OK this is probably gonna be long so please bear with me i really need some advice if you can only answer or give adivise on one please leave advise, all is welcome! (even links to websites with the info!

What i wanna know:

1.) How do stimulants effect or help AD/H/D (give links with extensive indepth articles i want to know stuff like "...the molecules binding to the senors to produce..." not "... it stimulates the brain causing the patient to focus" i understand it stimulates the brain but how and hwo does it help us wiht ADD?

2.) Just some completly off the wall treatments for ADD, i have tried everyhting but cylert (never will) and desoxyn i will NOT take methylphenidate meds EVER again they make me too zombilike, i am kinda feling depressed (mild not bad at all) due to the fact i cannot controll my ADD i just want to be able to get my school work done and pass just pass... do you know how many kids want A's when i jsut wanna pass!

3.) How does LEVO-amphetamine effect ADD, compared to DEXTRO-amphetamine. I personally think that the adderall (altough weak with many side effects) helped me in a way Dexedrine cannot, yet dexedrine helps me in a way Adderall cannot, i would like to see about getting a specially made 50/50 or 60/40 combination of DEXTROamphetamine/LEVOamphetamine to help as they each had different properties. thus i want to know more about em.

4.) How to control my ADD! (i doubt anyone can answer this but worth a shot)

again all is welcome to reply i really need some advise i have some big trouble with ADD and its startign to get the better of me... thus making me feel bad about it... thus starting to cause problems.

1.) Thats a tough one since we have a hard time even agreeing on what actually is add/adhd and the multiple variants. One of my running theories involving inattentives has to do with a certain variant of the COMT gene val/val which causes too much dopamine to be neutralized by enzymes in the brain. Stimulants simply pump a bunch of dopamine into your brain and it seems to relive some of the effects of this screwy gene variant. http://www.4therapy.com/consumer/conditions/article/7155/79/It+Seems+Gene+Enhances+Prefrontal+Function+at+a+Pr ice...

2.) EMSAM, but this isnt an option if you're not insured as its insanely expensive and you'd have to be willing to be very very careful with what meds you take and certain foods while on it. It works different than stimulants but it basically dumps a bunch of dopamine into your brain. The plus side is that its a patch and theres no ups and downs and redosing. Keep in mind this is experimental for ADD.

3.) Levo-amp is garbage and is considered an impurity of D-amp synthesis. Its like shire went out of their way to create a stimulant cocktail that mimmicks the effects of street crank. You see jimbob down at the local meth lab isnt to bright and cant figure out how to get rid of that pesky levo-methamp from his product either. Its primarily a cardio stimulant and is about half as effective of a CNS stimulant with alot less dopamine release. Its only upside is that it lasts 2 hours longer than d-amp, so you get 2 hours of being twitchy and having a high pulse HOORAY.

4.) Errrrr....no idea.

...
i thought levo had different ways to help your ADD compared to dextro (i thought dextro was stimulating (and helped that way) and levo was more helpfull in a different way, i guess not. are there any other experimental drugs out there and do you think that EMSAM will have more or less 'stigma' with prescribing it compared to desoxyn? (thats even if its allowed to be used in ADD) have you heard if this might be a hard to get drug?

...
i thought levo had different ways to help your ADD compared to dextro (i thought dextro was stimulating (and helped that way) and levo was more helpfull in a different way, i guess not. are there any other experimental drugs out there and do you think that EMSAM will have more or less 'stigma' with prescribing it compared to desoxyn? (thats even if its allowed to be used in ADD) have you heard if this might be a hard to get drug? I guess the physical effects of the levo could help some people....i cant imagine how. EMSAM has been around forever as an mao-b inhibitor called selegline. Unfortunately the oral selegline sucks because of how your body processes it. Which is where EMSAM comes in, theres no stigma about it. Its a realatively new drug (in name). its mostly being used for treatment resistant depressants so far. But it is definetly the most stimulating of the MAO drugs, not stimulating like you just took 20mg of dexedrine but more like a constant happy hum.

Theres other dopamine reuptake inhibitor drugs like mirapex that are primarily used for parkinsons but i've only vaguely heard of them being used.

im sensitve to antidepressants though so this product might be helpful to me, its a fairly low dose but you must watch what you eat while on it... which isnt too bad but it all depends on what... but does the product need to build up tolerance into your blood streat or is it same day effects?

ok i just found some new info on emsam (still wanna know about how long before it kicks in thought havent found out yet) but if im not mistaken, the full prescribing information on the emsam website it states if im not mistaken in the graph under the absorption section it shows that the pill form of selegiline metabolizes into methamphetmine amphetamine and desmethylselegiline and selegiline if thats true i might want to take the pill as its has a much greater chance of getting those stimulants to help your ADD? or would it metabolize too late in your body and no tbe effective (like would it metabolize in those stimulants in your stomach and be destroyed, or metabolize in your colon thus rendering it useless?)

ok i just found some new info on emsam (still wanna know about how long before it kicks in thought havent found out yet) but if im not mistaken, the full prescribing information on the emsam website it states if im not mistaken in the graph under the absorption section it shows that the pill form of selegiline metabolizes into methamphetmine amphetamine and desmethylselegiline and selegiline if thats true i might want to take the pill as its has a much greater chance of getting those stimulants to help your ADD? or would it metabolize too late in your body and no tbe effective (like would it metabolize in those stimulants in your stomach and be destroyed, or metabolize in your colon thus rendering it useless?)
Metabolizes into very small amounts. All MAOs metabolize into some form of amp, i dont even know if its an active compound but it will cause you to test positive for speed on drug tests. I think the problem with oral selegline was how its metabolized in the liver which causes problems with passing through the whole blood brain barrier.

im sensitve to antidepressants though so this product might be helpful to me, its a fairly low dose but you must watch what you eat while on it... which isnt too bad but it all depends on what... but does the product need to build up tolerance into your blood streat or is it same day effects? Some people were getting positive results within 2 days, it usually takes more like two weeks. The patch delivery system seems to speed things along. The food thing isnt much of an issue since even at its highest dose the level of mao-a in your brain is low. There was a study where they fed aged cheddar in good size quanities to people on all three doses for a few weeks without any negative consequences. While with a normal MAOI drug this might result in death.

The reason the two high doses even have the food warning is because the FDA didnt want to bother doing their own tests and just slapped the generic MAOI warning on it.


This was the drug i researched for a long time but just couldnt raise the finances to make it possible. Luckily, i found dextro-amphetamine and its been amazing so the emsam wont be nessecary for me.

Hi Ya!

"are there any other experimental drugs out there and do you think that EMSAM will have more or less 'stigma' with prescribing it compared to desoxyn? (thats even if its allowed to be used in ADD) have you heard if this might be a hard to get drug?

1, I knew a chap who was taking Meth/amphetamines (BOTH AT ONCE) in high doses. He started Emsam and quit the Amps, he seems satisfied with the results of it thus far.

2 YES Emsam, any Doc would rather script it than Desoxyn, which is indicated for ADD/HD, AND YES it is a last resort med, very tightly controled.<!-- / message -->

The answers to all your questions:
ADDFORUMS.COM



Really. Thats what this website is all about. Each topic is covered extensively, multiple times. Its better to do what research you can, then ask within a particular topic thread for more specific info on that subject....

People here are very helpful and love to volunteer information, but it also helps to ask
in the right forum too.

yea i know i didnt post in the right spot but i figured since i take dex... and was mainly wanting to know about dex... but i shoulda put it somewhere else (like general... or something) but i love addforums, and thank god for the mods (we love you guys alot)

I am interested to know what happened when you tried the methylphenidate class of stimulants, which ones, and at which doses?

yea i know i didnt post in the right spot but i figured since i take dex... and was mainly wanting to know about dex... but i shoulda put it somewhere else (like general... or something) but i love addforums, and thank god for the mods (we love you guys alot)
I didn't mean to be on your case, btw. In a way, you're in the right forum - in that you're asking about Dex......What I meant in my post was that you should focus on more specific issues. Some will fall in this forum, some in others. There are a few threads that address some of your questions. Most likely, they have what you're looking for. If not, try posting your questions within that specific thread. You will get a lot more responses, and, more importantly, from people who happen to have similar questions/issues such as yours. Its a good way to start a search. If this fails, then try creating a new thread to fill the gaps.

Just my way of helping you find the answers your questions in your original post.

Good luck.

Just a couple of things to start you off:

1) Information about stimulant effects on the brain could be found in forums like "add/adhd scientific discussions" http://www.addforums.com/forums/forumdisplay.php?f=310 or right here in the Meds forum.
2) Maybe try "misc treatments and approaches" http://www.addforums.com/forums/forumdisplay.php?f=159
3) Levo-dextro discussions are common within both the adderall and dexedrine forums
4) Behavior Modification forum: http://www.addforums.com/forums/forumdisplay.php?f=270


...Just from a quick search on this site - I'm sure there's a LOT more. This website is a great resource, take advantage of it.

for me the methylphenidate stimulants caused (at low doses of 20 mg's) increased anxiety, increased heart rate, decreased appetite, but the #1 reason for stopping it was it was flat-out inafffective (which i think is a good reason to stop... lol) at higher doses (50-70 mg's) well read my concerta story, but mostly zombification, fluid retention (very horrific), bad breath, VERY dangerously high heart rate (i could walk for 1 minute and have to stop b/c of pain), not effective, constipation, and more.

i am starting to feel as if dex is inaffective also, very dissapointed i had very very very high hopes for this one and theres no way in hell im gonna be able to get desoxyn. o' well i guess if the ADD gets bad enough i will just crawl into a hole and keep myself entertained until a new stimulant is made for ADD...:faint::(:faint::(:faint::(:faint::(:faint: