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Old 06-02-08, 01:50 PM
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Re: Problems with onions???

I love raw onions myself.

Interested in why they could make a person sleepy.
People with fructose intolerence are told to avoid onions according to this.

Another idea is fructan: "Vegetables with the highest quantity of fructans included garlic, artichoke, shallots, leek bulb, and onions".

Chocolate: 9.4%[3]

Onion: 1.1-10.1%[1]
Hmm that suggest chocolate would have to have the same effect in the amounts you likely eat. So fructan metabolism might not be it.

Another substance in onion is quercetin but its may even blocks substances involved in allergies. It mentions it can down-regulate histidine decarboxylase.
Which makes me think anti-histamine like action.

Interesting histidine decarboxylase knock-out mice had a hard time staying awake.

mice lacking brain histamine are unable to remain awake, a prerequisite condition for responding to behavioral and cognitive challenges.

Foods rich in quercetin include capers (1800mg/kg)[1], lovage (1700mg/kg), apples (440mg/kg), tea (Camellia sinensis), onions (higher concentrations of quercetin occur in the outermost rings.
it inhibits both the manufacture and release of histamine

Atomoxetine increases histamine release and improves learning deficits in an animal model of attention-deficit hyperactivity disorder.

Methylphenidate and atomoxetine increase histamine release in rat prefrontal cortex.
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