A lot of tiredness and lack of energy is not just becasue of the lack of vitamins, it is also because of irregularity in the digestive system. I would also suggest that you take a fiber supplement daily if you dont already (metamusil , Fiber one, Psyllium husk, etc..). When your body is backed up or not flowing properly then your brain will not work properly.

This is an open question for anyone with some knowledge on this...

Can a fast transit time of food in your body, play a role in how medicine is absorbed? In my case it's a 4 hour transit time...which is REALLY fast it seems, and I think this may be have played a negative role in my adderall efficacy/absorption. And to add, is there any type of food/vitamin/nutrient/supplement that can effectively slow down one's transit time?

Thanks!

This is an open question for anyone with some knowledge on this...

Can a fast transit time of food in your body, play a role in how medicine is absorbed? In my case it's a 4 hour transit time...which is REALLY fast it seems, and I think this may be have played a negative role in my adderall efficacy/absorption. And to add, is there any type of food/vitamin/nutrient/supplement that can effectively slow down one's transit time?

Thanks!

Food can definitely effect the way medicine is absorbed - The food is slowing down the process... Many types of medications state whether or not you should consume the medicine with food or not. Some medicine actually state to take it with food because it may bother your stomach on its own.

But is food the sole factor of one's transit time? Or is it also controlled by some biological factor within the digestive system?

And this is on the presumption that transit time is directly related to the absorption of nutrients, drugs, etc.

But is food the sole factor of one's transit time? Or is it also controlled by some biological factor within the digestive system?

And this is on the presumption that transit time is directly related to the absorption of nutrients, drugs, etc.

I will take an educated guess and say having a "fast" or "slow" metabolism won't impact the absorption of mediciation...

I will take an educated guess and say having a "fast" or "slow" metabolism won't impact the absorption of mediciation


I have problems with irregular metabolism especially when I was younger which renders me unable to make use of the longer acting versions of ADD medications. When my thyroid began acting up several month back one of the first things I noticed was my Adderall did not work like it should have. So I would have to say metabolism does effect medication absorption as well as length of time it take the meds to begin working and how long they are effective.

I see two issues here. Yes, people who are called "fast oxidizers," as well as people with malabsorption syndrome, will get less of the medication absorbed. This is particularly true for the XR or time release forms. For fast oxiders, food and meds pass through the digestive system too fast for them to be efficiently broken down and release their nutrients or medicines.

With malabsorption syndrom its the same thing although the digestive system may not be necessarily moving too fast.

Having an acidic system also affects absorption of amphetamine/stimulants. Too low of a pH level will interfere with absorption.

Having an alkaline system actually increases absorption. Some people take things like antacids and baking soda, which will prolong the onset of the drug, and slow the rate of absorption, but make the effects last longer. But too much of baking soda, etc can actually interfere with absorption altogether, so it is not recommended to try that. Or it can vastly potentiate the drug causing bad side effects.

There's lists on the web of foods/drinks that effectively acidify or alkalize your system.

If I were you I would go with the immediate release forms, as they are less likely to be affected by fast digestion, and increase my consumption of alkalizing foods/drinks.
Avoid taking the med with coffee or soda, both of which acidify your system.

There are really two seperate issues. Absorbtion vs clearance via the kidneys.

Taking antacids speed up the rate that stimulants are absorbed. Which increases the peak level of stimulants in the body and shortens duration. Its important to realize that this is similar to increasing the dosage and decreasing duration. The decrease in duration is generally not desirable as it makes it harder to stay within a theraputic dosage range.

Clearence of stimulants is done by the kidneys. Amphetamines are removed based upon the acidity of your body. Lower PH (more acid) increases the removal of amphetamines. Higher PH (less acid) slows the removal of amphetamines. The end result is body PH effects the duration of stimulants. It has a more passive effect on peak levels which only increases when an additional dose is taken. Due to there being more or less in the system from the previous doses taken. Body PH levels are influenced by diet + physical activity + respiration. Also there is a circadian rhythm where PH levels are lowest when you wake up + slowly increase during the day.

BobC

BobC, I didn't explain that as well as you did. But it's true, we're talking about urinary alkalizers, which increase renal reabsorption and thus reduce urine output, and keep the drug in the body for longer than usual.

And the urinary acidifiers increase renal clearance since the drug is removed more slowly.

I guess I wasn't talking about absorption in the GI tract, but rather the reabsorption in the kidneys, equating that to being "greater absorption" even though technically its not the case, rather it just keeps the meds in your system for longer and too much alkalizers can cause a toxic level of amphetamine to build up.