View Full Version : Inflammation is a big piece of the puzzle. Here's how to prove it


Technojunkie
08-18-08, 12:48 AM
I was given prednisolone acetate eyedrops following LASIK surgery, one drop four times per day. Prednisone breaks down into this, it's a very potent anti-inflammatory. The next day my foggy head was dramatically better. A couple days of prednisolone led to nearly two weeks of clarity. No one could tell me why, but now that my ADHD Inattentive has been diagnosed and Adderall has nudged my brain into gear I think it's obvious what happened. Dropping a potent anti-inflammatory that needs little to no further metabolism into an efficient pathway to the brain makes for a really neat test, though definitely not a cure since it's much too dangerous to use long-term.

Some researchers might want to use this as an experiment with some of their ADHD and autistic patients? It's possible this is a fluke, but...

Now, what to do about it? This is where I have to speculate. I'm almost certainly EFA deficient so I'm working on that (excessive thirst, dry skin, etc). I've been using a flax/fish/borage oil mix (mostly flax, 1 tablespoon per 100 pounds). Other messages on this site suggest that EPA is by far the most important EFA for ADHD. The Wikipedia Essential fatty acid interactions (http://en.wikipedia.org/wiki/Essential_fatty_acid_interactions) page offers some clues as to why this would be. A more modest dose of high-EPA fish oil might be more effective? 2 grams/day or so?

Sodium benzoate is suspected of interfering with arachidonic acid metabolism (http://allergyadvisor.com/Educational/Aug05.htm), which would be bad? It would help explain the results of the Lancet study showing that artificials and sodium benzoate aggravate ADHD (http://www.thelancet.com/journals/lancet/article/PIIS0140673607613063/abstract). Soft drinks are usually preserved with sodium benzoate, so if you're a soft drink addict like I used to be you're getting a pretty serious dose of that preservative plus assorted other bad things. My symptoms went from bad to much worse around the time I picked up that habit.

I've cleaned up my diet substantially and gotten in halfway decent shape, which reduced my symptoms noticeably. I'm sure I'd have needed a higher dose of Adderall otherwise.

Anyhow, is at least my first paragraph of any help?

haudenosaunee
09-09-08, 08:13 PM
Awesome post..
Very interesting and informative.
Thanks for sharing.

Batman55
09-10-08, 03:19 AM
What kind of ratio of EPA/DHA are we talking about?

I took a Nature Made Fish Oil supplement for a month which had nearly an equal ratio, and all it did was give me more energy, an irritable mood, and even a few mood swings. I quit the stuff after one month, and those symptoms have mostly disappeared. I can be quite irritable in my baseline state, however, so it's not like it came out of nowhere.

BondedCasinos
09-10-08, 05:27 AM
The next day my foggy head was dramatically better. A couple days of prednisolone led to nearly two weeks of clarity.

are you saying putting drops in your eyes made your adhd better?

Dropping a potent anti-inflammatory that needs little to no further metabolism into an efficient pathway to the brain makes for a really neat test

is adhd caused by something in your brain that becomes inflamed? Not sure I understood that part either.

Technojunkie
09-12-08, 03:09 PM
Batman55: I'm not sure what the correct ratio is. Amen Clinics (http://amenclinics.com/ac/waystohelp.php?refWays=adhd) seems to think that 4:1 is about right for Inattentive. I suspect that it varies from person to person. I haven't tried this yet.

BondedCasinos: yes. If the NIDS hypothesis (http://www.nids.net/hypothesis.htm) is correct and ADHD (and autism) is immune system driven, at least some of the time, sending an anti-inflammatory/immune system depressant into the brain might result in the effect I experienced. Barkley says that a small percentage of ADHD cases are caused by Group A Strep antibodies mistakenly attacking the basal ganglia in the brain, for example.

I've been hoping that someone smarter than me could explain this further and correct the parts I've inevitably misinterpreted. No such luck so far.

TygerSan
09-13-08, 04:27 PM
was given prednisolone acetate eyedrops following LASIK surgery, one drop four times per day. Prednisone breaks down into this, it's a very potent anti-inflammatory. The next day my foggy head was dramatically better. A couple days of prednisolone led to nearly two weeks of clarity. No one could tell me why, but now that my ADHD Inattentive has been diagnosed and Adderall has nudged my brain into gear I think it's obvious what happened. Dropping a potent anti-inflammatory that needs little to no further metabolism into an efficient pathway to the brain makes for a really neat test, though definitely not a cure since it's much too dangerous to use long-term.

I'm wondering if you've ever had an EEG done? Just thinking aloud here, but there are certain forms of epilepsy (Landau Kleffner (sp?) and CSES (chronic status epilepticus of slow wave sleep)) which respond well to steroid treatment. Not only that, but they are also syndromes whcih are associated with learning issues (i.e. a sort of regressive autism syndrome for LKS). . . steroids I believe can normalize the EEG patterns of these kids . . . makes you wonder whether they could do that for other milder abnormal EEG patterns as well.

Wisefolly
09-15-08, 11:51 AM
I went on prednisone once for a week after a dog bit me. (I'm highly allergic.)I'e probably ben on it at other times as well because of my asthma, etc. Anyhow, the prednisone aparently makes me very angry. My mom tells a story about how we were in the car, and I just threw my shoe at the windshield for no reason. When she asked me why I did that, I said I didn't know. That leads me to believe that this is probably not the best thing for everyone. (However, I take no position on whether or not inflammation is a factor with ADD/ADHD. It does seem that many of us have allergies/eczema, but I haven't actually done enough reading to know if a significantly high correlation has been found.)

The article on the NIDs hypothesis is extremely interesting. I am IgA deficient (or was when I was younger anyhow), and people with IgA deficiency have an increased suceptability to autoimmune disorders.

(Sorry for any mispellings. I cannot download the spell checker here.)

-M

Technojunkie
09-19-08, 12:18 PM
TygerSan: No, I've never had an EEG done. Sleep studies include those right? I've noticed that if I sleep less I'm often better, until the lack of sleep catches up with me. That trick hasn't worked in a while though. No other steroids other than prednisolone acetate have made a difference with me, including Patanol eye drops. Mast cell stabilizers (cromolyn sodium) work on my allergies but not the lesser corticosteroids.

Wisefolly: interesting. I have allergies, which immunotheraphy has helped with, and uesd to have very bad eczema which went away after a few years of allergy shots. I don't know what my IgA level is. My poor digestive system may be allergy related, not sure, but between cleaning up my diet and taking digestive enzyme supplements I've got that under control.

I'm going to guess that prednisone helps if your immune system is attacking a phantom problem but hurts if you have a real one?

Wisefolly
09-19-08, 01:44 PM
Wisefolly: interesting. I have allergies, which immunotheraphy has helped with, and uesd to have very bad eczema which went away after a few years of allergy shots. I don't know what my IgA level is. My poor digestive system may be allergy related, not sure, but between cleaning up my diet and taking digestive enzyme supplements I've got that under control.

I doubt you have IgA deficiency. Though it is probably the most common of the immune deficiency problems (if I remember my reading correctly), it is still very very rare. When I was three, I had pneumonia 6 times, so that's how we found out. However, some people never have any symptoms of IgA deficiency. Those people may only find out if they go for a blood transfusion and go into shock or if they develop another autoimmune issue and find the underlying IgA problem. The issue with blood transfusions doesn't happen with everyone either, and I'm sure some never develop any secondary problems and never find out.

Glad to hear the immunotherapy helped you. My allergist does not recommend immunotherapy for me. I'm not sure if it's because of the severity of my allergies, or if they are less effective in people with IgA deficiency, or what. I've been going to the same allergist since I was three though, and I'm kind of afraid to switch even though I would like to try immunotherapy and have some things retested. I don't know, I may still do it at some point, but this doctor has taken very good care of me, and I'm probably as healthy as I am in part due to his advice.

Have you actually been tested for food allergies? Your digestive problems may or may not have to do with allergies, but the only real way to find that out would be through testing or an elimination diet. If you do the elimination diet though, it may still be good to do it with an allergist so you don't wind up thinking there is an allergy when none exists. Many people are self-diagnosing allergies now, but that can affect nutrition, and often there is no allergy present. (Go to the American Academy of Allergists and Immunologists website for more details.)

If the enzyme supplements help, I would be inclined to think that it is not an allergy problem but a food intolerance, such as how lactose intolerant people are helped by the enzyme lactase (if I'm getting the name right). I don't know if autoimmunity (such as celiac) causes enzyme problems or not, and that is different from an allergy as well. (Though I think I've read that the celiac can cause leaky gut eventually leading to lactose intolerance, so it very well may.)

Have you spoken to a doctor or pharmacist about your use of enyzmes? It is great that they are helping you, but I don't know if your body will make fewer enzymes as a result of you taking them, and that could wind up hurting you more than it helps in the long run. You may also be fixing a problem on the surface while there is still an underlying problem such as celiac. Autoimmune problems like celiac differ from allergies because the body is attacking itself not the allergen. It is a different response, but the fact that they can remain hidden so long can make them pretty serious. Bottom line, if your having serious digestive problems, it would probably be a good idea to see a doctor and find out what is going on.

I'm going to guess that prednisone helps if your immune system is attacking a phantom problem but hurts if you have a real one?

I don't know. I believe it supresses the immune system. That would help for both allergies and autoimmune issues. I'm guessing that is why they warn that it can be easier to catch infections on prednisone. However, all of this is conjecture because I don't have the scientific knowlege to know if any of the guesses I just made are true.

Well, I hope at least some of this was helpful!

-M

Prusilusken
09-19-08, 07:13 PM
Hmmm...I got that too, the Prednisolon drops after Lasik, but I didn't notice any difference, I think. Maybe there's an effect for some, but it didn't work for me, or I'd be taking the rest of the drops right now...wow...I wish...! :P

Lunacie
09-19-08, 07:58 PM
I guess there's no one sure cure for everybody. I'm lucky that fish oil works pretty well for me (I can definately tell the difference between 'with' and 'without'. I seem to remember taking prednisone in the past for something (is that what I took a couple of months ago to treat the poison ivy?) and didn't notice any improvement in the ADHD.

Sleeping better seems to help, so when it's allergy season and I'm taking a Benedryl at bedtime and sleeping better, I think my brain works better even through the 'allergy fog.'


... gets up to look for empty meds box... it was Methylprednisolone (4MG), don't know if that's the same thing or not? I was so miserable from the rash on my face I might not have noticed anything else thought, but at least I wasn't allergic to the med (it happens) this time.

Technojunkie
09-20-08, 01:10 PM
I doubt you have IgA deficiency. Though it is probably the most common of the immune deficiency problems (if I remember my reading correctly), it is still very very rare. When I was three, I had pneumonia 6 times, so that's how we found out. However, some people never have any symptoms of IgA deficiency. Those people may only find out if they go for a blood transfusion and go into shock or if they develop another autoimmune issue and find the underlying IgA problem. The issue with blood transfusions doesn't happen with everyone either, and I'm sure some never develop any secondary problems and never find out.
That definitely doesn't sound like me. I did have lots of trouble with tonsillitis, which is usually caused by strep, see below.
Glad to hear the immunotherapy helped you. My allergist does not recommend immunotherapy for me. I'm not sure if it's because of the severity of my allergies, or if they are less effective in people with IgA deficiency, or what. I've been going to the same allergist since I was three though, and I'm kind of afraid to switch even though I would like to try immunotherapy and have some things retested. I don't know, I may still do it at some point, but this doctor has taken very good care of me, and I'm probably as healthy as I am in part due to his advice.
Have you looked into LDA therapy? I'm not sure it's a good idea in your case. I haven't found a local doc who's familiar with it yet.
Have you actually been tested for food allergies? Your digestive problems may or may not have to do with allergies, but the only real way to find that out would be through testing or an elimination diet. If you do the elimination diet though, it may still be good to do it with an allergist so you don't wind up thinking there is an allergy when none exists. Many people are self-diagnosing allergies now, but that can affect nutrition, and often there is no allergy present. (Go to the American Academy of Allergists and Immunologists website for more details.)
I haven't, but I do follow a GFCF diet (not strictly) that seems to have helped a little. I'm in the best shape of my life so I'm doing something right.
If the enzyme supplements help, I would be inclined to think that it is not an allergy problem but a food intolerance, such as how lactose intolerant people are helped by the enzyme lactase (if I'm getting the name right). I don't know if autoimmunity (such as celiac) causes enzyme problems or not, and that is different from an allergy as well. (Though I think I've read that the celiac can cause leaky gut eventually leading to lactose intolerance, so it very well may.)
You're probably right. With the enzymes I could eat a pint of ice cream without incident, something that was risky before. Refined sugar is bad so it's just as well that I quit dairy anyhow.
Have you spoken to a doctor or pharmacist about your use of enyzmes? It is great that they are helping you, but I don't know if your body will make fewer enzymes as a result of you taking them, and that could wind up hurting you more than it helps in the long run. You may also be fixing a problem on the surface while there is still an underlying problem such as celiac. Autoimmune problems like celiac differ from allergies because the body is attacking itself not the allergen. It is a different response, but the fact that they can remain hidden so long can make them pretty serious. Bottom line, if your having serious digestive problems, it would probably be a good idea to see a doctor and find out what is going on.
I've spoken with my family doc and allergist about enzymes. Neither knew much about them but had no arguments against them since they work. From what I've read they won't suppress your natural ability. That reminds me, I was going to research the pancreas (generates enzymes), one of these days...
I don't know. I believe it suppresses the immune system. That would help for both allergies and autoimmune issues. I'm guessing that is why they warn that it can be easier to catch infections on prednisone. However, all of this is conjecture because I don't have the scientific knowledge to know if any of the guesses I just made are true.
I need to get my Group A Strep antibody levels tested. High levels are supposed to account for a small percentage of ADHD, with the antibodies mistakenly attacking the basal ganglia in the brain. Given that I needed my tonsils and adenoids removed and that I've had strep since then... it's a possibility that needs to be ruled out. If that is my problem and prednisolone suppressed the antibodies that would explain my temporary recovery. In theory. Keeping my sinus allergies in check with Nasalcrom seems to help too (but not steroid sprays), mucous sustains all sorts of bacteria.
Well, I hope at least some of this was helpful!

-M

TygerSan
09-20-08, 06:30 PM
I need to get my Group A Strep antibody levels tested. High levels are supposed to account for a small percentage of ADHD, with the antibodies mistakenly attacking the basal ganglia in the brain. Given that I needed my tonsils and adenoids removed and that I've had strep since then... it's a possibility that needs to be ruled out. If that is my problem and prednisolone suppressed the antibodies that would explain my temporary recovery. In theory. Keeping my sinus allergies in check with Nasalcrom seems to help too (but not steroid sprays), mucous sustains all sorts of bacteria.

Hmm . . . I would definitely get those titers with that history. Do you get better on antibiotics too?

PANDAS is a syndrome where you can get very sudden onset symptoms of OCD/Tourette's/extreme hyperactivity (like overnight) following strep infection. Subtle symptoms with strep infection are a little more controversial (hell, the whole PANDAS thing is a little controversial).

But then again, any type of autoimmune problem, be it a primary cause or not, is going to interfere with your ability to cope. Same thing with gluten intolerance: if you have it and ADHD, and your body's spending oodles of energy "fighting" the toxing that is gluten, you have no reserves, and your ADHD is going to get worse because your ability to cope with life is lower than if you were at your best.

Technojunkie
09-20-08, 10:37 PM
I don't remember getting better on antibiotics, certainly nothing like prednisolone did, but I don't think antibiotics would suppress existing antibodies either. OTOH I don't remember having strep throat near the time my mind starting going but that was around two decades ago (10th grade). The one significant thing about that year was that I no longer had to take gym and I mostly stayed parked in front of my computer.

I need to dig into PANDAS more. I did see where a few Tourette's sufferers recovered temporarily with prednisone. The child-focus of PANDAS, like much of ADHD, is discouraging though.

I know what you mean about secondary problems. My bad days now are no where near as bad as my bad days 2-3 years ago, even without meds. Diet and exercise have been huge helps.

Someone mentioned that compounding pharmacists can mix up the generic version of Gastrocrom for much cheaper than the prescription name brand, which isn't cheap like over-the-counter Nasalcrom is. Since I react so well to Nasalcrom I should look into that. Searching for Gastrocrom led me to this page (http://www.ic-network.com/bev/sept03.html), which recommended Algonot (http://www.algonot.com/) instead, which led to Autism connection to rare disease (mastocytosis) offers new clues for possible treatment (http://www.algonot.com/news_details.php?ID=31) and... WOW! I'm still grokking the article but it says that autism is 5-7 more prevalent in people with systemic mastocytosis. I looked into that since I react so well to Nasalcrom (mast cell stabilizer) and not at all to steroid sprays. I didn't bother getting tested and probably wouldn't meet the definition anyhow, but having a higher than normal mast cell count would explain an awful lot including why prednisolone worked. There's enough overlap between ASDs and ADHD to make me think that this is very relevant to us. I've got some serious reading to do.

canukie
09-21-08, 02:25 AM
To find out about whether you have an intolerance to gluten go look at Enterolab's website. I did it and resolved my digestive issues, finding out I can't eat gluten...and subsequently finding out through allergy testing that I have a number of food allergies. However, I do not have ADHD but my son does--and he is next for testing. They even do gene testing...lots of interesting things to read on their website. Expensive but worth it! (Well, the test may be considered expensive, but in the long run...not really!)

Batman55
09-21-08, 05:28 AM
I have had serious digestive issues for a few years straight now. Only recently have I been looking into food intolerance/allergy issues, and the relation to Asperger (I have some version of it, I think) or ADD.

A salicylate intolerance is suspected for a few reasons, one of them being I had childhood asthma and was told not to take aspirin (factual: there is a link between asthma and aspirin-intolerance), another being an extreme reaction I had once to taking two Advils (Ibuprofen which is closely related to Aspirin, a salicylate.) I was taken to the hospital for that one, in fact.

Salicylates are in a *ton* of foods, and in probably half the foods I have in my regular diet. Are there any options for clearing up digestive distress/brain fog caused by food intolerance, other than the exclusion diet? I have heard of dietary enzymes helping some people.

What about probiotics? My digestive system is so screwed up right now it's probably something I would need whether or not I have an intolerance. My diet is high in carbs anyway, so candida is likely.

Technojunkie
09-27-08, 02:37 PM
You should check out the Feingold Association (http://www.feingold.org/). Their big thing is salicylate avoidance along with artificials. They maintain a book of "clean" foods.

Probiotics and digestive enzymes have helped me. I've been buying from Jigsaw Health (http://www.jigsawhealth.com/). Don't even bother with the stuff at Giant Nutrition Chain. Note that for the first few days you take probiotics you'll want to be home since the initial die-off is really nasty. I've cut back on supplements but digestive enzymes are a must-have for me.

Sugar, I suspect fructose more than anything else, is a big problem for me. Eating fruit is asking for trouble. A little now and then is OK at this point. Remove refined sugar from your diet, especially HFCS, and you'll take care of the #1 high-carb troublemaker.

Technojunkie
10-01-08, 12:21 AM
I think I've figured out why the Feingold program (low salicylates, no artificials) works. Acidosis is the key.

Acidosis, probably metabolic acidosis in this case, kills renal clearance of free salicylate. Arterial blood gas analysis tests that. 50-80% of salicylate is bound by protein (high protein diets, especially at breakfast, are reported to help by Feingolders). After that it's up to the kidneys. Respiration can help clear metabolic acidosis thus why exercise helps and oversleeping, sitting passively in front of the TV and computer, etc hurts.

Kidneys excrete ammonia to help produce more bicarbonate to neutralize acidosis. If that conversion process isn't completed that ammonia will feel like a hangover. Autistics often have high ammonia. Mine tested high.

Using up your bicarbonate reserves on neutralizing soft drinks is probably an exceptionally bad thing to do.

Salicylates also cause mast cell degranulation. I'm still working on that angle but I think it's important. It may be why prednisolone acetate eyedrops cleared my head for two weeks.

Acidosis will do all sorts of other bad things too.

I'm going to guess that arterial blood gas analysis is very rarely done on anyone the docs think isn't about to die. My doc did a whole mess of blood work on me and that wasn't one of the tests.

I hope this jumble of thoughts makes sense? This is speculative, testing by real docs is needed. I might not be bad enough anymore to be a viable test subject.

http://en.wikipedia.org/wiki/Aspirin
"There is a 10 to 20 fold increase in renal clearance when urine pH is increased from 5 to 8."
http://en.wikipedia.org/wiki/Standard_bicarbonate_concentration
http://en.wikipedia.org/wiki/Mixed_disorder_of_acid-base_balance
http://en.wikipedia.org/wiki/Metabolic_acidosis
http://en.wikipedia.org/wiki/Arterial_blood_gas

Batman55
10-01-08, 04:12 AM
It's clear that I have some serious problems.

I went through drug addiction, taking in tons of toxic substances of varying forms, then switched to alcohol addiction, which is apparently a killer for the digestive system and can cause vitamin deficiencies and Candida to get out of control. At least I'm sober from everything now.

Now I have all kinds of various symptoms, muscle spasms, spastic colon/IBS, constipation, pressure in my head, lessened skin sensation. I have also developed alcohol intolerance, just 1-2 drinks and I feel like I'm poisoned.

So I'm really thinking this probiotics/dietary enzymes stuff is the way to go. I just started taking a daily Magnesium supplement today (Magnesium Oxide, 63% of RDI in one pill, 1x a day) to see if it might help with the nervous system oddities/muscle spasms.

Due to problems with credit and other financial issues I can't get stuff online for the moment. I'm looking at Garden of Life probiotics (available locally) and this one in particular: http://www.gardenoflifeusa.com/ProductsforLife/SUPPLEMENTS/DigestiveHealth/PrimalDefense/tabid/638/Default.aspx

Would this work if it's not accompanied by strict dietary changes?

Technojunkie
10-01-08, 01:04 PM
I'm not familiar with Garden of Life. I generally prefer probiotics that come in dark glass bottles and are refrigerated.

I have head pressure too. No one's been able to tell me what that's about. MRI and CT scans were clean.

Magnesium oxide is the cheap stuff, not well absorbed.

Ideally I'd say you should buy Jigsaw Complete, Butyrex, probiotics, digestive enzymes, and do all that for a few months. Since that doesn't seem realistic, if there's a local Vitamin Shoppe you can get Butyrex from them and ask them to recommend a probiotic and digestive enzyme supplement. Getting your gut fixed is the priority, vitamin and mineral supplementation will be more effective and less necessary after that but a high-grade magnesium supplement sure wouldn't hurt.

Best free thing you can do: stop consuming refined sugar and fruit to starve out candida and other bad things. Absolutely no soft drinks, regular or diet, ever. You should start that a week or so before probiotics to moderate the detox reaction. Ideally I'd cut out wheat (gluten) and dairy (casein) too, especially milk, but you don't have to be too strict about that. Veggies, meat, beans, rice (especially brown rice) are good. Garlic and onion have good antimicrobial properties.

It sounds like you've really trashed your liver. It can grow back if you behave yourself.

Batman55
10-02-08, 05:51 AM
Pros: Noticeably purges ammonia
Cons: Yet another expense

"Bloodwork showed that my plasma ammonia level was higher than the normal range, as is common for people with autism spectrum disorders including Asperger's Syndrome. I read on health.groups.yahoo.com/group/EnzymesandAutism that calcium butyrate (Butyrex) helps purge ammonia. Sure enough, after 2-3 weeks the effect became very noticeable but I haven't confirmed it with bloodwork yet. Hyperammonemia will make you foggy-headed and worse.

My recipe for dealing with foggy-headedness and leaky gut so far: Butyrex, digestive enzymes, probiotics, Daily Essentials, and a low-sugar GFCF (Gluten Free Celiac Free, aka no wheat no dairy) diet (hooray Jigsaw Bars!). GFCF is critically important, gluten and celiac proteins are too big to fully digest even with enzyme supplements and if they pass into your bloodstream via leaky gut (I need to get an intestinal permeability test to confirm that) they'll wreak havoc, including amping up your allergies (mast cells go crazy). It takes 6-12 months for gluten to fully work its way out of your system. I thought that Liver Support was critical too when I wrote that product's review, now I think that and Brain Support are probably helpful but I'm short on cash as it is.

Also, NO SOFT DRINKS! I'm convinced that soda severely aggravates leaky gut. A synthetic-free diet (artificial coloring, flavoring and most preservatives are petroleum-based, see feingold.org) is critical too, doubly so for ADHD."

Found this from the jigsawhealth page on butyrex, it sounds suspiciously like you.

Are you sure you don't work for the company? :p

Batman55
10-02-08, 05:53 AM
Whether or not you work for the company (:p), is your head pressure not as bad with the Butyrex/probiotics/enzymes regimen?

That's one thing that really ruins everything for me. It seems to be the cause of brain fog in fact.

Technojunkie
10-02-08, 09:12 AM
I would like to see them stay in business. They keep dropping stuff I want to buy. The guy who started it wrote a book that gives a good overview of alternative/experimental medicine, you can get the eBook version for free by signing up for their newsletter. I like his approach to problem solving.

My head pressure is less bad than it used to be. How much of that is due to supplements vs. clean diet and exercise, I don't know. My gut is far, far better than it used to be and that I definitely attribute to the supplements in addition to diet. Exercise is absolutely critical, you need to get your heart and lungs working to clear your head.

No one wants to comment about my theory about acidosis? Too far out there? No one wants to think about having to give up Coke and Mountain Dew?

Technojunkie
10-02-08, 01:22 PM
My doc pointed out that acidosis would have very obvious symptoms, so another theory bites the dust. He did agree that wasting ones bicarbonate stores on soft drink is very bad though. Diet, exercise and Adderall are working so I should get out for a bike ride and be happy? I didn't bother with any bloodwork.

Batman55
10-03-08, 05:38 AM
My doc pointed out that acidosis would have very obvious symptoms, so another theory bites the dust. He did agree that wasting ones bicarbonate stores on soft drink is very bad though. Diet, exercise and Adderall are working so I should get out for a bike ride and be happy? I didn't bother with any bloodwork.

I would like to comment on the leaky gut theory, though. This has not been proven, not as yet, anyhow.

Liver support supps. necessary? After drugs and alcohol? I thought sobriety was good enough...

GFCF... this one is simply too hard for me. I live on the Mediterranean diet, mostly, as per my ethnicity anyway. I can't kiss this one goodbye.

If I was going to avoid anything it would be artificials and high salicylate foods, but even then, that's just a lot of change and Aspergians don't like change :p

I'd like to try the enzymes, probiotics, and Butyrex with only minimal dietary restrictions. Could it work?

I realize these are stupid questions but you seem to know a lot more than I do.

Technojunkie
10-06-08, 12:59 PM
I know enough to be dangerous :D.

I think enzymes, probiotics, Butyrex, and an artificial-free diet would give you the biggest bang for your buck. Low sugar too, assuming you're right about candida. I'm somewhat skeptical about salicylates being a problem in adults who haven't noticed any problem with aspirin sensitivity. Everything else can wait. Of the supplements, enzymes have been the biggest help for me. My diet is heavy in tomato (salicylate). Substituting rice and gluten-free oats for wheat I can deal with but no tomato would be a problem.

FrazzleDazzle
10-06-08, 08:47 PM
Techno, reading with interest. On the subject of butyric acid, how does that help you with the ADHD? I could not find on search of the connection, and would like to know more from your perspective. I am also pursuing healing my gut too, and have not heard of the butyric acid. :p

Technojunkie
10-06-08, 09:20 PM
It doesn't. It helps with fixing a broken gut. Butyric acid feeds the large intestine.

I am starting to think that I'm right and my doc's wrong about acidosis being a factor. There are a lot of references out there to body acidity being a problem, like this one:
Detailed Listing of Acid / Alkaline Forming Foods (http://www.rense.com/1.mpicons/acidalka.htm)
I'm wondering if the head pressure I feel, which was a lot worse before I quit soft drinks, has anything to do with acidosis? Would calcium butyrate help with that? Calcium would, not sure about butyric acid (some acids have an alkalizing effect, as the link above describes).

I've gone a few days without Adderall (ran out) and I've been soooo sleepy, though better today. Despite that my head's been fairly clear for most of that time. I'd suspected that Adderall was helping my energy level more than anything else, with exercise helping me think. I'll have to think about that some more.

Batman55
10-07-08, 03:56 AM
I am starting to think that I'm right and my doc's wrong about acidosis being a factor. There are a lot of references out there to body acidity being a problem, like this one:
Detailed Listing of Acid / Alkaline Forming Foods (http://www.rense.com/1.mpicons/acidalka.htm)
I'm wondering if the head pressure I feel, which was a lot worse before I quit soft drinks, has anything to do with acidosis? Would calcium butyrate help with that? Calcium would, not sure about butyric acid (some acids have an alkalizing effect, as the link above describes).

My head pressure started when my gut was in absolute peril from drug/alcohol addiction. My body must have been very acidic at that time, I wasn't sleeping or eating properly. Who really knows what happened.

Someone else on the autistic spectrum--on another forum--had a similar problem. Frequent head pressure, history of drug/alcohol use, digestive problems. She postulated that the toxins from drugs/alcohol and dietary intolerance, combined, had "burned out" the enzymes needed to remove them from the body and that was causing the head pressure.

She found a cure with Magnesium.. but not with the kind you take orally. Soaking feet in Epsom Salts apparently gets magnesium into the body in a "free" form as it doesn't have to go through the digestive system--the logic is autistics can't use oral magnesium, or something. And this cures her head pressure if done daily.

I just tried it the other night, but noticed nothing. What a disappointment. :(

Let me know if you can figure anything else out about the pressure. Mine is just out of control.

Technojunkie
10-07-08, 01:57 PM
I know that people with gout have had success with baking soda. I Cured My Gout (http://www.icuredmygout.org/) is the definitive site. I've wondered if the same treatment, perhaps at a smaller dose, would work here? Baking soda (sodium bicarbonate) is high in sodium so you have to be somewhat careful but so long as you stay well hydrated you should be OK. Ideally I'd only take baking soda on an empty stomach to avoid interfering with digestion. In the evening, well after dinner, would seem like the ideal time?

Soaking in an epsom salt bath would be more effective than a foot soak. Some Feingolders have mentioned doing that, though it doesn't always work and some people react badly. If the digestive system is broken then taking an alternative route seems logical.

Soft drinks have a pH of near 2.0 (VERY acidic), plus both HFCS and Aspartame are very acidifying so drinking 1-2 liters/day for years was really dumb.

Batman55
10-08-08, 05:38 AM
I know that people with gout have had success with baking soda. I Cured My Gout (http://www.icuredmygout.org/) is the definitive site. I've wondered if the same treatment, perhaps at a smaller dose, would work here? Baking soda (sodium bicarbonate) is high in sodium so you have to be somewhat careful but so long as you stay well hydrated you should be OK. Ideally I'd only take baking soda on an empty stomach to avoid interfering with digestion. In the evening, well after dinner, would seem like the ideal time?

Soaking in an epsom salt bath would be more effective than a foot soak. Some Feingolders have mentioned doing that, though it doesn't always work and some people react badly. If the digestive system is broken then taking an alternative route seems logical.

Soft drinks have a pH of near 2.0 (VERY acidic), plus both HFCS and Aspartame are very acidifying so drinking 1-2 liters/day for years was really dumb.

The thing is, I haven't identified the problem. Could it be dietary intolerance aggravated by substance abuse? Could it be that for some reason I can't use magnesium anymore? Could it be high acidity?

There's a lot of possibilities. You haven't done the addiction thing (which is when my head pressure started) so the cause for yours might be different than mine.

As far as acidity goes, I do drink 3-4 cups of coffee per day. I'm told it's not half as bad as soda is, though, which I avoid at all costs.

If you do try either the epsom salt or the baking soda "hypothesis", let me know what the result is, if any. The only thing I noticed from epsom salts was my skin getting dry.

Technojunkie
10-08-08, 09:56 AM
Coffee is listed as having a pH of 4 versus 2 for soft drinks and 2.5 for beer and the scale is nonlinear so while coffee isn't nearly as bad it's not good either. It probably varies between types of beans and where they were grown too. Green tea, pretty much any tea except black looks like a safer caffeine delivery system, but if your body is acidic then using a diuretic like caffeine is bad. Not that amphetamines are the safest thing...

I have to wonder whether magnesium and other minerals are being used to neutralize pH rather than put to work? I'm not sure how that works. I also don't know what it takes to rebuild mineral stores after depleting them with soft drinks, alcohol, etc.

We're going to need a real doctor with direct experience on the subject to weigh in here. What I've written is just too speculative.

Batman55
10-09-08, 03:56 AM
Coffee is listed as having a pH of 4 versus 2 for soft drinks and 2.5 for beer and the scale is nonlinear so while coffee isn't nearly as bad it's not good either. It probably varies between types of beans and where they were grown too. Green tea, pretty much any tea except black looks like a safer caffeine delivery system, but if your body is acidic then using a diuretic like caffeine is bad. Not that amphetamines are the safest thing...

I have to wonder whether magnesium and other minerals are being used to neutralize pH rather than put to work? I'm not sure how that works. I also don't know what it takes to rebuild mineral stores after depleting them with soft drinks, alcohol, etc.

We're going to need a real doctor with direct experience on the subject to weigh in here. What I've written is just too speculative.

Speculation will still get me closer to the answer. The more puzzle pieces you have, the more complex it gets; but you can't solve the puzzle without all the pieces. So speculation is good for "gathering" data. But solving, not so much.

I have someone else who had the head pressure thing helping me out. Their new idea is that amphetamine abuse--or even some people who used higher doses of the prescription amps, as directed--could leave some people with a "permanent" vasoconstriction. It makes sense for me because stimulants don't help my head pressure, they only make it worse; and amphetamines did indeed cause it.

Technojunkie
10-09-08, 09:39 AM
True. And it's a big hairy puzzle...

I don't drink, smoke (other than secondhand exposure), do nonprescription drugs, etc, and didn't start prescription amphetamines until recently. But there's probably more than one path to "permanent" vasoconstriction and it sure feels like a plausible answer. Caffeine, over time in the right person, might be adequate? Adderall ups my head pressure a bit too, which is one reason why I'm on a fairly low dose versus most ADHD-I people here.

I've tried taking 1/2 tsp of baking soda in 4 oz water before bed two nights in a row. If anything it makes my head feel worse in the morning but it might be slowing down my excessive thirst. I go through 2-3 liters of water per day. That started after I picked up my soft drink addiction, I think. Acidosis might cause excessive thirst? I had been guessing essential fatty acid deficiency but the usual EFA supplementation hasn't had much effect on that, possibly better skin though.

I've been given some good info on acidosis, reading as my poor brain permits.

AndyK
10-20-08, 09:42 PM
I was given prednisolone acetate eyedrops following LASIK surgery, one drop four times per day. Prednisone breaks down into this, it's a very potent anti-inflammatory. The next day my foggy head was dramatically better. A couple days of prednisolone led to nearly two weeks of clarity. No one could tell me why, but now that my ADHD Inattentive has been diagnosed and Adderall has nudged my brain into gear I think it's obvious what happened. Dropping a potent anti-inflammatory that needs little to no further metabolism into an efficient pathway to the brain makes for a really neat test, though definitely not a cure since it's much too dangerous to use long-term.


I doubt the dose of prednisolone in eyedrops would be enough to cause a systemic effect- at least I have not seen it in many years of experience. Furthermore the presence of an inflammatory process is easily tested for and those tests are amongst the commonest done in clinical medicine every day.

As a side comment- high doses of prednisolone can directly cause florid mania if you are unlucky.

qinkin
10-25-08, 03:03 PM
I do drink 3-4 cups of coffee per day.
coffee drinkers are like 30%(?) less likely of dying from heart related problems, compared to non-coffee drinkers/consumers

DesertDave
10-26-08, 03:06 AM
Even if it's decaff?

qinkin
10-29-08, 02:18 PM
Ya, decaff or no, I'm decently sure
http://en.wikipedia.org/wiki/Coffee#Health_and_pharmacology

qinkin
10-29-08, 02:51 PM
Actually ---crap
Research suggests that drinking caffeinated coffee can cause a temporary increase in the stiffening of arterial walls.<sup class="reference" id="cite_ref-76">[77] (http://en.wikipedia.org/wiki/Coffee#cite_note-76)</sup> Excess coffee consumption may lead to a magnesium deficiency (http://en.wikipedia.org/wiki/Magnesium_deficiency_%28medicine%29) or hypomagnesaemia (http://en.wikipedia.org/wiki/Hypomagnesaemia),<sup class="reference" id="cite_ref-77">[78] (http://en.wikipedia.org/wiki/Coffee#cite_note-77)</sup> and may be a risk factor for coronary heart disease (http://en.wikipedia.org/wiki/Coronary_heart_disease).

SB_UK
10-29-08, 03:15 PM
In 2007, wholesale coffee was about US$1/lb (e.g. 69 cents in London in March to 134 cents in New York in October), with robusta being about 70% of the price of arabica. Retail prices varied from an average of $3 in Poland to $3.50 in the US to $17 in the UK.from qk's link

Does the quote above mean that the price of coffee is 69 cents per lb for the shop owners to buy and where normal people (in the UK) like us have to pay $17.00 to a company which is paying only 69 cents for the product.

Presumably that extra money which we're paying is for packaging, transport and to make some lucky middle man with a dishonest moustache
not a coffee producer
- very rich indeed.

Middle men are such a waste of time.

Is there any way of buying coffee direct from the producer ?

Those figures are scandalous.

Whereas in the USA, the coffee costs $1.34 for shops to buy and is sold for $3.50.

If it does - then that means that we're (in the UK) paying 25 times more whereas in America it's costing the average citizen 2-3 times more -

am I missing something here?

- these figures are ridiculous.

If you'd have asked me to guess prior to reading wikiP -
I'd have suggested that I'd expect the markup to be close to 1.25- and not 2-
certainly not 3-

but

25-fold !!!

words fail me -

- I really can't believe that I've understood the paragraph correctly.

qinkin
10-29-08, 03:35 PM
a dishonest moustache
(if I started a band, that'd be it's name)

nice point, nontheless

ya, gasoline apparently is just as ridiculously priced, relatively(?)
right now----$2.45 in the St. Louis region of Missouri..

anyway, one more thing revolving about coffee

it takes about 140 litres of water to grow the coffee beans needed to produce one cup of coffee, and the coffee is often grown in countries where there is a water shortage

DesertDave
10-29-08, 04:13 PM
florid mania

What's florid mania?

Good grief. No wonder I spend hours on here going from here to Google, then to Wiki, then back here searching for things. Which then takes me off in some other direction. An hour later I remember why I got on earlier, then come back and start over again.

qinkin
10-29-08, 04:19 PM
I would say that the amphetamines,,,suchas those found in adderall and desoxyn, are a more affective benefactor to everyday life.. than that of caffeine..

positive benefit seems to be more highly efficient in amphetamine meds than from the caffeine sourced from coffee.....

3-4 cups per day of coffee, you may want to get half-caff, coffee

SB_UK
10-29-08, 05:47 PM
I would say that the amphetamines,,,suchas those found in adderall and desoxyn, are a more affective benefactor to everyday life.. than that of caffeine..

positive benefit seems to be more highly efficient in amphetamine meds than from the caffeine sourced from coffee.....

3-4 cups per day of coffee, you may want to get half-caff, coffee

dexedrine killed my attraction for alcohol
dexedrine killed my attraction for nicotine (patches)

and as I reduced my dosage of dexedrine - I noticed that I increased my dosage of coffee -

60 mg dexedrine + a cup or two of coffee -> 10 mg dexedrine + a litre or two of coffee

- until as of recently when dexedrine levels and coffee intake have dropped down to not much and a couple of cups respectively.

60 mg dexedrine + a cup or two of coffee -> 10 mg dexedrine + a litre or two of coffee
-> 5mg dexedrine + 200ml coffee

We've made a connection between mental development and a switch in steroid usage to increased risk of CHD previously

Transition in steroid usage with age and more importantly development of mind

sex steroid + mineralo-/gluco- corticoids
->-
cholesterol (cytoplasmic and lumenal) + immuno-suppressant bio-activity

eg #1 (http://www.google.fr/search?hl=en&client=firefox-a&rls=org.mozilla%3Aen-US%3Aofficial&hs=aLH&q=endogenous+immuno+steroid&btnG=Search) from this google search

Stress and Immunity - Google Books Result (http://books.google.fr/books?id=ecX46Asi8DUC&pg=PA329&lpg=PA329&dq=endogenous+immuno+steroid&source=web&ots=yFv27R88GA&sig=on0JK8frVN_VMdQqzh_FpCeGyno&hl=en&sa=X&oi=book_result&resnum=1&ct=result)
by Nicholas P. Plotnikoff, Anthony Murgo - 1991 - Medical - 558 pages.
Since steroids induce mental disturbances and alter immune function, a link between endocrine, nervous, and immune function was suggested
(Su et al., l988).
... books.google.fr/books?isbn=0849388457...If we put the dramatic reduction (in dexedrine and caffeine intake below)

---1---

60 mg dexedrine + a cup or two of coffee
->
10 mg dexedrine + a litre or two of coffee
->
5mg dexedrine + 200ml coffeealongside the transition to shift in steroid usage mentioned above

---2---

sex steroid + mineralo-/gluco- corticoids
->-
cholesterol (cytoplasmic and lumenal) + immuno-suppressant
and then connect

---3---

The mechanism of caffeine bio-activity with the development of mind with the metabolic shift (in ---2---)

desire to build mind -> desire for caffeine / dexedrine
as desire to build mind drops -> so does desire for caffeine / dexedrine drop
as mind is built -> shift in pattern of steroid usage from

hypothalamus - anterior pituitary - thyroid/adrenal gland
.............................->- to ->-
hypothalamus - posterior pituitary - parathyroid gland

axes

then

---4---

We'd arrive at a conclusion in which coffee drinking associates with CHD
[as qk describes above]

- however -
we're not observing a pathophysiological link of

coffee drinking -> CHD
per se

moreso
- affinity for drinking coffee running supportively alongside development of mind into state which we call 'wisdom'.
Mental state 'wisdom' arriving with peripheral physiological changes in tandem.

-*-

---(a)---

The connection described here
---3---
the mechanism of caffeine bio-activity with the development of mind with the metabolic shift (in ---2---)
and

---(b)---

Why CHD ? (a disease) should accompany change of the mind for the better (wisdom)

can be described in more detail
(if we like)

... ... in brief ... ...

---(a)---

---(i)---
adenosine antagonist

A appears to associate with stability
and
G with change

- in this case G (caffeine as A antagonist) - driving change in the structure of our mind - I'd guess that our desire to drink caffeine would decrease as the change which we'd like to introduce into our minds -
- occurs.

&

---(ii)---
principal metabolite theobromine cf. chocolate

http://en.wikipedia.org/wiki/Theobromine
-> reduced blood pressure
potentiates cAMP activity by inhibiting PDEs which break down cAMP

- the general tendency appears to be towards antagonising A(denosine) in every which way.

---(b)---

Cell membrane fluidity (particularly neuronal cell membrane)
- in association with a change which is described in 2 or 3 recent threads on science subforum as key neural circuitry / neuro-endocrine processes
-<- running -<- backwards -<-.

&

- A tendency towards stable aerobic respiration and away from anaerobic respiration -
- as far below us.

Those who do not act their mental age and engage in violent anaerobic processes will presumably be rewarded by summary death.

Batman55
10-30-08, 03:24 AM
I would say that the amphetamines,,,suchas those found in adderall and desoxyn, are a more affective benefactor to everyday life.. than that of caffeine..

positive benefit seems to be more highly efficient in amphetamine meds than from the caffeine sourced from coffee.....

3-4 cups per day of coffee, you may want to get half-caff, coffee

Is that an order?

I don't like commands; I tend to do just the opposite... :p

AndyK
10-30-08, 04:00 AM
What's florid mania?

Good grief. No wonder I spend hours on here going from here to Google, then to Wiki, then back here searching for things. Which then takes me off in some other direction. An hour later I remember why I got on earlier, then come back and start over again.




Well mania is a pretty simple thing to diagnose in its overt or florid state:
tremendously energetic- often on the go 24/7- may go days without stopping to eat or drink and then crash only to wake up running, talk incessantly, (mostly rubbiish)), get into fights ( verbal or physical ) with everyone, spend money rapidly and indiscrimainately, delusions of Grandeur ( I tell you I am Napoleon!), hypersexualized- will bonk anything that doesnt move faster than themselves. Their enthusiasm and energy are infectious and less wary people will be swept up in it. This true, psychotic, mania. Individuals often fall very rapidly inthis state and when there can bankrupt themselves, wreck their marriages, catch multiple STDs, and virtually starve and over exercise themselves to near death in a few short weeks. The term mania was coined to describe this syndrome.
The last patient I saw with it lost 10kg in 2 weeks. That is what I mean by florid mania.

The definition of mania has become progressively broader to cover hypomania and cyclothymia. The latest descriptions of childhood bipolar that I have read elsewhere on this forum puzzle me as they do not fit this picture at all.

meadd823
10-30-08, 04:17 AM
3-4 cups per day of coffee, you may want to get half-caff, coffee

The word may in the quote above indicts this is only a suggestion - I know qinkin and he doesn't do orders well either and request can be forgotten.:rolleyes:

AndyK
10-30-08, 04:17 AM
Coffee is listed as having a pH of 4 versus 2 for soft drinks and 2.5 for beer and the scale is nonlinear so while coffee isn't nearly as bad it's not good either. It probably varies between types of beans and where they were grown too. Green tea, pretty much any tea except black looks like a safer caffeine delivery system, but if your body is acidic then using a diuretic like caffeine is bad. Not that amphetamines are the safest thing...

I have to wonder whether magnesium and other minerals are being used to neutralize pH rather than put to work? I'm not sure how that works. I also don't know what it takes to rebuild mineral stores after depleting them with soft drinks, alcohol, etc.

We're going to need a real doctor with direct experience on the subject to weigh in here. What I've written is just too speculative.

Your body has a very sophisticated system to regulate internal pH. It principally involves the kidneys and the lungs and manipulation of the amounts of carbon dioxide and bicarbonate in your blood. It is designed to cope with foods in a range of acidities.pH is very narrowly controlled in a range of 7.35-7.45 and deviations are always explicable in terms of acute or chronic illness or acute exercise or starvation ( ketoacidosis when your body runs out of sugar to burn). Significant devaitionas are usually seen in gravelyill or moribund people. Yes, I do fit your required qualification.

meadd823
10-30-08, 04:21 AM
Well mania is a pretty simple thing to diagnose in its overt or florid state:
tremendously energetic- often on the go 24/7- may go days without stopping to eat or drink and then crash only to wake up running, talk incessantly, (mostly rubbiish)), get into fights ( verbal or physical ) with everyone, spend money rapidly and indiscrimainately, delusions of Grandeur ( I tell you I am Napoleon!), hypersexualized- will bonk anything that doesnt move faster than themselves.

Then we have my sister who tried to save the world so she can tell it what to do mania -

Half of all manias are manifested in irritability and paranoia - for family of the irritable type of manic delusions of grandeur that are pleasant would be an improvement.

The definition of mania has become progressively broader to cover hypomania and cyclothymia.

In my experience the term "hypo-mania" is employed to indicate a difference

AndyK
10-30-08, 04:29 AM
Actually ---crap

The research on coffee is all over the place- some says it is good for your heart - some says bad. I havent the time to get to the bottom of it. Having said that too much coffee WAS messing with my sleep and I didnt know it until I withdrew to have a SPECT scan. I was horribly sick for a day, then started sleeping better and lost my chronic tremor. Daniel Amen says it acts as a cerebral vasoconstrictor - I must look that up. Anyway fixing the sleep was a good step with helping the attention.
I'm fine with the occasional social coffee- but wont go back down that road of regular coffees again.

AndyK
10-31-08, 08:16 AM
Then we have my sister who tried to save the world so she can tell it what to do mania -

Half of all manias are manifested in irritability and paranoia - for family of the irritable type of manic delusions of grandeur that are pleasant would be an improvement.



In my experience the term "hypo-mania" is employed to indicate a difference
Irritability is pretty well universal. It comes on just as soon as somebody challenges your newfound insights with their own observations. Delusions of grandeur are really pretty scary for all but the patient. Paranoia is possible- but a lesser feature and different in character to what you see in schizophrenia for instance. The main difference between mania and hypomania is degree and time- most hypomanics will not quite fit the criteria for involuntary treatment at the time the are described as hypomanic-they can usually be reached by reason. True mania goes well past that. I still dont get what the relationship between the so called child bipolar and adult bipolar is. Symptomatically they are quite different. I trust the propopers of the diagnosis have some pretty good longitudinal data to follow up their assertion of a relationship.

Birdman123
11-04-08, 10:00 AM
i think prednisone dose have some effect on ADD or ADHD, when i was in the 7th grade i was on prednisone, and that year i was so smart, popular, and i had all A's and B's honor classes, the next year i did horrible when i got off the prednisone then i went back on it in the 10th grade and i was smart again.

SB_UK
11-04-08, 04:26 PM
psychiatric disorders
classical diseases of Western living -
which relate to development of mind

auto-immune disorders
classical diseases of Western living -
which relate to development of mind

metabolic disorders [cholesterol,glucose]
classical diseases of Western living -
which relate to development of mind

allergic disorders
classical diseases of Western living -
which relate to development of mind

cancer
classical diseases of Western living -
which relate to development of mind

-*-

google hit on s/t [diseases of Western living]
~s (http://www.heattreat.ca/insulin.php)ource~

... premature aging (degenerative) disease such as
diabetes / glaucoma,
arthritis / multiple sclerosis,
heart disease / vascular disease,
[allergy] / asthma,
cancer,
emphysema / liver cirrhosis,

osteoporosis --- part of the physiological switch to chilling out which occurs with age ?
--- warning sigjn that hormonal switch has not been thrown into reverse ?kidney disease --- inappropriate diet leading to unmanageable demands being placed on the kidney ?
related to an excess N (protein) diet ?underlining
pathology associated with addiction as consequence of development of mind also

SB_UK
11-04-08, 07:06 PM
prednisone
Quote:
<table border="0" cellpadding="6" cellspacing="0" width="100%"> <tbody><tr> <td class="alt2" style="border: 1px inset ;"> diabetes / glaucoma,
arthritis / multiple sclerosis,
heart disease / vascular disease,
[allergy] / asthma,
cancer,
emphysema / liver cirrhosis,

osteoporosis
Quote:

kidney disease
Quote
</td></tr></tbody></table>
http://en.wikipedia.org/wiki/Glucocorticoid
<table style="border-collapse: collapse;" border="1" cellpadding="3" cellspacing="3"><caption>
</caption> <tbody><tr> <td bgcolor="#dddddd">
</td> <td bgcolor="#dddddd">Glucocorticoid
potency</td> <td bgcolor="#dddddd">Mineralocorticoid
potency</td> </tr> <tr> <td>Hydrocortisone</td> <td>1</td> <td>1</td> </tr> <tr> <td>Prednisone</td> <td>3.5-5</td> <td>0.8</td> </tr> <tr> <td>Aldosterone</td> <td>0.3</td> <td>200-1000</td> </tr></tbody></table>

http://en.wikipedia.org/wiki/Osteoporosis may occur in anyone in the presence of particular hormonal disorders and other chronic diseases or as a result of medications, specifically glucocorticoids

------------------------------------------------------------------------

Glucocorticoid -> osteoporosis

Hydrocortisone -> cortisol -> mental and physical stress

Mineralocorticoid-> Aldosterone -> kidney disease

------------------------------------------------------------------------
wikiP/Aldosterone is a hormone that causes the tubules of the kidneys to retain sodium and water.


sodium -> sweaty
..................&
water -->-- pipi


-*-

crime-fighting

only

*smellier*

bleughhh!

SB_UK
11-05-08, 04:25 AM
As one species
speedballin' Steroids suckin' on PCP-laced Marrijuana
leaves

- another

reflects

-*-

http://tbn0.google.com/images?q=tbn:6yJmgTigJ9iT2M:http://www.watching-paint-dry.com/v7ndotcom-elursrebmem/black-hats/black-hat-steroid.gif

yes
- Captain PinHead looks 'dumb'

-*-

glucocorticoid->-osteoporosis

hydrocortisone (cortisol)->-physical stress->-mental stress

mineralocorticoid->-Aldosterone->-?->-kidney (disease)

prednisone->-?->-'Smarts'

wikiP/steroid
->-
The rate limiting step of steroid synthesis is the conversion of cholesterol to pregnenolone which occurs inside the mitochondrion.[/quote]
==
~s ADDF::Amy on Star War~s
midi-chlorians
hydrocortisone->-treats eczema though thinning skin

prednisolone (synthetic corticosteroid)->-anti-inflammatory->-treats asthma, RA,cancer

~s ource (http://www2.netdoctor.co.uk/medicines/100002901.html)~->-
The main androgen secreted by the testes is ... testosterone. However, in most of the body, the androgenic signal is not carried through by testosterone. In these tissues, which include the brain (CNS), skin, genitals practically everything but muscle the active androgen is actually DHT.
testosterone->- DHT->- {prostatic disease, acne, hairloss}

~s ource (http://www.mens-hormonal-health.com/types-of-anabolic-steroids.html)~
->-
Types of Steroids
1. Testosterone based steroids.
2. DHT based steroids. lean[/U] muscle mass]
3. Progestin (19-nor) based steroids. [an interesting class][/quote]


Progestin (19-nor)
joint relief
Weener droop

Ahhh!

If you're having a tough time getting it up or wanting to have sex, you most likely are running high in prolactin which progestin steroids tend to raise.http://upload.wikimedia.org/wikipedia/commons/thumb/6/6c/DHEA1.svg/350px-DHEA1.svg.png

A progestin is a synthetic progestagen that has progestinic effects similar to progesterone. The two most frequent uses of progestins are for hormonal contraception (either alone or with an estrogen), and to prevent endometrial hyperplasia from unopposed estrogen in hormone replacement therapy.
Oestrogen versus Progesterone
Growth .....versus Maintenance

Mitochondria
- the uncoupling proteins

ATP -> heat
generation

cf.
brown adipose tissue, hibernation, thermoregulation

cf. debaser
A versus G

ATP versus not ATP (heat generation)

feeling hot ! hot ! hot !

The force is strong in you

bleuggghhhh!

note to self
Try and find the name of the first person who decided to stand on the wings of a bi-plane in mid-flight
blaaaaaaaa!

[I]Ad hoc summary

The pattern here is of development to sexual maturity (physically and then mentally) -
- and then when mature -
to be freed from the constellation of desires which have been required to drive motivation of the organism (us) to develop body (physical abstraction layer), develop mind (mental abstraction layer)
(of mind:body duality)
and seed the next generation -
As such -
- these are non-negotiables, since we are products of a process of nature (evolution) -
- which has sole remit of structuring energy into
more complex (specific definition)
more efficient (specific definition)
space-filling geometries of (and regardless of the outer appearance of stuff (like your vacuum cleaner bags) not moving
- moves
Everything moves; there is only change.

-*-

Infommercial

Heck

- we all know google as the most wonderful company in the world which keeps on giving without demanding that we keep on paying for more

- but did any of you ever know that they sell something?

Let's all say a great big thankyou to google and buy their thoroughly ugly (Yay!)
- how vacuous we are not - ! -

open open open

platform

Yay!

The paranoid
Android
platform available under the Apache free-software and open source license

appears
open source
to
open source
have
open source
lost
open source
his
open source
paranoia

Just one thing google people -
- have you [I](you're gonna' kick yourselves) thought ?? of making an internet page for it -
(nothing too flashy)
- harnessing the power of the Internet to sell one's merchandise is all the rage today.


Reference

Adblock (http://www.fritscher.ch/blog/2008/09/03/google-chrome-adblock-with-privoxy/)

Google chrome
Naturally, I am missing all my nice add-ons from Firefox, mainly the adblock add-on!
Boo!

So I found an alternative solution: using PrivoxyYay!

:D

SB_UK
11-05-08, 11:39 AM
Inflammation is a big piece of the puzzleOur defining features.

anaerobic -> aerobic respiration

l'homme aerobic
l'homme neuronal

Mitochondria (in the neurone) -
generates ATP or uncouples -

ATP
- most important for the Na+/K+/ATPase -
the core mechanism of depolarization / repolarization

- of the action potential

http://en.wikipedia.org/wiki/Progesterone
:: functions ::

Progesterone converts the endometrium to its secretory stage to prepare the uterus for implantation. At the same time progesterone affects the vaginal epithelium and cervical mucus, making the mucussperm. If pregnancy does not occur, progesterone levels will decrease, leading, in the human, to menstruation. Normal menstrual bleeding is progesterone withdrawal bleeding. thick and impermeable ...
->-
(from previously) - (from wikiP) - mucous exchanges Ca<sup>2+</sup> for Na<sup>+</sup> and expands up to 600-fold.



During implantation and gestation, progesterone appears to decrease the maternal immune response to allow for the acceptance of the pregnancy
->-
(from previously) - dampens the exuberant immune response



Progesterone decreases contractility of the uterine smooth muscle<sup></sup>
->-
dampens over-excitable smooth muscle (cf asthma)



In addition progesterone inhibits lactation during pregnancy. The fall in progesterone levels following delivery is one of the triggers for milk production.
->-
(from previously) - casein story



A drop in progesterone levels is possibly one step that facilitates the onset of labor
->-
(from previously) - birth of a new structure
(the pattern of evolution)



Progesterone, like pregnenolone and dehydroepiandrosterone, belongs to the group of neurosteroids that are found in high concentrations in certain areas in the brain and are synthesized there.Neurosteroids affect synaptic functioning, are neuroprotective, and affect myelination.<sup id="cite_ref-pmid15135772_7-0" class="reference">[8]</sup> They are investigated for their potential to improve memory and cognitive ability.



Progesterone as neuroprotectant affects regulation of apoptoticIts effect as a neurosteroid works predominantly through the GSK-3 beta pathway, as an inhibitor. (Other GSK-3 beta inhibitors include bipolar mood stabilizers, lithium and valproic acid.) genes.



It raises epidermal growth factor-1 levels, a factor often used to induce proliferation, and used to sustain cultures, of stem cells.



It increases core temperature (thermogenic function) during ovulation.<sup id="cite_ref-GeorgiaPhysiology_8-0" class="reference">[9]
</sup>->-
(from previously) - uncoupling -> thermogenesis favoured<sup id="cite_ref-GeorgiaPhysiology_8-0" class="reference">
</sup>



It reduces gall-bladder activity.
->-
(from previously) - shift away from ingestion and towards de novo generation of cholesterol



It normalizes blood clotting and vascular tone, zinc and coppercell oxygen levels, and use of fat stores for energy levels
->-
(from previously) - shift away from simple carbs ->- fat as energy source



It assists in thyroid function, in bone building by osteoblasts, in bone, teeth, gums, joint, tendon, ligament and skin resilience and in some cases healing by regulating various types of collagen, and in nerve function and healing by regulating myelin
->-
(from previously) - the shift away from physiological link to day:night (light dark cycles) cf bipolar disorder



It appears to prevent endometrial cancer (involving the uterine lining) by regulating the effects of estrogen)
->-
(from previously) - anti-cancer / anti-inflammatory effects hand-in-hand

Ca2+
- yet again

milky starch solutions
milky milk solutions
milky calcium carbonate solutions

hydrophobic fat micelles in water -> 'milky' solution

An emulsion
- emulsification
->- gall bladder above

And the point is

~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
~ ~ ~ ~ ~ Water ~ ~ ~ ~ ~ ~ ~
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~


cosmic background microwave radiation (CMB) can be conducted through water -
cf a kitchen microwave -
imagine that CMB is an always on 'kitchen microwave' - which (and just as in the case of our kitchen microwaves) - only works when water is present within the item/food stuff.

cosmic background microwave radiation (CMB) can be conducted through water -
- with the sole proviso that the heat needs to do something
cf chemical evolution on a carbonaceous chondrite
- chemical evolution of chemical elements and organic structures within a crucible constructed by evolutionary events driven by the presence of water

- an (immiscible micelle) (a self-contained unit with protective (from aqueous) barrier) -

would be a great choice for structure to take up the energy which water seeks to confer.

~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ () ~ ~
~ () ~ ~ ~ ~ Water ~ ~ ~ ~ ~ ~ ~
~ ~ ~ ~ ~ ~ ~ ~ () ~ ~ ~ ~ ~ ~ ~

whereby

~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
~~ ~ ~ ~ -<- Water ->- brings energy down ~ ~ ~ ~ ~ ~ ~
~ ~ ~ ~ ~ ~ ~ ~~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~

and energy drives evolution of structures (emergent energetic evolution)

energy + () -> (())

energy + (()) -> ((()))

energy + ((())) -> (((())))
~etc~

-*-

Evolution is

~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ () ~ ~
~ () ~ ~ ~ ~ Water ~ ~ ~ ~ ~ ~ ~
~ ~ ~ ~ ~ ~ ~ ~ () ~ ~ ~ ~ ~ ~ ~

->-

~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ (()) ~ ~
~ (()) ~ ~ ~ ~ Water ~ ~ ~ ~ ~ ~ ~
~ ~ ~ ~ ~ ~ ~ ~ (()) ~ ~ ~ ~ ~ ~ ~

->-

~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ((())) ~ ~
~ ((())) ~ ~ ~ ~ Water ~ ~ ~ ~ ~ ~ ~
~ ~ ~ ~ ~ ~ ~ ~ ((())) ~ ~ ~ ~ ~ ~ ~

SB_UK
11-05-08, 12:53 PM
which is all to say

- that understanding

Inflammation

solves

a big piece of the puzzle ... ...

:-)

Cuddle me and I'll squeal BUT put me in a microwave and I'll inflame like an insurgent incendiary Christmas pudding that's over the limit
(in Hell)

- that's over the limit -

[/quote]- huh???
waaachoo drivin' at?

no religious speak (warnnnt no polytheistic pagan pud woz it ?) allowed on the forum
- capisch???

oh - yes right,
- thank you
erm...
I mean 'capisch' !

Ave Maria -
- what's a girl to do,
to find God and heaven on Earth ???
huh???

SB_UK
11-05-08, 06:26 PM
'a bad back'
(structural skeletal changes)
classical dis-ease of Western living -
which relate to development of mind

Bilateria (two arms, two feet, two eyes ~etc~)
- represent (left and right, in each case)
- two everted (and not symmetric) opposites

cf.
leg length inequality (from previously)

and the changes with 'mind' include also extend to -
http://tbn0.google.com/images?q=tbn:wNyIz4RJkf1cpM:http://www.ccaa.org.uk/images/treatment/podiatry/pod_foot.jpg
_ _ _ _ _ _ _
_ _ _/_ _ _ _\_ _ _ _

->-

_ _ _ _ _ _ _ _ _ _ _ _

dropped arches ->- flat feet

in line with the anaerobic -> aerobic shift with development of mind -
- we're being given the strongest of signs to stop
chasing our tails
...leading neatly on to...
libido
- decreases also
(as one would hope
- we've something 'better' (from our (personally) novel context) to do)

-*-

Inflammation is a big piece of the puzzle

- next -
a comparison of the chemical structure of progesterone (anti-inflammatory) versus oestrogen

for therein we shall find a link back to 6-6-6-5 and chimaerism.

Progesterone and Oestrogen are going to prove to be structural duals -
eversions which work together -
in processes of growth and maintenance -

(as we (actually do) know from (now) standard medical texts)

And then from steroid -
back to the
6C-6C-6C-5C (purine/pyrimidine) structure of DNA
alongside a structure formed from
Tyrosine,Trptophan,Tyrosine
(6C,6-5C,6C respectively)
Dopamine,Serotonin,Noradrenaline (respectively)
- the neurotransmitter triumviracy (from previously)

(not to mention tyramine,melatonin,melanin)

Tyrosine,Trptophan,Tyrosine
(6C,6-5C,6C respectively)

Dayvan Cowboy
Campfire Headphase

SB_UK
11-08-08, 07:14 AM
inflammationPoints

---1---
Indicates 'warfare' - how better to understand the experiential perspective of a chemical reaction where two precursor reactants 'fuse'

---2---
wikiP/Salbutamol is a short-acting β2-adrenergic receptor agonist
where an asthma attack (inflammatory reaction) which is triggered by excess anaerobic exercise
can be cured by
(i) meditating
(whilst in the zone)
(ii) getting angry
(at how ridiculous man behaves against fellow man for profit and lo$$)

->- mind over matter

---3---
cigarettes -> nicotinic (acetylcholine receptor of the PNS) agonism (central)

(cf muscarinic (acetylcholine receptor) agonism -> peripheral -> muscle)
The mind:body duality is represented by a
neuro:muscular dual

nicotine -> central PNS agonism
muscarine -> peripheral PNS agonism

cool :-)
->-
It was the first parasympathomimetic substance ever studied and causes profound activation of the peripheral parasympathetic nervous system that may end in convulsions and death.
...ermmm...
(well
you know)

---4---
Connect to
ADDFthread: Oxidative imbalance
- inflammation results in extensive oxidative damage (in warfare) -
and it's interesting that man is notable for our loss of the capacity to endogenously engineer 'Vitamin C' -
an anti-oxidant
Point
Oxidative damage (inflammation) is a necessary component of the remodelling process
- which evolution has needed to sequester in order to generate a novel (more complex) geometric structure for our mortal electrical coil.

---5---
The mitochondria -
- generate ATP,heat and superoxide free radicals -
which classical wisdom states need be 'disarmed' -
though which need only be 'disarmed' after their effects on our betterment have been realised
Aside
Exapatative consequences of free radical formation on the body (when we're supposed to have finished building mind) -
explains why we're prone to cancer -

Cancer can be cured by a change in society -
the need to be bad and earn money destroys the mind -
and the process of forcing change on our mind (remodelling above)
->- leads ->-
as it fails to have any effect on the chain$ within which we're repressed

to ->- blow -<- us apart.

Mind rides over Peripheral biochemistry
- as the pressure mounts for logical structure of mind to be aligned with 'proper' behaviour -
so do these effects bleed back causing damage to precursor substrate -
our body (the periphery).

It may help (with this idea) -
to imagine one box (mind) connected to another (body) -
- with the mind anchored by the body and the body having its strings pulled by the mind.

The processes which we're examining here are
mind (logical connect between knowledge and behaviour)
||||
body (classical biochemistry)

As illogical (logic is initially a local concept) behaviour predominates and the local mind develops -
the illogicality of that human's behaviour results in
||||
the anchor being yanked and then (eventually) pulled on
||||
'vvv
body

Peripheral disease -
and lots of it.

cf.
- the placebo effect
- psychosomatic disease
- mental (not neurological) disorders as contextual (defined by social context)

---6---
Leg length inequalities (see previously on ADDF)
can be eliminated by dropping an arch
(musculoskeletal shift)
on one side

- but one side?
We're not symmetrical - the two seemingly 'mirror image' halves of bilateria - as Picasso teaches us -
are everted opposites in duel -
and not simple symmetrical mirror images -

this general idea is in keeping with the
anaerobic -> aerobic shift which characterizes the evolution of man

- where no matter how lovely we find the taste of oxygen -
we should try an remember that oxygen is Highly reactive
- explosive in nature

- we are becoming more energetically imbued organisms -
and just as we see in your new 2000 Watt vacuum cleaner -

it sucks way more (on every level) than your 1000 Watt vacuum cleaner -
(and of course your electricity bill will also go up by two)
... ... ... and so I bought a dustpan and brush.

-NB-
That last bit wasn't a sophisticated metaphor.

110 litres
For a full load
in the washing machine

- good grief -
do we really get that dirty ?

SB_UK
11-08-08, 07:46 AM
Next - a connection between

~s profilins (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1253521) ~

<sup>1</sup>Immunobiochemistry Lab, Immunology Research Center, Bu-Ali Research Institute, Mashhad, Iran
<sup>2</sup>Molecular biology Lab, Immunology Research Center, Bu-Ali Research Institute, Mashhad, Iran

Yay !
reality is a broad church

This melon profilin showed substantial cross-reactivity with the tomato, peach, grape
and Cynodon dactylon (Bermuda grass) pollen profilins. Cantaloupe, watermelon, banana (boo!)
and Poa pratensis (Kentucky blue grass) displayed no notable inhibition.

In this highlight
- no personal data available upon which to base an opinion

->- I have allerges to all of these foodstuffs.
~s~ google hit ~paraphrase~
plant allergens -> heat labile
fresh fruit ->- fried chips ?
classes -
---(i)--- defence
[cf. inflammation - energy needs something to do]

---(ii)--- structural
[see below]

---(iii)--- storage protein
[cf. (endosperm) -> growth]~s~ google hit ~paraphrase~
profilin -> actin (cytoskeletal remodelling)

The cytoskelton
(microtubule assembly)

Ubiquitous, Highly conserved through the kingdoms of life
- the cytoskeleton is a form of internal electrical wiring which pervades and conducts energy to and throughout the organism.

->- An explanation of self-assembly of of microtubules

->- Connection ->-

ToEF :: Mikal
actin,listeriaWhat is the Root of all evil? - Page 389 - Theory of Everything
: .... cell: it induces directed polymerization of actin by the ActA transmembrane protein...
www.toequest.com/forum/ (http://www.google.co.uk/search?hl=en&client=firefox-a&rls=org.mozilla%3Aen-US%3Aofficial&hs=H26&q=site%3Awww.toequest.com+actin+SB_UK&btnG=Search&meta=)
- 147k

Campfire Headphase
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