View Full Version : Prescribed Desoxyn, and... it does nothing for me.


Monolith
02-16-08, 12:43 PM
Anyone else experience this? My shrink prescribed desoxyn for me, and let me titrate it up to no more than 15mg 2x/day to see how it worked. I've been on various stimulants for ADD for 8 years or so.

So, i started with 5mg, and it promptly put me to sleep. Literally. I woke up about an hour later rather annoyed. So, i took another 5mg, putting me at around 10mg total (some will have metabolized out in the couple hours since i took the first 5mg, but its marginal). I didn't fall asleep this time, but i was still kind of tired and definitely couldn't focus.

The next day i took 15mg, and while i didn't fall asleep, i was a little tired. I tried to do some studying (im in college), and that didn't go too well... this stuff wasn't doing anything to combat my ADD.

Another odd thing about this drug is that i didn't experience ANY euphoria with it. Typically with other stimulants there's at least a little of that "high", and while it's not something i chase, it serves as an indicator that the drug is actually working. Even after chronic use of therapeutic dosages of adderall i would still get a little of that euphoria, but not so with desoxyn. It was obviously doing something though since it put me to sleep.

The one thing i could come up with to explain my reaction to desoxyn is that i'm also taking fluoxetine. From a little digging on pubmed, it appears that fluoxetine has been used successfully to treat methamphetamine addiction/withdrawal. This leaves me in a bit of a predicament, since the fluoxetine works very well for me and i'm not sure i want to try coming off it just for the desoxyn.

Has anyone else had this type of experience?

Mincan
02-16-08, 12:51 PM
Dexedrine makes me sleepy. The first time I took 10mg dose I had a forced nap, so tired. It just gets rid of all my anxiety and mental clutter, my body is like "wow, I'm supposed to feel like this! Time to make up for all those anxious nights spent awake, go to sleep now! I know one of the metabolites of methamphetamine is dextroamphetamine. I think 25% of the meth becomes dex.

cyber_tublu
03-25-08, 12:31 PM
Fluvoxtine is an SSRI and the main action is against depression and affects some specific 5HT molecules only.
The reason why it's used for treating meth withdrawl is to treat the major depression which affects every stimulant abuser when he doesn't get meth anymore.....
Fluvoxtine doesn't effect Dopamine or norepinephrine....so doesn't effect the euphoric action of meth...not in a million years....

In fact when a meth addict does an OD of an SSRI along with meth.......that person can experience trips like XTC much more easily than normal meth abusers......it's kinda difficult to hallucinate for a chronic meth abuser...when he only takes meth......though in normal doses this doesn't happen so don't worry.

You should talk to ur doc......
My guess will be that your doc is testing you by giving you a placebo....instead of the actual thing...this is part of the treatment as adhd has no diagnostic tests....so this is how the doc tests you...
this is just a guess....just a guess...there could be many other reasons...

good luck:confused:

TheBrainiac
03-25-08, 01:46 PM
^ Excellent information, Fluoxetine (Prozac®) is indeed a selective serotonin reuptake inhibitor with primary pharmacokinetic effect upon the vesicles that release the neurotransmitter serotonin, thus allowing the open receptor to have a longer time frame for which to absorb the chemical from the synaptic space. Indirect effect upon dopamine or norepi has not been noted in effective bio-assay testing. Therefore preventing any type of psychoactive effect resulting in euphoria is pharmacologically speaking, not possible.

Perhaps there is a cross-tolerance issue with the desoxyephedrine and something you have taken in the past. The Desoxyn® brand of methamphetamine hydrochloride is seen by many as the most effective medication by effectiveness per dosage unit, your situation is not typical of the many people that have taken the drug so perhaps your biochemistry just does not respond to this particular drug, but would respond to something else better. I am assuming you have taken other medications prior to being prescribed this as it is often not considered a first line medication. I agree that you should speak to your physician and see about reverting back to another medication that worked better for you in the past.

ozchris
03-25-08, 07:56 PM
Were you on any other stimulants before Desoxyn? Might be cross tolerance? If you were on Adderall before you might be expecting that same kind of feeling which I find Dex. and Desoxyn don't have.

Adderall I find you can 'feel' lots more where as the others are much more subtle.

If I were you I'd stay on it for a week or two at the starting dose and see if anything changes (provided your doctor agrees)

I remember reading a bit about SSRI's reducing some of the effect of Desoxyn and I'm pretty sure methamp acts on the serotonin unlike the other amphetamines. Can anyone else verify? If not I'll have a dig and see if I can find the article again.


edit: oops Brainiac already covered most of my post :P

Mincan
03-25-08, 10:53 PM
I remember reading a bit about SSRI's reducing some of the effect of Desoxyn and I'm pretty sure methamp acts on the serotonin unlike the other amphetamines. Can anyone else verify? If not I'll have a dig and see if I can find the article again.


Dextroamphetamine does work on serotonin, but not to the degree of dopamine. In enough dose though, dextroamphetamine induces the release of serotonin.

lars
03-25-08, 11:20 PM
Anyone else experience this? Yes, I have experienced this with Desoxyn. However, it never actually put me to sleep in the way that a narcotic would, but it did relax me so much that it was very easy for me to drift off to sleep if I did not intentionally try and stay alert.




The next day i took 15mg, and while i didn't fall asleep, i was a little tired. I tried to do some studying (im in college), and that didn't go too well... this stuff wasn't doing anything to combat my ADD. I know exactly what you mean. Desoxyn was just too relaxing for me when it came to sitting through a long lecture, or trying to do hours of homework.

That being said, I did I find it to be a very nice drug, but as a student I need a little more mental clarity than the Desoxyn was able to provide me. I would still be willing to take Desoxyn if I did not have to be so attentive in a classroom setting, or at work.

lars
03-25-08, 11:37 PM
My guess will be that your doc is testing you by giving you a placebo....instead of the actual thing...this is part of the treatment as adhd has no diagnostic tests....so this is how the doc tests you...
this is just a guess....just a guess...there could be many other reasons...
You're certainly entitled to your opinion, and everyone is free to guess about anything they feel like, but I feel that the possibility of a Dr actually "testing" an ADHD patient with a placebo would be highly unlikely.

The only time I've ever heard of a Dr testing a patient with a placebo was after the Dr talked to the pharmacist, and they both agreed to a bogus chemical name for a drug that does not exist. For a Dr to write a prescription for a drug that actually exist (like Desoxyn), and then to have the patient pay full price (or their insurance company pay full price) would be illegal, not to mention immoral considering how over-priced Desoxyn is compared to all the other prescription stimulants. When a patient is sold a placebo (which rarely ever happens), the patient is charged a very low price.

Furthermore, Desoxyn is not the same thing as methamphetamine (which is a racemic molecule that contains both the levo & dextro methamphetamine isomers), just as Dexedrine is not the same thing as amphetamine (which contains both the levo and dextro amphetamine iomers).

Desoxyn, and Dexedrine are both just the dextro isomers of methamphetamine, and amphetamine respectively.

cyber_tublu
03-26-08, 11:17 AM
I'm a budding pharmacist with ADHD...and since my last post was written at night....
Hence I wasn't able to explain what i wished to convey....
Because like everyone... stimulants are a "NO....NO" at night....
So let me continue with what wanted to say.
Fluoxetine is a class of antidepressants called Selective Serotonin Reuptake Inhibitor or SSRI.
SSRIs mimic the effects of serotonin release (since actual increase in serotonin release due to SSRIs is
only marginal)...by blocking the reuptake of serotonin by the serotonin receptor...thus increasing the
concentration of serotonin in the synapse cleft.
(P.S. note: Serotonin is also known as 5-HT or 5-HydroxyTryptamine)
Now there are 7 different serotonin receptors which are further sub-categorized:
5-HT1 including 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT1F
5-HT2 including 5-HT2A, 5-HT2B, 5HT2C
5-HT3 including 5-HT3A, 5-HT3B
5-HT4
5-HT5A
5-HT6
5-HT7
Now the first “S” of the word SSRI stands for “selective” which refers to how these antidepressants work.
SSRIs do block the reuptake of serotonin but selectively…they primarily work by binding to the some 5-
HT1, some 5-HT2 and most 5-HT3 receptors. Especially all the 5-HT3 receptors is the most affected.
They have no or negligible effect on the other receptors….thus avoiding unwanted side-effects and to
counter whatever abuse potential it has.
Metabolism of serotonin occurs in its separate neural pathways.
And yes chronic methamphetamine abuse may affect serotonin levels in the brain…which is that they can
decrease the levels of serotonin instead of increasing it… so there is more chance of methamphetamine
interfering with fluoxetine’s action than vice versa.
So there is a very slim chance that a single high dose of methamphetamine may cause a similar effect
and at your indicated dose it is almost impossible.
Methamphetamine/Desoxyn works in the same way as other stimulant medication….it basically increases
the amount of dopamine, norepinephrine and acetylcholine in the Central Nervous System and adrenaline
in the Peripheral Nervous System…it is known that the CNS effects are used to treat ADHD….
Lars is right that dexidrine and desoxyn are both (+)dextro-structural isomers of their racemic/normal
mixture which has both dextro(+) and levo(-) isomers mixed in equal amounts….dextro isomer being the
more active part and the levo(-) isomer which is found in the popular Vicks Vapor Nasal Inhaler acts more
on the PNS than CNS…hence you may consider normal/racemic/generic version of methamphetamine is
half as powerful/strong as it’s dextro(+) isomer…..such type of isomerism is mainly found in chiral
compounds.
Though there are different theories of how these stimulants benefit people with ADHD and why they
affect non-ADHD people differently is not known yet.
Metabolism of serotonin, norepinephrine and dopamine occur in their own pathways…well pathways may
be more than one….like dopamine has eight neural pathways in which four are important….I’m not going
into naming them as it’s irrelevant here.
Apart from that…though the necessity or feasibility for a placebo trial is completely up to the clinician in
question, some clinicians who have a way of thinking similar to mine consider ADHD (more for ADD) to
be one of the most ideal disorders for placebo trials considering the relatively low risk of such
experimentation on such individuals (exceptions are always there). Some docs may even stop medicines
abruptly to see what effect it has (does his symptoms reoccur or not?) on the patient…..But lars also
right when they that such experimentation is kind of rare and according to his personal experience….so
docs generally choose cases which intrigue them more than others to do this experimentation. I’m really
confused that if placebos cost less than the actual thing…then the patient who buys them will know
about it immediately and prescribing a placebo in such a manner makes no sense at all. So my guess
was supposed to be a thought out educated guess.
Brainiac can make my opinion even clearer…if he may…

JR1973
03-26-08, 12:31 PM
Prozac is not a good med to take with any amphetamine. Prozac and many other SSRIs compete and block the 2D6 metabolic pathway which is the same one that amphetamine needs and uses.

Switch to a cleaner anti-depressant such as Lexapro (which causes no metabolic problems).

J

DenverMatt
04-08-08, 04:26 AM
You are wrong lars. The chirality of Desoxyn is only is not a racemic mixture. The levo is virtually inneffective and there fore only dextro is manufactured by Ovation. See below.

The active salt of Desoxyn is dextro (http://en.wikipedia.org/wiki/Dextrorotation)-methamphetamine hydrochloride. This is the right-hand isomer (http://en.wikipedia.org/wiki/Isomer) of methamphetamine bonded to hydrochloride. The left-handed isomer (http://en.wikipedia.org/wiki/Levorotation) of methamphetamine, levomethamphetamine (http://en.wikipedia.org/wiki/Levomethamphetamine), is less centrally (http://en.wikipedia.org/wiki/Central_nervous_system) acting and more peripherally (http://en.wikipedia.org/wiki/Peripheral_nervous_system) acting; therefore no racemic (http://en.wikipedia.org/wiki/Racemic) mixture of dextro (http://en.wikipedia.org/wiki/Dextrorotation)/levo (http://en.wikipedia.org/wiki/Levorotation)-methamphetamine salts is in production.

You're certainly entitled to your opinion, and everyone is free to guess about anything they feel like, but I feel that the possibility of a Dr actually "testing" an ADHD patient with a placebo would be highly unlikely.

The only time I've ever heard of a Dr testing a patient with a placebo was after the Dr talked to the pharmacist, and they both agreed to a bogus chemical name for a drug that does not exist. For a Dr to write a prescription for a drug that actually exist (like Desoxyn), and then to have the patient pay full price (or their insurance company pay full price) would be illegal, not to mention immoral considering how over-priced Desoxyn is compared to all the other prescription stimulants. When a patient is sold a placebo (which rarely ever happens), the patient is charged a very low price.

Furthermore, Desoxyn is not the same thing as methamphetamine (which is a racemic molecule that contains both the levo & dextro methamphetamine isomers), just as Dexedrine is not the same thing as amphetamine (which contains both the levo and dextro amphetamine iomers).

Desoxyn, and Dexedrine are both just the dextro isomers of methamphetamine, and amphetamine respectively.

lars
04-08-08, 01:57 PM
You are wrong lars. The chirality of Desoxyn is only is not a racemic mixture. The levo is virtually inneffective and there fore only dextro is manufactured by Ovation. See below.

The active salt of Desoxyn is dextro (http://en.wikipedia.org/wiki/Dextrorotation)-methamphetamine hydrochloride. This is the right-hand isomer (http://en.wikipedia.org/wiki/Isomer) of methamphetamine bonded to hydrochloride. The left-handed isomer (http://en.wikipedia.org/wiki/Levorotation) of methamphetamine, levomethamphetamine (http://en.wikipedia.org/wiki/Levomethamphetamine), is less centrally (http://en.wikipedia.org/wiki/Central_nervous_system) acting and more peripherally (http://en.wikipedia.org/wiki/Peripheral_nervous_system) acting; therefore no racemic (http://en.wikipedia.org/wiki/Racemic) mixture of dextro (http://en.wikipedia.org/wiki/Dextrorotation)/levo (http://en.wikipedia.org/wiki/Levorotation)-methamphetamine salts is in production.

Actually, you are the one who is wrong here DenverMatt. If you would take the time to read my post more carefully, you will see that I never said what you are accusing me of saying.

I stated clearly in my post that Desoxyn is not the same as methamphetamine which contains a racemic molecule that includes the dextro and levo isomers, and that Desoxyn only contains the dextro isomer of methamphetamine. In fact I went on to compare how Desoxyn is similar to the drug Dexedrine in the way that Dexedrine also does not contain a racemic molecule of two isomers, but only contains a dextro isomer of amphetamine.

JRayV
05-01-08, 12:23 PM
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fxfake
05-05-08, 11:54 PM
Prozac is not a good med to take with any amphetamine. Prozac and many other SSRIs compete and block the 2D6 metabolic pathway which is the same one that amphetamine needs and uses.

Source? While the two share metabolic pathways CYP2D6; up to half of amphetamine may leave the body without being metabolized.

Many people take the two without issue... There are many factors involved in the choice of SSRIs/SNRIs/etc; Lexapro, for example, is far more likely to lead to discontinuation syndrome than Prozac.

PinkFloyd1
05-10-08, 11:26 AM
I too am having no luck with Desoxyn!

speedo
05-10-08, 03:16 PM
Prozac won't keep desoxyn from working but prozac does reduce attention. Some SSRI's are less likely to do this , but from what I've read , prozac does it the most of the ssri's.

You should not feel euphoria. You should feel nothing and you should be able to focus better. If you feel euphoria you took too much. :p

ME :D

Anyone else experience this? My shrink prescribed desoxyn for me, and let me titrate it up to no more than 15mg 2x/day to see how it worked. I've been on various stimulants for ADD for 8 years or so.

So, i started with 5mg, and it promptly put me to sleep. Literally. I woke up about an hour later rather annoyed. So, i took another 5mg, putting me at around 10mg total (some will have metabolized out in the couple hours since i took the first 5mg, but its marginal). I didn't fall asleep this time, but i was still kind of tired and definitely couldn't focus.

The next day i took 15mg, and while i didn't fall asleep, i was a little tired. I tried to do some studying (im in college), and that didn't go too well... this stuff wasn't doing anything to combat my ADD.

Another odd thing about this drug is that i didn't experience ANY euphoria with it. Typically with other stimulants there's at least a little of that "high", and while it's not something i chase, it serves as an indicator that the drug is actually working. Even after chronic use of therapeutic dosages of adderall i would still get a little of that euphoria, but not so with desoxyn. It was obviously doing something though since it put me to sleep.

The one thing i could come up with to explain my reaction to desoxyn is that i'm also taking fluoxetine. From a little digging on pubmed, it appears that fluoxetine has been used successfully to treat methamphetamine addiction/withdrawal. This leaves me in a bit of a predicament, since the fluoxetine works very well for me and i'm not sure i want to try coming off it just for the desoxyn.

Has anyone else had this type of experience?

Adrupert
06-04-08, 01:40 PM
I have to say my experience on this drug is quite different, even from 5mg I could feel the "euphoria" you mentioned. I am currently only on 5mg three times a day, as I have just started treatment, but this is by far the greatest medication I have tried. I guess I am your "typical" A.D.H.D. case because I have responded to all the medications that I have tried, it's a matter of what was most effective for me with the least side effects.

arcadesproject
07-02-08, 12:57 AM
I'd like to point out that Prozac is well known as an 'activating' anti-depressant. I haven't tracked down a lot of citations, but the first that come to hand point to a kind of obvious reason why: it significantly increases catecholamine (dopamine, norepinephrine) concentrations in prefrontal cortex. The following study suggests that this is probably an indirect effect potentiated by blockade at the 5HT2C receptor. http://biopsychiatry.com/fluoxdopnor.htm

More animal model suggestions of dopaminergic behavior:
http://biopsychiatry.com/fluoxdop.htm

A suggestion that the mechanism may not be serotonergic:
http://www.ingentaconnect.com/content/bsc/jnc/1999/00000073/00000003/art00017

The point being, really, that 'SSRI' has more applicability as a marketing term than a precise statement of fact and Prozac, specifically, is by far the broadest acting (which may or may not be a good thing depending on what one needs).

That said, it seems unlikely that Prozac would be the culprit. It's possible that a mild, sustained increase in catecholamines like Prozac gives could lead to the up-regulation of their autoreceptors (which respond to the same chemicals, but switch the circuits off). That's probably one of the main factors in stimulant tolerance and might affect you.

On the other hand, something you're probably noticing in the difference between racemic amphetamine (adderall) and d-methamphetamine (desoxyn) is that d-meth is by far the most CNS specific stimulant. It crosses into the brain much more easily than the others, which is why it has less side effects and more effectiveness at a given unit of dosage. The L-amphetamines, which adderall contains, are much more active out in the body and are responsible for a lot of the somatic stuff that people associate with stimulants and that people think of when they think of the experience of taking them. You're a lot more likely to get a racing heart from too much Adderall than too much Desoxyn.

I think several people have also pointed out that d-meth has significant action on serotonin, which probably accounts for its being less jittery and more 'subtle'. And provides yet another point for possible alteration of effects.

Just a few tidbits . . .

bailee33
11-09-08, 07:38 PM
Does the tiredness wear off when using desoxyn? I used 5mg for 2 days, nothing. Tried 10mg, nothing-actually I felt worse I think (foggy head, trouble thinking, decreased my mood);

As you know, it's expensive. Should I stick with it for awhile? Its seems so beneficial for so many people. I know you can take up to 20mg, so I'll need to call my dr. I would like to try Focalin but I cannot seem to find the free trial coupon, perhaps it's no longer available.

I'd love to hear how others take their desoxyn (other meds, food, baking soda) and how many mgs they take at a time and the length of effectiveness. I did notice that I could not fall asleep last night after taking 5 or 10mg of desoxyn at 1:30 but I was unable to study b/c my head was tired, I couldn't think, last thing I wanted to do was to read, I felt awful and just wanted to sleep! UGGGG

Thanks

Contrapunctus
11-09-08, 08:05 PM
The good thing about Desoxyn is that you don't "feel it", but it does seem to work. It is not nearly as stimulating as d-amphetamine or Adderall, and it will not give you "buzz".

Desoxyn at dosages below 20mg is subtle, almost nootropic.

If you already have a tolerance to something like Adderall, you will likely need a significant dose to "feel" the desoxyn.

Methamphetamine does not "force" you to focus like d-amphetamine. Instead, it gently suggests the idea, and gives you the control.

If you have yet to try focalin, you should, as I think it is a great medication. In fact, I actually prefer Focalin to methamphetamine, because it doesn't leave me feeling "drained" the following day. However, keep in mind, I do not have ADHD-PI, and am extremely hyperactive. Still, Desoxyn still has its uses, and I take it from time to time...

Edit: also, the dose I find most effective is from 15-20mg. However, as little as 5mg can be good as a mild nootropic. The lower dosages make me a bit sleepy, while 15-20mg will make me neither sleepy nor stimulated.

bailee33
11-09-08, 10:30 PM
Thankyou for that feedback, I appreciate it. I have inattentive ADD and defiantly don't need to be sleepy. Sounds like I should try 20mg of desoxyn (wow, that will be sooooo expensive)

I've not tried Folcain, I've actually been searching for their free trial month coupon but have yet to find it. It sounds great.

Thanks again

jeffpuffer
12-15-08, 12:04 AM
Couple things. First of all, Methamphetamine acts more on serotonin than either dopamine or norepinephrine. It causes neurotransmitter inversion from storage vesicles at a ratio of 1:2 NE:DA, and 1:60 NE:5HT. For every 1 norepinephrine that is released, 2 dopamines and 60 serotonins are released. As far as re-uptake inhibition goes, meth blocks norepinephrine, serotonin, and dopamine, in a ratio of about 1:2.35 NE:DA, and 1:44.5 NE:5HT.

As you can see, it acts much more and much harder on serotonin, and the majority of its effects can presumably be attributed to serotonin. Some people can focus and motivate themselves much better with serotonin stimulation, than with dopamine stimulation. I found that when I started taking lexapro, 10mg a day, that I had INSANE motivation, focus, and understanding when I did school work. This wore off after about 1 week, but the anti-anxiety effects stayed around.

As for why you weren't seeing effects because of fluoxetine, I'm guessing that fluoxetine is keeping the meth from working as well because of the serotonin stimulation involved with meth. Though meth is no doubt a more potent serotonin re-uptake inhibitor, it may be less competitive for the serotonin transporter than fluoxetine, and thus fluoxetine occupies the inhibitor instead of meth.

Just food for though.

Contrapunctus
12-15-08, 12:25 AM
^^^You seem to be a bit confused about interpreting the potencies of these drugs. Methamphetamines most potent action is in releasing NE, followed by the release of dopamine, and finally the release of serotonin. The IC50's are 12.3nM, 24.5nM, and finally 736nM (these being NE,DA and serotonin, respectively). Keep in mind, the lower the number, the HIGHER the potency. Basically, you are reading the ratios backwards...

Also, fluoxetine has a far higher affinity (potency) in regards to the serotonin transporter, as it has a Ki value of ~9.5nM, whereas methamphetamine's affinity is around 2140nM. The difference is, fluoxetine is very slow acting, and has virtually no affinity for release.

At prescribed dosages, methamphetamine will release very little serotonin, but can work as a fast acting serotonin reuptake inhibitor. This feature also contributes to the euphoric properties of cocaine when compared with methylphenidate (MPH has no affinity for the SERT).

Fluoxetine would have little effect on methamphetamine, although it could potentially dampen the euphoria from very high doses.

jeffpuffer
12-15-08, 02:19 AM
^^^You seem to be a bit confused about interpreting the potencies of these drugs. Methamphetamines most potent action is in releasing NE, followed by the release of dopamine, and finally the release of serotonin. The IC50's are 12.3nM, 24.5nM, and finally 736nM (these being NE,DA and serotonin, respectively). Keep in mind, the lower the number, the HIGHER the potency. Basically, you are reading the ratios backwards...

Also, fluoxetine has a far higher affinity (potency) in regards to the serotonin transporter, as it has a Ki value of ~9.5nM, whereas methamphetamine's affinity is around 2140nM. The difference is, fluoxetine is very slow acting, and has virtually no affinity for release.

At prescribed dosages, methamphetamine will release very little serotonin, but can work as a fast acting serotonin reuptake inhibitor. This feature also contributes to the euphoric properties of cocaine when compared with methylphenidate (MPH has no affinity for the SERT).

Fluoxetine would have little effect on methamphetamine, although it could potentially dampen the euphoria from very high doses.

Ah, my mistake. Thanks for correcting me.

PhishHead
12-15-08, 12:48 PM
I just started and am really happy so far. I have tried ritalin, cylert, adderall, focalin, wellbutrin, dexedrine

so far it is AWESOME. Virtually no side effects and definatly feel it working on the seratonin too! I may have just found my missing link. Not getting hopes up too high in case it is the honeymoon effect

mammalspod
03-02-09, 05:04 PM
I have to disagree with many of the neurochemical assumptions being made here. It is not true that just because a drug effects other chemicals besides dopamine that it couldn't inhibit the stimulatory effects of dopamine. The brain's serotonergic and dopaminergic pathways do compete with each other in a lot of cases. It is entirely reasonable to assume that prozac attenuates the effect of stimulants. The fact that meth abusers will achieve greater euphoria from an overdose of prozac is because at supertherapeutic doses of both the brain's regulatory mechanisms cannot compete. Their is plenty of anecdotal evidence of SSRI's dampening stimulation.

merovingian
03-30-09, 02:23 AM
Anyone else experience this? My shrink prescribed desoxyn for me, and let me titrate it up to no more than 15mg 2x/day to see how it worked. I've been on various stimulants for ADD for 8 years or so.

So, i started with 5mg, and it promptly put me to sleep. Literally. I woke up about an hour later rather annoyed. So, i took another 5mg, putting me at around 10mg total (some will have metabolized out in the couple hours since i took the first 5mg, but its marginal). I didn't fall asleep this time, but i was still kind of tired and definitely couldn't focus.

The next day i took 15mg, and while i didn't fall asleep, i was a little tired. I tried to do some studying (im in college), and that didn't go too well... this stuff wasn't doing anything to combat my ADD.

Well perhaps taking things as prescribed might help. The warning for the medication itself specifically says to start at 5mg twice daily and increase by 5mg daily each week. I found that my body didn't respond well to the initial 5mg dose I took and had, amoung other side effects, the "sleepy" effect. This went away when I increased the increments of the medication starting at 1/4 pill twice daily by 1/4 pill twice daily to get to the full 5mg. Just a thought, this was only my experiance but that doesn't mean it will work for everyone. If your going to try my recommendation on increasing the dosages you should talk to a doc first, I am not a doctor.

I personally notice that while Desoxyn does help with some aspects of my ADD it does not focus for me the way that Adderall does, the Desoxyn allows me to be creative and to think outside the box when I want to and I have to have some amount of control and discipline to focus on what I need to focus on. But everyone is different, maybe this just isn't the right med for you but I might consider taking it as prescribed for a few weeks or even how I had before writing it off.

Yellow
05-19-09, 12:27 AM
are you also taking an SSRI or SNRI? that might be why its not doing anything??

PinK~Cloud
07-22-09, 04:42 AM
methamp is different to other amphetamines because it releases a flood of seratonin. much like MDMA does, but obviously not to the same effect. seratonin is often times relaxing and makes people tired.