / glutamine imbalance


SB_UK
08-13-15, 10:52 AM
While the neurobiological basis and developmental course of attention-deficit/hyperactivity disorder (ADHD) have not yet been fully established, an imbalance between inhibitory/excitatory neurotransmitters is thought to have an important role in the pathophysiology of ADHD. http://www.ncbi.nlm.nih.gov/pubmed/26101852

Epilepsy - imbalance between excitatory / inhibitory nts
eg
Gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tone that counterbalances neuronal excitation. When this balance is perturbed, seizures may ensue.

http://www.ncbi.nlm.nih.gov/pubmed/11520315

Ketone bodies (ketosis) -> treat -> epilepsy therefore re-establish inhibiory/excitatory balance ... ....

from previously

[1]
Ketone bodies [decrease] brain glutamate and [favour] GABA metabolism.
http://www.ncbi.nlm.nih.gov/pubmed/9778572

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Note

-a- Consistent with ADDers keto-adapted from the 'start' - as a sign of a transition from carb into exclusively fat usage in metabolism.

SB_UK
08-13-15, 10:53 AM
Personal note.

Parmesan (very high glutamate levels) -> triggers -> intense pain (hands + feet) - almost unbearable.

If you take a look at a large chunk of Parmesan cheese, you will find small white crystals. These are glutamate crystals which were formed during maturation.
The little salty type crackly bits in parmesan.

http://www.umamiinfo.com/2011/03/umami-rich-food-others.php/

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Salt taste receptor -> wired into reward system (ie food)
Sweet taste receptor -> wired into reward system (ie food) -> 'growth'-promoting -> pro-insulin -> glycolytic flux (see Warburg effect in cancer)
Umami taste receptor -> wired into reward system (ie food) -> 'growth'-promoting -> pro-insulin -> glycolytic flux (see Warburg effect in cancer)

So growth complete - switch to mitochondrial ketone body metabolism.

But - who wants to drink 100ml of oil a day ?
It's a neat solution but we can do better ?

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ADDers keto-adapted from the start.

Carb supercharges ADDers into T2D/obesity.

SB_UK
08-13-15, 11:12 AM
Type 1 diabetes

eg
Glutamic acid decarboxylase (GAD) is considered to be one of the strongest candidate autoantigens involved in triggering beta-cell-specific autoimmunity.
http://www.ncbi.nlm.nih.gov/pubmed/12530520

glutamate -> glutamic acid decarboxylase -> GABA

T1D knocks out the body's capacity to produce insulin.

The backdrop to this story - is of human beings shifting from an 'insulin' growth story to a 'leptin' aerobic respiration, maintenance story ... ...

Insulin to Leptin.

Pilgrim
08-13-15, 02:53 PM
So what's the answer?