View Full Version : Can I take zyrtec with Adderall?

07-22-09, 03:35 AM
Zyrtec is a 24 hour once a day allergy medication. On the box it says nothing about it interfering with amphetamines. Is adderall and zyrtec safe to mix together?

07-22-09, 12:05 PM
I can't directly answer your questions, but I did ask my pharmacist about Adderall and Loratadine (generic Claritin). He says this combination is OK. I did not ask about Claritin D or zyrtec.

07-22-09, 10:56 PM
Per my pharmacist, they do not interact.

07-22-09, 11:43 PM
I discussed htis a while back. The only ones that have any significant affect on amphetamine metabolism are the Generation 1 antihistamines ie Benadryl. These inhibit a particular enzyme partially responsible for amphetamine metabolism. Even then, most amphetamine is excreted via the kidneys, not metabolized (especially with acidic urine).