<o></o>I know it is still very early days and that it is too premature to form any conclusion on the overall effectiveness of this AD, however after my initial experience with moclobemide I feel the need to share it as it has been remarkably different from all the other AD meds I have tried without success (SSRI, SNRI & NARI).

I approached this medication with some apprehension, as I was expecting the usual side effects that I experienced with the other meds. I was also under the impression that it would take a couple of weeks, minimum, to feel any therapeutical effects – if any!

I started with one 300mg dose in the evening, about 5pm. By about 8pm I started to feel quite energised and didn’t realise how much until I noticed what I was actually doing. Before I knew it had done the dishes, cleaned the kitchen, disinfected the kitchen bin, took out the rubbish, tidied up a little and started on a task that I had procrastinated about for ages – editing and mastering hours of home videos so that I could send DVDs to the family!!!

As the night went on the stimulated feeling grew stronger – I decided to head to bed at 12:30am and then laid awake in bed until 2am (last memory) – my heart was racing!

Thanks to my beautiful 13month old son – the day started at 4:30am! I felt tired however somewhat upbeat about the day. I took the next dose (300mg) at 7am and it all began again about 11am! I was so productive at work – chatting to everyone, getting tasks done that had been hanging over my head for a long time, writing long emails and feeling very good!
Again, I took the next dose (300mg) at 6pm and here I am at midnight writing this post and not even feeling like sleeping!

The only side effects I have noticed is heightened anxiety and a very short temper, which has made it hard for my wife who often takes the brunt of it. Hopefully this will subside as time goes on – which I also need to consciously work on.

And there it is – my experience so far with a RIMA (reversible inhibitor of monoamine oxidase). It is so different from the other AD meds – and what has surprised me the most is it stimulating effect, increased motivation and mood elevation.

I have a theory on my depression situation – the meds that I have tried before have targeted serotonin and noradrenalin – which have all failed. MAOI work with all three – serotonin, noradrenalin & dopamine. Perhaps it is the dopamine factor that is driving my depression and moclobemide is assisting in that area.

I also wonder how much my 10+ years of daily pot usage (ceased 2 years ago!) has added to the situation – seeing as pot works on dopamine!

Are there are any merits of moclobemide for ADHD – with respects to the stimulating effects as it has done wonders for me over the last 24+ hours?

I would love to hear of anybody else’s experience with this medication.

Sorry for the long rant – I was hoping by the time I finished this that I would feel like bed however I don’t......hmmm! what can I do next ;)

3 days on from the last post and its a different story! No longer the motivational highs or sleeplessness - I'm now struggling to keep awake during the day! I'm also getting those yawns that I got with SSRI's...the ones that almost knock you out because they are so big & intense!

The anxiety and short temper has subdued and no more scrubbing kitchen bins ;)

WOW! great to hear you had such an awesome response to a class of medications that tend to cause more grief than they relieve (antidepressants in general).

Interesting coincedence - I've been doing a lot of reading on moclobemide lately and I am going to attempt to use 150mg starting tommorow for my adhd. I found stimulants themselves to make me too tense and anxious, even though they helped a lot. My doctor and I think that something that helps serotonin as well as dopamine and norepinephrine will maybe exert more of a calm focus and relieve my occasional depression.

I'll let you know how it goes. I'm very excited to try this med. It's not easily available in the US for some reason but it's apparently all the rage in europe (they prescribe it for practically everything because it's so much safer than older maoi's and so few side effects compared to ssri's and snri's).

Thanks for sharing your experience!! Just what i wanted to hear before I try this drug.

good luck with it all and I look forward to hearing your experience

I have now hit the 1 week mark and things have settled down a bit. The tiredness during the day has decreased and those 'knock out' yawns are gone. I am feeling quite content and have a slight energised feeling inside.

I have noticed a decrease in appetite and have lost 1kg over the last week - however my weight fluctuates between 68-75kg quite frequently (depending on my depression/mood swings)

Its a good feeling when you have found a medication that finally agrees with your body - I suppose time will only tell when it comes to knowing the full benefits of moclobemide, however for now I am happy to stick with it.

However, with that in mind I will need to talk to the psych about whether or not I can continue with it when I start on the dex - as I have read some contradictory things

update: wow, 10 days on and I feel like a normal person (well as normal as I can get! ;)) All side effects gone - totally!

I'm still taking 300mg twice a day and I'm feeling like I used to feel many, many years ago! Even my wife commented yesterday that she hasn't seen me like this for a long time!
Finally, an AD that works for me......now to just get on top of the innattentive ADHD side of things!

not to jump the gun, but glad to hear you're finding something which is helpful!

If your meds are giving you a "very short temper" and your Wife is "bearing the brunt of this", I think you might need to talk to your Doctor.

Medication side effects shouldn't cause you to emotionally abuse your wife.

Not acceptable...

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I used to take Aurorix (Manerix in Canada) and this is not a standard side effect!

If your meds are giving you a "very short temper" and your Wife is "bearing the brunt of this", I think you might need to talk to your Doctor.

Medication side effects shouldn't cause you to emotionally abuse your wife.

Not acceptable...

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I used to take Aurorix (Manerix in Canada) and this is not a standard side effect!

Firstly, I post here to share my experiences, hoping that it might help someone else in a similar situation. Not, to be criticised by someone who takes things out of context!

Who do you think you are coming on here and claiming that I am emotionally abusing my wife - no have no idea! Just because this medication didn't make you on edge for the first couple of days "quote: first couple of days!" doesn't mean it is the same for everybody else - how very ignorant!

How about I leave the advice to a trained medical professional and you think twice before posting non constructive crap!

One persons' "objective" and "helpful' advice or commentary is another persons' unwanted judgment or implied criticism.


Funny thing, both are valid.