View Full Version : Generic Manufacturers


bkaguy
06-12-08, 06:46 PM
Do we have any studies on the integrity of Generic Adderall (or other) manufacturers? I am very confident based upon personal experience that there are one or more of the following problems with these generic medications. They are made with lesser quality inputs, not being manufactured properly, or their shelf life is much shorter. At any rate I have recently noticed a significant decline in the quality, almost like I am taking a dirty pill, something or other. And it is not based upon the same dose nor the same pharmacy, however I know that 2 of the 3 instances about which I am referring were manufactured by the same company. I want to say Acme or similar was the manufacturer and I spoke with the pharmacist at walgreens and he told me that they changed manufacturers recently (about 2-3 months ago) and that he had, had some complaints, but I gave him a thorough description as to what I noticed.

At any rate there needs to be, if not done already, some serious inquiry as to the integrity of such manufacturers as discussed above-and any material is welcomed.

Maurice
06-12-08, 07:25 PM
Do we have any studies on the integrity of Generic Adderall (or other) manufacturers? I am very confident based upon personal experience that there are one or more of the following problems with these generic medications. They are made with lesser quality inputs, not being manufactured properly, or their shelf life is much shorter. At any rate I have recently noticed a significant decline in the quality, almost like I am taking a dirty pill, something or other. And it is not based upon the same dose nor the same pharmacy, however I know that 2 of the 3 instances about which I am referring were manufactured by the same company. I want to say Acme or similar was the manufacturer and I spoke with the pharmacist at walgreens and he told me that they changed manufacturers recently (about 2-3 months ago) and that he had, had some complaints, but I gave him a thorough description as to what I noticed.
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At any rate there needs to be, if not done already, some serious inquiry as to the integrity of such manufacturers as discussed above-and any material is welcomed.
bkaguy, all generic drugs have the same active ingredients in them as the name-brand. The difference in generic vs. name-brand comes into play by a couple of different ways. One difference can be what the generic manufacturer uses for a bonding agent, might be different than the name-brand. Another way the generics can be different is how much pressure is used compounding a pill together. If they use less pressure than the name brand, they can break up and get in your system faster. Or if they use more pressure than the name-brand, they can take a lot more time to break up and get into your system. And they also can use different fillers. Those are all of the different things I know about generic pills and name -brand prescription pills.

garykelly
06-12-08, 09:00 PM
My psychiatrist told me that Barr makes a better generic than the other manufacturer (sorry, can't remember their name). But that's all I can tell you. I'd say the name brand is of better quality, but if you have to go generic, he says go with Barr.

hoon
06-13-08, 12:29 AM
Barr purchased the rights to Adderall IR in 2006 (from what I have read). I recently started taking Adderall and my first couple of prescriptions were the Barr (peach colored oval shaped 20mg tabs). They worked well, no real bad side effects (some tremor, clench jaw at first - they all subsided).

I got a refill a couple of weeks ago and went to my same pharmacy (SavOn) and I got these round bright pink pills (I didn't notice until I got home). They are made by Ranbaxy or some company and I don't like them at all. I have to break my first dose into 2 smaller doses because when it 'kicks in' - it's almost too much at a full dose. Like if I am driving I will get light headed and a little confused for a few minutes- like a small panic attack.

So - is the Barr the same makeup as the Shire used to be? Or are there two Barr types - generic Barr and brand name Barr?

Does anyone know a pharmacy in the Orange County area that carries the brand name IR? Price is not an issue..my insurance will cover most of the cost (for example last refill cost me $3.04 for 20mgx60). I am willing to pay the difference.

I spoke to SavOn and they told me sometimes they get the Ranbaxy(sp?) and will fill with that - but if I call ahead they will get the Barr (mine did not have the 'AD' on the tab last time I got Barr), or send me to a pharmacy that does.

So - is there a brand name original formula and production process available for IR, which is the same as the Shire was? XR is not really the way I want to go with dosing.

Maurice
06-13-08, 04:16 AM
Hey hoon, Barr may have bought the right to produce their version of Adderall IR, but Shire is still making the name-brand. That generic company that you didn't care for is Danbury. I doubt that your insurance will pay for name brand, when there is a cheaper generic avalible. I don't know how much the 20mg. Adderall IRs made by Shire are but I take the 20mg. Adderall XL by Shire and it is very expensive.

asdfasdf
06-13-08, 05:40 PM
No, he was right- it was Ranbaxy.
I work at Walgreens, and we switch between Ranbaxy and Barr.
Whatever the company gets cheaper is what arrives through our warehouse.
You can request a specific generic brand though, and we can special order it through cardinal.

cwonderig
06-13-08, 06:15 PM
Brand name IR 10mg 90 tabs would cost me over $250. I stuck with Barr generic and havent had any issues.

hoon
06-13-08, 08:10 PM
Shire no longer makes the IR...they sold the rights to Barr

http://goliath.ecnext.com/coms2/gi_0199-5803932/Barr-Cleared-to-Launch-ADDERALL.html

Shire still has exclusive rights to the XR - (there are TWO adderalls - instant release[IR] and extended release[XR])..just in case someone was confused.

Now - does Barr make a generic AND brand name adderall? Or do they just have the orange/peach oval (at 20mg) tablets. Is there a brand name IR available anywhere?



Thanks for the info on Ranbaxy/Barr at Wallgreens!

Maurice
06-14-08, 02:00 AM
I stand corrected. Talking back and forth reminded me of something my doctor said when she was writing my first Rx for AdderallXR. My doctor had just finished arguing with my insurance company over giving me name brand Prozac, the generic had stopped working for me. She said I am writing you a Rx for extended release because there is no generic, they will have to give you name brand. I read that article from Goliath too. In the article it said Shire sold Barr the rights to make Adderall "Pills." Which makes sense because the Adderall XL are capsules. The 20mg. XLs are orange on both sides and say ADDERALL XL on on side and 20mg onthe other. The 25mg. Adderall capsules are orange and white and say ADDERALL XL on the white half and 25mg on the orange half. I am happy with two of the 25mg. ones a day. I don't know how long Shire says the extended release is supposed to last but I get about 6 or 7 hours out of them.

lilhotADDmama
06-17-08, 03:14 AM
You can get Barr from CVS drugstores and Target. These are the only two places I have found here in CA- I called Longs, Walgreens, and a few others and had no luck. From what I was told by CVS and Target- they all sell Barr for their generic. I tried Corepharm and thought I was given the wrong meds.

amyaub
06-17-08, 12:53 PM
I got Corepharma from the local drugstore I use and they are terrible. Thought I was given some placebo or something. I called around town and found out Rite-Aid carries Barr so that's where I'll be going to get my refill this weekend.

hoon
06-19-08, 03:36 PM
Well - I spoke with my Doc, he agreed that sometimes there is a reaction when people's generics get switched up. So he wrote me out 3 months (separate scripts) and put "Barr generic prefferd if no Brand name available". He said the Brand name IR can still be ordered - but it's expensive and most insurance will not cover if there is generic available by the same manufacturer.

So - I went to Target and did not use my insurance card as it had only been a couple of weeks since I was given the ranbaxy(corpharma) and there is no way my insurance would approve a refill this soon - I just didn't even give Target my card and paid cash for the Barr generic 20MGx60 IR. , it was like $60..with insurance it would have been $3.08 - but they won't cover until next month.

Sticking with Barr - I notice the difference right away. It's like two different medications to me. (I even did blind test - had my GF give me my dose and put inside a small piece of bread so I would not taste it not feel the shape of the pill in my mout) - We did 6 different tests - I never knew if she was giving me Ranbaxy or Barr but I guessed right 100% after waiting an hour for it to take affect.

So - good for now

btw - in CVS told me they switch between Barr and RBXY - and I would need to give notice by showing up in person with the script to get the Barr - would take a few days if they don't have it in stock (have to order)...

deadjed
06-21-08, 07:50 PM
I have been taking 30 mg of Barr for 3 mos. now , just switched to 30 mg of Corepharma and don't notice any difference in efficacy . The Corepharma tablets are scored twice unlike Barr 30mg -+-.

appleblaster
06-23-08, 05:14 PM
I like the Ranbaxy pills. Mine are 20mg round bright pink scored on one side with COR 135 on the other. They are more potent so I can't take as much at one time.

I do like them better than the football-shaped orange ones (Barr?). Those make me terribly sick!! After a few days of taking them I feel like i'm losing my mind! Weird.

bkaguy
06-26-08, 09:40 PM
I just found an interesting tid-bit. I have adderall from Eon labs, which is now Sandoz. I found this article on them. Its on other medication made by them, but certainly looks applicable.

http://www.healthnews.com/family-health/problem-found-generic-blood-pressure-medication-691.html

addperson
06-27-08, 01:04 AM
generic manufacturers have to have their drugs within about 20% potency of the original brand name drug.

bkaguy
06-28-08, 04:38 AM
http://www.glgroup.com/glgi-presentations/Louis%20Sanfilippo/Louis%20Sanfilippo,%20MD%20(Chicago&NYC)%20January%2008.ppt

Steve_Holt
06-30-08, 04:59 PM
Mine are 20mg round bright pink scored on one side with COR 135 on the other. They are more potent so I can't take as much at one time.

I do like them better than the football-shaped orange ones (Barr?). Those make me terribly sick!! After a few days of taking them I feel like i'm losing my mind! Weird.


I think that's my problem! My generic pills that worked for me were made by Ranboxy and had the "COR" name on the pill. The new pills that have been giving me wierd side effect (both generic and regular) adderall have been made by Barr. so wierd, but this has to be it!

ozchris
06-30-08, 11:03 PM
generic manufacturers have to have their drugs within about 20% potency of the original brand name drug.


Are you sure about that? I thought they'd have to be much more accurate...like 2% at most . 20% can be the difference between a working dose and an overdose in some drugs.

We need to find out what's up with these reported differences. Anyone have access to a lab for testing? Or maybe contact the FDA about it?

ozchris
06-30-08, 11:09 PM
Well - I spoke with my Doc, he agreed that sometimes there is a reaction when people's generics get switched up. So he wrote me out 3 months (separate scripts) and put "Barr generic prefferd if no Brand name available". He said the Brand name IR can still be ordered - but it's expensive and most insurance will not cover if there is generic available by the same manufacturer.

So - I went to Target and did not use my insurance card as it had only been a couple of weeks since I was given the ranbaxy(corpharma) and there is no way my insurance would approve a refill this soon - I just didn't even give Target my card and paid cash for the Barr generic 20MGx60 IR. , it was like $60..with insurance it would have been $3.08 - but they won't cover until next month.

Sticking with Barr - I notice the difference right away. It's like two different medications to me. (I even did blind test - had my GF give me my dose and put inside a small piece of bread so I would not taste it not feel the shape of the pill in my mout) - We did 6 different tests - I never knew if she was giving me Ranbaxy or Barr but I guessed right 100% after waiting an hour for it to take affect.

So - good for now

btw - in CVS told me they switch between Barr and RBXY - and I would need to give notice by showing up in person with the script to get the Barr - would take a few days if they don't have it in stock (have to order)...

nice work :) the blind test you did is the best evidence I've read of actual differences between the brands.

addperson
07-01-08, 12:31 PM
Are you sure about that? I thought they'd have to be much more accurate...like 2% at most . 20% can be the difference between a working dose and an overdose in some drugs.

We need to find out what's up with these reported differences. Anyone have access to a lab for testing? Or maybe contact the FDA about it?

thats what my dad said and hes a psychiatrist. im pretty sure i can trust an M.D. on this one.

bkaguy
07-03-08, 02:20 AM
thats what my dad said and hes a psychiatrist. im pretty sure i can trust an M.D. on this one.

Honestly do me a favor: ask him to read my posts and to comment on some of the concerns, comments, assumptions, etc. It would be nice to incorporate a professionals opinion here. Plus I think he would find great benefit interacting with people who can articulate what we really experience. I know for a fact that many of the doctors who prescribe medicine such as adderall have no (physical or physiological) idea how it works for obvious reasons, but also because many of their patients are children.

sorry if there are duplicates:

http://www.addforums.com/forums/showthread.php?p=606797#post606797

http://www.addforums.com/forums/showthread.php?p=607155#post607155

http://www.addforums.com/forums/showthread.php?p=514307#post514307

http://www.addforums.com/forums/showthread.php?p=511611

http://www.addforums.com/forums/showthread.php?p=514307#post514307

http://www.addforums.com/forums/showthread.php?t=54048

atonalapple
07-10-08, 05:33 PM
Every pharmacy that I have contacted in my area offers Barr by default it seems (Longs and Walgreens). Trying to get pharmacies to special order generic brands for you is tough, but doable. Smaller pharmacies can request certain brand name generics.

I was looking around for generic Mallinckrodt 20mg amphetamine salts, and no pharmacy seemed like they could find it. I finally called Mallinckrodt today and it turns out they are no longer producing any instant release amphetamine salts. I asked if their production had been taken up by another company or if they'd sold their tablets to anyone else, but she said that their company didn't generally do that, they just stopped production.

I also researched Abrika, another generic producer, and I found an article saying they had been obtained/taken over by Actavis. I looked at Actavis's website, and on their list of produced pharmaceuticals, amphetamine salts are not there.

I'm going to get a small pharmacy to request the Sandon/Eon labs stuff for me, which is what I've gotten from bigger pharmacies before, at least before Barr took over the world it seems. :rolleyes:

bkaguy
07-22-08, 06:02 PM
Yet again more material which may suggest that our well-being is being compromised.


http://us.ft.com/ftgateway/superpage.ft?news_id=fto072020081807230905

Ranbaxy probe highlights medical issues
By in London
Sunday Jul 20 2008 17:00

When US regulators raised concerns during their visit to a factory operated by Ranbaxy, the Indian generic drugs group, no one involved imagined that their inquiry would last so long, become so public or raise the stakes so high.

Since an inspection by the Food & Drug Administration (http://us.ft.com/ftgateway/superpage.ft?criteria_name=text&criteria_value=%22food%20&%20drug%20administration%22) (FDA) at the Paonta Sahib (http://us.ft.com/ftgateway/superpage.ft?criteria_name=text&criteria_value=%22paonta%20sahib%22) plant in February 2006 (http://us.ft.com/ftgateway/superpage.ft?criteria_name=text&criteria_value=%22february%202006%22), there has been a drawn-out battle for extra information, triggering raids and subpoenas last year from the Department of Justice (http://us.ft.com/ftgateway/superpage.ft?criteria_name=text&criteria_value=%22department%20of%20justice%22).

But it was only in the past few days, after the US attorney's office for Maryland filed a court motion to force disclosure of more internal documents from Ranbaxy, that unusually detailed claims have emerged.

bkaguy
07-22-08, 06:06 PM
[/quote]
I'm going to get a small pharmacy to request the Sandon/Eon labs stuff for me, which is what I've gotten from bigger pharmacies before, at least before Barr took over the world it seems. :rolleyes:[/quote]


From my experience Eon's medicine is no good. not in the least.