I has forgetted.

Also.... is Adderall supposed to give you an imaginary thirst? I've noticed during the months that I've been on it that I will often drink water until my pee is clear but then just want more water. If your pee is clear that's supposed to mean you aren't dehydrated, but I just want to drink more and more and more even though my body says, "enough!" so that it comes out cool and clear right after drinking.

The thirst is not imaginary.

Stimulants and SSRIs work on the same metabolic pathway ("2D4").

Some people find that side effects can build up b/c of this. (e.g. BP, muscle tightness, bowel/bladder issues, headaches)

+++++++

Several case reports suggest that patients treated with serotonin reuptake inhibitors (SRIs) may exhibit an increased sensitivity to sympathomimetic agents. The mechanism of interaction is unclear. The reaction has been reported when fluoxetine was used concomitantly with phentermine, amphetamine, or phenylpropanolamine. Additionally, some sympathomimetic agents (e.g., amphetamines) may possess serotonergic activity and should generally not be administered with SRIs because of the additive risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A receptors. The interaction occurred in a patient treated with dexamphetamine approximately 2 weeks after the addition of venlafaxine. The medications were discontinued and the patient was given cyproheptadine for suspected serotonin syndrome, whereupon symptoms promptly resolved. A second episode occurred when dexamphetamine was subsequently resumed and citalopram added. The patient improved following cessation of citalopram on his own, and residual symptoms were successfully treated with cyproheptadine.


In general, amphetamines should not be combined with serotonin reuptake inhibitors. Close monitoring for enhanced sympathomimetic effects is recommended if these agents must be used together. Patients should also be monitored for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia.

It's not imaginary.
Well why would my body tell me to drink more water if it had no intentions of absorbing it?

re: drugs and kidney function and thirst

That's a whole textbook kidney physiology chapter's lesson.

We spent 1/3 of a term on the Kidney in Critical Care Nursing.

Go read about kidneys and feedback loops and sympathomimetics and kidney hormones (vasopressin, aldosterone, etc etc) and conditions like SIADH {a great example of how chemicals/hormones/neurotransmitters/drugs influence urination/fluid balance} on Wikipedia yourself?

We aren't college teachers.

The thirst is not imaginary.

Stimulants and SSRIs work on the same metabolic pathway ("2D4").

Some people find that side effects can build up b/c of this. (e.g. BP, muscle tightness, bowel/bladder issues, headaches)

+++++++

Several case reports suggest that patients treated with serotonin reuptake inhibitors (SRIs) may exhibit an increased sensitivity to sympathomimetic agents. The mechanism of interaction is unclear. The reaction has been reported when fluoxetine was used concomitantly with phentermine, amphetamine, or phenylpropanolamine. Additionally, some sympathomimetic agents (e.g., amphetamines) may possess serotonergic activity and should generally not be administered with SRIs because of the additive risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A receptors. The interaction occurred in a patient treated with dexamphetamine approximately 2 weeks after the addition of venlafaxine. The medications were discontinued and the patient was given cyproheptadine for suspected serotonin syndrome, whereupon symptoms promptly resolved. A second episode occurred when dexamphetamine was subsequently resumed and citalopram added. The patient improved following cessation of citalopram on his own, and residual symptoms were successfully treated with cyproheptadine.


In general, amphetamines should not be combined with serotonin reuptake inhibitors. Close monitoring for enhanced sympathomimetic effects is recommended if these agents must be used together. Patients should also be monitored for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia.
I have gotten headaches and bladder issues... hmm.

I know lots of people take Adderall+ SSRI's though, and from what I've read, the only known cause of serotonin syndrom was a combination of MAOI's and other drugs.

re: drugs and kidney function and thirst

That's a whole textbook kidney physiology chapter's lesson.

We spent 1/3 of a term on the Kidney in Critical Care Nursing.

Go read about kidneys and feedback loops and sympathomimetics and kidney hormones (vasopressin, aldosterone, etc etc) and conditions like SIADH {a great example of how chemicals/hormones/neurotransmitters/drugs influence urination/fluid balance} on Wikipedia yourself?

We aren't college teachers.
So I have done something wrong with my kidneys perhaps? Yes?