View Full Version : Prevent drug induced damage (hepatotoxicity, cardiotoxicity, neurotoxicity)


steven d
02-09-07, 10:04 AM
Flavonoids have received very much attention in the research field. They are present in fruits, vegetables and tea leaves. Two of them, quercetin and diosmin are very interesting due to good bioavailability. They are anti-oxidants, cytoprotectants (protect cell against damage), anti-mutagens, hepatoprotectants, neuroprotectants, cardioprotectants and much more... They could protect your liver for example against Stattera induced hepatotoxicity.

Silymarin modulates Cisplatin-induced oxidative stress and hepatotoxicity in rats:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17129399&query_hl=1&itool=pubmed_docsum

Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17147953&query_hl=3&itool=pubmed_docsum

Inhibition of bacterial mutagenesis by Citrus flavonoids:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=8693033&query_hl=6&itool=pubmed_docsum

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16893904&query_hl=8&itool=pubmed_docsum

Abatement by naringenin of Doxorubicin-induced cardiac toxicity in rats:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17102822&query_hl=15&itool=pubmed_docsum

Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17045724&query_hl=17&itool=pubmed_docsum

Inhibitory effects of flavonoids on rabbit heart carbonyl reductase:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10739958&query_hl=19&itool=pubmed_docsum

jeaniebug
02-09-07, 12:42 PM
Wow, thanks Steven!

I have some increased liver enzymes and just found out that my daughter who is only 20 has some slightly increased levels as well. :eek:

This thread is great! THANK YOU, THANK YOU!!! :D :D

netsavy006
02-10-07, 04:28 PM
Thank you for posting good links with excillent information...

steven d
02-10-07, 06:11 PM
Additional information about silymarin:

http://en.wikipedia.org/wiki/Silibinin

Good luck. If you have any questions, just PM me.

steven d
02-12-07, 02:39 PM
And oh yes, vitamin C and E is important too.