New Adderall XR user here. I was on 10mg for 2 weeks, and then the Doc upped me to 15mg in the morning and 10mg in the afternoon.

Its been four days for me now since I started taking 15mg + 10mg and I am a bit worried. I have acid reflux and have been taking omeprazole (which I think is generic losec ? or prilosec? ) for about 2-3 months now to deal with it. The past 3-4 days had a lot going on (job interviews, tons of work, trouble at home) and I ended up getting pretty sick. The extra 10mg in the afternoon ensured that I could not sleep till very late, so I was not able to get much sleep either and on top of that the job interview process generally makes me very anxious. Couple all of that with troubles at home and I ended up feeling very sick.

I felt very anxious during the day the past few days, and could not eat properly because my acid reflux was just going nuts. On top of that I associated all of this with Adderall + Losec so I stopped taking my acid reflux meds for a few days too.

The job interview process is now for the most part done, I managed to get 12 hours of sleep last night so I woke up very rested, and I have managed to do fine today with my two adderalls so far.

Was these past few days just a result of all of these things happening at once ? Or is adderall + losec not a good combination? or am I not responding well to the increased adderall ? So many questions...and no answers. I stopped on the losec because I read online that adderall can have drug interactions with the proton pump inhibitors. Should I go back on it to manage my acid ?

Bah...I wish my next appointment with the doc wasnt so far. I am thinking I am gonna switch back to just 10mg in the morning because that seemed to be working much better and I didnt have anxiety, acid issues, etc etc. Or maybe I just need to give my body a few days to adjust ?

Are you taking Prilosec with Adderall at the same time? Make sure to take them 30-45 minutes apart. Try that out. If that doesn't make the difference then you may need to bring this drug interaction up to your pdoc. Try taking Adderall first then Prilosec and vice versa if you see a difference. Make sure you try every alternative before you visit your pdoc.

Good Luck.

PPI's will increase the amount of the stimulant in your system. Acidic substance such as vitamin C will decrease the amount of Adderall in your system if taken within an hour or two of each other.

Thanks guys, I am going to try taking my Prilosec an hour before Adderall. I am pretty sure I just need 10mg of Adderall so I`ll try that for this week and bring it up with the doctor.

PPI's last ~24 hours, so taking it an hour before won't help. For best results, try taking adderall in the morning around 8am, and prilosec around 12pm every day. That way you'll at least be towards less omeprazole in your system when you take the adderall.