theta
06-18-08, 10:31 AM
Response monitoring, repetitive behaviour and anterior cingulate abnormalities in ASD. (http://www.ncbi.nlm.nih.gov/pubmed/18550622)
These findings suggest that in ASD, structural and functional abnormalities of the anterior cingulate cortex compromise response monitoring and thereby contribute to behaviour that is rigid and repetitive rather than flexible and responsive to contingencies.
Looking up more articals on "anterior cingulate cortex".
Decreased brain volume in adults with childhood lead exposure. (http://www.ncbi.nlm.nih.gov/pubmed/18507499)
The most affected regions included frontal gray matter, specifically the anterior cingulate cortex (ACC).
These neuroanatomical findings were more pronounced for males, suggesting that lead-related atrophic changes have a disparate impact across sexes.
Right anterior cingulate: A neuroanatomical correlate of aggression and defiance in boys. (http://www.ncbi.nlm.nih.gov/pubmed/18513137)
Follow-up analyses showed that aggressive and defiant behavior is associated with decreased right ACC volume in boys and a nonsignificant reduction in left ACC volume in girls.
Role of anterior cingulate cortex during semantic coding in verbal working memory. (http://www.ncbi.nlm.nih.gov/pubmed/18375064)
The ACC was strongly activated under the Concrete condition in contrast to the Abstract condition. Based on this result, we argue that the ACC is responsible for the semantic coding process in verbal working memory.
Potential role in language problems with ASD?
Action Monitoring in Boys With Attention-Deficit/Hyperactivity Disorder, Their Nonaffected Siblings, and Normal Control Subjects: Evidence for an Endophenotype. (http://www.ncbi.nlm.nih.gov/pubmed/18339358)
Converging evidence from behavioral and event-related potential findings suggests that action monitoring and initial error processing, both related to dopaminergically modulated functions of anterior cingulate cortex, might be an endophenotype related to ADHD.
Eur Arch Psychiatry Clin Neurosci. 2008 Mar 11. [Epub ahead of print]
Links
Increased NAA and reduced choline levels in the anterior cingulum following chronic methylphenidate: a spectroscopic test-retest study in adult ADHD.
Kronenberg G, Ende G, Alm B, Deuschle M, Heuser I, Colla M.
Center for ADHD Research, Department of Psychiatry, Charité – University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050, Berlin, Germany.
The anterior cingulate cortex (ACC) is crucially involved in executive control of attention. Here, seven medication-naïve adult patients suffering from attention deficit/hyperactivity disorder (ADHD) were studied with 2D (1)H-magnetic resonance spectroscopic imaging (MRSI) of the ACC [Brodmann areas 24b'-c' and 32'] twice, once before initiation of stimulant treatment and once after 5-6 weeks of methylphenidate. Upon retest, all patients demonstrated marked clinical improvement. Analysis of regional brain spectra revealed a significantly decreased signal of choline containing compounds as well as increased N-acetyl-aspartate (NAA) levels following treatment with methylphenidate whereas total creatine remained unchanged. Our results add to a growing body of evidence implicating the ACC in the pathophysiology of ADHD and suggest that subtle structural changes might be associated with aspects of clinical improvement under stimulant treatment.
PMID: 18330668 [PubMed - as supplied by publisher]
These findings suggest that in ASD, structural and functional abnormalities of the anterior cingulate cortex compromise response monitoring and thereby contribute to behaviour that is rigid and repetitive rather than flexible and responsive to contingencies.
Looking up more articals on "anterior cingulate cortex".
Decreased brain volume in adults with childhood lead exposure. (http://www.ncbi.nlm.nih.gov/pubmed/18507499)
The most affected regions included frontal gray matter, specifically the anterior cingulate cortex (ACC).
These neuroanatomical findings were more pronounced for males, suggesting that lead-related atrophic changes have a disparate impact across sexes.
Right anterior cingulate: A neuroanatomical correlate of aggression and defiance in boys. (http://www.ncbi.nlm.nih.gov/pubmed/18513137)
Follow-up analyses showed that aggressive and defiant behavior is associated with decreased right ACC volume in boys and a nonsignificant reduction in left ACC volume in girls.
Role of anterior cingulate cortex during semantic coding in verbal working memory. (http://www.ncbi.nlm.nih.gov/pubmed/18375064)
The ACC was strongly activated under the Concrete condition in contrast to the Abstract condition. Based on this result, we argue that the ACC is responsible for the semantic coding process in verbal working memory.
Potential role in language problems with ASD?
Action Monitoring in Boys With Attention-Deficit/Hyperactivity Disorder, Their Nonaffected Siblings, and Normal Control Subjects: Evidence for an Endophenotype. (http://www.ncbi.nlm.nih.gov/pubmed/18339358)
Converging evidence from behavioral and event-related potential findings suggests that action monitoring and initial error processing, both related to dopaminergically modulated functions of anterior cingulate cortex, might be an endophenotype related to ADHD.
Eur Arch Psychiatry Clin Neurosci. 2008 Mar 11. [Epub ahead of print]
Links
Increased NAA and reduced choline levels in the anterior cingulum following chronic methylphenidate: a spectroscopic test-retest study in adult ADHD.
Kronenberg G, Ende G, Alm B, Deuschle M, Heuser I, Colla M.
Center for ADHD Research, Department of Psychiatry, Charité – University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050, Berlin, Germany.
The anterior cingulate cortex (ACC) is crucially involved in executive control of attention. Here, seven medication-naïve adult patients suffering from attention deficit/hyperactivity disorder (ADHD) were studied with 2D (1)H-magnetic resonance spectroscopic imaging (MRSI) of the ACC [Brodmann areas 24b'-c' and 32'] twice, once before initiation of stimulant treatment and once after 5-6 weeks of methylphenidate. Upon retest, all patients demonstrated marked clinical improvement. Analysis of regional brain spectra revealed a significantly decreased signal of choline containing compounds as well as increased N-acetyl-aspartate (NAA) levels following treatment with methylphenidate whereas total creatine remained unchanged. Our results add to a growing body of evidence implicating the ACC in the pathophysiology of ADHD and suggest that subtle structural changes might be associated with aspects of clinical improvement under stimulant treatment.
PMID: 18330668 [PubMed - as supplied by publisher]