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<![CDATA[ADD Forums - Attention Deficit Hyperactivity Disorder Support and Information Resources Community - Adult Diagnosis & Treatment]]> http://www.addforums.com/forums This forum is for the discussion of issues related to the diagnosis of AD/HD en Mon, 25 Jun 2018 00:41:30 GMT vBulletin 60 http://www.addforums.com/forums/images/misc/rss.jpg <![CDATA[ADD Forums - Attention Deficit Hyperactivity Disorder Support and Information Resources Community - Adult Diagnosis & Treatment]]> http://www.addforums.com/forums <![CDATA[How to get Adderall & How much does ADHD assessment test costs?]]> http://www.addforums.com/forums/showthread.php?t=192145&goto=newpost Sun, 24 Jun 2018 15:24:18 GMT I'm diagnosed as ADHD in China in the best hospital there, and there are only Concerta and Strattera in China.

I have already tried 18mg and 36mg Concerta and they don't work. The side effect of 36mg is strong so I'm not thinking about 54mg. I think maybe I just don't react well to Methylphenidate.

After summer vacation ends I will be able to come back to America and get Adderall. I wonder do I have to do the ADHD assessment test again to get Adderall? How much does it cost?

Thanks!! ]]>
liliyalich http://www.addforums.com/forums/showthread.php?t=192145
<![CDATA[SO Confused/Why Don't MY Meds Seem To Be Working?]]> http://www.addforums.com/forums/showthread.php?t=192039&goto=newpost Fri, 15 Jun 2018 21:00:29 GMT I would love any valuable input. I have finally been diagnosed with ADD Inattentive (Have known it for years and years). However, none of the meds seem to be making any noticeable difference. My first two weeks were on Ritalin - 20 mg, 2X daily. Now, I am on Adderal - 20 mg. 2X daily, and still no... I would love any valuable input. I have finally been diagnosed with ADD Inattentive (Have known it for years and years). However, none of the meds seem to be making any noticeable difference. My first two weeks were on Ritalin - 20 mg, 2X daily. Now, I am on Adderal - 20 mg. 2X daily, and still no noticeable difference. No side effects, no lack of sleep, etc. Let me say that there is no way I am misdiagnosed. I am textbook ADD Inattentive. I would greatly appreciate anyone's input as to why this is happening. I go back to m Dr. in four weeks. Thank you!!! ]]> GrayBulldog http://www.addforums.com/forums/showthread.php?t=192039 Insomnia on Dexedrine Vs. Ritalin (experiences?) http://www.addforums.com/forums/showthread.php?t=191927&goto=newpost Mon, 04 Jun 2018 23:43:10 GMT Hi,
Just curious - anyone have any experience with both of these meds and if say Ritalin has less chance of causing insomnia?

Twice I've tried dexedrine and by the second day (two doses a day), I had horrid insomnia. I will try the doses earlier but if i need coverage all day, this won't work out.

Or will the insomnia effects wear off after a week? Do i just have to regulate my body over time? Or will I know from the get-go how my body reacts sleep-wise.

Btw...the dexedrine made me sleepy , and then i felt it work mildly, and then wear off, and it was long out of my system as far as it's effects and yet i had horrid insomnia and did not feel good (happened twice and long after i felt the effects wore off)

Curious about others' experiences - thanks ]]>
JellyBeanBear http://www.addforums.com/forums/showthread.php?t=191927
ADHD and Methylation Analysis http://www.addforums.com/forums/showthread.php?t=191900&goto=newpost Sun, 03 Jun 2018 15:00:11 GMT Anyone got good info on this? Writing a letter to my GP but would appreciate any input

------
Hey, I was told I needed to write a letter to request my blood test

Was researching the link between EDS & ADHD and someone mentioned MTHFR. Ran my 23andme data through a gene genie and I have quite a few genes which could be exacerbating my symptoms. The science is still in it’s infancy but I’m pretty sure it isn’t pseudoscience. I believe I have 8 heterozygous mutations which are linked to EDS or ADHD in someway.

Checks I need : calcium, phosphate, vit D, B12, Serine, Threonine, Zinc, glycine, folate, homocysteine*levels.
Hoping most of these are fine just not sure which ones were tested for during my blood test - would you be able to email it over to me?


---research ive been doing---

You have 0 homozygous (+/+) mutations and 8 heterozygous (+/-) mutations.

There seems to be conflicting evidence over whether individuals with the mutation can supplement with folate or folic acid to the same effect.

Gene & Variation rsID Alleles Result
COMT V158M rs4680 AG +/-
COMT H62H rs4633 CT +/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAO-A R297R rs6323 GG -/-
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 AG +/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 TT -/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 AA -/-
MTRR H595Y rs10380 __ no call
MTRR K350A rs162036 AG +/-
MTRR R415T rs2287780 __ no call
MTRR A664A rs1802059 AG +/-
BHMT-02 rs567754 CC -/-
BHMT-04 rs617219 __ no call
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 TT -/-
AHCY-02 rs819134 __ no call
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 GG -/-
CBS A360A rs1801181 AG +/-
CBS N212N rs2298758 __ no call
SHMT1 C1420T rs1979277 __ no call



MTHFR: Another Piece of the ADHD-Genetics Puzzle from ADDitude Magazine

MTHFR Treatment: The Complete Guide

Reddit: "Finding Genetic Markers that can contribute to ADHD, and Can Help Treat A Slew of Issues"

Reddit: "IsItBull****: MTHFR gene mutation and it's consequences"


COMT V158M - As S-adenosylhomocysteine (SAH) accumulates, the COMT enzyme may become impaired. Inhibitiion of COMT can increase dopamine levels in COMT V158M (-/-)

combinations of variations COMT and VDR Taq can lead to a wide range of dopamine levels

VDR Mutations (+/-)
Checks : calcium and phosphate, vit D

VDR (Vitamin D Receptor) encodes the nuclear hormone receptor for vitamin D3. Low or low normal vitamin D values are often seen in those with chronic illness and even the general population. Low vitamin D is related to a lot of neurological and immunological conditions. Vitamin D stimulates enzymes that create dopamine.
VDR Tak and VDR Bsm are usually inverse from eachother. So if there is a (+/+) VDR Tak, there would be a (-/-) VDR Bsm. However, this is not always the case.
It has been clinically observed that the body may have trouble tolerating methyl donors with a COMT V158M + and a VDR Taq + status. VDR Taq (-/-) individuals may already have higher levels of dopamine, and combinations of variations COMT and VDR Taq can lead to a wide range of dopamine levels. Those that are VDR Taq (+/+) and COMT (-/-) may have lowest dopamine levels.
Note: Some have pointed out that VDR Taq is reported backwards since majority of medical journals report a different risk allele or use different notation. These arguments are well-founded, but Genetic Genie reports this way so results are compatible with existing methylation nutrigenomics literature. Many claims about VDR and methylation are clinical observations. There are no medical studies to support some of the observations.


MTR/MTRR Mutations - MTRR A664A(+/-) / MTRR K350A (+/-)
Checks : B12

MTRR (Methionine synthase reductase) helps recycle B12. The combination of MTR and MTRR mutations can deplete methyl B12. MTR A2756G, MTRR A66G, MTRR H595Y, MTRR K350A, MTRR R415T, MTRR S257T, and MTRR A664A all work together to convert homocysteine to methionine.
MTR (5-methyltetrahydrofolate-homocysteine methyltransferase) provides instructions for making the enzyme methionine synthase. Methionine synthase helps convert the amino acid homocysteine to methionine. To work properly, methionine synthase requires B12 (specifically in the form of methylcobalamin). An MTR A2756G mutation increases the activity of the MTR gene causing a greater need for B12 since the enzyme causes B12 to deplete since it is using it up at a faster rate. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency. Megaloblastic anemia can occur as a consequence of reduce methionine synthase activity.
A homozygous mutation of MTR A2756G is not very common (<1% of CEU population). Some studies have demonstrated that people with a combination of MTHFR C677T and MTR A2756G have persistently high homocysteine levels unless they are treated with both B12 and folate.

BHMT mutations 08 - +/-
Checks : Serine, Threonine, Zinc, glycine?
Main : Autism: Pathways to Recovery, She also states that a BHMT 08 mutation may "increase MHPG levels relative to dopamine breakdown (HVA)". This can result in attention type symptoms. It is common to see elevated glycine in someone with a homozygous BHMT 08 mutation.

BHMT*problems / Symptoms
* Problem with gut function
* Neural tube defects
* Liver detoxification problems
* Homocysteine imbalances

Serine deficiency*– Brain function, nervous system, immune system,*chronic fatigue syndrome (CFS), depression,*insomnia, confusion, anxiety, fibromyalgia.
Threonine deficiency*– Cardiovascular problems, liver, central nervous system, immune system, liver failure (fatty liver), depression,*Amyotrophic Lateral Sclerosis (ALS).

BHMT (betaine homocysteine methyltransferase) acts as a shortcut through the methylation cycle helping convert homocysteine to methionine. The activity of the enzyme can be negatively influenced by stress. The Information on this enzyme related to methylation is mostly based on Dr. Amy Yasko's clinical experience and research.
According to Dr. Yasko, a homozygous mutation of BHMT 01, BHMT 02, BHMT 04, can produce results similar to one with a CBS upregulation even if you don't have a CBS upregulation. In her book, Autism: Pathways to Recovery, She also states that a BHMT 08 mutation may "increase MHPG levels relative to dopamine breakdown (HVA)". This can result in attention type symptoms. It is common to see elevated glycine in someone with a homozygous BHMT 08 mutation.


CBS Mutations - A360A +/-
CBS (cystathionine beta synthase) catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine. CBS defects are actually an upregulation of the CBS enzyme. This means the enzyme works too fast. In these patients, it's common to see low levels of cystathionine and homocysteine since there is a rapid conversion to taurine. This leads to high levels of taurine and ammonia. The CBS upregulation has been clinically observed to result in sulfur intolerance in some patients. It has also been observed that BH4 can also become depleted with a CBS upregulation. BH4 helps regulate neurotransmitters and mood. Other mutations, such as MTHFR A1298C, Chronic bacterial infections, and aluminum can also lead to low BH4 levels. Lack of BH4 can lead to mast cell degranulation and possibly mast cell activation disorder (MCAD).
Note: While some physicians think the CBS mutation is one of the most important mutations to address, there is very little medical research to support these claims and some doctors in the field disagree. In normal populations, studies have shown CBS upregulations to be protective against high homocysteine. However, CBS upregulations have shown to be harmful in Down Syndrome. Medical research has not determined if CBS upregulations are harmful in those with syndromes or disorders leading to impaired methylation. ]]>
unomie http://www.addforums.com/forums/showthread.php?t=191900
My possible ADD http://www.addforums.com/forums/showthread.php?t=191872&goto=newpost Fri, 01 Jun 2018 13:21:02 GMT Hello. I have recently started looking into ADHD stuff due to finally being fed up with stuff I've struggled with and have came to some big realizations I think. For my first post I thought I'd explain my situation and get a few opinions as I have just started recently learning about it.

Here's what I believe may be ADD related. I have had some mild anxiety for several years and have started trying to analyze it to track down the cause. I'm starting to realize that I the anxiety is atleast partially stress from the ADD symptoms.
- I am a heavy procrastinator. I've always had a very hard time "getting around to" alot of projects and obligations. And it's like the thought of starting on some things sort of slips my mind alot of times and I end up doing something else.
- Forgetting things and somewhat absent mindedness at a moderate level.
- Definite focus problems. At work or home working on projects, or even talking to people I have a hard time maintaining focus. I'm constantly thinking and alot of times (more often than not) when I'm working I am constantly thinking of other things especially when the work is somewhat slow, my mind drifts to other subjects. Alot of times the thoughts are remembering things I was supposed to do previously but had forgot :D. Example: I'm working on something and I start thinking about something I was going to fix on my truck, then i might think "well while I'm thinking about it I better look up that part real quick on my phone so I dont forget again", go ahead and look up the part and get sidetracked looking up a few more things before I suddenly realize I'm supposed to be working. I'm constantly almost non stop thinking about all kinds of stuff when I'm trying to work. Other times I can get focused and it's almost like im obsessed or completely zoned out on what I'm working on. My boss (also my good friend) sometimes gives me a hard time when I'm in my "zone" because he'll say something to me and I won't even realize it because I'm so focused on what I'm doing, which is kind of funny. I just wish I could get in that zone when I wanted or more often so I could get more done because it feels good actually accomplishing something. But it usually just happens when it's something I'm interested in and fun or when I'm racing the clock to finish up stuff that I have previously slacked on and put off till the last minute and the adrenaline kicks in.
- When I'm talking to someone for a while and start losing focus, my thought will wonder a bit and I loose track of what's being said and I kind of have blank moments.

There's much more I'm not remembering at the moment. But I think having so much trouble keeping focused and finishing stuff in a timely manner and also the fact that I jump around and am always starting new projects before finishing others is causing the anxiety and stress dread and fatigue, which I had always just chalked up to simple anxiety.

I'm out of time at the moment, just realized I'm going to be late for work if I don't stop here lol. I'll have to finish my story later in my next post. ]]>
DieselFreak http://www.addforums.com/forums/showthread.php?t=191872
Getting back into the game http://www.addforums.com/forums/showthread.php?t=191825&goto=newpost Mon, 28 May 2018 16:34:01 GMT I've recently had some incidents at work that center around my memory issues (ADD). Most recently forgetting a binder on top of vehicle and driving off with it up there. Not the worst thing in the world..... except I did the same thing about 2 months ago. I've struggled with learning disabilities all my life (I suffered oxygen deprivation at birth). I've done okay for myself given my shortcomings, but have always had trouble being even "average" at any of my jobs.

Anyway i've decided my work issues are getting serious enough that my job could be in jeopardy and I need to address them. I don't really want to go the pharma route, it's been ten years but tried that already. I went to a specialist and we tried all sorts of drugs. By the end I was on four meds at the same time and felt like crap. I would like to go the natural route this time.

After research I thought a good starting place would be ALPHA-GPC & Uridine, 300 mg each. I received the ALPHA yesterday and took my first dose last night and also this AM when I woke up. Both times a headache almost immediately started. So far today it's worn off some but still is in the background. Otherwise I do feel a little jittery (somewhat elevated heartbeat) but no other issues. How long do i put up with the headaches before saying enough is enough? Will the addition of Uridine help? I'm wondering if anybody has any tips for these supplements, i've read that eating eggs isn't a great idea while using the ALPHA??? Any insight, help is greatly appreciated.

PS: I've been taking 40mg celexa for several years for my depression and frankly don't think it's working any longer. ]]>
slo-mo-dad http://www.addforums.com/forums/showthread.php?t=191825