View Full Version : Study shows lack of Omega-3 significantly depletes dopamine levels


Fuse
06-25-08, 09:16 AM
http://cat.inist.fr/?aModele=afficheN&cpsidt=1362478

We studied the effects of a chronic deficiency in n-3 polyunsaturated fatty acids (n-3 PUFA) on the vesicle dopaminergic compartment in the frontal cortex of rats. Electronic micrographic analysis showed that the synaptic density and the clear vesicle density were similar in deficient and control rats. However, dopaminergic immunolabeling revealed a significantly decreased number of gold-labeled vesicles in the dopaminergic presynaptic terminals of the deficient rats. These findings demonstrate that dopamine cortical vesicles are specifically decreased in n-3 PUFA deficiency. The mechanism leading to this modification could involve several abnormalities (vesicle turn-over, membrane fluidity, vesicular monoamine transporter). This reduction in the dopaminergic vesicle pool constitutes the first structural support for the previously described modifications of dopamine metabolism in the frontal cortex. Such changes in dopamine neurotransmission could be involved in behavioral abnormalities occurring in n-3 PUFA deficient rats.Thus it remains highly, highly unlikely that lack of fatty acids causes ADHD in the vast majority of cases. Nonetheless, it is highly probably that the vast majority of cases may be exacerbating their ADHD by not having an adequate intake of fatty acids, specifically Omega-3.

This includes me. I should probably go buy an Omega-3 supplement.

theta
06-25-08, 09:23 AM
Its important to note that some omega-3 fatty acid supplementation studies showed peoples problems got worst to. I think the theory is too much DHA is counterproductive. But then that leaves you with a very small number of studies that suggest perhaps a high ratio of EPA is good. Regardless you don't have overwhelming proof that omega-3 supplementation in any form will treat any disorders.

I'm taking 6 grams daily though. :)

Fuse
06-25-08, 09:31 AM
But what you do have is strong evidence that insufficient intake of n-3 fatty acids, as is prevalent in Western society, is likely to exacerbate various conditions.

We're not actually talking about cures or treatments at all; rather how to not make things worse.

theta
06-25-08, 09:56 AM
But what you do have is strong evidence that insufficient intake of n-3 fatty acids, as is prevalent in Western society, is likely to exacerbate various conditions.

We're not actually talking about cures or treatments at all; rather how to not make things worse.

No question most people are deficit in omega-3. We can assume for most of human evolution we ate a diet much richer in omega-3s. And I do not just mean fish. Free range animals that eat bugs and grass have a higher omega-3 content than grain feed animals.

Sandy4957
06-25-08, 12:10 PM
No question most people are deficit in omega-3. We can assume for most of human evolution we ate a diet much richer in omega-3s. And I do not just mean fish. Free range animals that eat bugs and grass have a higher omega-3 content than grain feed animals.

This is why I buy all grass-fed, pasture raised meats, eggs, and dairy products. The latter are more expensive than caged eggs and grain-fed dairy, etc., but the meats that I get aren't really much more expensive than regular meats because I buy farmer direct in bulk. I buy from a farm called Grass Run Farm.

I also get fish (though this won't do you any good, Fuse) from a fishing couple in Alaska. It's all wild, sustainably caught. I get Tuna, Copper River King and Copper River Coho Salmon, Halibut, and Black Cod. I pay $20 per pound for it, which is less than it would be at the high end fish market (but more than farmed fish would be, I'll grant). We could get a lot more Omega-3s from regular foods if we just turned back the clocks on farming methods. It'd be better for the animals, use fewer antibiotics (because there's less crowding and stress) and just be general all-around better animal husbandry, too.

Ok, I'm off the soap box.

Fuse, you are so smart, it's SCARY, dude. I love reading your threads. The same is true of you too, Theta.

Sandy