View Full Version : Xyrem


FishTits
12-11-10, 01:16 PM
I can sleep when I'm on dexedrine but only in 3-4 hour stretches and its not true sleep because I seem to be half awake. I hear xyrem (GHB) is prescribed for sleep quality issues. Is it ever prescribed in conjunction with stimulants to ADHD patients?

johnnyc00
05-09-11, 08:53 PM
I am positive you wont be prescribed Xyrem. Its classified as an orphan drug and your doctor would have to go though a bunch of steps to get it for you. And its only prescribed for narcolepsy w/ cataplexy or narcolepsy w/ excessive daytime sleepiness. And its about 2 thousand dollars a month, and chances are insurance wont cover it unless you have one of those above conditions.

Kaimei
05-09-11, 09:24 PM
GHB? Holy &#$% - that's some scary stuff, even as a prescription. That's a seriously hardcore drug, no matter which side of the law you're looking at it from.

There are a hundred different options that are significantly less drastic than Xyrem. It's definitely not indicated for treatment of a relatively simple sleep disorder. What else have you tried?!?

cread408
05-28-11, 08:51 AM
isn't GHB the "date rape" drug?

tambourine-man
05-28-11, 12:46 PM
Ha ha! Ask your doc about it. While your at it, ask if there is any way he could still prescribe methaqualone. Tell him it has been a long time since you dropped a lude but if there was anyway to get ahold of em you'd really owe him big.

Yes, Xyrem (GHB, or Gamma-Hydroxy-Butyrate) is a date rape drug and club drug. Never tried it but was recently at the hospital speaking to a little old lady with narcolepsy who took Xyrem an Provigil. She was quite alarmed that I knew more about her drugs than she did and wasn't even narcoleptic!

lolwut
06-09-11, 05:53 AM
Actually alcohol is the date rape drug.
GHB is a "seriously hardcore" drug? It's extremely similar to alcohol, which is legal, and it's also found naturally in the human brain. I guess you and me both are on a seriously hardcore drug right now, eh? :rolleyes:

VOltaire
02-15-13, 12:18 PM
Better chance of winning the lottery!

starry
02-16-13, 08:04 AM
..... Tell him it has been a long time since you dropped a lude but if there was anyway to get ahold of em you'd really owe him big.



Hehehe!!! :p Brilliant!

JR1973
03-08-13, 10:24 AM
I don't know about prescribing it for sleep issues for ADHD but it is only approved for narcolepsy and off label for fibromyalgia. Several of the internet sleep forums show that it is also prescribed for insomnia and sleep apnea as well.

Very few doctors (Neurologists are most common) are familiar with it and how to properly dose it. There are a couple of hurdles to getting it. It is majorly expensive from what I hear. Without insurance a 1 month bottle costs a couple thousand bucks. The other hurdle is that it requires the doctor to submit paperwork to the manufacturer to get registered then everything has to go to a centralized mail order pharmacy. The pharmacy gets the script then coordinates with the patient for delivery and dosing instructions.

quickiB
03-11-13, 12:10 AM
You won't get it trust me. Since some stupid pharma company got orphan status for it, its crazy expensive. The date-rape stuff was ********, the FDA saw an extremely effective and safe medicine/nutrient that could take a lot of business away from addictive downright dangerous sleep meds among other competing pharmaceuticals and also people were having fun with it. Its not a big bad scary drug, its non-toxic and actually safer than alcohol. People who combined the two ran in to trouble, but if you're that ******* stupid, i guess everyone is therefore we should ban it....But yeah its pretty much impossible for anybody who's not narcoleptic/cataplectic to get rxed for it. Pity, I hear it helps tremendously with depression, and really deep sleep.

sarahsweets
03-11-13, 07:13 AM
Generally speaking its usually the DEA that f**ks things up and not so much the FDA



You won't get it trust me. Since some stupid pharma company got orphan status for it, its crazy expensive. The date-rape stuff was ********, the FDA saw an extremely effective and safe medicine/nutrient that could take a lot of business away from addictive downright dangerous sleep meds among other competing pharmaceuticals and also people were having fun with it. Its not a big bad scary drug, its non-toxic and actually safer than alcohol. People who combined the two ran in to trouble, but if you're that ******* stupid, i guess everyone is therefore we should ban it....But yeah its pretty much impossible for anybody who's not narcoleptic/cataplectic to get rxed for it. Pity, I hear it helps tremendously with depression, and really deep sleep.

hawesg
03-12-13, 03:42 AM
It's not out of the realm of possibilities, very unlikely though. I take xyrem for insomnia, but it is a rather extreme case this is after years of going through every thing else there is, not to mention the fact that it's a combination sleep initiation and sleep maintenance, that is present all the time, that refused to be dealt with with less extreme measures. That being said I do have ADHD (Dexedrine spanules 30mg) and a sleeping disorder for which I take xyrem and ambien, so it's not impossible to picture a world where that might be necessary. As for GHB being a hardcore drug, it's about dose and context. The same is true of amphetamine, at a therapeutic dose for someone with ADHD it's not a hardcore drug, take someone who doesn't have ADHD and raise that does substantially and it fits the bill much more than GHB.

baical
10-10-15, 01:57 AM
Funny how the maker of Xyrem, Jazz Pharmaceuticals have their stock price way high and climbing. They are the sole manufacturer of prescription GHB in the U.S. I think. The stock price being high says something that there is money in a niche product/market. Someone is taking Xyrem, which means someone is prescribing them. And yes, someone approved prescription "date rape" drug (GHB), the FDA! Yay!

For the lack of knowledge, light dose GHB is a stimulant, a powerful aphrodisiac, boosts workouts/muscle pumps/HGH releaser, since it is used for weakened muscles (aka cataplexy) etc. At the dose it is prescribed, about 2.5 grams, it puts you to sleep in about 5 minutes. That's where it's "date rape" status came about yet I think it's really other drugs being used (something easier to find), it's just GHB got the bad rep. Ask Bill Cosby what's he using to drug those "women".

Oh and for the curious, it is gabaergic drugs, like GHB, that may be potent in ending all OCD-like symptoms (off-label). The Russian drug called Picamilon is a combo of GABA and Niacin, both over the counter supplements you can buy in stores. Picamilon can be bought without a prescription as well. I have tried it. Works for OCD symptoms. GABA supplements do not cross the blood brain barrier quite well unless niacin is attached to it so comes the creation of a new molecule called Picamilon (GABA/Niacin). GHB is derived from the over-the-counter dietary supplement, GABA added with some lye (sodium hydroxide). That's where GHB (gamma-hydroxybutyric acid) comes about. Shocking!

GHB is supposedly easier to make in the kitchen than meth!

GHB is only a schedule 3 drug, meaning MY Vyvanse (a schedule 2 drug) should be more "dangerous" than GHB. The dose makes the poison. Remember that!

Europe's version of Xyrem is called Alcover, used for the treatment of alcoholism.

"γ-Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, is a naturally occurring substance found in the human central nervous system, as well as in wine, beef, small citrus fruits, and in small amounts in almost all animals.[3]"

"GHB has been used in a medical setting as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance.[7]"

Wikipedia

baical
10-10-15, 01:59 AM
both DEA and FDA are in bed together just so you know.

Generally speaking its usually the DEA that f**ks things up and not so much the FDA

baical
10-10-15, 02:22 AM
Hawesg, how did you get Xyrem? Is it as complicated as how JR1973 explained it? I would assume a neurologist would have to prescribe it and NOT a psychiatrist? Must actual "physical" symptoms be "shown" for Xyrem to be prescribed to anyone? As you know psychiatric issues like ADHD does NOT always need to have "physical proof" you have ADHD, since there isn't one. It's all about how you feel, what the doctor thinks you may have, etc. and what's in the guidelines of those diagnostic books they usually go by.

Did you visit a neurologist? I don't buy what JR1973 is saying considering the manufacturer of Xyrem (Jazz Pharma) have its stock high, meaning people are getting their products without the hassle and that's how money is made. Also, consider Xyrem is only schedule 3, not schedule 2 like the amphetamines yet Vyvanse is easier to find. A schedule 3 drug like Xyrem should be easier to find without the hassle that was described by JR1973.

I don't know about prescribing it for sleep issues for ADHD but it is only approved for narcolepsy and off label for fibromyalgia. Several of the internet sleep forums show that it is also prescribed for insomnia and sleep apnea as well.

Very few doctors (Neurologists are most common) are familiar with it and how to properly dose it. There are a couple of hurdles to getting it. It is majorly expensive from what I hear. Without insurance a 1 month bottle costs a couple thousand bucks. The other hurdle is that it requires the doctor to submit paperwork to the manufacturer to get registered then everything has to go to a centralized mail order pharmacy. The pharmacy gets the script then coordinates with the patient for delivery and dosing instructions.

It's not out of the realm of possibilities, very unlikely though. I take xyrem for insomnia, but it is a rather extreme case this is after years of going through every thing else there is, not to mention the fact that it's a combination sleep initiation and sleep maintenance, that is present all the time, that refused to be dealt with with less extreme measures. That being said I do have ADHD (Dexedrine spanules 30mg) and a sleeping disorder for which I take xyrem and ambien, so it's not impossible to picture a world where that might be necessary. As for GHB being a hardcore drug, it's about dose and context. The same is true of amphetamine, at a therapeutic dose for someone with ADHD it's not a hardcore drug, take someone who doesn't have ADHD and raise that does substantially and it fits the bill much more than GHB.

farmreduction
07-17-16, 05:25 PM
I know that this a late reply to a year old post, but hopefully someone full find it helpful. I have both ADHD (mixed), and Delayed Sleep Phase Syndrome (severe classification). DSPS (newer texts call it DSPDisorder), in a nutshell is a consistent misalignment of your circadian rhythm, in my case (severe) my internal clock it pushed forward by about 6-8 hours (depending on the light levels of the season). I get tired about 5-7 am, just as the sun comes out, and am able to sleep normally at this time, but am unable to alter. It's been a lifelong issue, and adjusting to the 9-5 world has been difficult to say the least.

Now to the Xyrem part... Because of the severity of my DSPS, the ineffectiveness of traditional sedative/stimulant therapy, and the fact that many symptoms are actually shared with narcolepsy, I was prescribed Xyrem. I started out on 3.5grams, twice nightly, and after some adjustment, i settled at about 8.5grams 2x/night, a large dose, but not incredible. my sleep specialist, was one of only two Dr's in my state who had the very specific license that is required in order to prescribe Xyrem, and he only saw patients who were referred by other sleep specialists. There is a damn good reason that the government puts these restrictions in place...

Xyrem does not act like any sedative i've ever taken before or since; it is in it's own class. When it kicks in, you feel a bit drunk before you go to sleep, and "time travel" to 4 hours later, when you take your second dose. During these 4 hour periods- you appear to be comatose! You cannot be awakened, and you have to take your doses in bed, otherwise you can literally pass out walking, with fuzzy to no memory of simply getting out of bed to pee real quick. It fully treats DSPS, Narcolepsy, and actually helps ADHD, as your 8 hours of "time travel" sleep is entirely REM sleep (about 4x the restorative sleep you get from a normal 8-hr sleep).

Xyrem is both a wonder drug, and the most f'n dangerous drug on the planet. I stopped taking it about a decade ago, because of the dangers associated with it (a la i had a roommate who was stealing it whilst i slept, and i don't know if he was using it to get high, or to prey on women, or other people), the interactions (Xyrem + any CNS depressant = dead), and the intense controls placed on it (It a CIII for dependence, but is a CI Narcotic for any non-legal use [same penalties as heroin- more restricted than cocaine, pcp, methamphetamine) . I may consider going back on it one day, but will take soul-searching...

long story short- Unless you suffer from one of the rare few debilitating, lifelong conditions it is narrowly approved for, don't even consider it as a viable medicinal option (for your own sake)