Contrapunctus
10-25-08, 09:25 PM
One of the main reasons I do not like taking my ADHD medication is the anxiety it seems to cause as the drug wears off. Although I have found this anxiety to be less promiment with Desoxyn, it still can occur at dosages over 15mg.
A few days ago I ordered some phenibut. It is an unscheduled supplement, and can be bought legally and cheaply online.
It is a GABA(B) agonist, and to a lesser extent, a GABA(A) agonist, so it does have sedating qualities, perhaps similar to that of a mild benzodiazepine. However, it shares some structural similarities to phenethylamine (it looks sort of like GABA with a benzene ring), and because of this it competes with phenethylamine, and in turn acts as a phenethylamine antagonist. This would certainly reduce the effect of drugs like amphetamine/methamphetamine, which in my case, would be good as it is wearing off. I see it as a better alternative to benzodiazepines, as I am more interested in its properties as a phenethylamine antagonist than its GABAergic/benzodiazepine-like properties.
The top part resembles GABA:
http://upload.wikimedia.org/wikipedia/en/archive/e/e8/20070326185149%21Phenibut.png<---Benzene Ring (like in PEA)
I believe the half-life is slightly over 5 hours, which is good because it will not reduce the efficacy of your ADHD medication when you take it the following day (note: the half-life could be dose dependent). Caution should be used with this substance, as it could be habit forming, and should not be used for more than three-four days straight. I plan to use it perhaps once every 7-10 days. You should be very careful before combining Phenibut with benzodiazepines and alcohol, as it will have an additive effect (excessive sedation, CNS-depression etc).
Phenibut appears to be a decent anxiolytic (reduces anxiety), however its potency is somewhat low. However, it is quite cheap so the low potency is somewhat irrelevant (30 grams is ~15 dollars). Dosage ranges from 200mg-2 grams. Oddly enough, it also has some nootropic and possible neuroprotective properties.
I have yet to recieve it, but when I do I will post my impressions of the substance.
The wikipedia article about it is here: http://en.wikipedia.org/wiki/Phenibut
Here is an abstract about Phenibut:
Phenibut (beta-phenyl-gamma-aminobutyric acid HCl) is a neuropsychotropic drug that was discovered and introduced into clinical practice in Russia in the 1960s. It has anxiolytic and nootropic (cognition enhancing) effects. It acts as a GABA-mimetic, primarily at GABA(B) and, to some extent, at GABA(A) receptors. It also stimulates dopamine receptors and antagonizes beta-phenethylamine (PEA), a putative endogenous anxiogenic. The psychopharmacological activity of phenibut is similar to that of baclofen, a p-Cl-derivative of phenibut. This article reviews the structure-activity relationship of phenibut and its derivatives. Emphasis is placed on the importance of the position of the phenyl ring, the role of the carboxyl group, and the activity of optical isomers. Comparison of phenibut with piracetam and diazepam reveals similarities and differences in their pharmacological and clinical effects. Phenibut is widely used in Russia to relieve tension, anxiety, and fear, to improve sleep in psychosomatic or neurotic patients; as well as a pre- or post-operative medication. It is also used in the therapy of disorders characterized by asthenia and depression, as well as in post-traumatic stress, stuttering and vestibular disorders.
A few days ago I ordered some phenibut. It is an unscheduled supplement, and can be bought legally and cheaply online.
It is a GABA(B) agonist, and to a lesser extent, a GABA(A) agonist, so it does have sedating qualities, perhaps similar to that of a mild benzodiazepine. However, it shares some structural similarities to phenethylamine (it looks sort of like GABA with a benzene ring), and because of this it competes with phenethylamine, and in turn acts as a phenethylamine antagonist. This would certainly reduce the effect of drugs like amphetamine/methamphetamine, which in my case, would be good as it is wearing off. I see it as a better alternative to benzodiazepines, as I am more interested in its properties as a phenethylamine antagonist than its GABAergic/benzodiazepine-like properties.
The top part resembles GABA:
http://upload.wikimedia.org/wikipedia/en/archive/e/e8/20070326185149%21Phenibut.png<---Benzene Ring (like in PEA)
I believe the half-life is slightly over 5 hours, which is good because it will not reduce the efficacy of your ADHD medication when you take it the following day (note: the half-life could be dose dependent). Caution should be used with this substance, as it could be habit forming, and should not be used for more than three-four days straight. I plan to use it perhaps once every 7-10 days. You should be very careful before combining Phenibut with benzodiazepines and alcohol, as it will have an additive effect (excessive sedation, CNS-depression etc).
Phenibut appears to be a decent anxiolytic (reduces anxiety), however its potency is somewhat low. However, it is quite cheap so the low potency is somewhat irrelevant (30 grams is ~15 dollars). Dosage ranges from 200mg-2 grams. Oddly enough, it also has some nootropic and possible neuroprotective properties.
I have yet to recieve it, but when I do I will post my impressions of the substance.
The wikipedia article about it is here: http://en.wikipedia.org/wiki/Phenibut
Here is an abstract about Phenibut:
Phenibut (beta-phenyl-gamma-aminobutyric acid HCl) is a neuropsychotropic drug that was discovered and introduced into clinical practice in Russia in the 1960s. It has anxiolytic and nootropic (cognition enhancing) effects. It acts as a GABA-mimetic, primarily at GABA(B) and, to some extent, at GABA(A) receptors. It also stimulates dopamine receptors and antagonizes beta-phenethylamine (PEA), a putative endogenous anxiogenic. The psychopharmacological activity of phenibut is similar to that of baclofen, a p-Cl-derivative of phenibut. This article reviews the structure-activity relationship of phenibut and its derivatives. Emphasis is placed on the importance of the position of the phenyl ring, the role of the carboxyl group, and the activity of optical isomers. Comparison of phenibut with piracetam and diazepam reveals similarities and differences in their pharmacological and clinical effects. Phenibut is widely used in Russia to relieve tension, anxiety, and fear, to improve sleep in psychosomatic or neurotic patients; as well as a pre- or post-operative medication. It is also used in the therapy of disorders characterized by asthenia and depression, as well as in post-traumatic stress, stuttering and vestibular disorders.