View Full Version : Dexedrine and Prozac - Goodbye Prozac

07-31-17, 04:53 PM
So I've been on Prozac and countless other ssri's for ages. I started on Dexedrine in January.
I titrated from 40mg - 20 mg Prozac last year and dropped from 20mg - 0mg Prozac 3 weeks ago. It has been hell. There have been days I felt great about a week after dropping the Prozac but for the most part it has been hell.
And it's making me question the effecacy of my dex - which until now I have no issues with.
Im not sure if it's the Prozac discontinuation symptoms or what but it sure has screwed up my dex. I take 10mg every 3 hours or so BTW.
Ugh. This sucks. Do I just not touch my dex and stick it out? How long till this crazy ssri is GONE? Argh. I know this isn't clear at all - welcome to my head right now.
Anybody else quit an ssri while on Dexedrine or Adderall?...

08-24-17, 09:21 AM
So, I'll reply to my own post with an update:

I'm 6 weeks post Prozac. I Have gone to a special kind of hell and back with the discontinuation of that med. It kicked my but.

Anyways, the Dexedrine was much more noticable and strong after the 'zac got out of my system and suddenly I was in a massive IR rollercoaster! High crash high crash. I cut back on dosage and timing but it was still intense. So back to Spansules I go.

So I have 6x10mg spansules/day and I'm trying to re-discover the right dosing schedule... Again.... They feel stronger this time around. I know when I've taken too much Dex and yesterday was TOO much! Gotta re-figure out duration of action etc. Anybody else on just Spansules? Twice a day dosing?

08-25-17, 04:51 AM
I used to take the spansules and it was three times a day at 15mg.

08-25-17, 09:25 AM
Ya I'm figuring that out too.
Still trying to figure out dosage, yesterday was not bad - took 30mg @ 7:00, 20mg @ 12:30 and 10mg @ 4:30.. not bad - a little strong in the first half of the day.
Today 20, 20, 10...

Thanks for sharing your experiance.

11-27-17, 02:06 PM
Omg yes there is a huge interaction between Prozac and Dex. I’m in Australia also and my doctor recently tried me on our version of Prozac (lovan) with the Dex. She was very aware of the interaction and thought it could be managed. Be aware that this interaction isn’t life threatening but it makes the Dex useless.

What it does is amplify the effect of Dex. By 6-12 times. Which means you aren’t getting that nice therapeutic paradoxical efffct from a low dose of stimulant anymore that is necessary for ADD.

So when I started taking the two together at the Trial dose it was nuts. It was jut straight up speeding. Settled a bit down to that first week you start Dex where you just plain don’t sleep.

And I couldn’t find the balance to get the low dose benefits back while taking the Prozac.

Plus I just hate hate hate not sleeping.

I’ve ended up having a break from both in the aftermath and now have to start Dex all over again.

I have no idea if this is a problem peculiar to Aussie meds packaging but we have much much much stricter regulations on drug approval than the US and sometimes this means we use the same sort of drug in a different formulation.

Pretty bad your doc didn’t know this interaction. Is it a psych?

If it’s not a psych, honestly get one. GPS love to prescribe but just do not have the knowledge of drugs and effects to get the best medication regime for you.

11-27-17, 02:11 PM
Oh also I forgot to say that taken together it also increases the effective dose of the Prozac so it’s hard to work out which drug is the source of which side effect.

It’s worth sticking it out with the Dex even in the aftermath of Prozac. I’m going through the same roller coaster trying to get the old benefits from Dex back but getting the insane high crash coaster.

And it gets better. I’m told.. It’s just that Prozac has such an insanely long half life it’s still in your damn system months and months later, still causing the same increased effect even though you aren’t taking it.