View Full Version : Clues about Impulsivity from Parkinson's research

10-25-07, 06:44 PM

12-14-07, 04:46 PM
This makes sense. See one of my other posts about D2-like receptors and the inhibition of inhibitory neurons due to DAT/D4 receptor insensitivity.

This also highlights my questioning that inattentive subtype is even related to "normal" ADHD. The manifestations of inattentive type really seems to resemble a near-constant activation of the D2-like receptors due to an abundance of dopamine, which also correlates with the fatigue and sleep disturbances, as well as the insomnia.

The question is why do CNS stimulants help inattentive types? My guess would be that they address the symptoms that arise from the sleep disturbances/insomnia, not directly the DA thing.

Interesting stuff. Makes me wonder why ADHD patients aren't treated with some of the same things used to treat Parkinson's Disease pts, specifically L-dopa and dopamine agonists such as apomorphine.