I was just wondering how many of you have amalgam fillings or have ever been vaccinated as a child.

Is this ADHD relevant? How is this a scientific discussion?

I think he might be trying to suggest that vaccinations can cause an autistic spectrum disorder, and that amalgam fillings could aggravate the symptoms.

I'm guessing he thinks this is relevant because there's a lot of overlap between ASD and AD/HD, recent studies have suggested that similar genes may be involved in both, blah blah blah. So the same stuff that could be causal for ASD might be causal for ADHD, or at least cause the condition(s) to worsen.

That's my best guess.

Anyone else think vaccines/heavy metals cause autism?

Personally, I do not, the evidence is insufficient for me and the Andrew Wakefield study has recently been "debunked" again.

The bottom line is that there is NO link between amalgam fillings and ADHD nor is there a link between vaccines and ADHD

I believe that dentistry stopped using amalgam for temporary fillings years ago. Furthermore most vaccines don't use thimersal anymore.

You might want to ask people if they ever used tincture of merthiolate as it has thimersal in it too

It is all F.U.D., the deliberate creation of fear uncertainty and doubt in order to gain some control over the uninformed.

Me :D

Just for what its worth, there are still plenty of dentists who still use amalgam, at least in the U.S. Sometimes I wonder if my long term exposure to mercury (28 years as a dental assistant) has had any baring on my issues. (Brain fog, bi polar, etc.) I kind of doubt it, although I found one study that focused on that issue. The assistants involved used a completely different procedure for mixing the alloy involving heating it, which vaporizes mercury, so I'm not sure how much it applies to me, if at all. In any case, I don't believe that amalgam or immunizations have anything whatsoever to do with ADHD.

I know where this is going and the mercury in both is inert and therefore isnt capable of causing autism, adhd or to grow and extra limb. Ask a bio chemist and they'll explain it to you.

This is as real as UFOs, Bigfoot, crop circles and the federal agents that hide in my bushes.

It's 2008. Who hasn't been vaccinated against something?

I see the OP is another one-post wonder.

I have no amalgam fillings but my mum has had loads since childhood, and the FDA recently recommended that pregnant women don't get amalgam fillings (which doesn't solve the problem of the mercury that they admit will have built up their bodies from existing ones and is passed to the fetus :rolleyes:). At least one European country has banned amalgams completely this year, and others have banned them for children.

Funny, I just mentioned this in another post today: Here's a page about a possible mercury-ADHD link (http://www.generationrescue.org/survey.html). It's already common knowledge that lead poisoning can contribute to ADHD. So I came here with possible causal factors in mind to ask about rates between different countries (rates of people meeting the criteria, not rates of diagnosis or rates extrapolated from the USA) and might actually get round to it soon. Comparing populations would be an obvious step for scientists deciding how much is genetic and how much isn't, surely? But I can't find those kinds of statistics anywhere.

By the way, if you're worried about vaccines, the only childhood ones for the developed world that have mercury in now, since 2001, are flu vaccines (you know, the ones American children are supposed to get (http://www.webmd.com/cold-and-flu/news/20080924/flu-vaccine-recommended-more-children)every year now :rolleyes:). For adult ones you could find out whether they contain mercury if you can find out which company produced them. The FDA website has a page of tables showing which vaccines by which company have various amounts of mercury, including none.

SOME vaccines aren't made with mercury anymore, but they are still made with other metals which can also be toxic. I thought it was too good to be true that amalgram fillings were no longer used. All these things can add up, and while there may not be a direct link between getting a vaccination and developing ASD or ADHD - mothers who have had these vaccines and these fillings might be producing ovum with damaged DNA, eh? There are a lot more questionable things in our diets and our environment these days than ever before (such as pesticides, pollution, electro-magnetic fields, etc.). I don't think it's such a stretch to wonder if there is a link.

Of course, it's also possible that better diets and medical care is resulting in babies being born now that otherwise might have resulted in miscarriage 50 or 100 years ago, so we are seeing more babies with problems now than ever before.

Of course, it's also possible that better diets and medical care is resulting in babies being born now that otherwise might have resulted in miscarriage 50 or 100 years ago, so we are seeing more babies with problems now than ever before.
Medical care has made it possible to delay death for much longer, but I'm not convinced that on balance the developed world's diet is better than it was 80 years ago, and certainly health isn't or allergy, asthma, cancer rates etc. wouldn't have risen so much. Unless you eat organic you can eat what your grandparents did when they were growing up and get a fraction of some of the nutrients they did and a lot more hormones and antibiotics etc., due to a lack of crop rotation and other practices.

However I do think fertility treatment and improved post-natal emergency care (not that you could justify withholding the latter) may be contributing to the problem for the reason you describe. Pre- and post-natal problems are associated with ADHD and LDs. There are also lifestyle links to infertility and in some cases the woman may be infertile for a reason that also makes her body a less than ideal place for a human to have to develop.

I had all the routine vaccinations back in olden times (I'm a baby boomer), when thimersal was used extensively and we had lead-painted cribs and toys. I also have amalgam fillings. I also remember when thimersol was in my contact lens solution. Finally, I really was born in Roswell. I don't have ADHD, ASD, or extra limbs. But I may be an alien. :D

SOME vaccines aren't made with mercury anymoreWhich vaccines are still made with mercury?

they are still made with other metals which can also be toxic.Which other metals do vaccines contain?

I know where this is going and the mercury in both is inert and therefore isnt capable of causing autism, adhd or to grow and extra limb. Ask a bio chemist and they'll explain it to you.

This is as real as UFOs, Bigfoot, crop circles and the federal agents that hide in my bushes.Bigfoot isn't real? :confused: :o

Know you weren't asking me but hope you don't mind.
Which vaccines are still made with mercury?The flu vaccine, and some other adult and non-routine childhood ones. I don't know if every brand of the flu vaccine is though, I can't remember, you'd have to ask a clinic offering them.

Which other metals do vaccines contain?The only one I'm aware of is aluminum. I've seen it claimed that the presence of aluminum makes mercury more toxic, as does the presence of testosterone (which according to the theory may explain why boys and especially boys with high levels of testosterone are more likely to have autism and possibly ADHD). Doctors are not supposed to give vaccines to people on antibiotics either (at least not here in the UK) yet many people are on a constant stream of antibiotics whether they know it or not, from their water supply and dairy products, to an extent that they weren't earlier in the century.

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As for the mercury (thimerosal) being inert, I don't know of research either supporting or denying that, but I know it's disputed, with some saying it's worse than inorganic mercury:

http://uk.youtube.com/watch?v=4zJrkPJXAh0

So amalgam fillings + vaccines don't have a direct link to causation of ASD and ADHD, but an "indirect link" for causation has been established?

I personally don't know. I have Asperger + ADD. My mother has ADD and, it could be argued, some latent traits of Asperger. My father has Asperger traits. My mother's brother is undeniably PDD. My father has two brothers who exhibit traits of Asperger and/or ADD.

Is everyone really ready to say that genetics being the primary causation is too narrow, and start saying that the environment is really making "subclinical" cases of these disorders into the real deal? That's what I see from some of you, in this thread. And personally, I don't like it.

I'm surprised no one's posted this:

http://www.fda.gov/CBER/vaccine/thimerosal.htm

As for amalgam, one of the clinics in our city is conducting a clinical trial looking for allergic reactions connected with amalgam, so there is some valid question for it's continued use and it's effect on some individuals. But, that's allergies, not ADHD.

I'm surprised no one's posted this:

http://www.fda.gov/CBER/vaccine/thimerosal.htm

As for amalgam, one of the clinics in our city is conducting a clinical trial looking for allergic reactions connected with amalgam, so there is some valid question for it's continued use and it's effect on some individuals. But, that's allergies, not ADHD.

Thanks for providing the link. From that link - there's a chart that shows which preservatives are commonly used in particular vaccines. The vaccine for DiptheriaTetnus/Pertussis is commonly preserved with 2-phenoxyethanol. It is also used in the IPV vaccine given in combination with HiB vaccine at around 15 to 18 months.

I did a Google for that stuff and found this:

2-Phenoxyethanol (2-PE) is a chemical substance presently used as a preservative in several vaccines. 2-PE contains phenol, which has the ability to inhibit phagocyte activity, meaning it is toxic to all cells. The phenol in 2-PE is capable of disabling the immune system's primary response mechanism. It can also cause systemic poisoning, headache, shock, weakness, convulsions, kidney damage, cardiac failure, kidney failure, or death. 2-PE also contains ethylene oxide, which is an irritant causing dermatitis, burns, blisters, and eczema.
from: http://www.vaccinetruth.org/2-phenoxyethanol.htm (http://www.vaccinetruth.org/2-phenoxyethanol.htm)


So is that better than mercury? The more I learn about the toxins and chemicals that are going into these vaccines that we are supposed to give to our infants and ourselves, the less reassured I am.

According to that chart there is still one manufacturer that admits they are still using thimerosal as a preservative in the combination vaccine TT that is given to infants. However there seems to be some doubt that the pharmaceutical companies are being completely honest about removing themerosol completely from some vaccines even though their package inserts claim there isn't any mercury in the vaccine.

The following chart shows quite a few vaccines which still are being made with thimerosol as a preservative. In fact, almost half of the vaccines listed there still contain some thimerosol.


This website... http://www.incrediblehorizons.com/toxicity%20&%20Autistic-symtoms.chelating.htm ... posits the theory that maybe not all of the kids who seem to have autism actually do - they may have toxic heavy metal poisoning, along with the rest of the population:


The symptoms of toxic heavy metal poisoning and the symptoms of autism, PDD, Aspergers, & ADD/ ADHD are very similar. Toxic metals could be the cause of those symptoms. Memory loss, increased allergic reactions, high blood pressure, depression, mood swings, irritability, poor concentration, aggressive behavior, sleep disabilities, fatigue, speech disorders, high blood pressure, cholesterol, triglycerides, vascular occlusion, neuropathy, autoimmune diseases, and chronic fatigue are just some of the many conditions resulting from exposure to toxins.

Heavy metals originate within the Earth. However, we have opened Pandora’s Box by spreading these toxic metals throughout our environment. As levels rise in our air, water, and topsoil, they also rise within our bodies, contributing to chronic diseases, learning disorders, cancer, dementia, and premature aging.



I've said it before, and plenty of others are saying the same thing - we don't like being put in a position of only having two choices: expose our children to the risk of these deadly diseases -or- expose them to the chemical cocktails that are in vaccines.

I'm surprised no one's posted this:

http://www.fda.gov/CBER/vaccine/thimerosal.htm
That's the page of tables I was talking about. Scroll down and it shows you which vaccines have mercury, how much, and which don't. :)

It's worth noting that the FDA's policy allows them to review only those studies that are provided by the drug company soliciting approval. They don't demand to see any negative studies the company may have conducted about their product.

Edit: RE: Phenol. It's strange to me that wikipedia's page on phenol mentions among other things its use to kill people via injection in WWII concentration camps, yet fails to mention that it's still being injected into people today. I keep meaning to update that page and link to the FDA as a reference, to see how long it stays there. :D

I would just like to point out that, as a whole, we (in first and second world countries) are the healthiest generation of human beings to have ever existed. This is thanks mostly to the effective elimination of malnutrition in these countries. The biggest health risks we face today are the same ones we've faced for our entire existence as a species. We have always suffered from cancers (as do all complex organisms), and we have always suffered from cardiovascular related diseases.

I didn't realize that vaccines were different in Canada and the U.S.A. This is from Health Canada. (http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/misconception-eng.php)

Misconception: Vaccines contain toxic substances.
The Facts: Every batch of vaccine in Canada is tested for safety and quality before it is released for public use. The main ingredient in most vaccines is the killed or weakened germ (virus or bacterium), which stimulates the immune system to recognize and prevent future disease. Some vaccines also contain extremely small amounts of preservatives or antibiotics to prevent bacterial growth. One preservative called thimerosal received a lot of attention in the U.S. in 1999 because it contains a tiny amount of mercury and was used in some childhood vaccines. A review conducted by an independent panel of the U.S. Institute of Medicine found no evidence that the tiny amount of mercury in childhood vaccines causes damage to a child's nervous system.
In Canada, the only routine vaccine for children that contains thimerosal is the hepatitis <acronym>B</acronym> vaccine. A new generation of hepatitis <acronym>B</acronym> vaccine products with no thimerosal added as a preservative is now available.

The problem is that science has not yet found a direct link for causation of autism or ADHD by these environmental toxins.

Until that happens, people will be skeptical, especially some of us who have the conditions. For example, in my last post here, I documented how several people in my family have the same condition. Seems to be strong evidence for genetics, IMHO.

And lastly, and I think this is universal: Generally, people do not enjoy hearing that their neurological status is due to "damage."

Both sides are so firmly entrenched in this arguement there is no way to even argue about it. Its on par with a religious arguement between the pope and richard dawkins.

That would be a fabulous thunderdome style deathmatch although i'd throw noam chomsky into the mix for comedy.

The problem is that science has not yet found a direct link for causation of autism or ADHD by these environmental toxins.

Until that happens, people will be skeptical, especially some of us who have the conditions. For example, in my last post here, I documented how several people in my family have the same condition. Seems to be strong evidence for genetics, IMHO.

And lastly, and I think this is universal: Generally, people do not enjoy hearing that their neurological status is due to "damage."

I have not claimed that there is any link (direct or otherwise) between toxins present in our diets and our environment and the causation of neurological disorders. I have simply raised the question of the possibility. I really don't see why asking the question should lead to someone being so upset with me that they would leave me anonymous "nastygrams" via the rep system.

I've engaged in other discussions about the genetic link for these disorders and admitted that we have many instances in my own family - cousins and second cousins and such. However, even a proven genetic link for ASD and ADHD and BiPolar and other neurological disorders does not eliminate the possibility that we might not have as many instances or that they might not be as severe if not for the environmental toxins that we are bombarded with.

I would actually be happy to find out why there is such variation in neurological status and whether or not any of it can be linked to environmental causes - without using the label "damaged". I have often said that I have ADD... Attention Differential Diagnosis rather than the inaccurate (in my opinion) "Deficit Disorder".

The problem is that science has not yet found a direct link for causation of autism or ADHD by these environmental toxins.
Depends what science (and pseudo-science, such as the shameful Danish study (http://www.whale.to/a/danish.html)) you're talking about.

For example, in my last post here, I documented how several people in my family have the same condition. Seems to be strong evidence for genetics, IMHO.
The video I linked to mentioned the genetic issue, enough to draw attention to how genes don't rule out an environmental cause. Some of the genes involved, at least in autism, may be genes that impair mercury excretion. Therefore, having those genes would not cause autism if there were no mercury exposure. Just as having the genes for lactose intolerance won't lead to you having any stomach cramps, or eventually, weight loss and slowed growth, unless you are first exposed to lactose. Lactose intolerance is genetic but the associated symptoms are entirely absent without a certain environmental trigger, and this may be the case for autism.

And lastly, and I think this is universal: Generally, people do not enjoy hearing that their neurological status is due to "damage."
Of course not, but reality doesn't care what we enjoy and won't change to suit us. I don't enjoy the thought either; it makes me sick to my stomach. However I also believe the maxims 'deal with reality or reality will deal with you' and the more uplifting 'the truth will set you free'. Ignorance may be blissful but is unproductive. This is a section for scientific discussions and as such, feelings are irrelevant. Now I really do sound like Dawkins.

Depends what science (and pseudo-science, such as the shameful Danish study (http://www.whale.to/a/danish.html)) you're talking about.


The video I linked to mentioned the genetic issue, enough to draw attention to how genes don't rule out an environmental cause. Some of the genes involved, at least in autism, may be genes that impair mercury excretion. Therefore, having those genes would not cause autism if there were no mercury exposure. Just as having the genes for lactose intolerance won't lead to you having any stomach cramps, or eventually, weight loss and slowed growth, unless you are first exposed to lactose. Lactose intolerance is genetic but the associated symptoms are entirely absent without a certain environmental trigger, and this may be the case for autism.


Of course not, but reality doesn't care what we enjoy and won't change to suit us. I don't enjoy the thought either; it makes me sick to my stomach. However I also believe the maxims 'deal with reality or reality will deal with you' and the more uplifting 'the truth will set you free'. Ignorance may be blissful but is unproductive. This is a section for scientific discussions and as such, feelings are irrelevant. Now I really do sound like Dawkins.

I was giving my two cents and I happen to have feelings about the subject. This is a public forum and there is no stipulation here that emotions cannot be expressed in the Scientific forum. Okay, yes, that is "just stating the obvious."

But what's it to me? You keep insisting on mercury/vaccine links to various conditions that people on this forum have--is it any wonder no one in this thread wants to debate with you?

I'm not one to think of popularity first, and truth second; but your quest to expose this "neurodiversity=neurodamage" conspiracy is not conducive to hard evidence, first, and second, not conducive to weakening "anti-neurodiverse" campaigns like Autism Speaks.

If you want to put a good foot forward for helping autistic people, it won't be by spreading these demeaning theories that have been explored, time and time again, without conclusive proof.

If you want to put a good foot forward for helping autistic people, it won't be by spreading these demeaning theories that have been explored, time and time again, without conclusive proof.I just had a conversation with my mother who was upset that parents stubbornly refuse to seek a diagnosis for their children and try medication, if necessary. The only thing I could think to say to her is that some people are dumb, as in, not all of us are as smart as the next guy. It's easy to forget that not everyone has the ability to "get" things. When I remember this fact, it takes the emotion out of the situation.

But what's it to me? You keep insisting on mercury/vaccine links to various conditions that people on this forum have--is it any wonder no one in this thread wants to debate with you?
Yes, actually, it's not just a wonder, it's absolutey amazing to me. I have ADHD too you know. I hate it. That's why I want to look into these things. I am always surprised that there is reluctance from some people who actually have these conditions to consider the possibility that it may not be purely genetic, even though the medical establishment itself doesn't believe it's all genetic, as twin studies fairly conclusively prove that it isn't.

I'm not one to think of popularity first, and truth second; but your quest to expose this "neurodiversity=neurodamage" conspiracy is not conducive to hard evidence, first, and second, not conducive to weakening "anti-neurodiverse" campaigns like Autism Speaks.
I simply disagree about the first. As for the second, again, science is not obligated to serve anyone's personal/political agenda. In fact if studies are designed to do so, they're not classed as science at all. Any science worthy of the name will ignore the petty semantic squabbles between the autismspeaks crowd and the ND-movement and explore all promising avenues of objective facts without bias.

I just want to know what causes these conditions, and especially, what is likely to have caused mine. Is it so much to ask that other people's hurt feelings don't trump my or anyone else's right to the chance of new health care options, and opportunity to make an informed decision about how to avoid inflicting the traits we hate so much on to any children we may have? That's what will happen if scientists choose to study and conclude according to 'what will shut up the autismspeaks crowd' and that's why I don't intend to let little known information remain little known for the sake of vested interests.

The problem is that science has not yet found a direct link for causation of autism or ADHD by these environmental toxins.
The thread is about mercury, but I must point out that even the GlaxoSmithKline-sponsored webmd (http://www.webmd.com/add-adhd/guide/attention-deficit-hyperactivity-disorder-adhd-cause) disagrees with that. A quick google of 'ADHD causes' would demonstrate how very mainstream and undisputed it is that certain environmental toxins (cigarette smoke and alcohol exposure during pregnancy, and high lead levels) contribute to ADHD risk and associated problems, like disruptive classroom behaviour, low academic achievement and crime. Lead poisoning studies are especially interesting.

The thread is about mercury, but I must point out that even the GlaxoSmithKline-sponsored webmd (http://www.webmd.com/add-adhd/guide/attention-deficit-hyperactivity-disorder-adhd-cause) disagrees with that. A quick google of 'ADHD causes' would demonstrate how very mainstream and undisputed it is that certain environmental toxins (cigarette smoke and alcohol exposure during pregnancy, and high lead levels) contribute to ADHD risk and associated problems, like disruptive classroom behaviour, low academic achievement and crime. Lead poisoning studies are especially interesting.

Thank you. I've been getting all these red karma points for suggesting that with so many environmental toxins affecting us in ways that haven't been scientifically docomented - at least not all of them, not yet - that it seems foolish to me to categorically deny that mercury in vaccines could cause some kind of a negative reaction. All these pharmacuetical drugs are certainly making life easier and healthier for us, but when the list of recorded side effects is often longer than the information on what the drug helps with, I have to wonder if the risk is reasonable.

I simply disagree about the first. As for the second, again, science is not obligated to serve anyone's personal/political agenda. In fact if studies are designed to do so, they're not classed as science at all. Any science worthy of the name will ignore the petty semantic squabbles between the autismspeaks crowd and the ND-movement and explore all promising avenues of objective facts without bias.Excellent point.

Yes, actually, it's not just a wonder, it's absolutey amazing to me. I have ADHD too you know. I hate it. That's why I want to look into these things. I am always surprised that there is reluctance from some people who actually have these conditions to consider the possibility that it may not be purely genetic, even though the medical establishment itself doesn't believe it's all genetic, as twin studies fairly conclusively prove that it isn't.I would be interested in information from twin studies, if you would like to share. That's interesting considering that if a child has a parent and a sibling with ADHD, the chances of the child having ADHD are very high.

Roseblood: so you don't have a parent or grandparent with any ADHD symptoms? Interesting. I can see why you would want to find out where yours came from.

vaccination is very important thing for now a days because the world is polluting very much.I want to say thanks to all scientists who discovered the vaccines.
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Have we discussed the fact that a Tuna fish sandwich contains more mercury than a single vaccination yet?

All these pharmacuetical drugs are certainly making life easier and healthier for us, but when the list of recorded side effects is often longer than the information on what the drug helps with, I have to wonder if the risk is reasonable.

Quick fact: Side effect lists have a limited relationship with reality. It is impossible, for example, for a sterile medication to cause you to contract a bacterial or viral infection. And yet, many medications list side effects such as colds, flu, and related illnesses. The simple reason is that anything which happens to patients while trialing a drug is considered a side effect. After all, it is impossible to prove that the medication did not cause a head cold.

The length of a side effects list is an unreliable measure of how dangerous a medication may be.

Blueroo, thanks for the reality check. We need more of those.

First the illuminati and lizard men from the hollow earth are putting mercury in our vacines and now in our tuna? Have they no morals.

Have we discussed the fact that a Tuna fish sandwich contains more mercury than a single vaccination yet?


If testing ever shows a definate coorelation between murcury/thimerosol and Autism etc, then that would be included in the diet and environmental factors I have mentioned.

At one time "refrigerator mothers" were blamed for causing Autism in their children. I do hope that in time we can know for sure that our doctors and our mandated health measures are just as blameless. Until then I cannot and do not say what causes Autism, I only ask questions.

The heavy metal connection IS kinda interesting though...

Let me review:

1988-1990 I was working in a lab at the Pediatric research institute of the National hospital of Oslo, Norway, together with Karl Ludvig Reichelt, a pediatric researcher and neurochemist.

My research objective was some urinary peptides from kids with ADHD.
One of these peptides (small chains of amino acids) seemed to stimulate serotonine uptake in blood platelets. I was trying to confirm this in the blind.

It it known that people with ADHD have some serotonine irregularities.

My experiments showed that in fact one of the peptides found in the urine of many ADHD-kids DO stimulate serotonine uptake in the platelets!


Later (1999) Reichelt together with Pedersen reconfirmed this, and a publication was made.

So... the peptide was there, but where did it come from?

Reichelt suspected it came from foods, milk especially. (Caseomorphins) Later also gluten peptides has been in focus.

So a theory was that some people cannot break down milk protein (casein) and gluten properly, with the result of peptides from the gut sneaking into the bloodstream and even crossing the blood-brain barrier.

We strongly suspected a peptidase (enzyme that breaks down proteins and/or peptide chains) deficiency, as has been confirmed.

What causes this enzyme deficiency then? Here the theories are many, from genetics to environmental factors.

Or a combination.

Then in 2005 Reichelt published a paper on the AWARES-conference (autist spectrum net conference).
In this paper he confirms heavy metals as a possible factor for inhibiting these very enzymes!



So the link is possible:
Mercury (or lead) can inhibit an enzyme ( a certain peptidase) so it will not break down certain proline-rich peptides in the intestines!


These peptides can have different lengths and effects. So we have the "ADHD-peptide", the "autism-peptides", the "schizophrenic peptides" and so on.

Interesting fact is that a diet free of gluten and milk often "cures" these states .... ho ho ho!
Not onle does the strange hyperpeptiduria (great amounts of the peptides in the urine) disappear. At the same time the symptoms of ADHD, autism, "schizophrenia" and so on ALSO disappear!

Quite a few of these peptides have effect on the morphine receptors. They are called opioid peptides, and can originate from (milk protein) casein, gluten, egg, soy, spinach. Most usual casein and gluten.

Funny thing is we get addicted to these foods because of the morphine-receptor binding. So we even over-consume!


The peptides resemble endorphines (opioids made in the body).
They are often named exorphines. (originated from outside the body).

Very interesting field I assure you!

Choetso, thank you very much for that information. Would it be possible to post links to the publications you mentioned if they are available? You explained the mechanisms of how this works very well, thank you for posting this, and welcome aboard the forums.

Nice you appreciate my posting...
Yes, I will try to post the links or even the publications. Might take some time as I dont have it on hand.

I pasted in a link and a quote, below, about vaccination and autism. It's well referenced and indicates the reported cases are likely coincidence.

But, here's a digression (how ADD is that?)

I teach critical thinking and one of the biggest traps in human culture is acceptance of causal fallacies. Just because something happened BEFORE something doesn't mean it CAUSED something. Our brains are wired to build these associations for us automatically through a process of classical conditioning. This was a survival trait. If noticed you barfed after eating the curly mushroom and avoided curly mushrooms in the future, you lived to have children. Most of us come from a long line of people who lived long enough to have children. (Unless you were born near Roswell in the 40s.)

A by product of this learning is that we tend to see relationships that AREN't there. This is likely because you had a better chance of living to have children if you accidentally made the mistake of thinking something OK was bad rather than thinking something bad was OK. This may be what's happening with the vaccination and lead filling scare.

Causal fallacies are rampant in pop medicine and repeated over and over on the web.

My hair is started turning gray since I bought my Honda Accord in 1994; therefor my Honda caused my hair to turn gray! I was diagnosed with GAD, OCD, and ADD after I bought my Prius; therefore ... Priuses' cause GAD, OCD, andADD. Nailgun injuries are increasing at the same speed as Hybrid sales. Let's ban nailguns! etc etc etc.

Millions of children received vaccines WITHOUT getting autism. In addition, the sample size in the first study that posited vaccines as a problem was 12 children and may have been chosen by referral of patients already exhibiting symptoms. The people who ran the first 12 subject study later provided research that overturned their original proposed mechanism. If I'm reading this correctly, the best evidence is that ASD is passed on genetically.

Anyway, after my digression, here's the link and a quote:

http://www.quackwatch.org/03HealthPromotion/immu/autism.html

And here is the quote:
Some parents of children with autism believe that there is a link between measles, mumps, rubella (MMR) vaccine and autism. However, there is no sensible reason to believe that any vaccine can cause autism or any kind of behavioral disorder.

Typically, symptoms of autism are first noted by parents as their child begins to have difficulty with delays in speaking after age one. MMR vaccine is first given to children at 12-15 months of age. Since this is also an age when autism commonly becomes apparent, it is not surprising that autism follows MMR immunization in some cases. However, by far the most logical explanation is coincidence, not cause-and-effect.

If measles vaccine or any other vaccine causes autism, it would have to be a very rare occurrence, because millions of children have received vaccines without ill health effects. The only "evidence" linking MMR vaccine and autism was published in the British journal Lancet in 1998 [5]. An editorial published in the same issue, however, discussed concerns about the validity of the study [6]. Based on data from 12 patients, Dr. Andrew Wakefield (a British gastroenterologist) and colleagues speculated that MMR vaccine may have been the possible cause of bowel problems which led to a decreased absorption of essential vitamins and nutrients which resulted in developmental disorders like autism. No scientific analyses were reported, however, to substantiate the theory. Whether this series of 12 cases represent an unusual or unique clinical syndrome is difficult to judge without knowing the size of the patient population and time period over which the cases were identified. If there happened to be selective referral of patients with autism to the researchers' practice, for example, the reported case series may simply reflect such referral bias. Moreover, the theory that autism may be caused by poor absorption of nutrients due to bowel inflammation is senseless and is not supported by the clinical data. In at least 4 of the 12 cases, behavioral problems appeared before the onset of symptoms of inflammatory bowel disease. Furthermore, since publication of their original report in February of 1998, Wakefield and colleagues have published another study in which highly specific laboratory assays in patients with inflammatory bowel disease, the posited mechanism for autism after MMR vaccination, were negative for measles virus [7,8].
I remain skeptical.

These peptides can have different lengths and effects. So we have the "ADHD-peptide", the "autism-peptides", the "schizophrenic peptides" and so on.

Interesting fact is that a diet free of gluten and milk often "cures" these states .... ho ho ho!
Not onle does the strange hyperpeptiduria (great amounts of the peptides in the urine) disappear. At the same time the symptoms of ADHD, autism, "schizophrenia" and so on ALSO disappear!I know children and adults who are on gluten free and/or casein free diets, but they still have symptoms of Autism and ADHD. Does this mean they are doing something wrong?

So, similar to the way Native Americans lack the enzymes to properly digest milk, it could also be genetic that some people lack the enzymes or something to break down milk and wheat products, resulting in what looks like a family history of neurological disorders, eh?

There may be several reasons that a person on a casein/gluten free diet still exhibit symptoms of autism/ADHD.

One very obvious reason:
Not all autists/ADHDs have these peptides. The problem lies elsewhere, so to speak. It then helps nothing to remove casein/gluten.

Also there are other foodstuffs that can give opioid peptides, namely
eggs, soy, spinach and possibly others we don't know about yet.

The proper method is to first take a urine analysis to confirm the peptides are there, and which foodstuffs are involved. This is not at all so easy, as many doctors have never heard of this.
Also not so many labs do the test, as it is a difficult one and requires expensive lab equipment (HPLC among other things)
Neurozym labs do these analyses in Norway (neurozym.com)
also KEAC in Holland.

Still, as many as 50% with ADHD and about 80% with autism benefit from diet.
Of course some symptoms may remain.

There may also be the case that the diet is not followed 100% . A little casein/gluten can make biiig problems.
And some manufacturers say their product is gluten-free, and still there is small amounts of gluten there!
"Naturally gluten free" is the best alternative for very sensitive persons.

Some can be helped by an enzyme mixture that will take care of small amounts of the offending protein.
I have never tried this enzyme mixture myself, but I know some very sensitive people like it a lot.
It can also help when you accidentally have eaten something you should have avoided.

It is very important that diet is followed (100%) at least three weeks, often six weeks, before the results are obvious. This is individual.

Some gluten peptides can remain in your system for as long as a year, but caseomorphines usually wash out in about a week.

I am working on a list of publications, links etc connected to this field of research. Might take some time ;-)

PS. Jaak Panksepp have interesting ideas too....
Like the importance of (rough&tumble) play for brain development. Rats that were not allowed to play rough&tumble for a couple of hours everyday, exhibited symptoms of ADHD. (off topic..)
Just to say milk&gluten is NOT the only factor involved.

But the theories of dr. Reichelt et al certainly sets the heavy metal theories in an interesting perspective.

To Lunacie: this is correct.
It may "run in the family" as enzymes are coded for by genes.

I know children and adults who are on gluten free and/or casein free diets, but they still have symptoms of Autism and ADHD. Does this mean they are doing something wrong?


It is unusual to know people that have autism and adhd that have followed a GFCF diet. Did they do this diet specifically FOR autism/ADHD, what kind of protocol did they follow and under what kind of physician or practioner? I have understood that it can take up to a year of GFCF (etc.) for the guts to fully heal and any results that are forthcoming to be observed, and that one particular protocol I am aware of takes on several phases and other diet changes/adustments as well. I would be interested if you would go into more detail about that either here in another thread, as I am really interested in knowing more about their experiences from you.

Here comes the paper Dr Reichelt presented on the 2005 AWARES conference.
As the conference is restricted area I post the article in full.
It is quite long and a bit unreadable, but it shows the heavy metal link...
I have "zoomed in" a bit on the relevant passages ;-)
There are a few good references at the bottom...

Still looking for the paper on the serotonine-stimulating peptide though.

Dr Karl Reichelt
University of Oslo, Norway:

Genetics, environment and autism and their interaction
Full paperThoughts on the genetics of autism.



The data on homozygous twins (identical twins) compared to heterozygous twins show that there is a genetic basis for autism (Bailey et al 1995;Folstein and Rutter 1977 )


It I also a fact that increasing evidence points to an increase way beyond a solely genetic explanation because genetic drift is not that fast. Furthermore the presence of peptides with the same bioactivity in the urine, but with different chain lengths ( Reichelt and Knivbsberg 2003 ) in different patients points to a very probable multigenetic disposition.

Notes on general genetics.
The DNA changes usually involve single base mutations, deletions of single and several bases can cause anything from polymorphism to inactivity of the proteins (enzymes including transport , structure proteins and channels).

Furthermore the extensive editing of mRNA(messenger RNA)where different exons are joined and expressed as proteins also causes polymorphism .

Furthermore crossing over phenomena (between different DNA strings ) can cause vast changes as well as adding bases (Repeat sequences as in Huntingtons chorea) .
Finally there is also protein editing with removal of sequences and rejoining of the protein chains. The regulation is further complicated by small RNS molecules(sRNA) that by binding to the genome changes expression.
E1 E2 E3 E4 E5
A---B---C---D---E---P
A---------------- I
A metabolic chain running from A to P (final product) can due to the genetic changes be blocked in any enzyme (E 1-5) .

If the polymorphic enzyme with lower activity or no activity is for instance E4 , then metabolites will increase proximal to this step and insufficient product distal to the block (E and, or P).
Because of the feedback inhibition of E to enzyme E2 this can result in a very rapid increase in some or all of the metabolites A to D.

Increase in any metabolite may open up secondary pathways like a dam overflowing into new drainage patterns.

If metabollite D or derivatives of D are toxic this compounds may possibly be reduced by several possible approaches:


1: Reducing the input A such as is done in phenyl-ketonuria by removing phenyl-alanine(Phe).

Here the reduced activity of polymorphic enzyme E1 (Hydroxylase) is counteracted by reducing phenyl-alanine in the diet.
In fact if the ingested proteins had contained much less Phe (only enough for protein synthesis) the disorder might never have been discovered.
Thus reduced enzyme activity may sometimes be made manifest only by overloading the enzyme.

A clearly genetic disease is made manifest by overloading the least efficient enzyme of the chain.

In many autistic persons reducing gluten and casein prevents the increase in glutemorphins and casomorphins and other peptides with bioactivities that have been found ( Hole et al 1979; Drysdale et al 1982; Shattock et al 1990; Reichelt et al 1991; Cade et al 2000).

For effect of diet see Knivsberg et al 2002;)


2: If the feed back inhibitory metabolite is known, supplying this compound may reduce the flow in the given pathway .
In the figure E inhbits the enzyme E2, thus limiting the flow in the pathway.



3: Many enzymes are dependent on cofactors often vitamins and trace minerals.

Therefore a low activity enzyme can be stimulated to reach a higher level of activity by supplying increased levels of these cofactors ( changing the Km values)( Ames et al 2002; Vieth 2001 ).

Furthermore simply by the law of mass action in chemistry increasing cofactors should push the reaction in the wanted direction.

Rimlands Mg and B6 double blind data(Rimland et al 1978) have thus been confirmed by several groups also double blind.(Barthelemy et al 1981; Le Lord et al 1981)


4: Removing increased metabolite ,may if low molecular be done by dialysis ;if a protein or if a macromolecule by plasmaphoresis.
This has been done in schizophenia (Wagemaker and Cade 1977 ) but many negative studies have been reported too( Fogelson et al 1980 ).

If the source of the peptide increase in schizophrenia is not removed or decreased the effect will be manifest in only a subgroup with more active enzymes and or lower intake of precursors.(Reichelt 1996)


5.Increasing the temperature 1 degree centigrade generally increases a metabolic rate by 10 % and can thus reduce accumulated compound.
This may explain the effect of fevers on some behavioural syndromes.


7 Some enzymes can be induced (new synthesis ) by specific metabolites.
Thus neuroleptics induce peptidases and decrease peptide levels in schizophrenia ( Davis and Colling –Berglund 1987; Koning et al 90; Konkoy et al 93).

Mutation in operator genes can by controlling multiple enzymes have awesome effects as seen I Rett syndrome , where mutations in the gene coding X-linked methyl-CpG-bidning protein 2(MECP-2) localized to chromosome Xq28 have been identified as cause in many Rett girls (Amir et al 1999; Bienvenu et al 2000)
From these deliberations is clear that a metabolic defect due to genetic changes is a challenge to all us, and not a case for defeatism .






Enzyme poisons especially Hg (mercury) and lead ( Pb) often inactivates key enzymes by binding to SH (Sulphydryl) groups on the enzyme.



If the enzyme is of low efficiency (or the low end of a polymorphic activity distribution), this can of course also cause at times complete block in some but not in those with very efficient enzyme.



Diaminopeptidase IV ,which splits the Tyrosine-Proline (Y-P) group form found in many exorphins.



Diaminopeptidase IV is also known as the immunologically important proteins CD 26 and adenosine deamidase binding protein, and is severely inhibited by Hg.

It is probably one of the key enzymes in autism , also subject to auto-antibodies( Vojdani et al 2003;Vojdani et al2004), which of course can block even a normal enzyme activity.


In those cases of schizophrenia and autism where increase peptide accumulation is found in many( Reichelt et al 182; Drysdale et al 1982;: Shattock et al 1990; Reichelt et al 199;Cade et al 2000; Reichelt et al 2003), this increase will itself inhibit peptidases as peptides in general are good competitive inhibitors of peptidases ( La Bella et al 1985) , thus establishing vicious circles.



Low peptidase leading to dietary peptide overload and increased uptake (Mahe et al 89 ) and by further inhibition etc.

In puberty some peptidases are further repressed by the increase in sex hormones (Griffiths 75) possibly explaining the outbreak of schizophenia in late puberty or post-puberty mostly ( Reichelt et al 1996 ).

Not specified opioid increase has been found also by others in schizophrenia and autism ( Lindstrom et al 86)


It should be noted that mutations do not only occur in the enzymes involved in pathway directly , but may occur in enzymes or proteins binding to any given enzyme.

Thus adenosine deamidase which binds to diaminopeptidase IV or CD 26, has been found to be a probable genetic marker in autism ( Persico et al 2000;Stubbs et al 82 ).


The heterogeneity of peptides excreted clearly points to a multi-gene
state, and because of recent fast increases in cases points to toxic interaction of environmental factors on polymorphic gene expression.

Thus if mercury binds to SH groups in diaminopeptidase IV(CD 26) , decreased activity is to be expected and also the induction of autoantibodies ( Vojdani et al 03;Vojdani o4 ) further inhibiting the enzyme. This is also indicated to take place by binding of peptides to surface proteins and induction of anti peptidase antibodies. (Vojdani et al 03).)


Conclusions: These examples for autism and schizophrenia and Phenylketonuria should show that epi-genetic effects on genetics is and can be profound.

Not only is the messenger RNA edited, but also proteins and these are furthermore modulated by sulfation, glycosylation and phosphorylation .


References:
Ames BN , Elson_Schwab I and Silver EA (2002) High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): relevance to genetic disease and polymorphisms . Am J Clin Nutr 75: 616-658.
Amir RE, Van den Veyver IB, Wan M, Tran CQ,Francke U and Zoghbi HY (1999) Rett syndrome is caused by mutation in X-linked MECP2 .encoding methyl-CpG-binding protein 2. Nature Genetics 23: 185-188
Bailey A ,Le Couteur A, , Gottesman I. Bolton P. et al ( 1995) Autism as a strongly genetic disorder: evidence from a British twin study .Psychol Med 25: 63-77
Barthelemy C, Garreau B, Leddet I, Ernouf D, Muh JP and Le Lord G (1981) Behavioral and biological effects of oral magnesium, vitamin B6, and combined magnesium-B6 administration in autistic children .Magnesium Bulletin 3: 150-153.
Bienvenu T, Carrie A, DeRoux N, Vinet M-C et al (2000) MeCP2 mutations account for most cases of typical forms of Rett syndrome.Human Molec. Gebet.9: 1377-1384.
Cade R; Privette M, Fregly M, Rowland N, Sun Z, Zele V, Wagemaker H and Edelstein C (1999) Autism and schizophrenia : Intestinal disorders. Nutr.Neuroscience 2: 57-72
Davis MH and Colling-berglund A(1987) Neuroleptic drug trteatment alters in vitro central neurotensin metabolism .Psychoneuroendocrinol 12: 253-260
Drysdale A, Deacon R,Lewis P,Olly S, Electricwala A and Sherwood R (1982) A peptide containing fraction of plasma of schizophrenic patients which binds to opiate receptors and induces hyperactivity in rats .Neurosci. 7: 1567-1574.
Fogelson DI, Marder SR and VanPutten T(1980) Dialyisis in schizophrenia :Review of clinical trials and implications for further research . Am J Pschiat 137:605-609
Folstein S and Rutter M (1977) Infantile autism: a genetic study of 21 pairs. J Child Psychol Psychiat 18: 297-331
Griffiths EC ( 1975) Peptidase inactivation of hypothalamic releasing hormones. Horm.Res 7: 179-191
Hole K ,Bergslien HA ,Jorgensen H , Berge O-G, Reichelt KL and Trygstad OE(1979) A peptide containing fraction in urine of schizophrenic patients which stimulates opiate receptors and inhibits dopamine uptake .Neurosci. 4: 1883-1893
Knivsberg A-M, Reichelt KL, Nodland M and Hoen T (1995) Autistic syndromes and diet: A follow -up study. Scand J Educat. Res. 39:223-236
Knivsberg A-M, Reichelt K.L., Hoien T and Nodland M (2002)A randomized , controlled study of dietary intervention in autistic syndromes. Nurtr. Neuroscience 5: 251-261
Koning PAL, Colling-Berglund A and Davis TP (1990) Chronic haloperidol and chlorpromazine treatment alters in vitro beta-andoprhin metabolism in rat brain.Eur J Pharmacol 97: 15-28
Konkoy SK, Oakes MG and Davis TP (10093) Chronic treatment with neuroleptics alters neutral endopeptidase 24.11 activity in rat brain regions. Peptides 14: 1017-1020.
La Bella F.L, Geigeer JD and Glavin GB(1985)Adminsitraton of peptides inhibit the degradation of endogenous peptides.The dilemma of distinguishing direct from indirect effects.Peptides 6: 645-660.
Le Boyer M, Bouvard MP, Racasens G ,Phillipe A, et al ( 1994)Difference between plasma N-and C-.terminal directed beta-endorphin immunereactivity in infantile autism. Am J psychiat 151: 1797-1801. Am J psychiat 151: 1797-1801
LeLord G, Muh JP, Barthelemy C, Martineau J, GarreauB et al (1981) Effects of pyridoxine and magnesium on autistic symptoms :initial observations J Aut. And develop Disorders 11: 219-230
Lucarelli S, Frediani T, Zingoni A, Ferruzzi F, Giardini O,.(1995)Food allergy and infantile autism. Panminerva Medica 37: 137-141
Mahe S, Tome D, Dumontier AM and Desjeux JF ( 1989) Absorption of intact morphiceptin by di-siopropylfluorophosphate –treated rabbit ileum. Peptides 10: 45-52
Persico Am, Militerni R , Bravaccio C et al (2000) Adenosine deaminase alleles and auatistic disorder:case-control and family-based association studies .Am. J Med genetics (Neuropsychiatric Genetics) 96: 784-790
Reichelt Kl ,, Knivsberg A-M, Lind G and Nodland M (1991) Probable etology and possible treatment of childhood autism.brain Dysfunct 4: 308-319
Reichelt KL, Seim AR , Reichelt WH (1996) Could schizophrenia be reasonably explained by Dohan’s hypothesis on genetic interaction with a dietary peptide overload? Prog. Neuro-Psychopharmacol & Biol Psychiat 20: 1083-1114
Reichelt K.L.(1996) Dialysis in schizophrenia;successful only in a subtype ? Schizophrenia Research 19: 223-224
Reichelt Kl and Knivsberg A-M(2003) Can the pathophysiology of autism be explained by the nature of the discovered urine peptides? Nutr Neurosci 6: 19-28.
Rimland B Callaway E and Dreyfus P (1978) The effects of high doses of vitamin B6 on autistic children : a double blind crossover study : ASm J psychait 135: 472-475
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To Lunacie: this is correct.
It may "run in the family" as enzymes are coded for by genes.

Yay Me! I finally understood something scientific correctly. ;)

It is unusual to know people that have autism and adhd that have followed a GFCF diet.That would depend upon your frame of reference. If you worked in the school system, you would have a larger frame of reference. According to the Canadian Celiac Association (http://www.celiac.ca/EnglishCCA/eceliac.html):
1 in 133 persons in Canada are affected by celiac disease - that makes it a pretty common autoimmune disorder.

Did they do this diet specifically FOR autism/ADHD, what kind of protocol did they follow and under what kind of physician or practioner?I know some parents who put their children on the gluten free diet because of celiac disease - some of them have also been diagnosed with Autism. I never thought to ask who the practioner was, but they are knowledgeable, intelligent people and I trust their judgment. I work with adults who have been diagnosed with celiac disease and talk about it at lunch time. I was told that if a child with celiac disease is diagnosed and treated early, they can prevent some of the damage caused by the disease. I also listen to a parent who is lactose intolerant and her daughter has celiac disease - how she juggled meal preparation all those years is beyond me.

I have understood that it can take up to a year of GFCF (etc.) for the guts to fully heal and any results that are forthcoming to be observed, and that one particular protocol I am aware of takes on several phases and other diet changes/adustments as well. I would be interested if you would go into more detail about that either here in another thread, as I am really interested in knowing more about their experiences from you.That sounds like work and I don't see parents often enough to quiz them. My co-worker is trying to persuade me to try the GF diet to see if it helps my arthritis and she is going to lend me a good book. I have promised her I will at least read the book.

I would recommend those on a GF diet still having problems with autism/ADHD to try also avoiding casein!
In 1990 we almost exclusivly worked on the casein track.
Gluten came a bit later as I remember. But I was very buzy with making and bringing up four children 1992-2003. Still am, in a sense, but now I try to find time for some research too.

But it is true that celiacics have more risk also for certain mental disorders.

As for arthritis... funny you should mention that.
A norwegian guy named Stein Julius Tørrkvist(50) told his story on the state radio (NRK) in 2005. He had been depressed most of his life, and also had grave arthritis.. so much pain...
And just as he had chosen to end his life, a friend of his recommended paleolithic diet (which by the way is free of both gluten and dairy products.)
He woke up after two days on the diet... no pain!

This made me think. As I myself had growing pains in my joints, to the point of not getting up from my bed in the morning...
And depressions, mood swings... And always I have felt a bit akward sosially...
So I tried diet too!
Next morning: no pain!
And my life gradually transformed...

Really funny, as I have been doing research on this for so long, and never suspected myself to be a victim of these same protein intolerances ;-)
Karmic attraction the buddhists would call it...

I get the feeling (from diet breaks) that it is gluten that makes the joints ache. This is purely personal observations though.

Ooo, almost forgot.
Lactose intolerance is something completely different.
It won't help to go lactose-free, as it is the casein (milk protein) and not the lactose (milk sugar) that makes the problems in autism/ADHD. As far as I know.

So. Then.

IF it is the heavy metals that inhibit the enzymes (for some of us! not all!), making it impossible to break down proteins like gluten and casein properly, resulting in neuroactive peptides (exorphines) muddling our brain signal systems..... where do we go from there?

Of course it is an option (and a comparatively easy one I assure you) to go on diet free of these proteins.
Or put digestive enzymes in the food.
Or dialysis of the peptides.

But still, the heavy metals are there. Maybe having other detrimental effects on the system that we don't even know of yet.

Hg and Pb can interfere with more enzymes than the peptidases!
The proper thing would of course be getting rid of the heavy metals themselves!

Any suggestions how?
Chelation is NOT my favorite method, as it removes also other important minerals from the body.

Removing amalgam fillings is of course a start.
But these heavy metals have a tendency to cling very hard to proteins and they are extremely difficult to get rid of.

Homeopathic remedies may work. But I have seen no research on this.
Anyone tried homepathic Hg to remove the remaining quicksilver from the system? I would sure like to try it, but it's of no use (just now) since I still have two amalgam fillings left in my teeth...

Here is a resumé of Reichelts paper on the serotonin uptake-stimulating peptide from ADHD.

World J Biol Psychiatry. 2001 Jul;2(3):144-8.
A serotonin uptake-stimulating tetra-peptide found in urines from ADHD children.
Liu Y, Reichelt KL.
Department of Pediatric Research, Rikshospitalet, Oslo, Norway.

A tetra-peptide has been isolated from the urines of children with Attention Deficit Hyperactivity Disorder (ADHD) that we could not find in control urines. The tetra-peptide (G-S-E-N) stimulates the uptake of serotonin into platelets. The peptide may explain why serotonin is increased in platelets of ADHD children.
PMID: 12587197 [PubMed - indexed for MEDLINE]

For the benefit of you who REALLY want to dig into the research on dietary intervention, I post this link.
It has a list of research papers (hundreds of them...) on the theme, and is very useful for the interested.

http://gfcf-diet.talkaboutcuringautism.org/dietary-research-in-asd.htm

That sounds like work and I don't see parents often enough to quiz them. My co-worker is trying to persuade me to try the GF diet to see if it helps my arthritis and she is going to lend me a good book. I have promised her I will at least read the book.

When we suspected that my granddaughter might have Celiac's we tried going gluten free for a couple of months - and it was very difficult for us. We're still not sure whether eliminating fruit and juice (especially citrus) made the difference in her bowels or whether she simply outgrew a stage. But since her stools had been very soft and often runny for six years at the time, I feel pretty confident that it was eliminating the fruits. We have added them back in one at a time, and unless she OD's on fruit or juice she is still good with the bowel issues.

gluten
to nourish embryonic plants during germination

casein
- the animal equivalent to gluten

proteins ->- involved ->- in development/growth

We have two basic systems

growth and maintenance (metabolism)

an example
(used previously on site)
- insulin

with separate growth and metabolic properties

eg google s/t(s) [growth metabolic insulin IGF]
#2
Insulin Through the Ages: Phylogeny of a growth Promoting and Metabolic ...
Here we briefly review the structure and function of the insulin/IGF gene family
... icb.oxfordjournals.org/cgi/content/full/40/2/213


Arthritis is generally considered a disease of older age -
when maintenance (metabolism) and not growth characteristics are expected.

Autoimmune disorders (with nod to cancer) - are caused by over-exuberant growth characteristics -
- in the case of autoimmunity
- unwelcome expansion in immune cell numbers triggered by 'self'

Over exuberant growth when only maintenance (metabolism) pathways should be recruited.

And foods (casein,gluten) which are associated with growth and development -
being connected to diseases of over-exuberant growth
--- here ---

eminently possible -

the suggestion that our diet is not changing as we need it to change as we age -
- and we're pre-disposing ourselves to auto-immunity and cancer by failing to recognize that we're eating ourselves into an early painful grave.

And the mechanism ?

how about some hormonal component of {milk / endosperm} which is running antagonistically against the transition from

growth ->- maintenance (metabolism)

And that would be ?

Attempt I


Gluten exorphines are a group of opioid peptides which are formed during digestion of the gluten protein.

Casein has been documented to break down in the stomach to produce the peptide casomorphin, an opioid that acts as a histamine releaser.

POMC
- an enigmatic player in our endocrine system
pro-opioidmelanocortin

speedball characteristics

neural.........................-> <- endocrine
dopamine.....................-> <- endorphin

amphetamine/cocaine....-> <- morphine/heroine

speed up......................-> <- slow down

the duality of speed up versus slow down
- represents a kinda' balancing act in which one system follows the other -
and the other chases its partner also

At set-point when both duals have developed to optimal strengths and balance -
when duals form duality

presumably

ingestion of foodstuffs which the life form (us) -
no longer need
(a legacy desire to eat
- at least certain feeds) -

- gluten and casein appear to be two of these

digestion leading to opioids which upset a balance which has been set.

-*-

Great suggestion -
a remarkably credible association -
we're forcing a 'growth' context upon a system which is set to run on a steady-state maintenance (metabolism) trajectory.

the following reference is certainly consistent

enterolab/Faq (https://www.enterolab.com/StaticPages/Faq_Result_Interpretation.htm)

While formal studies of dairy-free diets, either alone or in combination with gluten-free, have not yet been conducted on a wide scale, the idea of a gluten-free/casein-free diet is not new, having been employed for decades by many health practitioners. From my objective assessment of this field, and my personal experience with my own dietary elimination for health, I recommend complete avoidance of all dairy products in anyone found to be immunologically sensitive to cow's milk protein by our tests, and anyone with an established autoimmune or chronic immune disease. I predict future research will support this recommendation. Do not bury your head in the sand waiting for such studies. Do your own study and go gluten-free/dairy-free.

What can affect man ?

the components present within

Physical factors - effects on body

Food --->
Air ----->
Water -->

pollution (for whatever reason)
from industrial waste to eating physiologically unfriendly food-stuffs

Mental factors - effects on mind

A polluted global mental workspace which enforces
'avoir 'over' e^tre'

Point

Pollution of both physical and mental domains of man occur through
(i) the desire/need to make money
and
(ii) the weakness of man in giving into legacy desires
(desires for products which (may or may not have achieved his conscious awareness) ... ...
products
... which ... are bad for him -

aware in the case of drugs of addiction (not that the awareness helps change behaviour when addicted)
- and less likely in the case of casein- and gluten- enriched foodstuffs).

Food allergies would make sense under this general concept -
for sure food allergies, allergies to pollen and auto-immune disorders appear pretty stupid for a process of nature which seems to be doing pretty well -
more likely -
- and as we're finding -
it's our instantiation of a process of nature which was maturing in its understanding of the process of nature which laid it in place -
nature isn't dumb
- we however were
(or are)
(... ... ... or sumptin')

Since
(i) the desire/need to make money
as prime example of a
(ii) legacy desire

- it may be removed from a summary of this idea -

-------------------------------------------------------------------------------------------------------------------------------------------------

Summary

Pollution of both physical and mental domains of man occur through

the weakness of man in (potentially unwittingly though nevertheless) giving into legacy desires

-------------------------------------------------------------------------------------------------------------------------------------------------

(we are in the process of defining those legacy desires -
- the solution will deliver our optimal physical and mental needs -
and meeting our optimal requirements
(on a one world level) -
will not permit the atrocitie$ over money which we have seen)

money is bad -
- it panders to our nastier side.

- it may be removed from a summary of this idea -
though with explicit statement that money is the chief engineer of the pollution of our physical and mental body and mindspaces -
the agent which our alluring inner evolutionary demons use to prevent our higher selves from gaining a foothold

money
- an agent which rather than being subservient to instinct -
has rather gained a life of its own and fixed itself
(or so it would like to belief)
as rationale within the 'things we do' -

- more stories (these days) of people eager to withdraw from curren$y-backed incarceration than enjoy the ??? pleasures ??? of materialism
->- There are no pleasures in materialism

freedom
from
worldly
desires

implies

materialism
................immaterial
immaterialism
................matterin'

->-

The information age

Dayvan Cowboy
Campfire Headphase

casein
Quote:
- the animal equivalent to glutendid you know in Australia we make KNITTING NEEDLES out of Casein ;)
Try telling customers their nice new knitting needles are made out of plasticized milk. I did recommend they don't use them to stir their cups of tea..

click here (http://www.arnos.com.au/swallow/home.html)

hmmm...

:-)

casein hardens

gluten, endosperm, starch hardens

arteries harden (with age) - atherosclerosis kills.

Starching our arteries would (all things considered) appear unwise given the consequences.

I'm not sure how we got onto milk protein and casien, but I can bottom line it, cow's milk is another species' milk, and as a human race, we have not evolved along to completely tolerate it the way calves are meant to. No wonder. Waddya think'd happen if them calves drank human milk, eh? :-)

I am afraid it was me setting the thread off in a casein/gluten direction.

;-)

This was caused by the relationships showed in Reichelts paper:

Mercury/lead (possibly from vaccines and/or amalgam fillings) CAN inhibit an enzyme that was supposed to break down opioid peptides originating from casein and/or gluten.

The peptides are then NOT broken down properly, and will eventually even show up in the urine. (Hyperpeptidurea)

These hyperpeptiduric conditions are in turn HEAVILY connected with ::
Autism, ADHD, "schizophrenia", "endogenic"depressions and even migraine, arthritis, MS, tiredness beyond normal, exhaustion symtoms etc etc...

So there WAS a clear link to the start of the thread, but then it trailed off a bit into the realms of gluten/casein generally and so on.

I suggest we start a new thread with these diet/food/ADDitives concerns, as I am sure some people here would like to discuss it seriously.

And I must say in full respect, I dont quite get it what SB_UK is on to. It gives me a kind of inspiration though... like a surrealistic poem about subjects maybe connected with my own field.
But scientists dont always understand each other... like different languages in a way...

Back to the mercury issue then:



David Kirby on AWARES autism spectrum online conference in 2005 wrote:



Could the mercury-containing vaccine additive thimerosal be fueling an apparent epidemic of autism, ADD, speech delay and other disorders in America?



Here comes the full paper:


Did mercury in vaccines cause an epidemic of autism, ADD, ADHD, speech delay and other childhood disorders? Evidence of Harm: Mercury in Vaccines and the Autism Epidemic: A Medical Controversy (St. Martin’s Press, April 2005, $26.95 Hardcover, ISBN: 0-312-32544-0), by New York Times contributor David Kirby, is a disturbing, important book that examines both sides of this brewing controversy—the personal stories of the affected families and the unfolding political drama in the courts and halls of Congress.
Evidence of Harm is essentially the story of a handful of parents with autistic children who, upon learning that their kids received levels of mercury in their vaccines that far exceeded Federal safety limits, set out to take on Big Business, Big Science and Big Government with a radical new theory on the cause. These parents have uncovered compelling evidence that vaccine mercury, in the form of the preservative Thimerosal, could very well have played a role in the disease, and their medical, scientific, legal, and political allies are getting closer to establishing their claim.
In November 2002, Kirby was researching alternative autism treatments on spec for a women's magazine when he came across the Thimerosal theory. He thought it was interesting, but a little far-fetched. One week later, the House of Representatives passed the Homeland Security Act, which included a secret and scandalous rider immunizing Eli Lilly and Co. from liability for any damage caused by Thimerosal in vaccines. The journalist in Kirby knew that something was fishy here. If Thimerosal were harmless, as government and drug industry leaders insisted (while also moving to phase it out of pediatric vaccines), then why was the cloak-and-dagger provision inserted anonymously in the middle of the night?
By most assessments, autism is now epidemic in the United States. In the 1990's reported autism cases among American children began spiking, from about 1 in 10,000 children in 1987 to a shocking 1 in 166 today. In this period, new shots containing Thimerosal were added to the nation's already crowded vaccination schedule. In 1999, the FDA announced that children were being exposed to mercury at very young ages at levels far exceeding federal regulations, but the public health establishment failed to take parental concerns about the impact seriously.
Evidence of Harm explores both sides of this issue, which has pitted families and their allies against the federal government, public health agencies, medical academies, and powerful pharmaceutical giants. It examines:
Story of Thimerosal: a mercury-based additive approved by the FDA in the 1930's as a vaccine preservative and never subsequently tested by the Agency
Increase in reported autism cases and apparent parallels to the increase in number and frequency of Thimerosal-containing vaccinations in the 1990s.
Private meeting at which FDA, CDC, medical and pharmaceutical company representatives discussed data on neurological childhood disorders related to mercury in vaccines
Mysterious rider to the 2002 Homeland Security bill, which would free drug companies of liability in lawsuits regarding Thimerosal
State and federal lawsuits filed by families against the drug makers seeking compensation for the lifelong care of their ill children
New biological research indicating a link between Thimerosal exposure and neurological disorders vs. government-sponsored epidemiological data which fails to show a link

Preliminary Federal investigations currently underway into allegations of fraud, malfeasance, and conflict of interest at pharmaceutical companies and among officials at the FDA and CDC
Recently discovered CDC data showing a shockingly high correlation between Thimerosal exposure and autism, ADD and other childhood disorders

Choetso,is this the full paper of the research? This reads like a book promo.

Choetso, I just checked and this is, in fact a book promo, not a paper discussing mercury in vaccines.

Yea I think it reads as a book promo too ;-)
Anyway, I took it from the AWARES 2005 conference papers.

Here comes another one.....from the very same conference..
Its a bit long so I had to cut it up into smaller pieces...


Sallie Bernard
SafeMinds:

Autism: a Novel Form of Mercury Poisoning
Full paper
Part 1
INTRODUCTION<o></o>

<o></o>


Autistic Spectrum Disorder (ASD) is a neurodevelopmental syndrome with onset prior to age 36 months. Diagnostic criteria consist of impairments in sociality and communication plus repetitive and stereotypic behaviors (1). Traits strongly associated with autism include movement disorders and sensory dysfunctions (2). Although autism may be apparent soon after birth, most autistic children experience at least several months, even a year or more of normal development -- followed by regression, defined as loss of function or failure to progress (2,3,4).
The neurotoxicity of mercury (Hg) has long been recognized (5). Primary data derive from victims of contaminated fish (Japan – Minamata Disease) or grain (Iraq, Guatemala, Russia); from acrodynia (Pink Disease) induced by Hg in teething powders; and from individual instances of mercury poisoning (HgP), many occurring in occupational settings (e.g., Mad Hatter's Disease). Animal and in vitro studies also provide insights into the mechanisms of Hg toxicity. More recently, the Food and Drug Administration (FDA) and the<st1><st1> American</st1><st1> Academy</st1></st1> of Pediatrics (AAP) have determined that the typical amount of Hg injected into infants and toddlers via childhood immunizations has exceeded government safety guidelines on an individual (6) and cumulative vaccine basis (7). The mercury in vaccines derives from thimerosal (TMS), a preservative which is 49.6% ethylmercury (eHg) (7).
Past cases of HgP have presented with much inter-individual variation, depending on the dose, type of mercury, method of administration, duration of exposure, and individual sensitivity. Thus, while commonalities exist across the various instances of HgP, each set of variables has given rise to a different disease manifestation (8,9,10,11). It is hypothesized that the regressive form of autism represents another form of mercury poisoning, based on a thorough correspondence between autistic and HgP traits and physiological abnormalities, as well as on the known exposure to mercury through vaccines. Furthermore, other phenomena are consistent with a causal Hg-ASD relationship. These include (a) symptom onset shortly after immunization; (b) ASD prevalence increases corresponding to vaccination increases; (c) similar sex ratios of affected individuals; (d) a high heritability rate for autism paralleling a genetic predisposition to Hg sensitivity at low doses; and (e) parental reports of autistic children with elevated Hg.
TRAIT COMPARISON<o>

</o>

ASD manifests a constellation of symptoms with much inter-individual variation (3,4). A comparison of traits defining, nearly universal to, or commonly found in autism with those known to arise from mercury poisoning is given in Table I. The characteristics defining or strongly associated with autism are also more fully described.<o></o>
Autism has been conceived primarily as a psychiatric condition; and two of its three diagnostic criteria are based upon the observable traits of (a) impairments in sociality, most commonly social withdrawal or aloofness, and (b) a variety of perseverative or stereotypic behaviors and the need for sameness, which strongly resemble obsessive-compulsive tendencies. Differential diagnosis may include childhood schizophrenia, depression, <o></o><o></o><o></o>
obsessive-compulsive disorder (OCD), anxiety disorder, and other neuroses. Related behaviors commonly found in ASD individuals are irrational fears, poor eye contact, aggressive behaviors, temper tantrums, irritability, and inexplicable changes in mood (1,2,12-17). Mercury poisoning, when undetected, is often initially diagnosed as a psychiatric disorder (18). Commonly occurring symptoms include (a) "extreme shyness," indifference to others, active avoidance of others, or “a desire to be alone”; (b) depression, “lack of interest” and “mental confusion;” (c) irritability, aggression, and tantrums in children and adults; (d) anxiety and fearfulness; and (e) emotional lability. Neuroses, including schizoid and obsessive-compulsive traits, problems in inhibition of perseveration, and stereotyped behaviors, have been reported in a number of cases; and lack of eye contact was observed in one 12 year old girl with mercury vapor poisoning (18-35).<o></o>
The third diagnostic criterion for ASD is impairment in communication (1). Historically, about half of those with classic autism failed to develop meaningful speech (2), and articulation difficulties are common (3). Higher functioning individuals may have language fluency but still show semantic and pragmatic errors (3,36). In many cases of ASD, verbal IQ is lower than performance IQ (3). Similarly, mercury-exposed children and adults show a marked difficulty with speech (9,19,37). In milder cases scores on language tests may be lower than those of unexposed controls (31,38). Iraqi children who were postnatally poisoned developed articulation problems, from slow, slurred word production to an inability to generate meaningful speech; while Iraqi babies exposed prenatally either failed to develop language or presented with severe language deficits in childhood (23,24,39). Workers with Mad Hatter's disease had word retrieval and articulation difficulties (21).
Nearly all cases of ASD and HgP involve disorders of physical movement (2,30,40). Clumsiness or lack of coordination has been described in many higher functioning ASD individuals (41). Infants and toddlers later diagnosed with autism may fail to crawl properly or may fall over while sitting or standing; and the movement disturbances typically occur on the right side of the body (42). Problems with intentional movement and imitation are common in ASD, as are a variety of unusual stereotypic behaviors such as toe walking, rocking, abnormal postures, choreiform movements, spinning; and hand flapping (2,3,43,44). Noteworthy because of similarities to autism are reports in Hg literature of (a) children in Iraq and Japan who were unable to stand, sit, or crawl (34,39); (b) Minamata disease patients whose movement disturbances were localized to one side of the body, and a girl exposed to Hg vapor who tended to fall to the right (18,34); (c) flapping motions in an infant poisoned from contaminated pork (37) and in a man injected with thimerosal (27); (d) choreiform movements in mercury vapor intoxication (19); (e) toe walking in a moderately poisoned Minamata child (34); (f) poor coordination and clumsiness among victims of acrodynia (45); (g) rocking among infants with acrodynia (11); and (h) unusual postures observed in both acrodynia and mercury vapor poisoning (11,31). The presence of flapping motions in both diseases is of interest because it is such an unusual behavior that it has been recommended as a diagnostic marker for autism (46).
Virtually all ASD subjects show a variety of sensory abnormalities (2). Auditory deficits are present in a minority of individuals and can range from mild to profound hearing loss (2,47). Over- or under-reaction to sound is nearly universal (2,48), and deficits in language comprehension are often present (3). Pain sensitivity or insensitivity is common, as is a general aversion to touch; abnormal sensation in the extremities and mouth may also be present and has been detected even in toddlers under 12 months old (2,49). There may be a variety of visual disturbances, including sensitivity to light (2,50,51,52). As in autism, sensory issues are reported in virtually all instances of Hg toxicity (40). HgP can lead to mild to profound hearing loss (40); speech discrimination is especially impaired (9,34,). Iraqi babies exposed prenatally showed exaggerated reaction to noise (23), while in acrodynia, patients reported noise sensitivity (45). Abnormal sensation in the extremities and mouth is the most common sensory disturbance (25,28). Acrodynia sufferers and prenatally exposed Iraqi babies exhibited excessive pain when bumping limbs and an aversion to touch (23,24,45,53). A range of visual problems has been reported, including photophobia (18,23,34).<o></o>

Sallie Bernard
SafeMinds:

Autism: a Novel Form of Mercury Poisoning
Full paper
Part 2
<o></o>
COMPARISON OF BIOLOGICAL ABNORMALITIES

<o></o>
The biological abnormalities commonly found in autism are listed in Table II, along with the corresponding pathologies arising from mercury exposure. Especially noteworthy similarities are described.
Autism is a neurodevelopmental disorder which has been characterized as "a disorder of neuronal organization, that is, the development of the dentritic tree, synaptogenesis, and the development of the complex connectivity within and between brain regions" (54). Depressed expression of neural cell adhesion molecules (NCAMs), which are critical during brain development for proper synaptic structuring, has been found in one study of autism (55). Organic mercury, which readily crosses the blood-brain barrier, preferentially targets nerve cells and nerve fibers (56); primates accumulate the highest Hg-levels in the brain relative to other organs (40). Furthermore, although most cells respond to mercurial injury by modulating levels of glutathione (GSH), metallothionein, hemoxygenase, and other stress proteins, neurons tend to be “markedly deficient in these responses” and thus are less able to remove Hg and more prone to Hg-induced injury (56). In the developing brain, mercury interferes with neuronal migration, depresses cell division, disrupts microtubule function, and reduces NCAMs (28,57-59).
While damage has been observed in a number of brain areas in autism, many nuclei and functions are spared (36). HgP’s damage is similarly selective (40). Numerous studies link autism with neuronal atypicalities within the amygdala, hippocampi, basal ganglia, the Purkinje and granule cells of the cerebellum, brainstem, basal ganglia, and cerebral cortex (36,60-69). Each of these areas can be affected by HgP (10,34,40,70-73). Migration of Hg, including eHg, into the amygdala is particularly noteworthy, because in primates this brain region has neurons specific for eye contact (74) and it is implicated in autism and in social behaviors (65,66,75).<o></o>
Autistic brains show neurotransmitter irregularities which are virtually identical to those arising from Hg exposure: both high or low serotonin and dopamine, depending on the subjects studied; elevated epinephrine and norepinephrine in plasma and brain; elevated glutamate; and acetylcholine deficiency in hippocampus (2,21,76-83).<o></o>
Gillberg and Coleman (2) estimate that 35-45% of autistics eventually develop epilepsy. A recent MEG study reported epileptiform activity in 82% of 50 regressive autistic children; in another study, half the autistic children expressed abnormal EEG activity during sleep (84). Autistic EEG abnormalities tend to be non-specific and have a variety of patterns (85). Unusual epileptiform activity has been found in a number of mercury poisoning cases (18,27,34,86-88). Early mHg exposure enhances tendencies toward epileptiform activity with a reduced level of seizure-discharge amplitude (89), a finding consistent with the subtlety of seizures in many autism spectrum children (84,85). The fact that Hg increases extracellular glutamate would also contribute to epileptiform activity (90).
Some autistic children show a low capacity to oxidize sulfur compounds and low levels of sulfate (91,92). These findings may be linked with HgP because (a) Hg preferentially binds to sulfhydryl molecules (-SH) such as cysteine and GSH, thereby impairing various cellular functions (40), and (b) mercury can irreversibly block the sulfate transporter NaSi cotransporter NaSi-1, present in kidneys and intestines, thus reducing sulfate absorption (93). Besides low sulfate, many autistics have low GSH levels, abnormal GSH-peroxidase activity within erythrocytes, and decreased hepatic ability to detoxify xenobiotics (91,94,95). GSH participates in cellular detoxification of heavy metals (96); hepatic GSH is a primary substrate for organic-Hg clearance from the human (40); and intraneuronal GSH participates in various protective responses against Hg in the CNS (56). By preferentially binding with GSH, preventing absorption of sulfate, or inhibiting the enzymes of glutathione metabolism (97), Hg might diminish GSH bioavailability. Low GSH can also derive from chronic infection (98,99), which would be more likely in the presence of immune impairments arising from mercury (100). Furthermore, mercury disrupts purine and pyrimidine metabolism (97,10). Altered purine or pyrimidine metabolism can induce autistic features and classical autism (2,101,102), suggesting another mechanism by which Hg can contribute to autistic traits.
Autistics are more likely to have allergies, asthma, selective IgA deficiency (sIgAd), enhanced expression of HLA-DR antigen, and an absence of interleukin-2 receptors, as well as familial autoimmunity and a variety of autoimmune phenomena. These include elevated serum IgG and ANA titers, IgM and IgG brain antibodies, and myelin basic protein (MBP) antibodies (103-110). Similarly, atypical responses to Hg have been ascribed to allergic or autoimmune reactions (8), and genetic predisposition to such reactions may explain why Hg sensitivity varies so widely by individual (88,111). Children who developed acrodynia were more likely to have asthma and other allergies (11); IgG brain autoantibodies, MBP, and ANA have been found in HgP subjects (18,111,112); and mice genetically prone to develop autoimmune diseases "are highly susceptible to mercury-induced immunopathological alterations" even at the lowest doses (113). Additionally, many autistics have reduced natural killer cell (NK) function, as well as immune-cell subsets shifted in a Th2 direction and increased urine neopterin levels, indicating immune system activiation (103,114-116). Depending upon genetic predisposition, Hg can induce immune activation, an expansion of Th2 subsets, and decreased NK activity (117-120).
<o></o>
POPULATION CHARACTERISTICS

<o></o>
In most affected children, autistic symptoms emerge gradually, although there are cases of sudden onset (3). The earliest abnormalities have been detected in 4 month olds and consist of subtle movement disturbances; subtle motor-sensory disturbances have been observed in 9 month olds (49). More overt speech and hearing difficulties become noticeable to parents and pediatricians between 12 and 18 months (2). TMS vaccines have been given in repeated intervals starting from infancy and continuing until 12 to 18 months. While HgP symptoms, may
arise suddenly in especially sensitive individuals (11), usually there is a preclinical "silent stage" in which subtle neurological changes are occuring (121) and then a gradual emergence of symptoms. The first symptoms are typically sensory- and motor-related, which are followed by speech and hearing deficits, and finally the full array of HgP characteristics (40). Thus, both the timing and nature of symptom emergence in ASD are fully consistent with a vaccinal Hg etiology. This parallel is reinforced by parental reports of excessive amounts of mercury in urine or hair from younger autistic children, as well as some improvement in symptoms with standard chelation therapy (122).
The discovery and rise in prevalence of ASD mirrors the introduction and spread of TMS in vaccines. Autism was first described in 1943 among children born in the 1930s (123). Thimerosal was first introduced into vaccines in the 1930s (7). In studies conducted prior to 1970, autism prevalence was estimated, at 1 in 2000; in studies from 1970 to 1990 it averaged 1 in 1000 (124). This was a period of increased vaccination rates of the TMS-containing DPT vaccines among children in the developed world. In the early 1990s, the prevalence of autism was found to be 1 in 500 (125), and in 2000 the CDC found 1 in 150 children affected in one community, which was consistent with reports from other areas in the country (126). In the late 1980s and early 1990s, two new TMS vaccines, the HIB and Hepatitis B, were added to the recommended schedule (7).
Nearly all US children are immunized, yet only a small proportion develop autism. A pertinent characteristic of mercury is the great variability in its effects by individual, so that at the same exposure level, some will be affected severely while others will be asymptomatic (9,11,28). An example is acrodynia, which arose in the early 20^th Century from mercury in teething powders and afflicted only 1 in 500-1000 children given the same low dose (28). Studies in mice as well as humans indicate that susceptibility to Hg effects arises from genetic status, in some cases including a propensity to autoimmune disorders (113,34,40). ASD exhibits a strong genetic component, with high concordance in monozygotic twins and a higher than expected incidence among siblings (4); autism is also more prevalent in families with autoimmune disorders (106).
Additionally, autism is more prevalent among boys than girls, with the ratio estimated at 4:1 (2). Mercury studies in mice and humans consistently report greater effects on males than females, except for kidney damage (57). At high doses, both sexes are affected equally; at low doses only males are affected (38,40,127).
<o></o>
DISCUSSION


We have shown that every major characteristic of autism has been exhibited in at least several cases of documented mercury poisoning. Recently, the FDA and AAP have revealed that the amount of mercury given to infants from vaccinations has exceeded safety levels. The timing of mercury administration via vaccines coincides with the onset of autistic symptoms. Parental reports of autistic children with measurable mercury levels in hair and urine indicate a history of mercury exposure. Thus the standard primary criteria for a diagnosis of mercury poisoning - observable symptoms, known exposure at the time of symptom onset, and detectable levels in biologic samples (11,31) - have been met in autism. As such, mercury toxicity may be a significant etiological factor in at least some cases of regressive autism. Further, each known form of HgP in the past has resulted in a unique variation of mercurialism – e.g., Minamata disease, acrodynia, Mad Hatter’s disease – none of which has been autism, suggesting that the Hg source which may be involved in ASD has not yet been characterized; given that most infants receive eHg via vaccines, and given that the effect on infants of eHg in vaccines has never been studied (129), vaccinal thimerosal should be considered a probable source. It is also possible that vaccinal eHg may be additive to a prenatal mercury load derived from maternal amalgams, immune globulin injections, or fish consumption, and environmental sources.
<o></o>

http://en.wikipedia.org/wiki/Heavy_metals

Living organisms require varying amounts of "heavy metals."

Iron, cobalt, copper, manganese, molybdenum, and zinc are required by humans.

(a section of the periodic table)

----------------------------------------B---C
---------------------------------------Al---Si
V---Cr---Mn---Fe---Co---Ni---Cu---Zn----------
----Mo-----------------------Ag---Cd----------
----Tu-----------------------Au---Hg--------Pb

Certain elements that are normally toxic are, for certain organisms or under certain conditions, beneficial. Examples include vanadium, tungsten, and even cadmium.

Other heavy metals such as mercury, plutonium, and lead are toxic metals that have no known vital or beneficial effect on organisms, and their accumulation over time in the bodies of animals can cause serious illness.

The thiol group also has a high affinity for heavy metals, so that proteins containing cysteine will bind metals such as mercury, lead, and cadmium tightly.S-S
S-H
S-heavy metal

S-H + H-S ->- oxidizes ->- S-S + 2H+ + 2e-

-*-

cysteine (via disulphide bridge) is the key (3d) structural amino acid
- heavy metals destroy structure at this level.

-*-

Aside

http://staff.jccc.net/PDECELL/chemistry/bonds.html

The 4 (cf. physics and love (RDF: Doug ToEf: Austin)) bonds of chemistry
ionic
+
covalent
->-
polar covalent

hydrogen bond

http://staff.jccc.net/PDECELL/chemistry/polarcov.GIF

In blue - rotate 90degrees CCW -> the butterfly / bunny

http://tbn0.google.com/images?q=tbn:SGrwjKiJdCdlSM:http://www.butterflyutopia.com/COLOR/3-butterfly_coloring_page.jpg

http://tbn0.google.com/images?q=tbn:d87svoNErAG1NM:http://www.sillyjokes.co.uk/images/dress-up/masks/face-masks/small-rabbit.jpg

note - central body of butterfly (in black) and nose->forehead of rabbit
- are in same orientation to the duals of
left side and right sides of butterfly and rabbit, respectively.

-*-

The 'body' of the butterfly and the 'nose -> forehead' of the rabbit -
takes us from the plane of duality of left and right sides
- into an orthogonal plane -


./|\
|.|.|
|.|.|
|/.\|.

^.^.^
|.|.|
1 2 3

laptop balanced on its side

1-screen
2-hinge
3-keyboard

The screen -> <- keyboard are the duals
- with the child product as the tabletop upon which the laptop has been placed (on its side) (above)

Point

We live in a 2 dimensional Universe -
- the apparence of three dimensions arises through manifolds.

ref::ADDF::Brian (Stabile,Chris) The two planes
- the duals above (keyboard and screen above)
- the duality on a 2 dimensional plane -
- evolve when the limit of the energy of the duality has been exceeded -
through the third dimension.

Hence

./|\
|.|.|
|.|.|
|/.\|
1...2

1 wing
2.wing

./|//
|.//|
|//.|
//.\|.
3

3 - attempt to show that the body of a butterfly (in red)
- runs parallel to the surface upon which the laptop has been placed (on its side) (above)

-*-

The path between body and wings of the butterfly -
can then be extrapolated onto water -

and we then see in the definition of the hydrogen bond
- that love which Jesus described
(an egalitarian love between all people)

egality,fraternity,liberty
- reality in the making

:-) - the French revolution did not end way back then ...


- instead just beginning
to end around about now.

.......................................http://staff.jccc.net/PDECELL/chemistry/polarcov.GIF
.................................................. ....................//
......................http://staff.jccc.net/PDECELL/chemistry/polarcov.GIF
.............................................//
http://staff.jccc.net/PDECELL/chemistry/polarcov.GIF.

/hydrogen bonds /

And the general (meandering) point would be that ?

The thiol group also has a high affinity for heavy metals, so that proteins containing cysteine will bind metals such as mercury, lead, and cadmium tightly.polar
covalent
polar covalent
hydrogen bond

- the general point would be that the pattern of evolution is away from selfish virulence (see evolution of the virus previously)
and
into settling back into sync with nature

- that the evolution away from ripping electrons away from one's fellow dual (ionic interactions) -
settles into a lovely model of each person sharing the little that each person has -
- so that each person in a community has a really great deal
- the hydrogen bond
- linking hands between people in the orthogonal plane (the third of our dimensions)

From which we obtain a mechanism for this general idea (from previously on ADDF)

http://tbn0.google.com/images?q=tbn:LU9sb11WvKmh3M:http://www.unco.edu/counseling/images/papermen.jpg

(an NMDA -> cannabinoid -> oxytocin
retrograde switch within our internal system
which results in extension of the pair bond)

So what's going on?
polar
->-
covalent

Evolved form - covalent
- is being antagonized by really selfish polar heavy metal 2+ ions
- really selfish cations
where cations are pussitive and cats are no good, because dogs rule.

Presumably the H- covalent set will be affected
- particularly H-S because of the relative weakness of the bond

H2O -> hydrogen bond of some note
H and O (from the link above (http://staff.jccc.net/PDECELL/chemistry/bonds.html)) -> polar covalent
- however - HS
- attested to by the ease with which the body manipulates the reduction/oxidation state of sulphydryl/thiol groups
is particularly susceptible to attack from a particularly strong lesser 'evil'

(a section of the periodic table)

C---N---O
--------S

where 'evil' represents pure usage

-*-

'Evil'
has only one useful definition

state 1 -> state 2

'Evil' represents any 'power' which prevents state 1 from speciation event into state 2.

This may be due to the allure of state 1 (instinct) -
or
force.

- Above -
presumably sulphydryls are being prevented from proper disulphide bridge formation on account of the forceful aggression of (lesser) heavy metal divalent cations
(mercury and lead of particular note).

- put simply -
Hg2+ and Pb2+ are bullies


The term 'bully' here is used in proper context -
- the 'bully' is seen as the precursor group in reaction to better,
preventing reaction to better by holding onto an anachronistic status quo within which they as beneficiaries.

There is only one rule of physics -
evolution by geometric series

--- where ---
the 'bullie$' we see in the workplace -
- demonstrate -
state of mind from which we are evolving away from
->- towards
->-better-<-

- the 'bullies' at the level of 'fundamental forces of chemistry' are the lower, lesser forces -
more aggressive -
less in tune with their community

who strive only for themselves

In this case there is a complete transfer of electrons.

nothing good about these people

- need to get better

sadly though -
their 'lesser' nature prevents higher perspective

in other words
- eyes
which cannot see.

http://staff.jccc.net/PDECELL/chemistry/polarcov.GIF

http://tbn0.google.com/images?q=tbn:SGrwjKiJdCdlSM:http://www.butterflyutopia.com/COLOR/3-butterfly_coloring_page.jpg

http://tbn0.google.com/images?q=tbn:d87svoNErAG1NM:http://www.sillyjokes.co.uk/images/dress-up/masks/face-masks/small-rabbit.jpg




==


http://i79.photobucket.com/albums/j132/sb_camsci/LittleRedRidingHoods.gif

the face of the rabbit with the body of man -
the central point in the forehead of rabbit (in man - a chakra point - #6) with the central point in the neck of man (thyroid/parathyroid chakra point - #5)

where #7 therefore reflects connection to outside of our classical physical form

#5 -> #6 -{...}->-{...}- #7

http://tbn0.google.com/images?q=tbn:qVksmKcg_VXetM:http://education.psinergy.info/v3/images/chakra_map-large.jpg


although a little freaky -
perfectly ordinary deliverable from just one simple rule
->-
evolution to complexity by simple recursive geometric series

Talk about revenge of the white rabbit . . .


{Quote from Article} Studies in mice as well as humans indicate that susceptibility to Hg effects arises from genetic status, in some cases including a propensity to autoimmune disorders (113,34,40). ASD exhibits a strong genetic component, with high concordance in monozygotic twins and a higher than expected incidence among siblings (4); autism is also more prevalent in families with autoimmune disorders {End Quote}

Close but cigar with held - they are bad for your health any way

Please direct your attention to the following publication produced by some one not selling a book

Comparative Genomics of Autism, Tourette syndrome and Autoimmune/Inflammatory Disorders 4-23-03 (http://www.grc.nia.nih.gov/branches/rrb/dna/pubs/cgoatad.pdf)


Additionally, within this simple marker co-localization, the observation that linkage of a high percentage of identical polymorphic markers between autism and autoimmune disorders or Tourette syndrome and autoimmune disorders provides evidence that simple co-localization may not be coincidental.

Overlapping or co-localization of Autism and Tourette syndrome loci alone is
interesting given overlapping clinical characteristics between autism and Tourette syndrome, suggesting a shared genetic basis between these neurodevelopmental disorders of language and movement. Co-localization of Autism and Tourette syndrome loci with loci of disorders of immune dysregulation is consistent with a hypothesis of a relationship between immune phenomena and both autism and Tourette syndrome. While there is
little evidence of classical immune mediated tissue destruction in either autism or Tourette syndrome, there is evidence of immune imbalance in both disorders. Also, colocalization of linkage between autism and inflammatory gut disorders such as Crohn’s disease and celiac disease, allows a testable genetic approach in teasing out a potential relationship between autism and enterocolitis. Of additional interest is linkage of autism and Tourette syndrome to 4p16.3-16.1. This region was recently genetically linked to
SLE patients having neuropsychiatric manifestations that, like Tourette syndrome [67], have been associated with antiphospholipid antibodies [97].


Immune influence on neuronal development is well established. Families of
cytokines, chemokines, signal transduction molecules, molecules of cell-cell contact, as well as developmental regulatory molecules originally characterized in the immune system have pleiotropic and overlapping functional effects on the developing immune system and the developing brain. Similarly, considerable overlap has been noted between hematopoetic and neuronal stem cell lineages. In addition, prenatal or neonatal infection
has been shown to have a profound influence on brain development with neonatal infection used as a model for autism [98,99].


Co-localization of genetic loci between these clinically distinct disorders suggests a genetic relatedness between all three types of diseases and suggests an underlying genetic basis for immune pathological mechanisms in the etiology of both autism and Tourette syndrome.

For those into the genetics and stuff

Composite Genetic Data For Autism, Tourette Syndrome and Autoimmune/Inflammatory Disorders (http://www.grc.nia.nih.gov/branches/rrb/dna/atsmap.htm)

The stuff in the vaccines may trigger the autoimmune response but I agree with the source I provided that autoimmune is probably more of an influencing factor - I think virus are going to be major contributing factors in many illness and conditions for the same reason.

How much you wanna bet they find the frontal cortex especially vulnerable to extreme immune response to viral attacks such as that herpes virus that is supposed to go dormant - Our immune system would increase response to perceived attacks to that area as a matter of evolution - Autoimmune and frontal cortex sensitivities would also explain the various conditions blamed upon this organ as well as align not only traditional data but non some traditional . . .