Just wondering what I'm putting into my body... and how does it become dangerous?

Maybe this should be moved to the scientific forum?

Just wondering what I'm putting into my body... and how does it become dangerous?
Good question. Here are a couple of links that may help you find the answer your looking for:

http://exploration.vanderbilt.edu/news/news_galli.htm

http://www.rnceus.com/meth/methpharm.html

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The methyl molecule that causes it to pass through the blood brain barrier easier. Thats really the only difference.

So... this isn't a question so that I can go get high, I'd be way too chicken to do it... but would somebody od'ing on Dexedrine be simliar to someone od'ing on meth?

I only ask because meth has such a bad rap, and I think the bad rap is deserved... I just don't want to be on something so dangerous... Is 15 MG a day (What I'm on right now) anywhere near the amount that people would be on illegally (In a different forum of course..>) Or would any increases in my medication in the future, be anywhere close? I'm sorry, this fear is probbably unwaranted... but I like to know what I am putting in my body... at what point does this drug become dangerous?

Recreational meth users take massive amounts but yes it would be similar.

Ok... I'm just sensitive to medications......

After being on the medication for 3 weeks though... I have no idea in hell why someone would want to take high amounts... I've already backed down on my low dose.

D. B. Cooper has it right. Meth also has a much longer half life so it lasts over 3 times longer than dex. The blood/brain issue should not be understated. The brain will naturaly regulate how much standard amphatamine it will take in and as such it's almost impossible to have a fatal OD on dex. Not so for meth. It can fry your brain very fast with a large enough single dose. (I have personaly met someone who swallowed an 8-ball and it's not pretty) The dex dose may put you in the ER but you won't get anywhere near the brain damage if at all.

Don't forget that you don't really know what street meth really is. Might have all sorts of other crap not the even mention other possible active drugs and isomers. You know exactly what your getting with dex. Remember with meth it's mostly the other crap that makes your teeth fall out and your skin turn you leather.

I tried meth (orally) a few years ago when I was partying. I remember having extreme clarity of thought, energy, lots of ideas running through my head, and very chatty.

These days I'm on adderall and I'm barely able to get to a normal level of energy and mental clarity. If I take more I just get shaky and feel crap. It certainly doesn't feel like recreational speed. I wish I knew why as it might be the clue to finding out what makes me "normal"...

Yup. Methylation.

For example, codeine is just methylated morphine. The body converts codeine to morphine.

So...this means that Methamphetamine is converted to amphetamine. (However, when street users abuse Meth, they are INJECTING IT (mostly), or SMOKING it...the two most powerful delivery routes!

I am not sure if there are BBB issues, too. (Blood Brain barrier. Some drugs can pass thru it, like heroin (di-acetyl-morphine).

NB. Smoking a chemical is the fastest delivery route to the body/brain. (Even faster than IV administration, which is the second fasted route!!)

Ok. I'm not snorting, injecting, or smoking my dex, so I hope I will be fine :)

<TABLE cellSpacing=6 cellPadding=0 width="100%" border=0><TBODY><TR><TD noWrap>FuriousBroccoli


</TD><TD width="100%">: You may want to try Dex instead based on your responce. But then again streets drugs can never compared to pharms... even the same drug. (disoxyn for example)


</TD></TR></TBODY></TABLE>

I just switched from Dexedrine to Desoxyn (dextroamphetamine to methamphetamine). I just started today, and I feel great. I haven't fealt this calm and ok with everything in a very long time. I hope this continues and is not just a first time feeling that wears off.

As far as overdose - as long as you take what your Doctor prescripes then you should be fine. The people on the street are taking 10 to 100 times more per dose and taking a couple of doses at a time, that is why they are so messed up.

I hate the fact methamphetamine has such a bad rap, because it makes it extremely difficult for people who can benefit from the drug to get it.

I have had so many problems in my life. I was just diagnosed ADHD this summer, and when I started Dex my whole life did a 360. Not dramatic for the person on the outside looking in - but dramatic for me - I went from having a severe eating disorder that consumed my life (yet I was able to hide it from others and function) to not thinking about food at all. I had the disorder for 19 years, and even when I went into inpatient treatment I was still doing it. Nothing stopped it, that is nothing till I found Dex. Now I'm on Desoxyn and it is wonderful. I think sometimes what my life would have been like had I been properly diagnosed years ago. But I love my life now, I have a nice husband and two wonderful children. If I could just keep a job and get along with others then everything would be great.

I hate the fact methamphetamine has such a bad rap, because it makes it extremely difficult for people who can benefit from the drug to get it.

Yeah...its just impossible to rehabilitate at this point, the DEA has demonized it to the point that it probably wont recover for a long time. At best we can hope for them just forgetting about it and it becoming sort of what valium is as far as status.

Luckily, the DEA are busy fighting the new boogeyman drug oxycontin and havent had the time to pass more prescription stimulant laws.

http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/images/P05328E6.jpg

Because the secondary effects of methamphetamine hydrochloride are least among the amphetamine-class stimulants or methylphenidate but the highest degree of primary effectiveness (i.e., most effective at enhancing concentration and decreasing distractibility, with the least occurrence of side effects), Desoxyn can be useful for patients who find other medications ineffective or for whom the side effects of such other medications are too severe.
The greater primary effectiveness of Desoxyn is believed to be caused by the extra methyl group (http://en.wikipedia.org/wiki/Methyl_group) of methamphetamine hydrochloride which is lacking in basic amphetamine, which may increase the solubility of methamphetamine hydrochloride in lipids (http://en.wikipedia.org/wiki/Lipid) (and therefore be more deeply and thoroughly absorbed into the fatty tissue of the brain (http://en.wikipedia.org/wiki/Brain)).



It's a pity the above Med is stigmatised as being comparable to street Methamphetamine, i's not, it's got a measured amount of pure compound, and many describe it as being the most suitable of the stimulant meds-most effectiveness Vs negative SEs. It's been said by many that Dexedrine has a greater euphoria-producing abuse potential while desoxyn is 'smoother' and clearer head action, but alas mud sticks.

I am more than likely asking for desoxyn tabs to go with the spansules next month because they still dont have the regular dex tabs

I've been on Desoxyn for 2 days now and the difference is amazing. I was on dexedrine 5mg IR, and I would deffinately feel the "high" and I would feel the "coming down" so to speak at night. But the desoxyn is much different, it is hard to explain. I actually went to bed early last night, I went to bed at 11:00pm instead of 2am, and I had absolutely no side effects. When I would "come down" off the others (I've tried many) I would get anxious and start pulling my hair out, paceing, cleaning, checking for anything and everything around the house, paranoid, numerous things till I would force myself to go to sleep. But not at all with the desoxyn. With this it is a nice "calm" feeling all day and all night. This morning I started checking and stuff like that, then I remembered to take my pills and I was better. I think I am going to leave a pill box and glass of water on my nightstand so that I take my pills as soon as I wake up.


I HIGHLY RECOMMEND DESOXYN - JUST ASK YOUR PHYSICAN AND TAKE ARTICALES AND RESEARCH WITH YOU TILL YOU PROVE YOUR POINT

"I am more than likely asking for desoxyn tabs to go with the spansules next month because they still dont have the regular dex tabs"

They don't have the regular dex tabs because they have been discontinued, they will never get anymore. that is the main reason why my physican finally prescriped the desoxyn, because the barr generic dosen't work for me and it is hard to get the mallincrokt.
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Yup. Methylation.

For example, codeine is just methylated morphine. The body converts codeine to morphine.

So...this means that Methamphetamine is converted to amphetamine.

A clarification

Codeine is converted to morphine by the liver, and this de-methylation is not involved in the psychoactive effects. With codeine the methyl group allows the drug to cross into the blood stream more effectively from the gut.
On a slightly different note: heroin (diacetylmorphine) is also considered a 'prodrug' (principal pharmacological effects being caused by a metabolite, as opposed to the drug itself) in that it is metabolized to morphine before binding to receptors.

Just to clarify - methamphetamine (as far as i know) is not considered a 'prodrug', in that, while the methyl groups allow it to cross the BBB quicker, they also serve to allow it to bind better and faster to receptors as well, and it is not demethylated to amphetamine until it is broken down.

I believe methamphetamine has stronger effect on serotonin than amphetamine. The increased serotonin effect, may account for the more mellow felling people have described. But please Don't quote me on this.:eyebrow:

Hi fellow Kiwi!-i'l quote you on this, comparing the actions of Methamphetamine Vs Dextroamphetamine:

DESOXYN:

-<TABLE cellPadding=3 width="125%" align=center border=2><TBODY><TR><TD>methamphetamine <TD>Desoxyn, Methampex, Methedrine, Pervitin, Temmler <TD>ADD, ADHD, obesity <TD>10-25mg <TD>10-25 hrs
CYP-2D6 <TD><A href="http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html#ABBR">* psychostimulant:
NE release +++
DA release ++
DA reuptake inhibition +
NE reuptake inhibition + ("] psychostimulant:
5-HT release +++
NE release +++
DA release ++
DA reuptake inhibition
NE reuptake inhibition [/url]</TD></TR></TBODY></TABLE>


DEXEDRINE, DEXAMPHETAMINE:

-<TABLE cellPadding=3 width="125%" align=center border=2><TBODY><TR><TD>dextroamphetamine
(d-amphetamine) <TD>Dexedrine, DextroStat <TD>ADD, ADHD, narcolepsy, obesity <TD>5-30mg
(40mg max) <TD>10-25 hrs
CYP-2D6 <TD><A href="http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html#ABBR">*[url=")</TD></TR></TBODY></TABLE>




*Note the 5HT (Serotonin) release properties ***, this is why above folks (who have been fortunate enought to trial Desoxyn) describe it as 'smoother'.

gi day mate, your a kiwi too?:)

WOW!!! Y'all taught this 'ol former narc investigator a thing or two!!
But then, the only meth I dealt with was made from house cleaning products, cold medicines and anhydrous ammonia! lol


I absolutely love the fact that people are becoming educated on medications.

Knowledge IS power.

:)

NZKIWI Gday m8-yep, no Desoxyn or Aderall here ha?.

I'll post the Pharmakinetics again-didn't stick:

DEXTROAMPHETAMINE:

- psychostimulant:
NE release +++
DA release ++
DA reuptake inhibition +
NE reuptake inhibition +

METHYLAMPHETAMINE:

-psychostimulant:
5-HT release +++
NE release +++
DA release ++
DA reuptake inhibition
NE reuptake inhibition


RITALIN:

-psychostimulant:
DA reuptake inhibition
NE reuptake inhibition
NE release

Knowledge IS power.
Applied knowledge is power... ;)

attention (member.php?u=3217),

The link you posted, do you know where he got that info?
I'd very much like to find that info on a reliable site.

Google "Psychiatric and associated drugs"-VERY informative Psych Drug info.

Applied knowledge is power... ;)
I DO believe I stand corrected ;)

Wow... I didn't know about the 5-HT binding... very interesting.

I would caution anyone looking to switch over to it unless you feel you REALLY, REALLY need it... you may get dirty looks unless you happen to have a liberal doctor or perhaps a phyc if your luckly.

Most doctors are not in the mood to jepordize their DEA licence by perscribing something so controversial. If you have had issues trying to get your meds uped in the past I wouldn't even go there. I would hate to see anyone labled as a "drug seeker" or cut off.

It has little to do with the drug itself as I'm sure it's highly effective but the reality is we live in a world where drug abusers get more time the murderers.

I cooked some (shut up don't ask) one time a while back and it made me feel like I was on drugs.

You silly man, you were on drugs.:)