cause neurotransmitters to burn out? and never get them back to normal. i think this has happened to me cause no meds seem to work properly

Have you done it a long time?
......I did meth 22 years, and was clean a year, found I was ADHD
and they don't work as well as they would if I had'nt, but they DO work. (somewhat)

4 years using weed everyday for 4 years. occasionally cocaine and chronic use of dextromethorphan(active ingredient in cough syrup) tons of prescription meds but mostly the dextromethorphan was wat i most used

4 years using weed everyday for 4 years. occasionally cocaine and chronic use of dextromethorphan(active ingredient in cough syrup) tons of prescription meds but mostly the dextromethorphan was wat i most used

I have the same problem. I abused amphetamines for a couple years, and I'm stimulant sensitive, so the drugs caused powerful effects for me. Then I moved on to alcohol addiction.

Now I'm sober, and everything's been boring for a long time. I wonder if I'll ever get my normal "state of consciousness" back... :(

Now I'm sober, and everything's been boring for a long time. I wonder if I'll ever get my normal "state of consciousness" back... :(

i still smoke a lil bit of mary jane everynow and then(when i can get my hands on it) lol, but yea i feel the same as you do sumtimes i feel like i need to get high to feel better. if i didnt have the meds i have now i have no idea what id'e be doing rite now.

Its an open question very hard to define i guess. Usually the brain gets re-loaded, and you should be fine. ( I know a lot of people who did drugs-more than me, and theyre ok) I was talking some drugs over a time, and went into a terrible depression. When i got rid of that and got back on track again, I felt normal and super. . but kinda comes back to me, and now I dont now if my ADD symptons are because of the drugs, or if Ive always been like this :)

Neurotoxicity totally depends on the substance you're ingesting. Very few things will literally cause receptor burn out.

IV meth? Yep
Alcohol? Yep
MDMA? yep

I could see glutamate toxicity from NMDA antagonists like ketamine, dxm, pcp.

Neurotoxicity totally depends on the substance you're ingesting. Very few things will literally cause receptor burn out.

IV meth? Yep
Alcohol? Yep
MDMA? yep

I could see glutamate toxicity from NMDA antagonists like ketamine, dxm, pcp.

I wonder what the day to day effects of neurotoxicity are, meaning how they effect normal functioning (school, work, relationships, etc...)