View Full Version : maternalregulator/infant-toddler relationship and epigenetic inheritance


mildadhd
11-27-16, 07:31 AM
This thread is meant to explore the relationship between the maternalregulationship and epigenesis inheritance.

Are all infants/toddlers with the 7-repeat allele born more influenced by positive and negative, internal and external circumstances, than all infant/toddlers born without the 7-repeat allele?

Surely all people with and without the 7-repeat allele are influenced by positive and negative, internal and external circumstances?

Parenting awareness/attitude, verses, parenting quality?

Thoughts?

..children without the 7-repeat allele were uninfluenced by parenting quality.

http://www.ncbi.nlm.nih.gov/pubmed/17931433


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mildadhd
11-27-16, 08:15 AM
-infants/toddlers without the 7-repeat allele were less influenced by parenting awareness/attitude?


-infants/toddlers with the 7-repeat allele were more influenced by parenting awareness/attitude?


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namazu
11-27-16, 04:47 PM
Are you talking about the DRD4 gene with variable number tandem repeats (https://www.ncbi.nlm.nih.gov/gene/1815) (in this case, n=7; a 48 nucleotide sequence within the DRD4 gene is repeated 7 times)? EDIT: Yes?

What epigenetic mechanisms are you talking about? Variable number tandem repeats (VNTRs) are inherited genetically (http://www.nature.com/scitable/topicpage/Tandem-Repeats-and-Morphological-Variation-40690).

Yes, all people are "influenced by positive and negative internal and external circumstances" in general. But the sensation-seeking of 18-21 month old kids (as defined/measured by the authors) may not be influenced by parenting style (as determined by only 10 minutes of observation in a controlled setting). I have only read the abstract, so can't comment on whether or not the analysis is valid or meaningful.

mildadhd
11-27-16, 10:56 PM
Yes.

If the research accurate, individuals who recently epigenetically inherited (Back 3 to 5 generations) higher numbers of genetic variants associated with deficits of self-regulation, maybe some type of possible epigenetic markers for the possibility that the infant/toddler is more hyperreactive, born with a slightly more emotional, homeostatic, sensory hypersensitive temperament to internal and external circumstances?

"Epigenesis: This biological principal suggests that individual development arise from gradual, individualized differentiation of each organism, a process that is now being understood at a genetic level.

While the mammalian genome (successive DNA base pairs) establishes the primal template for body and brain construction (genotype), a more complex and variable process of gene-expression controls the production of the final organismic forms (phenotype).

It is recognized that these developmentally variable "epigenetic" processes enable differential expressions of the genotype, allowing environmental control over the final phenotypes.

The biochemistry of epigenetics involves modifications in the degree to which gene expression can be controlled by histone methylation and related changes of nuclear chromatin, which provide for fine-tuning of patterns and intensities of gene expressions during development, along with the mechanisms by which gene expressions can be amplified or silenced."


-Panksepp/Biven, "From the Couch to the Lab: Trends in Psychodynamic Neuroscience", (Box 9.1 Definitions) p 146.



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namazu
11-27-16, 11:34 PM
There seem to be two separate (but related) things mixed up in there.

1. Variants in genetic sequences related to sensitivity to environment.

2. Epigenetic modifications to genetic sequences affecting the expression of genes related to sensitivity to environment.

VNTRs like the DRD4 7-repeat variant are genetic (not epigenetic) differences. The repeats are part of the sequence of DNA/RNA itself, unlike epigenetic modifications. However, the repeated segments do seem to influence the expression of the gene, so in that way, they're not totally dissimilar from epigenetic modifications.

Yes, the presence of genetic variants or epigenetic markers could potentially tell us about the likelihood that a person may be particularly sensitive to certain environmental factors.