Here's the story:

I currently take 30 mg of Lexapro 1x per day (for OCD) and 10 mg of Adderall IR 2x per day for a total of 20 mg in one day. My Lexapro dose is optimal for my OCD.

I take the Adderall to counteract the following side effects of Lexapro:

-Lack of motivation induced by long term usage of an SSRI

-Horrible sexual side effects of Lexapro (my wife is losing her patience with this)

-The SSRI side effect of diminshed concentration and attention span

All of the above side effects are caused by Lexapro's potent boosting of serotonin in the brain; this in turn decreases dopamine in the frontal cortex.

My focus has gradually improved on the Adderall at the current dosage.

However, I feel like I have built up a tolerance to the following Adderall effects. After taking it for 4 months, the Adderall doesn't work nearly as well as it used to for the following:

-Increased motivation (an effect I love; It's amazing how much I can get done; My work performance has sky-rocketed)

-Increased sexual desire (losing this effect really bothers me)

-Increased confidence (While on Adderall for the first 2-3 months, I felt like anything was possible and I had no limit to my potential)

-Decreased food intake (My appetite has returned to normal after feeling like I was anorexic for a couple of months)

In short, the Adderall is only working for improved focus now.

Is the decreased effectiveness of Adderall normal? Have I built up a tolerance?

Should I ask my pdoc about raising my dose of Adderall?

Are there any other medications out there that would help (already tried Wellbutrin and it didn't do anything)?

Comments? Suggestions?

P.S. - Please note I take a medication vacation from the Adderall 2 days per week.

if Adderall doesn't work as well as you'd like it to then perhaps an increase is needed. When you talk w/ your doc make sure you tell him the reasons you want an increase. (even print out your post)

There are several other ADHD meds to try if Adderall isn't for you. On the ADHD medication forums initial page is a long list of ADHD meds.