View Full Version : Methamphetamine and histamine.


theta
06-06-08, 04:55 PM
I get 60 hits for methamphetamine and histamine on pubmed. So I thought I post a few abstracts.

1: Nihon Shinkei Seishin Yakurigaku Zasshi. 2002 Jun;22(3):73-8.
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Modulation of the discriminative stimulus effects of cocaine and methamphetamine by the histaminergic system.
Mori T, Narita M, Onodera K, Suzuki T.

Department of Toxicology, School of Pharmacy, Hoshi University, Shinagawa-ku, Tokyo, 142-8501 Japan.

The role of the histaminergic system in the discriminative stimulus effects of cocaine and methamphetamine was examined in rats trained to discriminate between saline and cocaine (10 mg/kg) or methamphetamine (1.0 mg/kg). L-histidine (400 mg/kg), a precursor of histamine, significantly enhanced the discriminative stimulus effects of cocaine and methamphetamine. Previous studies have revealed the existence of several histamine receptor types, H1-, H2-, and H3-receptors. These enhancing effects of L-histidine on the discriminative stimulus effects of cocaine and methamphetamine were attenuated by 5.0 mg/kg of pyrilamine (an H1-receptor antagonist), but not by 1.0 mg/kg of zolantidine (an H2-receptor antagonist), suggesting that these enhancing effects of L-histidine were mediated through the activation of H1-receptors. Thioperamide (7.5 mg/kg), an H3-receptor antagonist, also significantly enhanced the discriminative stimulus effects of cocaine and methamphetamine. However, neither pyrilamine nor zolantidine affected the enhancing effects of thioperamide, unlike the results attained with L-histidine. Therefore our findings suggest that the histaminergic system may modify the discriminative stimulus effects of cocaine and methamphetamine mediated through H1- and H3-receptors.

PMID: 12166087 [PubMed - indexed for MEDLINE]

L-histidine (400 mg/kg) in rats. HED is about 65 mg /kg.

1: Psychopharmacology (Berl). 1997 Apr;130(4):362-7.
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Effects of histamine agents on methamphetamine-induced stereotyped behavior and behavioral sensitization in rats.
Ito C, Onodera K, Watanabe T, Sato M.

Department of Psychiatry, Tohoku University School of Medicine, Aobo-ku, Sendai, Japan.

In this study, effects of histamine (HA) agents on methamphetamine (METH)-induced stereotyped behavior and behavioral sensitization were examined in rats. Pretreatment with a precursor of HA, L-histidine (750mg/kg), significantly inhibited the METH (3 mg/kg)-induced stereotyped behavior, whereas pretreatment with an inhibitor of HA synthesis, alpha-fluoromethylhistidine (FMH) (100 mg/kg), an H1 antagonist pyrilamine (5 mg/kg) or an H2 antagonist zolantidine (5 mg/kg) enhanced it. The inhibitory effect of L-histidine on METH-induced stereotyped behavior was significantly blocked by coadministration of pyrilamine and zolantidine, indicating that the effect is mediated through H1 and H2 receptors. Moreover, chronic treatment with METH (3 mg/kg) significantly enhanced stereotyped behavior at the rechallenge with METH (1 mg/kg). Chronic treatment with L-histidine (750 mg/kg) plus METH inhibited the METH-induced argumentation of stereotyped behavior, while that with FMH (100 mg/kg), pyrilamine (5 mg/kg) or zolantidine (5 mg/kg) potentiated it. These findings suggest that the HA neuron system has an inhibitory role in METH-induced stereotyped behavior and behavioral sensitization.

PMID: 9160852 [PubMed - indexed for MEDLINE]

L-histidine (750mg/kg) in rats. HED is about 121 mg/kg.

1: Indian J Physiol Pharmacol. 1979 Oct-Dec;23(4):291-6.
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Effect of L-histidine pretreatment on methamphetamine induced sterotyped behaviour in rats.
Muley MP, Balsara JJ, Chandorkar AG.

Pretreatment with L-histidine precursor of histamine was found to delay the onset, shorten the duration and decrease the intensity of stereotyped behaviour induced by methamphetamine while chlorcylizine a H1 receptor blocker was found not only to potentiate methamphetamine induced sterotyped behaviour but also to block the inhibitory effect of L-histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.

PMID: 43281 [PubMed - indexed for MEDLINE]