View Full Version : Has anyone ever taken Yohimbine HCL?

06-23-10, 07:57 AM
It seems to be pretty much NRI and a very mild MAOI, so it should have similar effects to Ritalin or Modafinil, but has anyone here ever taken it or know anything about its usefulness to treat adhd?

06-23-10, 04:12 PM
I researched that it has a very narrow therapeutic index, that means you have to be very careful in how much you take.
If you take accidentally a smidge too much you'll OD on it.

focus pocus
09-20-14, 12:31 PM
I find its effects great at low doses <2.5mg.

Now can i combine them with a stimulant like Ritalin with good synergy?

ANyone with any experience?

09-20-14, 12:51 PM
ALL supplements should be discussed with your prescribing physician before starting and not just with members of an online forum as there could be, and often are, interactions with medications.

as a medication for sexual dysfunction, it's available only by prescription. so, again, talking with your doctor is key.

09-20-14, 11:42 PM
Just saying... Monoamine oxidase inhibitors are contraindicated with practically every psychoactive drug I've ever seen, including most (if not all) discussed here.

09-21-14, 12:05 AM
Here is an excerpt from Wikipedia:

When MAOIs were first introduced, these risks were not known, and, over the following four decades, fewer than 100 people have died from hypertensive crisis.[citation needed] Presumedly due to the sudden onset and violent appearance of the reaction, MAOIs gained a reputation for being so dangerous that, for a while, they were taken off the market in America entirely. However, it is now believed that, used as directed under the care of a qualified psychiatrist, this class of drugs is a viable alternative treatment for intermediate- to long-term use.

The most significant risk associated with the use of MAOIs is the potential for interactions with over-the-counter and prescription medicines, illicit drugs or medications, and some supplements (e.g., St. John's Wort, tryptophan). It is vital that a doctor supervise such combinations to avoid adverse reactions. For this reason, many users carry an MAOI-card, which lets emergency medical personnel know what drugs to avoid. (E.g., adrenaline dosage should be reduced by 75%, and duration is extended.)[27] The risk of the interaction of MAOI medications with other drugs or certain foods is particularly dangerous because those on the medication who would have to restrict their diets often are depressed patients who "don't care if they live or die."[28]

Tryptophan supplements should not be consumed with MAOIs as the potentially fatal serotonin syndrome may result.[29]

MAOIs should not be combined with other psychoactive substances (antidepressants, painkillers, stimulants, both legal and illegal etc.) except under expert care. Certain combinations can cause lethal reactions, common examples including SSRIs, tricyclics, MDMA, meperidine,[30] tramadol, and dextromethorphan.[citation needed] Agents with actions on epinephrine, norepinephrine, or dopamine must be administered at much lower doses due to potentiation and prolonged effect.