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Old 02-09-18, 03:55 PM
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Re: Genetics of ADHD presentation?

Quote:
Originally Posted by sarahsweets View Post
I wonder if certain genetic variants can be "activated" or "deactivated" over a lifetime? Like lets say someone was ADHD-C or H their whole childhood and then abruptly when they are 24 its like it all changes to just PI? They would still be considered C or subthreshold C? Can someone's diagnosis or presentation change like that officially or is it always the same no matter what?
It is possible -- maybe even likely -- that genes related to ADHD could be up-regulated (more gene expression) or down-regulated (less gene expression) throughout life, and that this upregulation or downregulation could influence symptoms/presentation.

In a lot of cases, I'd think that these changes wouldn't be quite so abrupt. Take something like puberty, which occurs over a period of years -- and which can affect ADHD symptoms in a lot of people. But in theory, even relatively abrupt changes could be possible, with the right triggers.

I think ADHD (and its presentation) is more complicated than just a gene or three being upregulated or downregulated, though, and we don't know all of the genes that are relevant to ADHD.

Per DSM-5, presentation is based only on recent symptoms. Yes, presentation can change throughout life. You just have the single diagnosis ADHD throughout your lifetime (once diagnosed, and assuming you don't grow out of it!), and its presentation can vary.

Russell Barkley would consider anyone who ever met (or came close to meeting) the criteria for ADHD (combined presentation) to have "classic" (combined presentation) ADHD, even if they become less physically hyperactive over time, to the point that the presentation of their ADHD becomes predominantly inattentive.
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