despirit
03-20-08, 02:19 PM
Adele Diamond wrote an excellent paper on how the truely inattentive subtype of ADHD is a distinct disorder from ADHD with hyperactivity.
(link (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811))
Attention-deficit disorder (attention-deficit/ hyperactivity disorder without hyperactivity): A neurobiologically and behaviorally distinct disorder from attention-deficit/hyperactivity disorder (with hyperactivity)
ADELE DIAMOND
University of British Columbia, Vancouver, and BC Children's Hospital, Vancouver
Abstract
Most studies of attention-deficit/hyperactivity disorder (ADHD) have focused on the combined type and emphasized a core problem in response inhibition. It is proposed here that the core problem in the truly inattentive type of ADHD (not simply the subthreshold combined type) is in working memory. It is further proposed that laboratory measures, such as complex-span and dual-task dichotic listening tasks, can detect this. Children with the truly inattentive type of ADHD, rather than being distractible, may instead be easily bored, their problem being more in motivation (underarousal) than in inhibitory control. Much converging evidence points to a primary disturbance in the striatum (a frontal–striatal loop) in the combined type of ADHD. It is proposed here that the primary disturbance in truly inattentive-type ADHD (ADD) is in the cortex (a frontal–parietal loop). Finally, it is posited that these are not two different types of ADHD, but two different disorders with different cognitive and behavioral profiles, different patterns of comorbidities, different responses to medication, and different underlying neurobiologies.On treatment:Most children with ADHD (perhaps as high as 90%; Barkley, 2001 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R13); Barkley et al., 1991 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R15); Milich et al., 2001 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R113); Weiss et al., 2003 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R167)) respond positively to methylphenidate (Ritalin) and over two-thirds of such children respond positively to methylphenidate in moderate to high doses (Barkley, 2001 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R13); Barkley et al., 1991 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R15); Milich et al., 2001 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R113); Weiss et al., 2003 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R167)). In contrast, a significant percentage of children with ADD are not helped by methylphenidate and those who are helped often do best at low doses (Barkley, 2001 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R13); Barkley et al., 1991 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R15); Milich et al., 2001 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R113); Weiss et al., 2003 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R167)). Many individuals with ADD are helped by amphetamines, such as Adderall. There is considerable overlap in the mechanisms of action of methylphenidate and amphetamines, but there is a significant difference. Although both methylphenidate and amphetamines inhibit reuptake of dopamine and norepinephrine, only amphetamines also promote release of those neurotransmitters. Recent research also suggests that low doses of methylphenidate (the dosages likely to be efficacious in treating ADD) preferentially release norepinephrine in the rat brain (Ishimatsu, Kidani, Tsuda, & Akasu, 2002 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R84)). Possible problems with the neural release of norepinephrine in ADD are relevant to motivational issues discussed later.It's definitely an interesting, albeit long, read. I spent a good while last night getting through it all.
Also, a few good threads on the inattentive type:
Inattentives, I need your advice on stimulants (http://www.addforums.com/forums/showthread.php?t=48710)
Sluggish Cognitive Tempo (SCT) (http://www.addforums.com/forums/showthread.php?t=25541)
ADD and ADHD very different (http://www.addforums.com/forums/showthread.php?t=41941)
(link (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811))
Attention-deficit disorder (attention-deficit/ hyperactivity disorder without hyperactivity): A neurobiologically and behaviorally distinct disorder from attention-deficit/hyperactivity disorder (with hyperactivity)
ADELE DIAMOND
University of British Columbia, Vancouver, and BC Children's Hospital, Vancouver
Abstract
Most studies of attention-deficit/hyperactivity disorder (ADHD) have focused on the combined type and emphasized a core problem in response inhibition. It is proposed here that the core problem in the truly inattentive type of ADHD (not simply the subthreshold combined type) is in working memory. It is further proposed that laboratory measures, such as complex-span and dual-task dichotic listening tasks, can detect this. Children with the truly inattentive type of ADHD, rather than being distractible, may instead be easily bored, their problem being more in motivation (underarousal) than in inhibitory control. Much converging evidence points to a primary disturbance in the striatum (a frontal–striatal loop) in the combined type of ADHD. It is proposed here that the primary disturbance in truly inattentive-type ADHD (ADD) is in the cortex (a frontal–parietal loop). Finally, it is posited that these are not two different types of ADHD, but two different disorders with different cognitive and behavioral profiles, different patterns of comorbidities, different responses to medication, and different underlying neurobiologies.On treatment:Most children with ADHD (perhaps as high as 90%; Barkley, 2001 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R13); Barkley et al., 1991 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R15); Milich et al., 2001 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R113); Weiss et al., 2003 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R167)) respond positively to methylphenidate (Ritalin) and over two-thirds of such children respond positively to methylphenidate in moderate to high doses (Barkley, 2001 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R13); Barkley et al., 1991 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R15); Milich et al., 2001 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R113); Weiss et al., 2003 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R167)). In contrast, a significant percentage of children with ADD are not helped by methylphenidate and those who are helped often do best at low doses (Barkley, 2001 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R13); Barkley et al., 1991 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R15); Milich et al., 2001 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R113); Weiss et al., 2003 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R167)). Many individuals with ADD are helped by amphetamines, such as Adderall. There is considerable overlap in the mechanisms of action of methylphenidate and amphetamines, but there is a significant difference. Although both methylphenidate and amphetamines inhibit reuptake of dopamine and norepinephrine, only amphetamines also promote release of those neurotransmitters. Recent research also suggests that low doses of methylphenidate (the dosages likely to be efficacious in treating ADD) preferentially release norepinephrine in the rat brain (Ishimatsu, Kidani, Tsuda, & Akasu, 2002 (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1474811#R84)). Possible problems with the neural release of norepinephrine in ADD are relevant to motivational issues discussed later.It's definitely an interesting, albeit long, read. I spent a good while last night getting through it all.
Also, a few good threads on the inattentive type:
Inattentives, I need your advice on stimulants (http://www.addforums.com/forums/showthread.php?t=48710)
Sluggish Cognitive Tempo (SCT) (http://www.addforums.com/forums/showthread.php?t=25541)
ADD and ADHD very different (http://www.addforums.com/forums/showthread.php?t=41941)