My wife and I are keen to start trying for a family this year however I currently take a low dose of dexamphetamine (10-15mg per day) for Adult ADHD and I am concerned that this may affect my sperm quality or create other pregnancy problems/side effects. I would really like to know if anyone knows (or has experience) whether dexamphetamines affects sperm quality and if it is too risky to consider starting a family. I am quite scared as I have been taking this medication for the past 5 years and feel somewhat dependent on it so would prefer to continue on it, however I would never want to risk the health of my future children.
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Any information, advice or research would be greatly appreciated. <o:p></o:p>
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Oh my, for a moment I though you were pregnant. Just get a check out, both of you. I don't think it affects your sperm quality but ask the Dr.

Insanely high dose of methamphetamine might reduce sperm motility. A lot of these mega-dose drug studies that observe a negative effect are somewhat dishonest. The study below says "Department of Legal Medicine" makes me think they got a big fat grant from the Japanese equivalent of the DEA. Anyway I estimate the high dose might be 30+ times what a person would take to treat ADHD. Could even water prove lethal at 30 times the recommended dose? :D

1: J Obstet Gynaecol Res. 1999 Oct;25(5):353-8.
Links
Effect of methamphetamine on male mice fertility.
Yamamoto Y, Yamamoto K, Hayase T.

Department of Legal Medicine, Kyoto University Faculty of Medicine, Japan.

The effect of methamphetamine (MAMP) on the ability of males to mate with females and to impregnate them was examined in 8-week-old ICR mice. Male mice that had been administered an intraperitoneal injection of MAMP (15 mg/kg, 7.5 mg/kg, or 3.75 mg/kg) or saline were housed with females 24 or 48 hours later. The vaginal plugs were checked, and the number of births was counted. The effect of MAMP on sperm motility and the serum testosterone (TS) concentration was also examined. Methamphetamine was observed to have harmful effects only at the highest dose level. In the mice housed 24 hours after the injection of 15 mg/kg MAMP, the increase in the cumulative number of vaginal plugs lagged, and the total number of vaginal plugs decreased significantly. A significant decrease was also observed in the total number of births. Methamphetamine, at a dose of 15 mg/kg, decreased sperm motility. The TS concentration decreased initially, then increased.

PMID: 10533332 [PubMed - indexed for MEDLINE]