so ive read many threads on this mix and havent been able to come to any conclusion as to whether or not the wellbutrin affects the adderall...my doctor said they would work together positively....but were getting different responses on here...any final conclusions????

someone said that WB is a dopamine blocker???? which doesnt make sense to me if it is a strong DA reuptake inhibitor????

i need my adderall to work to the best of its ability...i dont want anything to hinder the medication that helps my condition the most...as you would know.

nah man bad idea. a DRI will only regulate the amount available to the cell properly, usually dri's are used to increase da by inhibitin the reuptake into storage and leavin it in the synapses for use, but floodin da into the recepter thru adderall with a dri workin, will actually mediate the flood so it becomes kinda like a reservioir, where addys the broken dam, da is the obviously the water thast supposed to flood, but a DRI is sandbagging the break so that the flood is contained, hence the reservior.

Pick 1 or the other.

How does DRI affect DA's release from the transporters?? this doesnt quite make sense to me....it would seem that the flood in the neurons would be larger? amphetamines release more DA AND N through the transporters right? not the reuptake pumps...??? or are they the same thing??? <<<confused

Yes it blocks the transporter (DAT), it doesnt actually block (DA), i meant da reuptake via dat. DAT brings da back into the pump, inhibitors block their entry back into the reuptake pump to keep them in synapses. adderall directly releases DA and it is much stronger than wellbutrin in boostin da.

so what your really asking is if they block DAT then wouldnt there be more DA, especially with adderall added? that makes sense.

wellbutrin alone does boost DA levels, but were talking a slight increase to your baseline, especially in comparison to adderall. wellbutrin is actually an NDRI, its main affinity is towards NET, not DAT. while it actually has a weak affinity for DAT, it is significant enough to slightly raise DA in people not responsiveness to SSRI/SNRI's, or atypical depression, with low dopamine as possibly responsible for their depression. Main action is NE so what's happening is i higher increase in NE than DA. So if youve tried wellbutrin alone im sure you noticed amphatmine like stimulation without the drive or any mood elevation that you might notice on the adderall.

Adderall is much stronger in direct DA release obviously, but since Wellbutrin already has increased your baseline DA levels, then Adderall will not be as effective as if you used adderall alone. Also, adderalls affinity for dopamine receptors is way stronger than wellbutrin, like i said its weak in comparison even to its NET work as is, adderall will totally overpower it and probably make it unnoticable, but since ur basline was elevated, it doesnt seem as effective. Also, the seizure risk is higher.

I would only take one, which is addy, or switch to a stronger DRI if thats what you like, like ritalin.

hmmmm...well ive been on the wellbutrin 150 for like 3 weeks...and started the adderall 3 days ago....ive been on adderall before....and obviously the adderall helps more. can i ask why it doesnt work well when your DA/NI levels are already past baseline???? im not quite sure what to do....seems to be a low dose of wellbutrin from waht ive read.....and am on 35mg of adderall daily...any thoughts?

if the levels are already raised, the recognizable/familiar fx w/o wellbutrin wont be as familar. they have already slightly been helped by the dri. eventually these receptors supposedly get downregulated, so they simply stay at an even level, maybe thats why some stop wroking afteer a while? its the lowest startin dose, but in any case, if you are on wellbutrin for depression, and it works, stick with it, but dont excpect the same adderall effects. if ur not depressed, wellbutrin does nothing for add contrary to some psychs persuasive ideas. if ur depressed n dont like wellbutrin, switch to an ssri (zoloft) or an snri (pristiq).

adderall would help more. wellbutrin is simply and only for depression. it has a lower sfx profile than ssri's and less sexual side fx, so people that dont really do well on ssris usually end up tryin wellbutrin next. they often skip snris, and they are simply the best in my opinion, SE/NE levels are much more relevant to mood than NE/DA and they also are complimentary (too complex to get into, if u want read Stahls pscyhopharmacology), but well people dont respond, they give wellbutrin a shot, and for some people, its sfx profile is usually better than ssri/nri's. u gotta be generally healthy (good bp,hr,cholesterol,liver,kidney, heart in normal order) to take certain meds, and those might be troublesome for some.

my thoughts: lose wellbutrin, get pristiq, stick with adderall regaurdless of whether you want pristiq. (ssri: zoloft, paxil or prozac, maybe high dose paxil as it has nri effect and also some calmin effect which can be good for some adderall jitters)

i cant tell you what to do wit ur doc, but i do recommend stickin with adderall and taking an snri instead of wellbutrin. good luck peace

yea...i am/was depressed and noticed that my passion for life or my old hobbies came back when the wellbutrin started kicking in so i dont think its wise to stop it. i do notice a huge improvement in my concentration and handwriting abilities when i take the adderall with it though...especially the 15mg of instant release i take in the afternoon. the 20mg xr i take in the morning....just kinda wakes me up and gives me a lift....do you think IR works better than xr??? thats what im thinking....???

yea...i am/was depressed and noticed that my passion for life or my old hobbies came back when the wellbutrin started kicking in so i dont think its wise to stop it. i do notice a huge improvement in my concentration and handwriting abilities when i take the adderall with it though...especially the 15mg of instant release i take in the afternoon. the 20mg xr i take in the morning....just kinda wakes me up and gives me a lift....do you think IR works better than xr??? thats what im thinking....???

i only take IR, i wont take an XR pill of any psychoactive kind except an antidepressant. if ur depressed and wellbutrin is helpin dont stop, but also expect adderall not to be as effective for reasons above. most say ir is better

idk man, its u and ur docs call, try IR and maybe try switchin to an SNRI later or something, whatever u guys think is best

yellow,

what if you are depressed and wellbutrin lifts you out of the depression , yet you still cannot focus as good since adding wellbutrin along with your stims. I am in this boat at times wellbutrin seems to help my ability to focus but at other times I cannot focus as smoothly as I did or do at given times with precision like I do without wellbutrin. What is the answer to this equation-