Does anyone know if 100mg Zoloft could possibly make my low dose 10mg adderall ineffective or cancel it out?

i have been taking 100 mg. Zoloft and 25 mg. Adderall XR, same DX as you. I recently quit Wellbutrin. The only change I see is that when I get sleepy from too much sugar or stress during the day, I REALLY get sleepy! Can't keep my eyes open. Usually happens between 3-5 pm and 6-7 pm. I'm not at an optimal dose of Adderall yet, so I can't say there won't be issues later. My pdoc assures me they do well together.

I have taken prozac with my adderall. prozac is an ssri like zoloft. It never seemed to affect the effectiveness of adderall, but did help me with the depressed feelings I would have when the adderall stopped working in the evenings.

I noticed yesterday, I took my adderall at 7am and then took my 100mg zoloft at 11am and within a half hour it kicked my blood pressure into overdrive.

I noticed yesterday, I took my adderall at 7am and then took my 100mg zoloft at 11am and within a half hour it kicked my blood pressure into overdrive.


I have to take the Zoloft between 5-7pm or I won't stay awake during day or sleep through the night. I was surprised to hear you take it in the morning.

hmmm I might have to try that schedule instead.