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dirusali 03-08-18 03:29 PM

Is Vyvanse duration a huge lie?
Hi guys

I have tried Vyvanse myself and researched its mechanism of action.

Please guys, correct me if I am wrong but basically the only difference I can see between taking Vyvanse and taking pure Dexamphetamine (Dexedrine IR for example) is the 1-2 hours that takes to break lisdexamphetamine molecules and convert them into Dextroamphtetamine.

So, obviously the duration of Vyvanse action should be maximum 1-2 hours longer than dexedrine. If dexedrine IR lasts 5 hourse then Vyvanse lasts 5-7 hours. Period.

So Vyvanse 12 advertised hours of action sound like a joke to me.

Am I missing something or they are just openly lying to us with Vyvanse?


Lunacie 03-08-18 05:55 PM

Re: Is Vyvanse duration a huge lie?
Vyvanse did a study of adults that shows that Vyvanse lasts 14 hours.
I don't know if this study has been replicated. But a controlled study is often
very different from everyday life. Everyone metabolizes meds differently, and
many report anything from 6 to 8 hour duration, with a few saying that they
get 10 or more hours of coverage.

sarahsweets 03-09-18 05:56 AM

Re: Is Vyvanse duration a huge lie?
Well at least I do not have to disclose my bias against vyvanse in this thread. I hate it. It never seems to last as long as its purported to. Shire has the patent and its grossly expensive (even though oversees there is a generic) its heavily marketed as THE solution to taking those pesky pills more than once a day. Its heavily marketed towards children. It takes a couple of hours to work. Its the weakest mg per mg of all amphetemines. Dexedrine already exists, and in people who do not tolerate it well there can be extreme moodiness and awful headaches. I could go on and on. But no, OP you are not imagining things.

Lash107 03-09-18 07:26 AM

Re: Is Vyvanse duration a huge lie?
Vyvanse was quite disappointing for me. It didnít start working for at least two hours and it always wore off by ten I was benefitting from the medication eight hours, maximum. I switched to Adderall IR and have had better results. Good luck.

Little Nut 03-09-18 11:28 AM

Re: Is Vyvanse duration a huge lie?
My understanding is the reaction of interest occurs in your bloodstream and it does not ALL happen at the SAME time. I look at it as the Vyvanse is metabolized to the amphetamine over a period of time. Then in-turn the available amphetamine is metabolized over time. I never looked into the kinetics of the reactions involved, but it seems reasonable that when compared to taking a single dose of Dexedrine IR the effects would be spread out over a longer duration. How long a duration I have always assumed is different for each individual. -LN

tristmegitus2 03-10-18 01:50 PM

Re: Is Vyvanse duration a huge lie?
One of the things that suppose to make Vyvanse be really long lasting and act as a non abusable alternative to Adderall is how the formulation consists of a Lysine amino acid cleaved to the detroamphetimine. Since lysine is a amino acid, the dextro does not enter your blood stream through your stomach but becomes metabolized by your liver which slowly turns the dextro in a useable form for your body to use. For me I did not really get the 14 hours of coverage like it said. The length to me was just the same as an instant release tablet which I honestly cant tell the difference between instant release and long acting. I was on 40mg vyvanse which I couldn't afford so I switched back to what I was originally on which was 20mg Adderall twice a day which I never really bothered discussing the change until I found I a Np that I feel comfortable with and have an established patient-doctor relationshionship with. The lysine was very smart for shire to formulate into the stimulate since its provides what a lot of users say as a smooth come up and a smooth comedown which when I was on it, the comedown was really smooth somewhat more smoother than the instant release Adderall but I tolerate comedowns pretty well. The studies that shire did to estimate the length of effect of vyvanse was on patients who ate a certain protein diet. Protein to my understanding allows the liver to excrete more of the enzyme that breaks down the lysine so your body will have more bioavailability of the dextro from the vyvanse.

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